| Year |
Citation |
Score |
| 2022 |
Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, ... ... Majumdar S, et al. Structure-based design of bitopic ligands for the µ-opioid receptor. Nature. PMID 36450356 DOI: 10.1038/s41586-022-05588-y |
0.486 |
|
| 2022 |
Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, et al. Insights into distinct signaling profiles of the µOR activated by diverse agonists. Nature Chemical Biology. PMID 36411392 DOI: 10.1038/s41589-022-01208-y |
0.475 |
|
| 2021 |
Varga B, Streicher JM, Majumdar S. Strategies towards safer opioid analgesics - a review of old and upcoming targets. British Journal of Pharmacology. PMID 34826881 DOI: 10.1111/bph.15760 |
0.631 |
|
| 2021 |
Gutridge AM, Chakraborty S, Varga BR, Rhoda ES, French AR, Blaine AT, Royer QH, Cui H, Yuan J, Cassell RJ, Szabó M, Majumdar S, van Rijn RM. Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder. Frontiers in Pharmacology. 12: 764885. PMID 34803709 DOI: 10.3389/fphar.2021.764885 |
0.513 |
|
| 2021 |
Chakraborty S, Uprety R, Slocum ST, Irie T, Le Rouzic V, Li X, Wilson LL, Scouller B, Alder AF, Kruegel AC, Ansonoff M, Varadi A, Eans SO, Hunkele A, Allaoa A, ... ... Majumdar S, et al. Oxidative Metabolism as a Modulator of Kratom's Biological Actions. Journal of Medicinal Chemistry. PMID 34783240 DOI: 10.1021/acs.jmedchem.1c01111 |
0.75 |
|
| 2021 |
Liu S, Kang WJ, Abrimian A, Xu J, Cartegni L, Majumdar S, Hesketh P, Bekker A, Pan YX. Alternative Pre-mRNA Splicing of the Mu Opioid Receptor Gene, : Insight into Complex Mu Opioid Actions. Biomolecules. 11. PMID 34680158 DOI: 10.3390/biom11101525 |
0.695 |
|
| 2021 |
Chakraborty S, DiBerto JF, Faouzi A, Bernhard SM, Gutridge AM, Ramsey S, Zhou Y, Provasi D, Nuthikattu N, Jilakara R, Nelson MNF, Asher WB, Eans SO, Wilson LL, Chintala SM, ... ... Majumdar S, et al. A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects. Journal of Medicinal Chemistry. PMID 34505767 DOI: 10.1021/acs.jmedchem.1c01273 |
0.578 |
|
| 2021 |
Chakraborty S, Uprety R, Daibani AE, Rouzic VL, Hunkele A, Appourchaux K, Eans SO, Nuthikattu N, Jilakara R, Thammavong L, Pasternak GW, Pan YX, McLaughlin JP, Che T, Majumdar S. Kratom Alkaloids as Probes for Opioid Receptor Function: Pharmacological Characterization of Minor Indole and Oxindole Alkaloids from Kratom. Acs Chemical Neuroscience. PMID 34213886 DOI: 10.1021/acschemneuro.1c00149 |
0.788 |
|
| 2021 |
Bhowmik S, Galeta J, Havel V, Nelson M, Faouzi A, Bechand B, Ansonoff M, Fiala T, Hunkele A, Kruegel AC, Pintar JE, Majumdar S, Javitch JA, Sames D. Site selective C-H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy. Nature Communications. 12: 3858. PMID 34158473 DOI: 10.1038/s41467-021-23736-2 |
0.589 |
|
| 2021 |
Uprety R, Che T, Zaidi SA, Grinnell SG, Varga BR, Faouzi A, Slocum ST, Allaoa A, Varadi A, Nelson M, Bernhard SM, Kulko E, LeRouzic V, Eans SO, Simons CA, ... ... Majumdar S, et al. Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site. Elife. 10. PMID 33555255 DOI: 10.7554/eLife.56519 |
