| Year |
Citation |
Score |
| 2018 |
Franklin D, Zhang Y. Nutrient availability dictates the regulation of metabolism by the ribosomal protein-MDM2-p53 pathway. Molecular & Cellular Oncology. 5: e1302904. PMID 30250882 DOI: 10.1080/23723556.2017.1302904 |
0.389 |
|
| 2018 |
Leslie PL, Franklin DA, Liu Y, Zhang Y. p53 Regulates the Expression of LRP1 and Apoptosis through a Stress Intensity-Dependent MicroRNA Feedback Loop. Cell Reports. 24: 1484-1495. PMID 30089260 DOI: 10.1016/J.Celrep.2018.07.010 |
0.35 |
|
| 2018 |
Liu Y, Leslie PL, Jin A, Itahana K, Graves LM, Zhang Y. p32 regulates ER stress and lipid homeostasis by down-regulating GCS1 expression. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701004RR. PMID 29465311 DOI: 10.1096/Fj.201701004Rr |
0.335 |
|
| 2017 |
Tian H, Tackmann NR, Jin A, Zheng J, Zhang Y. Inactivation of the MDM2 RING domain enhances p53 transcriptional activity in mice. The Journal of Biological Chemistry. PMID 29123033 DOI: 10.1074/Jbc.Ra117.000122 |
0.41 |
|
| 2017 |
Di J, Tang J, Qian H, Franklin DA, Deisenroth C, Itahana Y, Zheng J, Zhang Y. p53 upregulates PLCε-IP3-Ca(2+) pathway and inhibits autophagy through its target gene Rap2B. Oncotarget. 8: 64657-64669. PMID 29029384 DOI: 10.18632/Oncotarget.18112 |
0.398 |
|
| 2017 |
Okumu DO, East MP, Levine M, Herring LE, Zhang R, Gilbert TSK, Litchfield DW, Zhang Y, Graves LM. BIRC6 mediates imatinib resistance independently of Mcl-1. Plos One. 12: e0177871. PMID 28520795 DOI: 10.1371/Journal.Pone.0177871 |
0.305 |
|
| 2017 |
Liu S, Kim TH, Franklin DA, Zhang Y. Protection against High-Fat-Diet-Induced Obesity in MDM2(C305F) Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure. Cell Reports. 18: 1005-1018. PMID 28122227 DOI: 10.1016/J.Celrep.2016.12.086 |
0.315 |
|
| 2016 |
Liu Y, Deisenroth C, Zhang Y. RP-MDM2-p53 Pathway: Linking Ribosomal Biogenesis and Tumor Surveillance. Trends in Cancer. 2: 191-204. PMID 28741571 DOI: 10.1016/J.Trecan.2016.03.002 |
0.368 |
|
| 2016 |
Deisenroth C, Franklin DA, Zhang Y. The Evolution of the Ribosomal Protein-MDM2-p53 Pathway. Cold Spring Harbor Perspectives in Medicine. 6. PMID 27908926 DOI: 10.1101/Cshperspect.A026138 |
0.38 |
|
| 2016 |
Franklin DA, He Y, Leslie PL, Tikunov AP, Fenger N, Macdonald JM, Zhang Y. p53 coordinates DNA repair with nucleotide synthesis by suppressing PFKFB3 expression and promoting the pentose phosphate pathway. Scientific Reports. 6: 38067. PMID 27901115 DOI: 10.1038/Srep38067 |
0.382 |
|
| 2016 |
Kamio T, Gu BW, Olson TS, Zhang Y, Mason PJ, Bessler M. Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop a Defect in Erythropoiesis. Plos One. 11: e0152263. PMID 27042854 DOI: 10.1371/Journal.Pone.0152263 |
0.392 |
|
| 2015 |
Wienken M, Dickmanns A, Nemajerova A, Kramer D, Najafova Z, Weiss M, Karpiuk O, Kassem M, Zhang Y, Lozano G, Johnsen SA, Moll UM, Zhang X, Dobbelstein M. MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53. Molecular Cell. PMID 26748827 DOI: 10.1016/J.Molcel.2015.12.008 |
0.36 |
|
| 2015 |
Leslie PL, Ke H, Zhang Y. The MDM2 RING domain and central acidic domain play distinct roles in MDM2 protein homodimerization and MDM2-MDMX protein heterodimerization. The Journal of Biological Chemistry. 290: 12941-50. PMID 25809483 DOI: 10.1074/Jbc.M115.644435 |
0.334 |
|
| 2014 |
Meng X, Franklin DA, Dong J, Zhang Y. MDM2-p53 pathway in hepatocellular carcinoma. Cancer Research. 74: 7161-7. PMID 25477334 DOI: 10.1158/0008-5472.Can-14-1446 |
0.336 |
|
| 2014 |
