Keir C. Neuman, Ph.D. - Publications

Affiliations: 
Princeton University, Princeton, NJ 
Area:
biophysics, single molecules, motor proteins, transcription

77 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Devi A, Neupane K, Jung H, Neuman KC, Woodside MT. Non-linear effects in optical trapping of titanium dioxide and diamond nanoparticles. Biophysical Journal. PMID 37496270 DOI: 10.1016/j.bpj.2023.07.018  0.561
2023 Jian JY, McCarty KD, Byl JAW, Guengerich FP, Neuman KC, Osheroff N. Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases. Nucleic Acids Research. PMID 36999602 DOI: 10.1093/nar/gkad190  0.304
2022 Dalvie ED, Stacy JC, Neuman KC, Osheroff N. Recognition of DNA Supercoil Handedness during Catenation Catalyzed by Type II Topoisomerases. Biochemistry. 61: 2148-2158. PMID 36122251 DOI: 10.1021/acs.biochem.2c00370  0.319
2022 Yang X, Saha S, Yang W, Neuman KC, Pommier Y. Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3β. Nature Communications. 13: 4656. PMID 35945419 DOI: 10.1038/s41467-022-32221-3  0.34
2022 Harami GM, Pálinkás J, Seol Y, Kovács ZJ, Gyimesi M, Harami-Papp H, Neuman KC, Kovács M. The toposiomerase IIIalpha-RMI1-RMI2 complex orients human Bloom's syndrome helicase for efficient disruption of D-loops. Nature Communications. 13: 654. PMID 35115525 DOI: 10.1038/s41467-022-28208-9  0.674
2022 McKie SJ, Desai P, Seol Y, Allen AM, Maxwell A, Neuman KC. Topoisomerase VI is a chirally-selective, preferential DNA decatenase. Elife. 11. PMID 35076393 DOI: 10.7554/eLife.67021  0.311
2021 McKie SJ, Neuman KC, Maxwell A. DNA topoisomerases: Advances in understanding of cellular roles and multi-protein complexes via structure-function analysis. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2000286. PMID 33480441 DOI: 10.1002/bies.202000286  0.321
2020 McKie SJ, Maxwell A, Neuman KC. Mapping DNA Topoisomerase Binding and Cleavage Genome Wide Using Next-Generation Sequencing Techniques. Genes. 11. PMID 31941152 DOI: 10.3390/Genes11010092  0.395
2020 Seol Y, Dinh YT, Neuman KC. Domain Rigidity Modulates the Catalytic Activity of E. coli Type IA DNA Topoisomerases Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.570  0.359
2020 Kovacs ZJ, Hubert Á, Baráth V, Farkas L, Seol Y, Neuman KC, Harami G, Kovacs M. Probing and Visualization of the RecQ Helicase-Induced DNA Binding Mode Change of the Bacterial Single-Stranded DNA Binding (SSB) Protein Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.2136  0.404
2020 Desai PR, Das S, Neuman KC. Coarse-Grained Modeling of DNA Plectoneme Formation in the Presence of Base-Pair Mismatches Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1312  0.358
2019 Gibson EG, Oviatt AA, Cacho M, Neuman KC, Chan PF, Osheroff N. Bimodal actions of a naphthyridone/aminopiperidine-based antibacterial that targets gyrase and topoisomerase IV. Biochemistry. PMID 31617352 DOI: 10.1021/Acs.Biochem.9B00805  0.341
2019 Seol Y, Harami GM, Kovács M, Neuman KC. Homology sensing via non-linear amplification of sequence dependent pausing by RecQ helicase. Elife. 8. PMID 31464683 DOI: 10.7554/Elife.45909  0.445
2019 Harami GM, Palinkas J, Seol Y, Gyimesi M, Kovacs ZJ, Neuman KC, Kovacs M. Novel Assay Resolves D-Loop Processing Pathways by E. Coli RecQ and Human BLM Helicases Biophysical Journal. 116: 74a. DOI: 10.1016/J.Bpj.2018.11.442  0.657
2019 Craig JM, Mills KM, Laszlo AH, Neuman KC, Gundlach JH. Taking a Closer Look at RecQ Helicase with Nanopore Tweezers Biophysical Journal. 116: 319a. DOI: 10.1016/J.Bpj.2018.11.1730  0.35
