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Nathan D. Trinklein, Ph.D. - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Avanzino BC, Prabhakar K, Dalvi P, Hartstein S, Kehm H, Balasubramani A, Boudreau AA, Buelow B, Chang K, Davison LM, Iyer S, Kalwit V, Lewis Wilson K, Malik-Chaudhry HK, Pierson W, ... ... Trinklein ND, et al. A T-cell engaging bispecific antibody with a tumor-selective bivalent folate receptor alpha binding arm for the treatment of ovarian cancer. Oncoimmunology. 11: 2113697. PMID 36016696 DOI: 10.1080/2162402X.2022.2113697  0.385
2021 Dang K, Castello G, Clarke SC, Li Y, Balasubramani A, Boudreau A, Davison L, Harris KE, Pham D, Sankaran P, Ugamraj HS, Deng R, Kwek S, Starzinski A, Iyer S, ... ... Trinklein ND, et al. Attenuating CD3 affinity in a PSMAxCD3 bispecific antibody enables killing of prostate tumor cells with reduced cytokine release. Journal For Immunotherapy of Cancer. 9. PMID 34088740 DOI: 10.1136/jitc-2021-002488  0.317
2021 Malik-Chaudhry HK, Prabhakar K, Ugamraj HS, Boudreau AA, Buelow B, Dang K, Davison LM, Harris KE, Jorgensen B, Ogana H, Pham D, Schellenberger U, Van Schooten W, Buelow R, Iyer S, ... Trinklein ND, et al. TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL. Mabs. 13: 1890411. PMID 33818299 DOI: 10.1080/19420862.2021.1890411  0.428
2020 Vafa O, Trinklein ND. Perspective: Designing T-Cell Engagers With Better Therapeutic Windows. Frontiers in Oncology. 10: 446. PMID 32351885 DOI: 10.3389/Fonc.2020.00446  0.472
2020 Lam N, Trinklein ND, Buelow B, Patterson GH, Ojha N, Kochenderfer JN. Author Correction: Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains. Nature Communications. 11: 1319. PMID 32152289 DOI: 10.1038/S41467-020-15145-8  0.344
2020 Lam N, Trinklein ND, Buelow B, Patterson GH, Ojha N, Kochenderfer JN. Anti-BCMA chimeric antigen receptors with fully human heavy-chain-only antigen recognition domains. Nature Communications. 11: 283. PMID 31941907 DOI: 10.1038/S41467-019-14119-9  0.455
2020 Buelow B, Avanzino B, Balasubramani A, Boudreau A, Davison L, Ganesan P, Harris K, Hartstein S, Malik-Chaudhry H, Pham D, Prabhakar K, Rangaswamy U, Saiganesh S, Schellenberger U, Ugamraj H, ... ... Trinklein N, et al. A CD3 x FRα T-cell engaging bispecific antibody for efficient killing of ovarian cancer cells with minimal cytokine release. Journal of Clinical Oncology. 38: e18050-e18050. DOI: 10.1200/Jco.2020.38.15_Suppl.E18050  0.548
2019 Trinklein ND, Pham D, Schellenberger U, Buelow B, Boudreau A, Choudhry P, Clarke SC, Dang K, Harris KE, Iyer S, Jorgensen B, Pratap PP, Rangaswamy US, Ugamraj HS, Vafa O, et al. Efficient tumor killing and minimal cytokine release with novel T-cell agonist bispecific antibodies. Mabs. PMID 30698484 DOI: 10.1080/19420862.2019.1574521  0.811
2019 Clarke S, Dang K, Li Y, Sankaran P, Pham D, Balasubramani A, Davison L, Harris K, Jorgensen B, Schellenberger U, Trinklein N, Ugamraj H, Buelow R, Van Schooten W, Force Aldred S, et al. A novel CD3xPSMA bispecific antibody for efficient T cell mediated killing of prostate tumor cells with minimal cytokine release. Journal of Clinical Oncology. 37: 324-324. DOI: 10.1200/Jco.2019.37.7_Suppl.324  0.808
