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Orion D. Weiner, Ph.D. - Publications

Affiliations: 
University of California, San Francisco, San Francisco, CA 
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79 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 De Belly H, Weiner OD. Follow the flow: Actin and membrane act as an integrated system to globally coordinate cell shape and movement. Current Opinion in Cell Biology. 89: 102392. PMID 38991476 DOI: 10.1016/j.ceb.2024.102392  0.365
2024 Nagy TL, Strickland E, Weiner OD. Neutrophils actively swell to potentiate rapid migration. Elife. 12. PMID 38953885 DOI: 10.7554/eLife.90551  0.562
2023 Town JP, Weiner OD. Local negative feedback of Rac activity at the leading edge underlies a pilot pseudopod-like program for amoeboid cell guidance. Plos Biology. 21: e3002307. PMID 37747905 DOI: 10.1371/journal.pbio.3002307  0.413
2023 Nagy TL, Strickland JD, Weiner OD. Neutrophils actively swell to potentiate rapid migration. Biorxiv : the Preprint Server For Biology. PMID 37292824 DOI: 10.1101/2023.05.15.540704  0.608
2023 Saha S, Town JP, Weiner OD. Mechanosensitive mTORC2 independently coordinates leading and trailing edge polarity programs during neutrophil migration. Molecular Biology of the Cell. 34: ar35. PMID 36857159 DOI: 10.1091/mbc.E22-05-0191  0.602
2022 Friedl P, Konstantopoulos K, Sahai E, Weiner O. Adhesion-independent topography-based leukocyte migration. Faculty Reviews. 11: 18. PMID 35979144 DOI: 10.12703/r-01-0000013  0.441
2022 Brunetti RM, Kockelkoren G, Raghavan P, Bell GRR, Britain D, Puri N, Collins SR, Leonetti MD, Stamou D, Weiner OD. WASP integrates substrate topology and cell polarity to guide neutrophil migration. The Journal of Cell Biology. 221. PMID 34964841 DOI: 10.1083/jcb.202104046  0.45
2021 Pipathsouk A, Brunetti RM, Town JP, Graziano BR, Breuer A, Pellett PA, Marchuk K, Tran NT, Krummel MF, Stamou D, Weiner OD. The WAVE complex associates with sites of saddle membrane curvature. The Journal of Cell Biology. 220. PMID 34096975 DOI: 10.1083/jcb.202003086  0.784
2020 Tischer D, Weiner OD. Optogenetic Tuning of Protein-protein Binding in Bilayers Using LOVTRAP. Bio-Protocol. 10: e3745. PMID 33659405 DOI: 10.21769/BioProtoc.3745  0.448
2019 Graziano BR, Town JP, Sitarska E, Nagy TL, Fošnarič M, Penič S, Iglič A, Kralj-Iglič V, Gov NS, Diz-Muñoz A, Weiner OD. Cell confinement reveals a branched-actin independent circuit for neutrophil polarity. Plos Biology. 17: e3000457. PMID 31600188 DOI: 10.1371/Journal.Pbio.3000457  0.817
2019 Alexander JM, Guan J, Li B, Maliskova L, Song M, Shen Y, Huang B, Lomvardas S, Weiner OD. Live-cell imaging reveals enhancer-dependent transcription in the absence of enhancer proximity. Elife. 8. PMID 31124784 DOI: 10.7554/Elife.41769  0.594
2019 Mclaurin JD, Weiner OD. Multiple sources of signal amplification within the B cell Ras/MAPK pathway. Molecular Biology of the Cell. mbcE18090560. PMID 31042097 DOI: 10.1091/Mbc.E18-09-0560  0.43
2019 Tischer DK, Weiner OD. Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling. Elife. 8. PMID 30947808 DOI: 10.7554/Elife.42498  0.456
2019 Tischer DK, Weiner OD. Author response: Light-based tuning of ligand half-life supports kinetic proofreading model of T cell signaling Elife. DOI: 10.7554/Elife.42498.032  0.418