2018 Jung HS, Cho KJ, Seol Y, Takagi Y, Dittmore A, Roche PA, Neuman KC. Polydopamine encapsulation of fluorescent nanodiamonds for biomedical applications. Advanced Functional Materials. 28. PMID 30686957 DOI: 10.1002/Adfm.201801252  0.328
2018 Mills M, Tse-Dinh YC, Neuman KC. Direct observation of topoisomerase IA gate dynamics. Nature Structural & Molecular Biology. 25: 1111-1118. PMID 30478267 DOI: 10.1038/S41594-018-0158-X  0.447
2018 Dittmore A, Silver J, Neuman KC. Kinetic Pathway of Torsional DNA Buckling. The Journal of Physical Chemistry. B. PMID 30346755 DOI: 10.1021/Acs.Jpcb.8B07504  0.365
2018 Bharti SK, Sommers JA, Awate S, Bellani MA, Khan I, Bradley L, King GA, Seol Y, Vidhyasagar V, Wu Y, Abe T, Kobayashi K, Shin-Ya K, Kitao H, Wold MS, ... ... Neuman KC, et al. A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair. Nucleic Acids Research. PMID 29788478 DOI: 10.1093/Nar/Gky403  0.407
2018 Brahmachari S, Dittmore A, Takagi Y, Neuman KC, Marko JF. Defect-facilitated buckling in supercoiled double-helix DNA. Physical Review. E. 97: 022416. PMID 29548184 DOI: 10.1103/Physreve.97.022416  0.396
2018 Seol Y, Neuman KC. Combined Magnetic Tweezers and Micro-mirror Total Internal Reflection Fluorescence Microscope for Single-Molecule Manipulation and Visualization. Methods in Molecular Biology (Clifton, N.J.). 1665: 297-316. PMID 28940076 DOI: 10.1007/978-1-4939-7271-5_16  0.326
2018 Dittmore A, Neuman KC. Unexpected Discontinuous Supercoiling of Torsionally Buckled DNA: Evidence for a Solenoid? Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.514  0.4
2018 Harami GM, Seol Y, Pálinkás J, Gyimesi M, Kovács ZJ, Martina M, Budai A, Németh JB, Neuman KC, Kovács M. Conserved Domain Architecture of Human BLM Helicase Maintains Balance between D-Loop Disruption and Extension Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.1214  0.648
2017 Mills M, Harami GM, Seol Y, Gyimesi M, Martina M, Kovács ZJ, Kovács M, Neuman KC. RecQ helicase triggers a binding mode change in the SSB-DNA complex to efficiently initiate DNA unwinding. Nucleic Acids Research. PMID 29059328 DOI: 10.1093/nar/gkx939  0.723
2017 Dittmore A, Brahmachari S, Takagi Y, Marko JF, Neuman KC. Supercoiling DNA Locates Mismatches. Physical Review Letters. 119: 147801. PMID 29053317 DOI: 10.1103/Physrevlett.119.147801  0.417
2017 Ashley RE, Dittmore A, McPherson SA, Turnbough CL, Neuman KC, Osheroff N. Activities of gyrase and topoisomerase IV on positively supercoiled DNA. Nucleic Acids Research. 45: 9611-9624. PMID 28934496 DOI: 10.1093/Nar/Gkx649  0.429
2017 Zhang H, Seol Y, Agama K, Neuman KC, Pommier Y. Distribution bias and biochemical characterization of TOP1MT single nucleotide variants. Scientific Reports. 7: 8614. PMID 28819183 DOI: 10.1038/S41598-017-09258-2  0.303
2017 Hu L, Vecchiarelli AG, Mizuuchi K, Neuman KC, Liu J. Brownian Ratchet Mechanism for Faithful Segregation of Low-Copy-Number Plasmids. Biophysical Journal. 112: 1489-1502. PMID 28402891 DOI: 10.1016/J.Bpj.2017.02.039  0.394
2017 Harami GM, Seol Y, In J, Ferencziová V, Martina M, Gyimesi M, Sarlós K, Kovács ZJ, Nagy NT, Sun Y, Vellai T, Neuman KC, Kovács M. Shuttling along DNA and directed processing of D-loops by RecQ helicase support quality control of homologous recombination. Proceedings of the National Academy of Sciences of the United States of America. PMID 28069956 DOI: 10.1073/Pnas.1615439114  0.723