Tollini LA, Jin A, Park J, Zhang Y. Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage. Cancer Cell. 26: 235-47. PMID 25117711 DOI: 10.1016/J.Ccr.2014.06.006 |
0.413 |
|
| 2014 |
Liu Y, He Y, Jin A, Tikunov AP, Zhou L, Tollini LA, Leslie P, Kim TH, Li LO, Coleman RA, Gu Z, Chen YQ, Macdonald JM, Graves LM, Zhang Y. Ribosomal protein-Mdm2-p53 pathway coordinates nutrient stress with lipid metabolism by regulating MCD and promoting fatty acid oxidation. Proceedings of the National Academy of Sciences of the United States of America. 111: E2414-22. PMID 24872453 DOI: 10.1073/Pnas.1315605111 |
0.376 |
|
| 2014 |
He Y, Tollini L, Kim TH, Itahana Y, Zhang Y. The anaphase-promoting complex/cyclosome is an E3 ubiquitin ligase for Mdm2. Cell Cycle (Georgetown, Tex.). 13: 2101-9. PMID 24804778 DOI: 10.4161/Cc.29106 |
0.376 |
|
| 2014 |
Kim TH, Leslie P, Zhang Y. Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability. Oncotarget. 5: 860-71. PMID 24658219 DOI: 10.18632/Oncotarget.1784 |
0.41 |
|
| 2014 |
Kamio T, Gu B, Olson TS, Zhang Y, Mason PJ, Bessler M. Mice with a Mutation in the Mdm2 Gene That Interferes with MDM2/Ribosomal Protein Binding Develop Bone Marrow Failure Blood. 124: 4381-4381. DOI: 10.1182/Blood.V124.21.4381.4381 |
0.377 |
|
| 2013 |
Kim T, Zhang Y. Abstract A29: Mdm2 E3 ubiquitin ligase function is dispensable for the degradation of Mdm2 itself Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-A29 |
0.399 |
|
| 2012 |
Tollini LA, Zhang Y. p53 Regulation Goes Live-Mdm2 and MdmX Co-Star: Lessons Learned from Mouse Modeling. Genes & Cancer. 3: 219-25. PMID 23150755 DOI: 10.1177/1947601912454732 |
0.445 |
|
| 2012 |
Clegg HV, Itahana Y, Itahana K, Ramalingam S, Zhang Y. Mdm2 RING mutation enhances p53 transcriptional activity and p53-p300 interaction. Plos One. 7: e38212. PMID 22666487 DOI: 10.1371/Journal.Pone.0038212 |
0.426 |
|
| 2012 |
Pei D, Zhang Y, Zheng J. Regulation of p53: a collaboration between Mdm2 and Mdmx. Oncotarget. 3: 228-35. PMID 22410433 DOI: 10.18632/Oncotarget.443 |
0.427 |
|
| 2011 |
Sasaki M, Kawahara K, Nishio M, Mimori K, Kogo R, Hamada K, Itoh B, Wang J, Komatsu Y, Yang YR, Hikasa H, Horie Y, Yamashita T, Kamijo T, Zhang Y, et al. Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nature Medicine. 17: 944-51. PMID 21804542 DOI: 10.1038/Nm.2392 |
0.403 |
|
| 2011 |
Deisenroth C, Zhang Y. The Ribosomal Protein-Mdm2-p53 Pathway and Energy Metabolism: Bridging the Gap between Feast and Famine. Genes & Cancer. 2: 392-403. PMID 21779508 DOI: 10.1177/1947601911409737 |
0.394 |
|
| 2011 |
Deisenroth C, Itahana Y, Tollini L, Jin A, Zhang Y. p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation. The Journal of Biological Chemistry. 286: 28343-56. PMID 21659514 DOI: 10.1074/Jbc.M111.254227 |
0.333 |
|
| 2011 |
Li DQ, Pakala SB, Reddy SD, Ohshiro K, Zhang JX, Wang L, Zhang Y, Moreno de Alborán I, Pillai MR, Eswaran J, Kumar R. Bidirectional autoregulatory mechanism of metastasis-associated protein 1-alternative reading frame pathway in oncogenesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 8791-6. PMID 21555589 DOI: 10.1073/Pnas.1018389108 |
0.385 |
|
| 2011 |
Kawahara K, Sasaki M, Nishio M, Mimori K, Kogo R, Zhang Y, Maehama T, Mori M, Suzuki A. Abstract PR9: PICT1/GLTSCR2 is a critical nucleolar binding partner of RPL11 that regulates the MDM2-p53 pathway and tumor growth Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-Pr9 |
0.414 |
|
| 2010 |
Frum RA, Zhang Y. The RP-p53-Mdm2 pathway Cell Cycle. PMID 21135577 DOI: 10.4161/Cc.9.22.13606 |
0.361 |
|
| 2010 |