0.864 |
|
| 2021 |
Wilson LL, Chakraborty S, Eans SO, Cirino TJ, Stacy HM, Simons CA, Uprety R, Majumdar S, McLaughlin JP. Kratom Alkaloids, Natural and Semi-Synthetic, Show Less Physical Dependence and Ameliorate Opioid Withdrawal. Cellular and Molecular Neurobiology. PMID 33433723 DOI: 10.1007/s10571-020-01034-7 |
0.496 |
|
| 2020 |
Atigari DV, Paton KF, Uprety R, Váradi A, Alder AF, Scouller B, Miller JH, Majumdar S, Kivell BM. The mixed kappa and delta opioid receptor agonist, MP1104, attenuates chemotherapy-induced neuropathic pain. Neuropharmacology. 108445. PMID 33383089 DOI: 10.1016/j.neuropharm.2020.108445 |
0.652 |
|
| 2020 |
Zhou Y, Ramsey S, Provasi D, El Daibani A, Appourchaux K, Chakraborty S, Kapoor A, Che T, Majumdar S, Filizola M. Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom's Alkaloids with Reported Antinociception . Biochemistry. PMID 33274929 DOI: 10.1021/acs.biochem.0c00658 |
0.544 |
|
| 2020 |
Faouzi A, Uprety R, Gomes I, Massaly N, Keresztes AI, Le Rouzic V, Gupta A, Zhang T, Yoon HJ, Ansonoff M, Allaoa A, Pan YX, Pintar J, Morón JA, Streicher JM, ... ... Majumdar S, et al. Synthesis and Pharmacology of a Novel μ-δ Opioid Receptor Heteromer-Selective Agonist Based on the Carfentanyl Template. Journal of Medicinal Chemistry. PMID 33170687 DOI: 10.1021/acs.jmedchem.0c00901 |
0.682 |
|
| 2020 |
Faouzi A, Varga BR, Majumdar S. Biased Opioid Ligands. Molecules (Basel, Switzerland). 25. PMID 32948048 DOI: 10.3390/molecules25184257 |
0.693 |
|
| 2020 |
Chakraborty S, Majumdar S. Natural products for the treatment of pain: chemistry and pharmacology of salvinorin A, mitragynine and collybolide. Biochemistry. PMID 32930582 DOI: 10.1021/acs.biochem.0c00629 |
0.63 |
|
| 2020 |
Grinnell SG, Uprety R, Varadi A, Subrath J, Hunkele A, Pan YX, Pasternak GW, Majumdar S. Synthesis and Characterization of Azido Aryl Analogs of IBNtxA for Radio-Photoaffinity Labeling Opioid Receptors in Cell Lines and in Mouse Brain. Cellular and Molecular Neurobiology. PMID 32424771 DOI: 10.1007/S10571-020-00867-6 |
0.864 |
|
| 2020 |
Ulker E, Toma W, White A, Uprety R, Majumdar S, Damaj MI. The antinociceptive effects of a dual kappa-delta opioid receptor agonist in the mouse formalin test. Behavioural Pharmacology. 31: 174-178. PMID 32168026 DOI: 10.1097/Fbp.0000000000000541 |
0.513 |
|
| 2020 |
Stoeber M, Jullié D, Li J, Chakraborty S, Majumdar S, Lambert NA, Manglik A, von Zastrow M. Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells. Elife. 9. PMID 32096468 DOI: 10.7554/Elife.54208 |
0.52 |
|
| 2019 |
Gutridge AM, Robins MT, Cassell RJ, Uprety R, Mores KL, Ko MJ, Pasternak GW, Majumdar S, van Rijn RM. G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder. British Journal of Pharmacology. PMID 31705528 DOI: 10.1111/Bph.14913 |
0.642 |
|
| 2019 |