2019 Buelow B, Clarke S, Dang K, Li J, Rancan C, Li Y, Sankaran P, Pham D, Balasubramani A, Davison L, Harris K, Jorgensen B, Schellenberger U, Trinklein N, Ugamraj H, et al. Evaluation of monovalent versus biparatopic CD3xPSMA bispecific antibodies for t-cell mediated killing of prostate tumor cells with minimal cytokine release. Journal of Clinical Oncology. 37: e16519-e16519. DOI: 10.1200/Jco.2019.37.15_Suppl.E16519  0.809
2019 Mikkilineni L, Manasanch EE, Lam N, Vanasse D, Brudno JN, Maric I, Rose JJ, Stetler-Stevenson M, Wang H, Yuan CM, Stroncek DF, Mann J, Ganadan M, Patel R, Trinklein N, et al. T Cells Expressing an Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptor with a Fully-Human Heavy-Chain-Only Antigen Recognition Domain Induce Remissions in Patients with Relapsed Multiple Myeloma Blood. 134: 3230-3230. DOI: 10.1182/Blood-2019-129088  0.42
2019 Malik H, Buelow B, Rangaswamy U, Balasubramani A, Boudreau A, Dang K, Davison L, Force Aldred S, Harris KM, Iyer S, Jorgensen B, Pham D, Prabhakar K, Schellenberger U, Ugamraj H, ... Trinklein N, et al. TNB-486, a Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills CD19-Positive Tumor Cells with Minimal Cytokine Secretion Blood. 134: 4070-4070. DOI: 10.1182/Blood-2019-123226  0.809
2019 Lorentsen K, Sankaran P, Trinklein ND, Pham D, Schellenberger U, Buelow B, Boudreau A, Choudhry P, Clarke SC, Dang K, Harris KE, Iyer S, Jorgensen B, Pratap P, Rangaswamy US, et al. Abstract 1554: Uncoupling tumor-cell cytotoxicity from cytokine release with novel T-cell engaging bispecific antibodies Cancer Research. 79: 1554-1554. DOI: 10.1158/1538-7445.Am2019-1554  0.554
2018 Clarke SC, Ma B, Trinklein ND, Schellenberger U, Osborn MJ, Ouisse LH, Boudreau A, Davison LM, Harris KE, Ugamraj HS, Balasubramani A, Dang KH, Jorgensen B, Ogana HAN, Pham DT, et al. Multispecific Antibody Development Platform Based on Human Heavy Chain Antibodies. Frontiers in Immunology. 9: 3037. PMID 30666250 DOI: 10.3389/fimmu.2018.03037  0.761
2018 Harris KE, Aldred SF, Davison LM, Ogana HAN, Boudreau A, Brüggemann M, Osborn M, Ma B, Buelow B, Clarke SC, Dang KH, Iyer S, Jorgensen B, Pham DT, Pratap PP, ... ... Trinklein ND, et al. Sequence-Based Discovery Demonstrates That Fixed Light Chain Human Transgenic Rats Produce a Diverse Repertoire of Antigen-Specific Antibodies. Frontiers in Immunology. 9: 889. PMID 29740455 DOI: 10.3389/Fimmu.2018.00889  0.404
2018 Bradbury ARM, Trinklein ND, Thie H, Wilkinson IC, Tandon AK, Anderson S, Bladen CL, Jones B, Aldred SF, Bestagno M, Burrone O, Maynard J, Ferrara F, Trimmer JS, Görnemann J, et al. When monoclonal antibodies are not monospecific: hybridomas frequently express additional functional variable regions. Mabs. 1-19. PMID 29485921 DOI: 10.1080/19420862.2018.1445456  0.399
2018 Buelow B, Choudhry P, Clarke S, Dang K, Davison L, Force Aldred S, Harris K, Pham D, Pratap P, Rangaswamy U, Schellenberger U, Shah N, Trinklein N, Ugamraj H, Wiita A, et al. Development of a fully human t-cell engaging bispecific antibody for the treatment of multiple myeloma. Journal of Clinical Oncology. 36: 60-60. DOI: 10.1200/Jco.2018.36.5_Suppl.60  0.81
2018 Force Aldred S, Boudreau A, Buelow B, Clarke S, Dang K, Davison L, Harris K, Iyer S, Jorgensen B, Ogana H, Pham D, Pratap P, Rangaswamy U, Schellenberger U, Trinklein N, et al. Multispecific antibodies targeting CD38 show potent tumor-specific cytotoxicity. Journal of Clinical Oncology. 36: 57-57. DOI: 10.1200/Jco.2018.36.5_Suppl.57  0.792