Macias E, Jin A, Deisenroth C, Bhat K, Mao H, Lindström MS, Zhang Y. An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. Cancer Cell. 18: 231-43. PMID 20832751 DOI: 10.1016/J.Ccr.2010.08.007 |
0.429 |
|
| 2010 |
Deisenroth C, Thorner AR, Enomoto T, Perou CM, Zhang Y. Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53. Molecular and Cellular Biology. 30: 3981-93. PMID 20547751 DOI: 10.1128/Mcb.01284-09 |
0.398 |
|
| 2010 |
Clegg HV, Zhang Y. Regulation of the p53 tumor suppressor pathway: the problems and promises of studying Mdm2's E3 ligase function. Critical Reviews in Eukaryotic Gene Expression. 20: 77-86. PMID 20528739 DOI: 10.1615/Critreveukargeneexpr.V20.I1.60 |
0.427 |
|
| 2009 |
Zhang Y, Lu H. Signaling to p53: ribosomal proteins find their way. Cancer Cell. 16: 369-377. PMID 19878869 DOI: 10.1016/J.Ccr.2009.09.024 |
0.387 |
|
| 2009 |
Li DQ, Reddy SDN, Pakala SB, Wu X, Zhang Y, Rayala SK, Kumar R. MTA1 coregulator regulates p53 stability and function. Journal of Biological Chemistry. 284: 34545-34552. PMID 19837670 DOI: 10.1074/Jbc.M109.056499 |
0.373 |
|
| 2009 |
Fu W, Ma Q, Chen L, Li P, Zhang M, Ramamoorthy S, Nawaz Z, Shimojima T, Wang H, Yang Y, Shen Z, Zhang Y, Zhang X, Nicosia SV, Zhang Y, et al. MDM2 acts downstream of p53 as an E3 ligase to promote FOXO ubiquitination and degradation. The Journal of Biological Chemistry. 284: 13987-4000. PMID 19321440 DOI: 10.1074/Jbc.M901758200 |
0.401 |
|
| 2009 |
Huang M, Itahana K, Zhang Y, Mitchell BS. Depletion of guanine nucleotides leads to the Mdm2-dependent proteasomal degradation of nucleostemin. Cancer Research. 69: 3004-12. PMID 19318567 DOI: 10.1158/0008-5472.Can-08-3413 |
0.357 |
|
| 2009 |
Itahana Y, Ke H, Zhang Y. p53 Oligomerization is essential for its C-terminal lysine acetylation. The Journal of Biological Chemistry. 284: 5158-64. PMID 19106109 DOI: 10.1074/Jbc.M805696200 |
0.386 |
|
| 2008 |
Itahana K, Clegg HV, Zhang Y. ARF in the mitochondria: the last frontier? Cell Cycle (Georgetown, Tex.). 7: 3641-6. PMID 19033735 DOI: 10.4161/Cc.7.23.7105 |
0.395 |
|
| 2008 |
Zhang YP, Holbro N, Oertner TG. Optical induction of plasticity at single synapses reveals input-specific accumulation of alphaCaMKII. Proceedings of the National Academy of Sciences of the United States of America. 105: 12039-44. PMID 18697934 DOI: 10.1073/Pnas.0802940105 |
0.61 |
|
| 2008 |
Itahana K, Zhang Y. Mitochondrial p32 Is a Critical Mediator of ARF-Induced Apoptosis Cancer Cell. 13: 542-553. PMID 18538737 DOI: 10.1016/J.Ccr.2008.04.002 |
0.388 |
|
| 2008 |
Lindström MS, Zhang Y. Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation. Journal of Biological Chemistry. 283: 15568-15576. PMID 18420587 DOI: 10.1074/Jbc.M801151200 |
0.304 |
|
| 2008 |
Clegg HV, Itahana K, Zhang Y. Unlocking the Mdm2-p53 loop: ubiquitin is the key. Cell Cycle (Georgetown, Tex.). 7: 287-92. PMID 18235222 DOI: 10.4161/Cc.7.3.5358 |
0.403 |
|
| 2008 |
Huang M, Ji Y, Itahana K, Zhang Y, Mitchell B. Guanine nucleotide depletion inhibits pre-ribosomal RNA synthesis and causes nucleolar disruption. Leukemia Research. 32: 131-41. PMID 17462731 DOI: 10.1016/J.Leukres.2007.03.025 |
0.326 |
|
| 2007 |
Itahana K, Mao H, Jin A, Itahana Y, Clegg HV, Lindström MS, Bhat KP, Godfrey VL, Evan GI, Zhang Y. Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell. 12: 355-66. PMID 17936560 DOI: 10.1016/J.Ccr.2007.09.007 |
0.41 |
|
| 2007 |
Lindström MS, Deisenroth C, Zhang Y. Putting a Finger on Growth Surveillance Insight into MDM2 Zinc Finger-Ribosomal Protein Interactions Cell Cycle. 6: 434-437. PMID 17329973 DOI: 10.4161/Cc.6.4.3861 |
0.378 |
|