Kruegel AC, Uprety R, Grinnell SG, Langreck C, Pekarskaya EA, Le Rouzic V, Ansonoff M, Gassaway MM, Pintar JE, Pasternak GW, Javitch JA, Majumdar S, Sames D. 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects. Acs Central Science. 5: 992-1001. PMID 31263758 DOI: 10.1021/Acscentsci.9B00141 |
0.861 |
|
| 2019 |
Gangangari KK, Váradi A, Majumdar S, Larson SM, Pasternak GW, Pillarsetty NK. Imaging Sigma-1 Receptor (S1R) Expression Using Iodine-124-Labeled 1-(4-Iodophenyl)-3-(2-adamantyl)guanidine ([I]IPAG). Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 31165385 DOI: 10.1007/S11307-019-01369-8 |
0.475 |
|
| 2019 |
Atigari DV, Uprety R, Pasternak GW, Majumdar S, Kivell BM. MP1104, a mixed kappa-delta opioid receptor agonist has anti-cocaine properties with reduced side-effects in rats. Neuropharmacology. PMID 30768946 DOI: 10.1016/J.Neuropharm.2019.02.010 |
0.58 |
|
| 2018 |
Majumdar S, Devi LA. Strategy for making safer opioids bolstered. Nature. 553: 286-288. PMID 32076275 DOI: 10.1038/D41586-018-00045-1 |
0.633 |
|
| 2018 |
Uprety R, Váradi A, Allaoa A, Redel-Traub GN, Palmer TC, Feinberg EN, Ferris AC, Pande VS, Pasternak GW, Majumdar S. Synthesis of spiro-2,6-dioxopiperazine and spiro-2,6-dioxopyrazine scaffolds using amino acids in a three-component reaction to generate potential Sigma-1 (σ) receptor selective ligands. European Journal of Medicinal Chemistry. 164: 241-251. PMID 30597325 DOI: 10.1016/J.Ejmech.2018.12.048 |
0.561 |
|
| 2018 |
Le Rouzic V, Narayan A, Hunkle A, Marrone GF, Lu Z, Majumdar S, Xu J, Pan YX, Pasternak GW. Pharmacological Characterization of Levorphanol, a G-Protein Biased Opioid Analgesic. Anesthesia and Analgesia. PMID 29649035 DOI: 10.1213/Ane.0000000000003360 |
0.801 |
|
| 2018 |
Majumdar S, Devi LA. Strategy for making safer opioids bolstered. Nature. 553: 286-288. PMID 29345640 DOI: 10.1038/d41586-018-00045-1 |
0.572 |
|
| 2018 |
Che T, Majumdar S, Zaidi SA, Ondachi P, McCorvy JD, Wang S, Mosier PD, Uprety R, Vardy E, Krumm BE, Han GW, Lee MY, Pardon E, Steyaert J, Huang XP, et al. Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor. Cell. PMID 29307491 DOI: 10.1016/J.Cell.2017.12.011 |
0.725 |
|
| 2017 |
Lu Z, Xu J, Xu M, Rossi GC, Majumdar S, Pasternak GW, Pan YX. Truncated μ-Opioid Receptors With 6 Transmembrane Domains Are Essential for Opioid Analgesia. Anesthesia and Analgesia. PMID 28991118 DOI: 10.1213/Ane.0000000000002538 |
0.714 |
|
| 2017 |
Baumann MH, Majumdar S, Le Rouzic V, Hunkele A, Uprety R, Huang XP, Xu J, Roth BL, Pan YX, Pasternak GW. Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace. Neuropharmacology. PMID 28807672 DOI: 10.1016/J.Neuropharm.2017.08.016 |
0.758 |
|
| 2017 |
Urai Á, Váradi A, Szőcs L, Komjáti B, Le Rouzic V, Hunkele A, Pasternak GW, Majumdar S, Hosztafi S. Synthesis and pharmacological evaluation of novel selective MOR agonist 6β-pyridinyl amidomorphines exhibiting long-lasting antinociception. Medchemcomm. 8: 152-157. PMID 28603600 DOI: 10.1039/C6Md00450D |
0.633 |
|
| 2017 |
