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Richard M. Van Rijn, Ph.D. - Publications

Affiliations: 
2013- Medicinal Chemistry and Molecular Pharmacology Purdue University, West Lafayette, IN, United States 
Area:
opioid receptors, addiction, alcoholism
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57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Hennessy MR, Creed SM, Gutridge AM, Rusali LE, Luo D, Sepehri B, Rhoda ES, Villegas JA, van Rijn RM, Riley AP. Discovery of Potent Kappa Opioid Receptor Agonists Derived from Akuammicine. Journal of Medicinal Chemistry. PMID 39565354 DOI: 10.1021/acs.jmedchem.4c00736  0.837
2024 Meqbil YJ, Aguilar J, Blaine AT, Chen L, Cassell RJ, Pradhan AA, van Rijn RM. . The Journal of Pharmacology and Experimental Therapeutics. PMID 38621994 DOI: 10.1124/jpet.123.001735  0.835
2023 French AR, Meqbil YJ, van Rijn RM. ClickArr: a novel, high-throughput assay for evaluating β-arrestin isoform recruitment. Frontiers in Pharmacology. 14: 1295518. PMID 38027002 DOI: 10.3389/fphar.2023.1295518  0.783
2023 Blaine AT, van Rijn RM. Receptor expression and signaling properties in the brain, and structural ligand motifs that contribute to delta opioid receptor agonist-induced seizures. Neuropharmacology. 109526. PMID 37004753 DOI: 10.1016/j.neuropharm.2023.109526  0.779
2023 Hennessy MR, Gutridge AM, French AR, Rhoda ES, Meqbil YJ, Gill M, Kashyap Y, Appourchaux K, Paul B, Wang ZJ, van Rijn RM, Riley AP. Modified Akuamma Alkaloids with Increased Potency at the Mu-opioid Receptor. Journal of Medicinal Chemistry. PMID 36827198 DOI: 10.1021/acs.jmedchem.2c01707  0.815
2022 Blaine AT, Miao Y, Yuan J, Palant S, Liu RJ, Zhang ZY, van Rijn RM. Exploration of beta-arrestin isoform signaling pathways in delta opioid receptor agonist-induced convulsions. Frontiers in Pharmacology. 13: 914651. PMID 36059958 DOI: 10.3389/fphar.2022.914651  0.773
2022 Van Rijn RM, Spetea M. Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery II. Molecules (Basel, Switzerland). 27. PMID 35630616 DOI: 10.3390/molecules27103140  0.422
2022 French AR, Gutridge AM, Yuan J, Royer QH, van Rijn RM. Sex- and β-arrestin-dependent effects of kappa opioid receptor-mediated ethanol consumption. Pharmacology, Biochemistry, and Behavior. 216: 173377. PMID 35364122 DOI: 10.1016/j.pbb.2022.173377  0.83
2022 French AR, van Rijn RM. An updated assessment of the translational promise of G-protein-biased kappa opioid receptor agonists to treat pain and other indications without debilitating adverse effects. Pharmacological Research. 177: 106091. PMID 35101565 DOI: 10.1016/j.phrs.2022.106091  0.822
2021 Meqbil YJ, Su H, Cassell RJ, Mores KL, Gutridge AM, Cummins BR, Chen L, van Rijn RM. Identification of a Novel Delta Opioid Receptor Agonist Chemotype with Potential Negative Allosteric Modulator Capabilities. Molecules (Basel, Switzerland). 26. PMID 34885825 DOI: 10.3390/molecules26237236  0.806
2021 Sharma KK, Cassell RJ, Meqbil YJ, Su H, Blaine AT, Cummins BR, Mores KL, Johnson DK, van Rijn RM, Altman RA. Modulating β-arrestin 2 recruitment at the δ- and μ-opioid receptors using peptidomimetic ligands. Rsc Medicinal Chemistry. 12: 1958-1967. PMID 34825191 DOI: 10.1039/d1md00025j  0.833
2021 Gutridge AM, Chakraborty S, Varga BR, Rhoda ES, French AR, Blaine AT, Royer QH, Cui H, Yuan J, Cassell RJ, Szabó M, Majumdar S, van Rijn RM. Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder. Frontiers in Pharmacology. 12: 764885. PMID 34803709 DOI: 10.3389/fphar.2021.764885  0.822
2021 Chakraborty S, DiBerto JF, Faouzi A, Bernhard SM, Gutridge AM, Ramsey S, Zhou Y, Provasi D, Nuthikattu N, Jilakara R, Nelson MNF, Asher WB, Eans SO, Wilson LL, Chintala SM, ... ... van Rijn RM, et al. A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects. Journal of Medicinal Chemistry. PMID 34505767 DOI: 10.1021/acs.jmedchem.1c01273  0.836