| 2007 |
Zhang YP, Oertner TG. Optical induction of synaptic plasticity using a light-sensitive channel. Nature Methods. 4: 139-41. PMID 17195846 DOI: 10.1038/Nmeth988 |
0.625 |
|
| 2007 |
Lindström MS, Jin A, Deisenroth C, White Wolf G, Zhang Y. Cancer-associated mutations in the MDM2 zinc finger domain disrupt ribosomal protein interaction and attenuate MDM2-induced p53 degradation. Molecular and Cellular Biology. 27: 1056-68. PMID 17116689 DOI: 10.1128/Mcb.01307-06 |
0.396 |
|
| 2006 |
Dai MS, Shi D, Jin Y, Sun XX, Zhang Y, Grossman SR, Lu H. Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism. The Journal of Biological Chemistry. 281: 24304-13. PMID 16803902 DOI: 10.1074/Jbc.M602596200 |
0.344 |
|
| 2006 |
Itahana Y, Yeh ET, Zhang Y. Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2. Molecular and Cellular Biology. 26: 4675-89. PMID 16738331 DOI: 10.1128/Mcb.01830-05 |
0.34 |
|
| 2006 |
Vigot R, Barbieri S, Bräuner-Osborne H, Turecek R, Shigemoto R, Zhang YP, Luján R, Jacobson LH, Biermann B, Fritschy JM, Vacher CM, Müller M, Sansig G, Guetg N, Cryan JF, et al. Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron. 50: 589-601. PMID 16701209 DOI: 10.1016/J.Neuron.2006.04.014 |
0.635 |
|
| 2006 |
Enomoto T, Lindström MS, Jin A, Ke H, Zhang Y. Essential role of the B23/NPM core domain in regulating ARF binding and B23 stability. The Journal of Biological Chemistry. 281: 18463-72. PMID 16679321 DOI: 10.1074/Jbc.M602788200 |
0.3 |
|
| 2004 |
Jin A, Itahana K, O'Keefe K, Zhang Y. Inhibition of HDM2 and activation of p53 by ribosomal protein L23 Molecular and Cellular Biology. 24: 7669-7680. PMID 15314174 DOI: 10.1128/Mcb.24.17.7669-7680.2004 |
0.346 |
|
| 2004 |
Bhat KP, Itahana K, Jin A, Zhang Y. Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation. The Embo Journal. 23: 2402-12. PMID 15152193 DOI: 10.1038/Sj.Emboj.7600247 |
0.348 |
|
| 2003 |
Itahana K, Bhat KP, Jin A, Itahana Y, Hawke D, Kobayashi R, Zhang Y. Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Molecular Cell. 12: 1151-64. PMID 14636574 DOI: 10.1016/S1097-2765(03)00431-3 |
0.383 |
|
| 2003 |
Zhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA, Xiong Y. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Molecular and Cellular Biology. 23: 8902-12. PMID 14612427 DOI: 10.1128/Mcb.23.23.8902-8912.2003 |
0.439 |
|
| 2003 |
O'Keefe K, Li H, Zhang Y. Nucleocytoplasmic shuttling of p53 is essential for MDM2-mediated cytoplasmic degradation but not ubiquitination. Molecular and Cellular Biology. 23: 6396-405. PMID 12944468 DOI: 10.1128/Mcb.23.18.6396-6405.2003 |
0.401 |
|
| 2001 |
Zhang Y, Xiong Y. A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation Science. 292: 1910-1915. PMID 11397945 DOI: 10.1126/Science.1058637 |
0.401 |
|
| 2000 |
Furukawa M, Zhang Y, McCarville J, Ohta T, Xiong Y. The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. Molecular and Cellular Biology. 20: 8185-97. PMID 11027288 DOI: 10.1128/Mcb.20.21.8185-8197.2000 |
0.338 |
|
| 1999 |
Stewart S, Sundaram M, Zhang Y, Lee J, Han M, Guan KL. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Molecular and Cellular Biology. 19: 5523-34. PMID 10409742 DOI: 10.1128/Mcb.19.8.5523 |
0.312 |
|
| 1999 |
Zhang Y, Xiong Y. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53. Molecular Cell. 3: 579-91. PMID 10360174 DOI: 10.1016/S1097-2765(00)80351-2 |
0.405 |
|
| 1998 |
Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell. 92: 725-34. PMID 9529249 DOI: 10.1016/S0092-8674(00)81401-4 |
0.435 |
|
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