2017 Dittmore A, Neuman KC. Energetic Contributions of Plectoneme Tips and Tails Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.424  0.436
2016 Seol Y, Neuman KC. The dynamic interplay between DNA topoisomerases and DNA topology. Biophysical Reviews. 8: 101-111. PMID 28510219 DOI: 10.1007/S12551-016-0240-8  0.428
2016 Seol Y, Neuman KC. The Dynamic Interplay Between DNA Topoisomerases and DNA Topology. Biophysical Reviews. 8: 221-231. PMID 27942270 DOI: 10.1007/s12551-016-0206-x  0.319
2016 Yi J, Manna A, Barr VA, Hong J, Neuman KC, Samelson LE. madSTORM: a Super-Resolution Technique for Large-Scale Multiplexing at Single Molecule Accuracy. Molecular Biology of the Cell. PMID 27708141 DOI: 10.1091/Mbc.E16-05-0330  0.316
2016 Seol Y, Strub MP, Neuman KC. Single molecule measurements of DNA helicase activity with magnetic tweezers and t-test based step-finding analysis. Methods (San Diego, Calif.). PMID 27131595 DOI: 10.1016/J.Ymeth.2016.04.030  0.432
2016 Taylor JA, Vecchiarelli AG, Neuman KC, Mizuuchi K. Transportation of an Artifical Cargo by a Par-Min Hybrid System Biophysical Journal. 110: 576a. DOI: 10.1016/J.Bpj.2015.11.3079  0.362
2016 Mills KM, Neuman KC. Single Molecule Measurements of DNA Decatenation by the Topoisomerase III-RecQ Helicase Complex Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.1325  0.446
2015 Herbert KM, Sarkar SK, Mills M, Delgado De la Herran HC, Neuman KC, Steitz JA. A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting. Rna (New York, N.Y.). PMID 26683315 DOI: 10.1261/Rna.054684.115  0.702
2015 Hu L, Vecchiarelli AG, Mizuuchi K, Neuman KC, Liu J. Directed and persistent movement arises from mechanochemistry of the ParA/ParB system. Proceedings of the National Academy of Sciences of the United States of America. PMID 26647183 DOI: 10.1073/Pnas.1505147112  0.359
2015 Seol Y, Zhang H, Agama K, Lorence N, Pommier Y, Neuman KC. Single-molecule supercoil-relaxation assay as a screening tool to determine the mechanism and efficacy of human topoisomerase IB inhibitors. Molecular Cancer Therapeutics. PMID 26351326 DOI: 10.1158/1535-7163.Mct-15-0454  0.326
2015 Harami GM, Nagy NT, Martina M, Neuman KC, Kovács M. The HRDC domain of E. coli RecQ helicase controls single-stranded DNA translocation and double-stranded DNA unwinding rates without affecting mechanoenzymatic coupling. Scientific Reports. 5: 11091. PMID 26067769 DOI: 10.1038/Srep11091  0.411
2015 Litwin TR, Solà M, Holt IJ, Neuman KC. A robust assay to measure DNA topology-dependent protein binding affinity. Nucleic Acids Research. 43: e43. PMID 25552413 DOI: 10.1093/Nar/Gku1381  0.414
2015 Silver J, Li Z, Neuman K. Tethered-bead, immune sandwich assay. Biosensors & Bioelectronics. 63: 117-23. PMID 25064819 DOI: 10.1016/J.Bios.2014.07.011  0.348
2015 Harami GM, Nagy NT, Martina M, Neuman KC, Kovács M. The HRDC domain of E. coli RecQ helicase controls single-stranded DNA translocation and double-stranded DNA unwinding rates without affecting mechanoenzymatic coupling Scientific Reports. 5. DOI: 10.1038/srep11091  0.313
2015 Mills KM, Seol Y, Neuman KC. Functional Implications of the RecQ Helicase - Topoisomerase III - SSB Complex: Insights from Single Molecule Measurements Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2776  0.446
2014 Vecchiarelli AG, Neuman KC, Mizuuchi K. A propagating ATPase gradient drives transport of surface-confined cellular cargo. Proceedings of the National Academy of Sciences of the United States of America. 111: 4880-5. PMID 24567408 DOI: 10.1073/Pnas.1401025111  0.334