2019 Alexander JM, Guan J, Li B, Maliskova L, Song M, Shen Y, Huang B, Lomvardas S, Weiner OD. Author response: Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity Elife. DOI: 10.7554/Elife.41769.054  0.418
2018 Diz-Muñoz A, Weiner OD, Fletcher DA. In pursuit of the mechanics that shape cell surfaces. Nature Physics. 14: 648-652. PMID 31007706 DOI: 10.1038/S41567-018-0187-8  0.436
2018 Allard CAH, Decker F, Weiner OD, Toettcher JE, Graziano BR. A size-invariant bud-duration timer enables robustness in yeast cell size control. Plos One. 13: e0209301. PMID 30576342 DOI: 10.1371/Journal.Pone.0209301  0.772
2018 Liu Z, Woo S, Weiner OD. Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation. Development (Cambridge, England). PMID 30111654 DOI: 10.1242/Dev.163535  0.779
2018 Saha S, Nagy TL, Weiner OD. Joining forces: crosstalk between biochemical signalling and physical forces orchestrates cellular polarity and dynamics. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29632270 DOI: 10.1098/Rstb.2017.0145  0.708
2018 Genuth MA, Allen CDC, Mikawa T, Weiner OD. Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration. Developmental Biology. PMID 29501457 DOI: 10.1016/J.Ydbio.2018.02.016  0.532
2017 Yang Y, Xiong D, Pipathsouk A, Weiner OD, Wu M. Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning. Developmental Cell. 43: 507-521.e4. PMID 29161594 DOI: 10.1016/J.Devcel.2017.10.028  0.481
2017 Graziano BR, Gong D, Anderson KE, Pipathsouk A, Goldberg AR, Weiner OD. A module for Rac temporal signal integration revealed with optogenetics. The Journal of Cell Biology. PMID 28687663 DOI: 10.1083/Jcb.201604113  0.8
2016 Reade A, Motta-Mena LB, Gardner KH, Stainier DY, Weiner OD, Woo S. TAEL: A zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control. Development (Cambridge, England). PMID 27993986 DOI: 10.1242/Dev.139238  0.769
2016 Liu Z, Weiner OD. Positioning the cleavage furrow: All you need is Rho. The Journal of Cell Biology. 213: 605-7. PMID 27325786 DOI: 10.1083/Jcb.201606010  0.512
2016 Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD. Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration. Plos Biology. 14: e1002474. PMID 27280401 DOI: 10.1371/Journal.Pbio.1002474  0.535
2016 Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD. Gβ Regulates Coupling between Actin Oscillators for Cell Polarity and Directional Migration. Plos Biology. 14: e1002381. PMID 26890004 DOI: 10.1371/Journal.Pbio.1002381  0.736
2016 Buckley CE, Moore RE, Reade A, Goldberg AR, Weiner OD, Clarke JD. Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo. Developmental Cell. 36: 117-26. PMID 26766447 DOI: 10.1016/J.Devcel.2015.12.011  0.521
2016 Graziano BR, Weiner OD. Abstract A181: Dissecting the spatiotemporal functions of WAVE complex during chemotaxis using CRISPR and optogenetics Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A181  0.56
2016 Graziano BR, Gong D, Anderson KE, Weiner OD. Abstract B096: Optogenetics-based dissection of chemotactic signaling in neutrophils Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B096  0.646
2015 Genuth MA, Weiner OD. Cell Migration: Recoiling from an Embrace. Current Biology : Cb. 25: R566-8. PMID 26126284 DOI: 10.1016/J.Cub.2015.05.015  0.494
2015 Yu D, Baird MA, Allen JR, Howe ES, Klassen MP, Reade A, Makhijani K, Song Y, Liu S, Murthy Z, Zhang SQ, Weiner OD, Kornberg TB, Jan YN, Davidson MW, et al. A naturally monomeric infrared fluorescent protein for protein labeling in vivo. Nature Methods. PMID 26098020 DOI: 10.1038/Nmeth.3447  0.429