2018 Rangaswamy U, Boudreau A, Buelow B, Clarke S, Dang K, Davison L, Force Aldred S, Harris K, Iyer S, Jorgensen B, Ogana H, Pham D, Pratap P, Trinklein N, Schellenberger U, et al. A novel T-cell bispecific antibody platform for efficient T-cell mediated killing of tumor cells with minimal cytokine release. Journal of Clinical Oncology. 36: 209-209. DOI: 10.1200/Jco.2018.36.5_Suppl.209  0.812
2018 Buelow B, Choudry P, Clarke S, Dang K, Davison L, Force Aldred S, Harris K, Pratap P, Pham D, Rangaswamy U, Schellenberger U, Shah N, Trinklein N, Ugamraj H, Wiita A, et al. Pre-clinical development of TNB-383B, a fully human T-cell engaging bispecific antibody targeting BCMA for the treatment of multiple myeloma. Journal of Clinical Oncology. 36: 8034-8034. DOI: 10.1200/Jco.2018.36.15_Suppl.8034  0.789
2018 Malik H, Buelow B, Avanzino B, Balasubramani A, Boudreau A, Clarke S, Dang K, Davison L, Force Aldred S, Harris K, Jorgensen B, Li Y, Medlari H, Narayan K, Ogana H, ... ... Trinklein N, et al. A Novel Fully Human Bispecific CD19 x CD3 Antibody That Kills Lymphoma Cells with Minimal Cytokine Secretion Blood. 132: 1671-1671. DOI: 10.1182/Blood-2018-99-118913  0.808
2017 Lam N, Alabanza L, Trinklein N, Buelow B, Kochenderfer JN. T Cells Expressing Anti-B-Cell Maturation Antigen (BCMA) Chimeric Antigen Receptors with Antigen Recognition Domains Made up of Only Single Human Heavy Chain Variable Domains Specifically Recognize Bcma and Eradicate Tumors in Mice Blood. 130: 504-504. DOI: 10.1182/Blood.V130.Suppl_1.504.504  0.497
2017 Buelow B, Pham D, Choudhry P, Dang K, Pratap P, Clarke S, Harris K, Jorgensen B, Aldred SF, Schellenberger U, Shah N, Trinklein N, Wiita AP, Iyer S, Schooten WV. T Cell Engagement without Cytokine Storm: A Novel Bcma x CD3 Antibody Killing Myeloma Cells with Minimal Cytokine Secretion Blood. 130: 501-501. DOI: 10.1182/Blood.V130.Suppl_1.501.501  0.496
2016 Trinklein N, Aldred SF, Schellenberger U, Harris K, Clarke S, Dang K, Pham D, Bruggemann M, Wv. Abstract LB-090: Sequence-based discovery of fully human anti-CD3 and anti-PDL1 single domain antibodies using novel transgenic rats Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-090  0.472
2014 Smith RP, Eckalbar WL, Morrissey KM, Luizon MR, Hoffmann TJ, Sun X, Jones SL, Force Aldred S, Ramamoorthy A, Desta Z, Liu Y, Skaar TC, Trinklein ND, Giacomini KM, Ahituv N. Genome-wide discovery of drug-dependent human liver regulatory elements. Plos Genetics. 10: e1004648. PMID 25275310 DOI: 10.1371/Journal.Pgen.1004648  0.77
2012 Hastak K, Adimoolam S, Trinklein ND, Myers RM, Ford JM. Identification of a Functional In Vivo p53 Response Element in the Coding Sequence of the Xeroderma Pigmentosum Group C Gene. Genes & Cancer. 3: 131-40. PMID 23050045 DOI: 10.1177/1947601912456288  0.532
2012 Whitfield TW, Wang J, Collins PJ, Partridge EC, Aldred SF, Trinklein ND, Myers RM, Weng Z. Functional analysis of transcription factor binding sites in human promoters. Genome Biology. 13: R50. PMID 22951020 DOI: 10.1186/Gb-2012-13-9-R50  0.521
2010 Landolin JM, Johnson DS, Trinklein ND, Aldred SF, Medina C, Shulha H, Weng Z, Myers RM. Sequence features that drive human promoter function and tissue specificity. Genome Research. 20: 890-8. PMID 20501695 DOI: 10.1101/Gr.100370.109  0.588
2009 Hartzell DD, Trinklein ND, Mendez J, Murphy N, Aldred SF, Wood K, Urh M. A functional analysis of the CREB signaling pathway using HaloCHIP-chip and high throughput reporter assays. Bmc Genomics. 10: 497. PMID 19860899 DOI: 10.1186/1471-2164-10-497  0.416