2014 Mills M, Neuman K. ATP Binding Induced Conformational Change in RecQ Helicase Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.3589  0.394
2014 Harami G, Seol Y, In J, Sarlos K, Sun Y, Martina M, Neuman KC, Kovacs M. Domain Architecture of RecQ Helicase Defines Mechanochemical Linkage via Multipartite Interactions with DNA Substrate during Unwinding Activity Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.1601  0.454
2013 Neuman KC. The tail that wags the dog: topoisomerase IV ParC C-terminal domain controls strand passage activity through multipartite topology-dependent interactions with DNA. Journal of Molecular Biology. 425: 3025-8. PMID 23851170 DOI: 10.1016/J.Jmb.2013.07.004  0.439
2013 Seol Y, Neuman KC. SnapShot: force spectroscopy and single-molecule manipulation. Cell. 153: 1168-1168.e1. PMID 23706746 DOI: 10.1016/J.Cell.2013.04.047  0.304
2013 Bumb A, Sarkar SK, Billington N, Brechbiel MW, Neuman KC. Silica encapsulation of fluorescent nanodiamonds for colloidal stability and facile surface functionalization. Journal of the American Chemical Society. 135: 7815-8. PMID 23581827 DOI: 10.1021/Ja4016815  0.304
2013 Seol Y, Gentry AC, Osheroff N, Neuman KC. Chiral discrimination and writhe-dependent relaxation mechanism of human topoisomerase IIα. The Journal of Biological Chemistry. 288: 13695-703. PMID 23508957 DOI: 10.1074/Jbc.M112.444745  0.402
2013 Seol Y, Hardin AH, Strub MP, Charvin G, Neuman KC. Comparison of DNA decatenation by Escherichia coli topoisomerase IV and topoisomerase III: implications for non-equilibrium topology simplification. Nucleic Acids Research. 41: 4640-9. PMID 23460205 DOI: 10.1093/Nar/Gkt136  0.421
2013 Sun Y, In J, Seol Y, Sarkar S, Strub M, Sarlós K, Kovács M, Neuman K. Sequence Specific pausing of RecQ Helicase Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.2346  0.434
2013 Litwin TR, Sarkar SS, Hardin AH, Neuman KC. Below-Equilibrium DNA Topology Simplification by Type II Topoisomerases can be Explained by DNA Linking Number-Dependent Binding Affinity Biophysical Journal. 104: 1-8. DOI: 10.1016/J.Bpj.2012.11.1119  0.424
2012 Seol Y, Zhang H, Pommier Y, Neuman KC. A kinetic clutch governs religation by type IB topoisomerases and determines camptothecin sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 109: 16125-30. PMID 22991469 DOI: 10.1073/Pnas.1206480109  0.43
2012 Seol Y, Hardin AH, Charvin G, Neuman KC. Non-Equilibrium Topology Simplification by Type II Topoisomerases: A Test of Kinetic Proofreading Biophysical Journal. 102: 4-6. DOI: 10.1016/J.Bpj.2011.11.2667  0.387
2012 Seol Y, Zhang H, Dalla Rosa I, Pommier Y, Neuman KC. Distinct Uncoiling Mechanisms of Human Nuclear and Mitochondrial Type IB Topoisomerases Biophysical Journal. 102: 485a. DOI: 10.1016/J.Bpj.2011.11.2658  0.425
2011 Seol Y, Neuman KC. Magnetic tweezers for single-molecule manipulation. Methods in Molecular Biology (Clifton, N.J.). 783: 265-93. PMID 21909894 DOI: 10.1007/978-1-61779-282-3_15  0.377
2011 Seol Y, Neuman KC. Single-molecule measurements of topoisomerase activity with magnetic tweezers. Methods in Molecular Biology (Clifton, N.J.). 778: 229-41. PMID 21809210 DOI: 10.1007/978-1-61779-261-8_15  0.396
2011 Hardin AH, Sarkar SK, Seol Y, Liou GF, Osheroff N, Neuman KC. Direct measurement of DNA bending by type IIA topoisomerases: implications for non-equilibrium topology simplification. Nucleic Acids Research. 39: 5729-43. PMID 21421557 DOI: 10.1093/Nar/Gkr109  0.429