2015 Jost AP, Weiner OD. Probing Yeast Polarity with Acute, Reversible, Optogenetic Inhibition of Protein Function. Acs Synthetic Biology. 4: 1077-85. PMID 26035630 DOI: 10.1021/Acssynbio.5B00053  0.792
2015 Lou SS, Diz-Muñoz A, Weiner OD, Fletcher DA, Theriot JA. Myosin light chain kinase regulates cell polarization independently of membrane tension or Rho kinase. The Journal of Cell Biology. 209: 275-88. PMID 25918227 DOI: 10.1083/Jcb.201409001  0.549
2015 Wu J, Pipathsouk A, Keizer-Gunnink A, Fusetti F, Alkema W, Liu S, Altschuler S, Wu L, Kortholt A, Weiner OD. Homer3 regulates the establishment of neutrophil polarity. Molecular Biology of the Cell. 26: 1629-39. PMID 25739453 DOI: 10.1091/Mbc.E14-07-1197  0.743
2015 Wu J, Pipathsouk A, Keizer-Gunnink A, Alkema W, Fusetti F, Liu S, Atschuler S, Wu L, Kortholt A, Weiner O. Abstract B48: Homer3 regulates the establishment of neutrophil polarity Cancer Immunology Research. 3. DOI: 10.1158/2326-6074.Tumimm14-B48  0.729
2014 Tischer D, Weiner OD. Illuminating cell signalling with optogenetic tools. Nature Reviews. Molecular Cell Biology. 15: 551-8. PMID 25027655 DOI: 10.1038/Nrm3837  0.472
2014 Graziano BR, Weiner OD. Self-organization of protrusions and polarity during eukaryotic chemotaxis. Current Opinion in Cell Biology. 30: 60-7. PMID 24998184 DOI: 10.1016/J.Ceb.2014.06.007  0.806
2014 Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA. Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proceedings of the National Academy of Sciences of the United States of America. 111: 5896-901. PMID 24711398 DOI: 10.1073/Pnas.1402087111  0.775
2014 Hoeller O, Gong D, Weiner OD. How to understand and outwit adaptation. Developmental Cell. 28: 607-16. PMID 24697896 DOI: 10.1016/J.Devcel.2014.03.009  0.601
2014 Motta-Mena LB, Reade A, Mallory MJ, Glantz S, Weiner OD, Lynch KW, Gardner KH. An optogenetic gene expression system with rapid activation and deactivation kinetics Nature Chemical Biology. 10: 196-202. PMID 24413462 DOI: 10.1038/Nchembio.1430  0.43
2013 Toettcher JE, Weiner OD, Lim WA. Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell. 155: 1422-34. PMID 24315106 DOI: 10.1016/J.Cell.2013.11.004  0.759
2013 Dandekar SN, Park JS, Peng GE, Onuffer JJ, Lim WA, Weiner OD. Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20130008. PMID 24062580 DOI: 10.1098/Rstb.2013.0008  0.752
2013 Parent CA, Weiner OD. The symphony of cell movement: how cells orchestrate diverse signals and forces to control migration. Current Opinion in Cell Biology. 25: 523-5. PMID 23927870 DOI: 10.1016/J.Ceb.2013.07.011  0.527
2013 Hoeller O, Bolourani P, Clark J, Stephens LR, Hawkins PT, Weiner OD, Weeks G, Kay RR. Two distinct functions for PI3-kinases in macropinocytosis. Journal of Cell Science. 126: 4296-307. PMID 23843627 DOI: 10.1242/Jcs.134015  0.428
2013 Yang X, Jost AP, Weiner OD, Tang C. A light-inducible organelle-targeting system for dynamically activating and inactivating signaling in budding yeast. Molecular Biology of the Cell. 24: 2419-30. PMID 23761071 DOI: 10.1091/Mbc.E13-03-0126  0.792
2013 Wang Y, Ku CJ, Zhang ER, Artyukhin AB, Weiner OD, Wu LF, Altschuler SJ. Identifying network motifs that buffer front-to-back signaling in polarized neutrophils. Cell Reports. 3: 1607-16. PMID 23665220 DOI: 10.1016/J.Celrep.2013.04.009  0.538