2021 Ko MJ, Chiang T, Mukadam AA, Mulia GE, Gutridge AM, Lin A, Chester JA, van Rijn RM. β-Arrestin-dependent ERK signaling reduces anxiety-like and conditioned fear-related behaviors in mice. Science Signaling. 14. PMID 34344831 DOI: 10.1126/scisignal.aba0245  0.793
2021 Sharifi F, Meqbil YJ, Otte A, Gutridge AM, Blaine AT, van Rijn RM, Park K. Engineering Quick- and Long-acting Naloxone Delivery Systems for Treating Opioid Overdose. Pharmaceutical Research. PMID 34114163 DOI: 10.1007/s11095-021-03069-x  0.791
2021 Ganzen L, Ko MJ, Zhang M, Xie R, Chen Y, Zhang L, James R, Mumm J, van Rijn RM, Zhong W, Pang CP, Zhang M, Tsujikawa M, Leung YF. Drug screening with zebrafish visual behavior identifies carvedilol as a potential treatment for an autosomal dominant form of retinitis pigmentosa. Scientific Reports. 11: 11432. PMID 34075074 DOI: 10.1038/s41598-021-89482-z  0.757
2020 Bertels Z, Witkowski WD, Asif S, Siegersma K, van Rijn RM, Pradhan AA. A non-convulsant delta-opioid receptor agonist, KNT-127, reduces cortical spreading depression and nitroglycerin-induced allodynia. Headache. PMID 33326598 DOI: 10.1111/head.14019  0.41
2020 Creed SM, Gutridge AM, Argade MD, Hennessy MR, Friesen JB, Pauli GF, van Rijn RM, Riley AP. Isolation and Pharmacological Characterization of Six Opioidergic Alkaloids. Journal of Natural Products. PMID 33326237 DOI: 10.1021/acs.jnatprod.0c01036  0.847
2019 Cassell RJ, Sharma KK, Su H, Cummins BR, Cui H, Mores KL, Blaine AT, Altman RA, van Rijn RM. The Meta-Position of Phe in Leu-Enkephalin Regulates Potency, Selectivity, Functional Activity, and Signaling Bias at the Delta and Mu Opioid Receptors. Molecules (Basel, Switzerland). 24. PMID 31842282 DOI: 10.3390/Molecules24244542  0.821
2019 Gutridge AM, Robins MT, Cassell RJ, Uprety R, Mores KL, Ko MJ, Pasternak GW, Majumdar S, van Rijn RM. G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder. British Journal of Pharmacology. PMID 31705528 DOI: 10.1111/Bph.14913  0.821
2019 Cai B, Kim D, Akhand S, Sun Y, Cassell R, Alpsoy A, Dykhuizen EC, van Rijn RM, Wendt MK, Krusemark C. Selection of DNA-encoded Libraries to Protein Targets Within and On Living Cells. Journal of the American Chemical Society. PMID 31613623 DOI: 10.1021/Jacs.9B08085  0.511
2019 Ko MJ, van Rijn RM. Response: Commentary: Commonly Used Anesthesia/Euthanasia Methods for Brain Collection Differentially Impact MAPK Activity in Male and Female C57BL/6 Mice. Frontiers in Cellular Neuroscience. 13: 379. PMID 31474837 DOI: 10.3389/fncel.2019.00379  0.45
2019 Mores KL, Cummins BR, Cassell RJ, van Rijn RM. A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists. Frontiers in Pharmacology. 10: 407. PMID 31057409 DOI: 10.3389/fphar.2019.00407  0.693
2019 Ko MJ, Mulia GE, van Rijn RM. Commonly Used Anesthesia/Euthanasia Methods for Brain Collection Differentially Impact MAPK Activity in Male and Female C57BL/6 Mice. Frontiers in Cellular Neuroscience. 13: 96. PMID 30983972 DOI: 10.3389/fncel.2019.00096  0.493
2019 Robins MT, Blaine AT, Ha JE, Brewster AL, van Rijn RM. Repeated Use of the Psychoactive Substance Ethylphenidate Impacts Neurochemistry and Reward Learning in Adolescent Male and Female Mice. Frontiers in Neuroscience. 13: 124. PMID 30837836 DOI: 10.3389/Fnins.2019.00124  0.763
2019 Ko MJ, Ganzen LC, Coskun E, Mukadam AA, Leung YF, van Rijn RM. A critical evaluation of TRPA1-mediated locomotor behavior in zebrafish as a screening tool for novel anti-nociceptive drug discovery. Scientific Reports. 9: 2430. PMID 30787340 DOI: 10.1038/S41598-019-38852-9  0.795