2011 Pitts SL, Liou GF, Mitchenall LA, Burgin AB, Maxwell A, Neuman KC, Osheroff N. Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV. Nucleic Acids Research. 39: 4808-17. PMID 21300644 DOI: 10.1093/Nar/Gkr018  0.33
2010 Neuman KC. Evolutionary twist on topoisomerases: conversion of gyrase to topoisomerase IV. Proceedings of the National Academy of Sciences of the United States of America. 107: 22363-4. PMID 21169503 DOI: 10.1073/Pnas.1016041108  0.318
2010 Neuman KC. Single-molecule measurements of DNA topology and topoisomerases. The Journal of Biological Chemistry. 285: 18967-71. PMID 20382732 DOI: 10.1074/Jbc.R109.092437  0.44
2010 Seol Y, Gentry AC, Osheroff N, Neuman KC. Single-Molecule Study of Human Topoisomerase II Biophysical Journal. 98: 660a. DOI: 10.1016/J.Bpj.2009.12.3624  0.428
2010 Hardin AH, Liou GF, Osheroff N, Neuman KC. Determining the Role DNA of Bending in Topology Simplification by Type II Topoisomerases Biophysical Journal. 98: 660a. DOI: 10.1016/J.Bpj.2009.12.3623  0.409
2009 Neuman KC, Charvin G, Bensimon D, Croquette V. Mechanisms of chiral discrimination by topoisomerase IV. Proceedings of the National Academy of Sciences of the United States of America. 106: 6986-91. PMID 19359479 DOI: 10.1073/Pnas.0900574106  0.43
2008 Bouthier de la Tour C, Amrani L, Cossard R, Neuman KC, Serre MC, Duguet M. Mutational analysis of the helicase-like domain of Thermotoga maritima reverse gyrase. The Journal of Biological Chemistry. 283: 27395-402. PMID 18614530 DOI: 10.1074/Jbc.M800867200  0.371
2008 Neuman KC, Nagy A. Single-molecule force spectroscopy: optical tweezers, magnetic tweezers and atomic force microscopy. Nature Methods. 5: 491-505. PMID 18511917 DOI: 10.1038/Nmeth.1218  0.306
2006 Dalal RV, Larson MH, Neuman KC, Gelles J, Landick R, Block SM. Pulling on the nascent RNA during transcription does not alter kinetics of elongation or ubiquitous pausing. Molecular Cell. 23: 231-9. PMID 16857589 DOI: 10.1016/J.Molcel.2006.06.023  0.736
2006 Herbert KM, La Porta A, Wong BJ, Mooney RA, Neuman KC, Landick R, Block SM. Sequence-resolved detection of pausing by single RNA polymerase molecules. Cell. 125: 1083-94. PMID 16777599 DOI: 10.1016/J.Cell.2006.04.032  0.755
2005 Neuman KC, Abbondanzieri EA, Block SM. Measurement of the effective focal shift in an optical trap. Optics Letters. 30: 1318-20. PMID 15981519 DOI: 10.1364/Ol.30.001318  0.721
2005 Neuman K, Dholakia K. Shedding light on life Physics World. 18: 35-37. DOI: 10.1088/2058-7058/18/10/35  0.355
2004 Neuman KC, Block SM. Optical trapping. The Review of Scientific Instruments. 75: 2787-809. PMID 16878180 DOI: 10.1063/1.1785844  0.495
2004 Lang MJ, Fordyce PM, Engh AM, Neuman KC, Block SM. Simultaneous, coincident optical trapping and single-molecule fluorescence. Nature Methods. 1: 133-9. PMID 15782176 DOI: 10.1038/Nmeth714  0.758
2003 Neuman KC, Abbondanzieri EA, Landick R, Gelles J, Block SM. Ubiquitous transcriptional pausing is independent of RNA polymerase backtracking. Cell. 115: 437-47. PMID 14622598 DOI: 10.1016/S0092-8674(03)00845-6  0.777
1999 Neuman KC, Chadd EH, Liou GF, Bergman K, Block SM. Characterization of photodamage to Escherichia coli in optical traps. Biophysical Journal. 77: 2856-63. PMID 10545383 DOI: 10.1016/S0006-3495(99)77117-1  0.561
1998 Neuman KC, Liou GF, Block SM, Bergman K. Characterization of photodamage induced by optical tweezers Conference On Lasers and Electro-Optics Europe - Technical Digest. 203-204.  0.474
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