Marrone GF, Le Rouzic V, Varadi A, Xu J, Rajadhyaksha AM, Majumdar S, Pan YX, Pasternak GW. Genetic dissociation of morphine analgesia from hyperalgesia in mice. Psychopharmacology. PMID 28343361 DOI: 10.1007/S00213-017-4600-2 |
0.822 |
|
| 2016 |
Marrone GF, Lu Z, Rossi G, Narayan A, Hunkele A, Marx S, Xu J, Pintar J, Majumdar S, Pan YX, Pasternak GW. Tetrapeptide endomorphin analogs require both full length and truncated splice variants of the mu opioid receptor gene Oprm1 for analgesia. Acs Chemical Neuroscience. PMID 27648914 DOI: 10.1021/Acschemneuro.6B00240 |
0.817 |
|
| 2016 |
Váradi A, Marrone GF, Palmer TC, Narayan A, Szabó MR, Le Rouzic V, Grinnell SG, Subrath JJ, Warner E, Kalra S, Hunkele A, Pagirsky J, Eans SO, Medina JM, Xu J, ... ... Majumdar S, et al. Mitragynine/corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and delta antagonism which do not recruit β-arrestin-2. Journal of Medicinal Chemistry. PMID 27556704 DOI: 10.1021/Acs.Jmedchem.6B00748 |
0.862 |
|
| 2016 |
Grinnell SG, Ansonoff M, Marrone GF, Lu Z, Narayan A, Xu J, Rossi G, Majumdar S, Pan YX, Bassoni DL, Pintar J, Pasternak G. Mediation of buprenorphine analgesia by a combination of traditional and truncated mu opioid receptor splice variants. Synapse (New York, N.Y.). PMID 27223691 DOI: 10.1002/Syn.21914 |
0.844 |
|
| 2016 |
Kruegel AC, Gassaway MM, Kapoor A, Váradi A, Majumdar S, Filizola M, Javitch JA, Sames D. Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators. Journal of the American Chemical Society. PMID 27192616 DOI: 10.1021/Jacs.6B00360 |
0.709 |
|
| 2016 |
Marrone GF, Grinnell SG, Lu Z, Rossi GC, Le Rouzic V, Xu J, Majumdar S, Pan YX, Pasternak GW. Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS. Proceedings of the National Academy of Sciences of the United States of America. PMID 26976581 DOI: 10.1073/Pnas.1523894113 |
0.857 |
|
| 2015 |
Váradi A, Marrone GF, Eans SO, Ganno ML, Subrath JJ, Le Rouzic V, Hunkele A, Pasternak GW, McLaughlin JP, Majumdar S. Synthesis and Characterization of a Dual Kappa-Delta Opioid Receptor Agonist Analgesic Blocking Cocaine Reward Behavior. Acs Chemical Neuroscience. PMID 26325040 DOI: 10.1021/Acschemneuro.5B00153 |
0.825 |
|
| 2015 |
Marrone GF, Majumdar S, Pasternak GW. Radioligand Binding Assay for an Exon 11-Associated Mu Opioid Receptor Target. Methods in Molecular Biology (Clifton, N.J.). 1335: 241-9. PMID 26260605 DOI: 10.1007/978-1-4939-2914-6_16 |
0.799 |
|
| 2015 |
Varadi A, Palmer TC, Haselton N, Afonin D, Subrath JJ, LeRouzic V, Hunkele A, Pasternak GW, Marrone GF, Borics A, Majumdar S. Synthesis of carfentanil amide opioids using the Ugi multicomponent reaction. Acs Chemical Neuroscience. PMID 26148793 DOI: 10.1021/Acschemneuro.5B00137 |
0.821 |
|
| 2015 |
Lu Z, Xu J, Rossi GC, Majumdar S, Pasternak GW, Pan YX. Mediation of opioid analgesia by a truncated 6-transmembrane GPCR. The Journal of Clinical Investigation. PMID 26011641 DOI: 10.1172/Jci81070 |
0.798 |
|
| 2015 |