2013 Diz-Muñoz A, Fletcher DA, Weiner OD. Use the force: membrane tension as an organizer of cell shape and motility. Trends in Cell Biology. 23: 47-53. PMID 23122885 DOI: 10.1016/J.Tcb.2012.09.006  0.496
2012 Woo S, Housley MP, Weiner OD, Stainier DY. Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1. The Journal of Cell Biology. 198: 941-52. PMID 22945937 DOI: 10.1083/Jcb.201203012  0.817
2012 Ku CJ, Wang Y, Weiner OD, Altschuler SJ, Wu LF. Network crosstalk dynamically changes during neutrophil polarization. Cell. 149: 1073-83. PMID 22632971 DOI: 10.1016/J.Cell.2012.03.044  0.5
2012 Millius A, Watanabe N, Weiner OD. Diffusion, capture and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells by single-molecule imaging. Journal of Cell Science. 125: 1165-76. PMID 22349699 DOI: 10.1242/Jcs.091157  0.785
2012 Houk AR, Jilkine A, Mejean CO, Boltyanskiy R, Dufresne ER, Angenent SB, Altschuler SJ, Wu LF, Weiner OD. Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration. Cell. 148: 175-88. PMID 22265410 DOI: 10.1016/J.Cell.2011.10.050  0.751
2012 Toettcher J, Gong D, Lim WA, Weiner O. A Light-Based Feedback Control System for Generating User-Defined Intracelullar Signaling Dynamics Biophysical Journal. 102: 41a. DOI: 10.1016/J.Bpj.2011.11.253  0.795
2011 Toettcher JE, Gong D, Lim WA, Weiner OD. Light-based feedback for controlling intracellular signaling dynamics. Nature Methods. 8: 837-9. PMID 21909100 DOI: 10.1038/Nmeth.1700  0.811
2011 Peng GE, Wilson SR, Weiner OD. A pharmacological cocktail for arresting actin dynamics in living cells. Molecular Biology of the Cell. 22: 3986-94. PMID 21880897 DOI: 10.1091/Mbc.E11-04-0379  0.554
2011 Toettcher JE, Gong D, Lim WA, Weiner OD. Light control of plasma membrane recruitment using the Phy-PIF system. Methods in Enzymology. 497: 409-23. PMID 21601096 DOI: 10.1016/B978-0-12-385075-1.00017-2  0.792
2011 Toettcher JE, Voigt CA, Weiner OD, Lim WA. The promise of optogenetics in cell biology: interrogating molecular circuits in space and time. Nature Methods. 8: 35-8. PMID 21191370 DOI: 10.1038/Nmeth.F.326  0.769
2010 Puthenveedu MA, Lauffer B, Temkin P, Vistein R, Carlton P, Thorn K, Taunton J, Weiner OD, Parton RG, von Zastrow M. Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell. 143: 761-73. PMID 21111236 DOI: 10.1016/J.Cell.2010.10.003  0.447
2010 Millius A, Weiner OD. Manipulation of neutrophil-like HL-60 cells for the study of directed cell migration. Methods in Molecular Biology (Clifton, N.J.). 591: 147-58. PMID 19957129 DOI: 10.1007/978-1-60761-404-3_9  0.82
2009 Kress H, Park JG, Mejean CO, Forster JD, Park J, Walse SS, Zhang Y, Wu D, Weiner OD, Fahmy TM, Dufresne ER. Cell stimulation with optically manipulated microsources. Nature Methods. 6: 905-9. PMID 19915561 DOI: 10.1038/Nmeth.1400  0.513
2009 Houk AR, Millius A, Weiner OD. Compete globally, bud locally. Cell. 139: 656-8. PMID 19914160 DOI: 10.1016/J.Cell.2009.10.028  0.789
2009 Millius A, Weiner OD. Chemotaxis in neutrophil-like HL-60 cells. Methods in Molecular Biology (Clifton, N.J.). 571: 167-77. PMID 19763966 DOI: 10.1007/978-1-60761-198-1_11  0.82
2009 Levskaya A, Weiner OD, Lim WA, Voigt CA. Spatiotemporal control of cell signalling using a light-switchable protein interaction. Nature. 461: 997-1001. PMID 19749742 DOI: 10.1038/Nature08446  0.67