2008 Johnson DS, Li W, Gordon DB, Bhattacharjee A, Curry B, Ghosh J, Brizuela L, Carroll JS, Brown M, Flicek P, Koch CM, Dunham I, Bieda M, Xu X, Farnham PJ, ... ... Trinklein ND, et al. Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Genome Research. 18: 393-403. PMID 18258921 DOI: 10.1101/Gr.7080508  0.484
2007 Collins PJ, Kobayashi Y, Nguyen L, Trinklein ND, Myers RM. The ets-related transcription factor GABP directs bidirectional transcription. Plos Genetics. 3: e208. PMID 18020712 DOI: 10.1371/Journal.Pgen.0030208  0.556
2007 Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, ... ... Trinklein ND, et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 447: 799-816. PMID 17571346 DOI: 10.1038/Nature05874  0.667
2007 Lin JM, Collins PJ, Trinklein ND, Fu Y, Xi H, Myers RM, Weng Z. Transcription factor binding and modified histones in human bidirectional promoters. Genome Research. 17: 818-27. PMID 17568000 DOI: 10.1101/Gr.5623407  0.572
2007 Trinklein ND, Karaöz U, Wu J, Halees A, Force Aldred S, Collins PJ, Zheng D, Zhang ZD, Gerstein MB, Snyder M, Myers RM, Weng Z. Integrated analysis of experimental data sets reveals many novel promoters in 1% of the human genome. Genome Research. 17: 720-31. PMID 17567992 DOI: 10.1101/Gr.5716607  0.773
2007 Cooper SJ, Trinklein ND, Nguyen L, Myers RM. Serum response factor binding sites differ in three human cell types. Genome Research. 17: 136-44. PMID 17200232 DOI: 10.1101/Gr.5875007  0.647
2006 Cooper SJ, Trinklein ND, Anton ED, Nguyen L, Myers RM. Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome. Genome Research. 16: 1-10. PMID 16344566 DOI: 10.1101/Gr.4222606  0.683
2005 Kim TH, Barrera LO, Qu C, Van Calcar S, Trinklein ND, Cooper SJ, Luna RM, Glass CK, Rosenfeld MG, Myers RM, Ren B. Direct isolation and identification of promoters in the human genome. Genome Research. 15: 830-9. PMID 15899964 DOI: 10.1101/Gr.3430605  0.696
2004 Feingold EA, Good PJ, Guyer MS, Kamholz S, Liefer L, Wetterstrand K, Collins FS, Gingeras TR, Kampa D, Sekinger EA, Cheng J, Hirsch H, Ghosh S, Zhu Z, Patel S, ... ... Trinklein ND, et al. The ENCODE (ENCyclopedia of DNA Elements) Project Science. 306: 636-640. PMID 15499007 DOI: 10.1126/Science.1105136  0.746
2004 Trinklein ND, Chen WC, Kingston RE, Myers RM. Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation. Cell Stress & Chaperones. 9: 21-8. PMID 15270074 DOI: 10.1379/1466-1268(2004)009<0021:Traboh>2.0.Co;2  0.495
2004 Murray JI, Whitfield ML, Trinklein ND, Myers RM, Brown PO, Botstein D. Diverse and specific gene expression responses to stresses in cultured human cells. Molecular Biology of the Cell. 15: 2361-74. PMID 15004229 DOI: 10.1091/Mbc.E03-11-0799  0.495
2004 Trinklein ND, Aldred SF, Hartman SJ, Schroeder DI, Otillar RP, Myers RM. An abundance of bidirectional promoters in the human genome. Genome Research. 14: 62-6. PMID 14707170 DOI: 10.1101/Gr.1982804  0.76
2004 Trinklein ND, Murray JI, Hartman SJ, Botstein D, Myers RM. The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response. Molecular Biology of the Cell. 15: 1254-61. PMID 14668476 DOI: 10.1091/Mbc.E03-10-0738  0.507
2003 Trinklein ND, Aldred SJ, Saldanha AJ, Myers RM. Identification and functional analysis of human transcriptional promoters. Genome Research. 13: 308-12. PMID 12566409 DOI: 10.1101/Gr.794803  0.606
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