2018 Cassell RJ, Mores KL, Zerfas BL, Mahmoud AH, Lill MA, Trader DJ, van Rijn RM. Rubiscolins are naturally occurring G protein-biased delta opioid receptor peptides. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 30591345 DOI: 10.1016/J.Euroneuro.2018.12.013  0.681
2018 Mores KL, Cassell RJ, van Rijn RM. Arrestin recruitment and signaling by G protein-coupled receptor heteromers. Neuropharmacology. PMID 30419245 DOI: 10.1016/j.neuropharm.2018.11.010  0.615
2018 Robins MT, Chiang T, Mores KL, Alongkronrusmee D, van Rijn RM. Critical Role for G-Protein Activity in the Dorsal Striatum in the Reduction of Voluntary Alcohol Intake in C57Bl/6 Mice. Frontiers in Psychiatry. 9: 112. PMID 29686629 DOI: 10.3389/Fpsyt.2018.00112  0.795
2018 Robins MT, Chiang T, Berry JN, Ko MJ, Ha JE, van Rijn RM. Behavioral Characterization of β-Arrestin 1 Knockout Mice in Anxiety-Like and Alcohol Behaviors. Frontiers in Behavioral Neuroscience. 12: 54. PMID 29615880 DOI: 10.3389/Fnbeh.2018.00054  0.797
2017 Márquez-Gómez R, Robins MT, Gutiérrez-Rodelo C, Arias JM, Olivares-Reyes JA, van Rijn RM, Arias-Montaño JA. Functional histamine H3 and adenosine A2A receptor heteromers in recombinant cells and rat striatum. Pharmacological Research. PMID 29217157 DOI: 10.1016/J.Phrs.2017.11.036  0.772
2017 Brust TF, Alongkronrusmee D, Soto-Velasquez M, Baldwin TA, Ye Z, Dai M, Dessauer CW, van Rijn RM, Watts VJ. Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Science Signaling. 10. PMID 28223412 DOI: 10.1126/Scisignal.Aah5381  0.781
2017 Zeng L, Alongkronrusmee D, van Rijn RM. An integrated perspective on diabetic, alcoholic, and drug-induced neuropathy, etiology, and treatment in the US. Journal of Pain Research. 10: 219-228. PMID 28176937 DOI: 10.2147/Jpr.S125987  0.796
2016 Alongkronrusmee D, Chiang T, van Rijn RM. Involvement of delta opioid receptors in alcohol withdrawal-induced mechanical allodynia in male C57BL/6 mice. Drug and Alcohol Dependence. PMID 27567436 DOI: 10.1016/J.Drugalcdep.2016.08.017  0.823
2016 Robins MT, DeFriel JN, van Rijn RM. Adolescent intake of caffeinated energy drinks does not affect adult alcohol consumption in C57BL/6 and BALB/c mice. Alcohol (Fayetteville, N.Y.). 54: 1-9. PMID 27565749 DOI: 10.1016/J.Alcohol.2016.05.001  0.76
2016 Yang S, Ben-Shalom R, Ahn M, Liptak AT, van Rijn RM, Whistler JL, Bender KJ. β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment. Cell Reports. PMID 27452469 DOI: 10.1016/J.Celrep.2016.06.098  0.598
2016 Robins MT, Lu J, van Rijn RM. Unique Behavioral and Neurochemical Effects Induced by Repeated Adolescent Consumption of Caffeine-Mixed Alcohol in C57BL/6 Mice. Plos One. 11: e0158189. PMID 27380261 DOI: 10.1371/Journal.Pone.0158189  0.765
2016 Alongkronrusmee D, Chiang T, van Rijn RM. Delta Opioid Pharmacology in Relation to Alcohol Behaviors. Handbook of Experimental Pharmacology. PMID 27316912 DOI: 10.1007/164_2016_30  0.804
2015 Chiang T, Sansuk K, van Rijn RM. Beta-arrestin 2 dependence of delta opioid receptor agonists is correlated with alcohol intake. British Journal of Pharmacology. PMID 26507558 DOI: 10.1111/Bph.13374  0.815
2013 van Rijn RM, Defriel JN, Whistler JL. Pharmacological traits of delta opioid receptors: pitfalls or opportunities? Psychopharmacology. 228: 1-18. PMID 23649885 DOI: 10.1007/S00213-013-3129-2  0.699
2013 Milan-Lobo L, Enquist J, van Rijn RM, Whistler JL. Anti-analgesic effect of the mu/delta opioid receptor heteromer revealed by ligand-biased antagonism. Plos One. 8: e58362. PMID 23554887 DOI: 10.1371/Journal.Pone.0058362  0.841
2013 Harvey JH, van Rijn RM, Whistler JL. A FLIPR assay for evaluating agonists and antagonists of GPCR heterodimers. Methods in Molecular Biology (Clifton, N.J.). 995: 43-54. PMID 23494371 DOI: 10.1007/978-1-62703-345-9_4  0.601