Pescatore R, Marrone GF, Sedberry S, Vinton D, Finkelstein N, Katlowitz YE, Pasternak GW, Wilson KR, Majumdar S. Synthesis and Pharmacology of Halogenated δ-Opioid-Selective [d-Ala(2)]Deltorphin II Peptide Analogues. Acs Chemical Neuroscience. 6: 905-10. PMID 25844930 DOI: 10.1021/Acschemneuro.5B00060 |
0.802 |
|
| 2015 |
Pickett JE, Váradi A, Palmer TC, Grinnell SG, Schrock JM, Pasternak GW, Karimov RR, Majumdar S. Mild, Pd-catalyzed stannylation of radioiodination targets. Bioorganic & Medicinal Chemistry Letters. 25: 1761-4. PMID 25777268 DOI: 10.1016/J.Bmcl.2015.02.055 |
0.729 |
|
| 2014 |
Wieskopf JS, Pan YX, Marcovitz J, Tuttle AH, Majumdar S, Pidakala J, Pasternak GW, Mogil JS. Broad-spectrum analgesic efficacy of IBNtxA is mediated by exon 11-associated splice variants of the mu-opioid receptor gene. Pain. 155: 2063-70. PMID 25093831 DOI: 10.1016/J.Pain.2014.07.014 |
0.735 |
|
| 2014 |
Grinnell SG, Majumdar S, Narayan A, Le Rouzic V, Ansonoff M, Pintar JE, Pasternak GW. Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA. The Journal of Pharmacology and Experimental Therapeutics. 350: 710-8. PMID 24970924 DOI: 10.1124/Jpet.114.213199 |
0.822 |
|
| 2014 |
Váradi A, Palmer TC, Notis PR, Redel-Traub GN, Afonin D, Subrath JJ, Pasternak GW, Hu C, Sharma I, Majumdar S. Three-component coupling approach for the synthesis of diverse heterocycles utilizing reactive nitrilium trapping. Organic Letters. 16: 1668-71. PMID 24580074 DOI: 10.1021/Ol500328T |
0.411 |
|
| 2013 |
Váradi A, Hosztafi S, Le Rouzic V, Tóth G, Urai Á, Noszál B, Pasternak GW, Grinnell SG, Majumdar S. Novel 6β-acylaminomorphinans with analgesic activity. European Journal of Medicinal Chemistry. 69: 786-9. PMID 24103580 DOI: 10.1016/J.Ejmech.2013.09.031 |
0.859 |
|
| 2013 |
Pickett JE, Nagakura K, Pasternak AR, Grinnell SG, Majumdar S, Lewis JS, Pasternak GW. Sandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: studies on the endogenous opioid peptide α-neoendorphin. Bioorganic & Medicinal Chemistry Letters. 23: 4347-50. PMID 23796454 DOI: 10.1016/J.Bmcl.2013.05.090 |
0.828 |
|
| 2012 |
Majumdar S, Subrath J, Le Rouzic V, Polikar L, Burgman M, Nagakura K, Ocampo J, Haselton N, Pasternak AR, Grinnell S, Pan YX, Pasternak GW. Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants. Journal of Medicinal Chemistry. 55: 6352-62. PMID 22734622 DOI: 10.1021/Jm300305C |
0.846 |
|
| 2011 |
Majumdar S, Grinnell S, Le Rouzic V, Burgman M, Polikar L, Ansonoff M, Pintar J, Pan YX, Pasternak GW. Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects. Proceedings of the National Academy of Sciences of the United States of America. 108: 19778-83. PMID 22106286 DOI: 10.1073/Pnas.1115231108 |
0.851 |
|
| 2011 |
Majumdar S, Burgman M, Haselton N, Grinnell S, Ocampo J, Pasternak AR, Pasternak GW. Generation of novel radiolabeled opiates through site-selective iodination. Bioorganic & Medicinal Chemistry Letters. 21: 4001-4. PMID 21621410 DOI: 10.1016/J.Bmcl.2011.05.008 |
0.841 |
|
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