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Joshua C. Grieger, Ph.D. - Publications

Affiliations: 
2005 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Microbiology Biology, Molecular Biology
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Kim AY, Duerr FM, Phillips JN, Samulski RJ, Grieger JC, Goodrich LR. Serotype-specific transduction of canine joint tissue explants and cultured monolayers by self-complementary adeno-associated viral vectors. Gene Therapy. PMID 36261499 DOI: 10.1038/s41434-022-00366-x  0.545
2022 Thampi P, Samulski RJ, Grieger JC, Phillips JN, McIlwraith CW, Goodrich LR. Gene therapy approaches for equine osteoarthritis. Frontiers in Veterinary Science. 9: 962898. PMID 36246316 DOI: 10.3389/fvets.2022.962898  0.347
2018 Tan YZ, Aiyer S, Mietzsch M, Hull JA, McKenna R, Grieger J, Samulski RJ, Baker TS, Agbandje-McKenna M, Lyumkis D. Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant. Nature Communications. 9: 3628. PMID 30194371 DOI: 10.1038/S41467-018-06076-6  0.546
2018 Samulski RJ, Smith JM, Grieger JC, Cornetta K, Snyder R. The Growing Promise of Gene Therapy Approaches Cell and Gene Therapy Insights. 4: 1043-1049. DOI: 10.18609/cgti.2018.104  0.485
2016 Clément N, Grieger JC. Manufacturing of recombinant adeno-associated viral vectors for clinical trials. Molecular Therapy. Methods & Clinical Development. 3: 16002. PMID 27014711 DOI: 10.1038/Mtm.2016.2  0.495
2016 Wang G, Evans CH, Benson JM, Hutt JA, Seagrave J, Wilder JA, Grieger JC, Samulski RJ, Terse PS. Safety and biodistribution assessment of sc-rAAV2.5IL-1Ra administered via intra-articular injection in a mono-iodoacetate-induced osteoarthritis rat model. Molecular Therapy. Methods & Clinical Development. 3: 15052. PMID 26817025 DOI: 10.1038/Mtm.2015.52  0.539
2015 Grieger JC, Soltys SM, Samulski RJ. Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26437810 DOI: 10.1038/Mt.2015.187  0.598
2015 Goodrich LR, Grieger JC, Phillips JN, Khan N, Gray SJ, McIlwraith CW, Samulski RJ. scAAVIL-1ra dosing trial in a large animal model and validation of long-term expression with repeat administration for osteoarthritis therapy. Gene Therapy. 22: 536-45. PMID 25902762 DOI: 10.1038/Gt.2015.21  0.574
2015 Monahan PE, Sun J, Gui T, Hu G, Hannah WB, Wichlan DG, Wu Z, Grieger JC, Li C, Suwanmanee T, Stafford DW, Booth CJ, Samulski JJ, Kafri T, McPhee SW, et al. Employing a gain-of-function factor IX variant R338L to advance the efficacy and safety of hemophilia B human gene therapy: preclinical evaluation supporting an ongoing adeno-associated virus clinical trial. Human Gene Therapy. 26: 69-81. PMID 25419787 DOI: 10.1089/Hum.2014.106  0.602
2014 Qiao C, Li C, Zhao C, Li J, Bian T, Grieger J, Li J, Samulski RJ, Xiao X. K137R mutation on adeno-associated viral capsids had minimal effect on enhancing gene delivery in vivo. Human Gene Therapy Methods. 25: 33-9. PMID 24116972 DOI: 10.1089/Hgtb.2013.176  0.614
2013 Goodrich LR, Phillips JN, McIlwraith CW, Foti SB, Grieger JC, Gray SJ, Samulski RJ. Optimization of scAAVIL-1ra In Vitro and In Vivo to Deliver High Levels of Therapeutic Protein for Treatment of Osteoarthritis. Molecular Therapy. Nucleic Acids. 2: e70. PMID 23385523 DOI: 10.1038/Mtna.2012.61  0.572
2012 Grieger JC, Samulski RJ. Adeno-associated virus vectorology, manufacturing, and clinical applications. Methods in Enzymology. 507: 229-54. PMID 22365777 DOI: 10.1016/B978-0-12-386509-0.00012-0  0.637
2012 Bowles DE, McPhee SW, Li C, Gray SJ, Samulski JJ, Camp AS, Li J, Wang B, Monahan PE, Rabinowitz JE, Grieger JC, Govindasamy L, Agbandje-McKenna M, Xiao X, Samulski RJ. Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 443-55. PMID 22068425 DOI: 10.1038/Mt.2011.237  0.639
2012 Federici T, Taub JS, Baum GR, Gray SJ, Grieger JC, Matthews KA, Handy CR, Passini MA, Samulski RJ, Boulis NM. Robust spinal motor neuron transduction following intrathecal delivery of AAV9 in pigs. Gene Therapy. 19: 852-9. PMID 21918551 DOI: 10.1038/Gt.2011.130  0.555
2009 Li W, Zhang L, Johnson JS, Zhijian W, Grieger JC, Ping-Jie X, Drouin LM, Agbandje-McKenna M, Pickles RJ, Samulski RJ. Generation of novel AAV variants by directed evolution for improved CFTR delivery to human ciliated airway epithelium. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2067-77. PMID 19603002 DOI: 10.1038/Mt.2009.155  0.575
2007 Grieger JC, Johnson JS, Gurda-Whitaker B, Agbandje-McKenna M, Samulski RJ. Surface-exposed adeno-associated virus Vp1-NLS capsid fusion protein rescues infectivity of noninfectious wild-type Vp2/Vp3 and Vp3-only capsids but not that of fivefold pore mutant virions. Journal of Virology. 81: 7833-43. PMID 17507473 DOI: 10.1128/Jvi.00580-07  0.556
2006 Grieger JC, Choi VW, Samulski RJ. Production and characterization of adeno-associated viral vectors. Nature Protocols. 1: 1412-28. PMID 17406430 DOI: 10.1038/Nprot.2006.207  0.629
2006 Wu Z, Asokan A, Grieger JC, Govindasamy L, Agbandje-McKenna M, Samulski RJ. Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes. Journal of Virology. 80: 11393-7. PMID 16943302 DOI: 10.1128/Jvi.01288-06  0.57
2006 Grieger JC, Snowdy S, Samulski RJ. Separate basic region motifs within the adeno-associated virus capsid proteins are essential for infectivity and assembly. Journal of Virology. 80: 5199-210. PMID 16699000 DOI: 10.1128/Jvi.02723-05  0.57
2005 Grieger JC, Samulski RJ. Adeno-associated virus as a gene therapy vector: vector development, production and clinical applications. Advances in Biochemical Engineering/Biotechnology. 99: 119-45. PMID 16568890 DOI: 10.1007/10_005  0.669
2005 Grieger JC, Samulski RJ. Packaging capacity of adeno-associated virus serotypes: impact of larger genomes on infectivity and postentry steps. Journal of Virology. 79: 9933-44. PMID 16014954 DOI: 10.1128/Jvi.79.15.9933-9944.2005  0.574
2004 Grieger JC, Rabinowitz JE, Bowles DE, Samulski RJ. 17. Role of Vp2 in AAV Packaging Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.05.098  0.595
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