2013 van Rijn RM, Harvey JH, Brissett DI, DeFriel JN, Whistler JL. Novel screening assay for the selective detection of G-protein-coupled receptor heteromer signaling. The Journal of Pharmacology and Experimental Therapeutics. 344: 179-88. PMID 23097213 DOI: 10.1124/Jpet.112.198655  0.685
2012 Brissett DI, Whistler JL, van Rijn RM. Contribution of mu and delta opioid receptors to the pharmacological profile of kappa opioid receptor subtypes. European Journal of Pain (London, England). 16: 327-37. PMID 22337177 DOI: 10.1002/J.1532-2149.2011.00022.X  0.721
2012 van Rijn RM, Brissett DI, Whistler JL. Distinctive modulation of ethanol place preference by delta opioid receptor-selective agonists. Drug and Alcohol Dependence. 122: 156-9. PMID 22018601 DOI: 10.1016/J.Drugalcdep.2011.09.024  0.677
2012 van Rijn RM, Brissett DI, Whistler JL. Emergence of functional spinal delta opioid receptors after chronic ethanol exposure. Biological Psychiatry. 71: 232-8. PMID 21889123 DOI: 10.1016/J.Biopsych.2011.07.015  0.679
2010 van Rijn RM, Brissett DI, Whistler JL. Dual efficacy of delta opioid receptor-selective ligands for ethanol drinking and anxiety. The Journal of Pharmacology and Experimental Therapeutics. 335: 133-9. PMID 20605909 DOI: 10.1124/Jpet.110.170969  0.662
2010 van Rijn RM, Whistler JL, Waldhoer M. Opioid-receptor-heteromer-specific trafficking and pharmacology. Current Opinion in Pharmacology. 10: 73-9. PMID 19846340 DOI: 10.1016/J.Coph.2009.09.007  0.818
2009 van Rijn RM, Whistler JL. The delta(1) opioid receptor is a heterodimer that opposes the actions of the delta(2) receptor on alcohol intake. Biological Psychiatry. 66: 777-84. PMID 19576572 DOI: 10.1016/J.Biopsych.2009.05.019  0.735
2009 He L, Kim J, Ou C, McFadden W, van Rijn RM, Whistler JL. Methadone antinociception is dependent on peripheral opioid receptors. The Journal of Pain : Official Journal of the American Pain Society. 10: 369-79. PMID 19327642 DOI: 10.1016/J.Jpain.2008.09.011  0.716
2008 van Rijn RM, Whistler JL. The only way is up: preventing opioid tolerance by promoting cell surface expression of MOR-DOR heterodimers? Molecular Interventions. 8: 277-80. PMID 19144899 DOI: 10.1124/Mi.8.6.4  0.644
2008 van Rijn RM, van Marle A, Chazot PL, Langemeijer E, Qin Y, Shenton FC, Lim HD, Zuiderveld OP, Sansuk K, Dy M, Smit MJ, Tensen CP, Bakker RA, Leurs R. Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor. The Biochemical Journal. 414: 121-31. PMID 18452403 DOI: 10.1042/Bj20071583  0.746
2006 van Rijn RM, Chazot PL, Shenton FC, Sansuk K, Bakker RA, Leurs R. Oligomerization of recombinant and endogenously expressed human histamine H(4) receptors. Molecular Pharmacology. 70: 604-15. PMID 16645125 DOI: 10.1124/Mol.105.020818  0.76
2006 Bakker RA, Lozada AF, van Marle A, Shenton FC, Drutel G, Karlstedt K, Hoffmann M, Lintunen M, Yamamoto Y, van Rijn RM, Chazot PL, Panula P, Leurs R. Discovery of naturally occurring splice variants of the rat histamine H3 receptor that act as dominant-negative isoforms. Molecular Pharmacology. 69: 1194-206. PMID 16415177 DOI: 10.1124/Mol.105.019299  0.587
2005 Lim HD, van Rijn RM, Ling P, Bakker RA, Thurmond RL, Leurs R. Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. The Journal of Pharmacology and Experimental Therapeutics. 314: 1310-21. PMID 15947036 DOI: 10.1124/jpet.105.087965  0.585
2004 Terzioglu N, van Rijn RM, Bakker RA, De Esch IJ, Leurs R. Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 14: 5251-6. PMID 15454206 DOI: 10.1016/j.bmcl.2004.08.035  0.59
2003 Rhee IK, van Rijn RM, Verpoorte R. Qualitative determination of false-positive effects in the acetylcholinesterase assay using thin layer chromatography. Phytochemical Analysis : Pca. 14: 127-31. PMID 12793457 DOI: 10.1002/Pca.675  0.322
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