2009 Millius A, Dandekar SN, Houk AR, Weiner OD. Neutrophils establish rapid and robust WAVE complex polarity in an actin-dependent fashion. Current Biology : Cb. 19: 253-9. PMID 19200726 DOI: 10.1016/J.Cub.2008.12.044  0.785
2007 Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. An actin-based wave generator organizes cell motility. Plos Biology. 5: e221. PMID 17696648 DOI: 10.1371/Journal.Pbio.0050221  0.648
2006 Pestonjamasp KN, Forster C, Sun C, Gardiner EM, Bohl B, Weiner O, Bokoch GM, Glogauer M. Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis Blood. 108: 2814-2820. PMID 16809619 DOI: 10.1182/Blood-2006-01-010363  0.539
2006 Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. Plos Biology. 4: e38. PMID 16417406 DOI: 10.1371/Journal.Pbio.0040038  0.804
2002 Bourne HR, Weiner O. A chemical compass. Nature. 419: 21. PMID 12214215 DOI: 10.1038/419021A  0.601
2002 Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nature Cell Biology. 4: 509-13. PMID 12080346 DOI: 10.1038/Ncb811  0.748
2002 Wang F, Herzmark P, Weiner OD, Srinivasan S, Servant G, Bourne HR. Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils. Nature Cell Biology. 4: 513-8. PMID 12080345 DOI: 10.1038/Ncb810  0.663
2002 Weiner OD. Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. Current Opinion in Cell Biology. 14: 196-202. PMID 11891119 DOI: 10.1016/S0955-0674(02)00310-1  0.541
2002 Desai A, Holleran EA, Incardona JP, Weiner O, Aasland R, Weinzierl RO, Ponnambalam V, Slesinger PA, Ramos JW, Matter ML, Benton R, Hukriede N, Tsang M, Guacci V, Heck MM. Cell biology Current Opinion in Cell Biology. 14: 1-9. DOI: 10.1016/S0955-0674(01)00286-1  0.489
2001 Insall RH, Weiner OD. PIP3, PIP2, and cell movement--similar messages, different meanings? Developmental Cell. 1: 743-7. PMID 11740936 DOI: 10.1016/S1534-5807(01)00086-7  0.449
2001 Desai A, Holleran EA, Incardona JP, Weiner O, Aasland R, Weinzierl RO, Ponnambalam V, Slesinger PA, Ramos JW, Matter ML, Benton R, Tsang M, Hukriede N. Paper alert: Cell biology Current Opinion in Cell Biology. 13: 513-521. DOI: 10.1016/S0955-0674(00)00244-1  0.46
2000 Rickert P, Weiner OD, Wang F, Bourne HR, Servant G. Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends in Cell Biology. 10: 466-73. PMID 11050418 DOI: 10.1016/S0962-8924(00)01841-9  0.681
2000 Servant G, Weiner OD, Herzmark P, Balla T, Sedat JW, Bourne HR. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (New York, N.Y.). 287: 1037-40. PMID 10669415 DOI: 10.1126/Science.287.5455.1037  0.755
2000 Desai A, Holleran EA, Roche S, Servant G, Weiner O, Aasland R, Weinzierl RO, Ponnambalam V, Slesinger PA, Pfaff M, Schuldt A, Kudoh T, Sclafani RA. Cell biology Current Opinion in Cell Biology. 12: 265-275. DOI: 10.1016/S0955-0674(00)00086-7  0.489
1999 Kalman D, Weiner OD, Goosney DL, Sedat JW, Finlay BB, Abo A, Bishop JM. Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals. Nature Cell Biology. 1: 389-91. PMID 10559969 DOI: 10.1038/14087  0.657
1999 Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR. Spatial control of actin polymerization during neutrophil chemotaxis. Nature Cell Biology. 1: 75-81. PMID 10559877 DOI: 10.1038/10042  0.773
1999 Servant G, Weiner OD, Neptune ER, Sedat JW, Bourne HR. Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Molecular Biology of the Cell. 10: 1163-78. PMID 10198064 DOI: 10.1091/Mbc.10.4.1163  0.739
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