Wataru Araki - Publications

Affiliations: 
Natl Inst Neurosci, Japan 

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Mamada N, Tanokashira D, Hosaka A, Kametani F, Tamaoka A, Araki W. Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons. Molecular Brain. 8: 73. PMID 26552445 DOI: 10.1186/s13041-015-0163-5  1
2015 Araki W, Tamaoka A. Amyloid beta-protein and lipid rafts: focused on biogenesis and catabolism. Frontiers in Bioscience (Landmark Edition). 20: 314-24. PMID 25553453 DOI: 10.2741/4311  1
2014 Araki W, Minegishi S, Motoki K, Kume H, Hohjoh H, Araki YM, Tamaoka A. Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway. Molecular Neurobiology. 50: 1049-58. PMID 24477737 DOI: 10.1007/s12035-014-8644-6  1
2014 Ohno M, Hiraoka Y, Lichtenthaler SF, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T, Nishi E. Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model. Neurobiology of Aging. 35: 213-22. PMID 23954170 DOI: 10.1016/j.neurobiolaging.2013.07.014  1
2013 Araki W. Potential repurposing of oncology drugs for the treatment of Alzheimer's disease. Bmc Medicine. 11: 82. PMID 23531187 DOI: 10.1186/1741-7015-11-82  1
2013 Hosaka A, Araki W, Oda A, Tomidokoro Y, Tamaoka A. Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons. Neurochemical Research. 38: 589-600. PMID 23269484 DOI: 10.1007/s11064-012-0956-1  1
2013 Araki W, Oda A, Motoki K, Hattori K, Itoh M, Yuasa S, Konishi Y, Shin RW, Tamaoka A, Ogino K. Reduction of β-amyloid accumulation by reticulon 3 in transgenic mice. Current Alzheimer Research. 10: 135-42. PMID 22742855 DOI: 10.2174/1567205011310020003  1
2012 Hayes CD, Dey D, Palavicini JP, Wang H, Araki W, Lakshmana MK. Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice. Plos One. 7: e45841. PMID 23056220 DOI: 10.1371/journal.pone.0045841  1
2012 Motoki K, Kume H, Oda A, Tamaoka A, Hosaka A, Kametani F, Araki W. Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant. Brain and Behavior. 2: 270-82. PMID 22741101 DOI: 10.1002/brb3.52  1
2012 Mutoh T, Kawamura N, Hirabayashi Y, Shima S, Miyashita T, Ito S, Asakura K, Araki W, Cazzaniga E, Muto E, Masserini M. Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3065-74. PMID 22508690 DOI: 10.1096/fj.11-198630  1
2012 Deng J, Hou H, Giunta B, Mori T, Wang YJ, Fernandez F, Weggen S, Araki W, Obregon D, Tan J. Autoreactive-Aβ antibodies promote APP β-secretase processing. Journal of Neurochemistry. 120: 732-40. PMID 22188568 DOI: 10.1111/j.1471-4159.2011.07629.x  1
2011 Marutani T, Maeda T, Tanabe C, Zou K, Araki W, Kokame K, Michikawa M, Komano H. ER-stress-inducible Herp, facilitates the degradation of immature nicastrin. Biochimica Et Biophysica Acta. 1810: 790-8. PMID 21600962 DOI: 10.1016/j.bbagen.2011.04.017  1
2010 Araki W, Kametani F, Oda A, Tamaoka A. MEK inhibitors suppress beta-amyloid production by altering the level of a beta-C-terminal fragment of amyloid precursor protein in neuronal cells. Febs Letters. 584: 3410-4. PMID 20600008 DOI: 10.1016/j.febslet.2010.06.038  1
2010 Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M. Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. The Journal of Biological Chemistry. 285: 14920-31. PMID 20299451 DOI: 10.1074/jbc.M109.038760  1
2010 Oda A, Tamaoka A, Araki W. Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells. Journal of Neuroscience Research. 88: 1137-45. PMID 19885829 DOI: 10.1002/jnr.22271  1
2009 Maeda T, Marutani T, Zou K, Araki W, Tanabe C, Yagishita N, Yamano Y, Amano T, Michikawa M, Nakajima T, Komano H. An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein. The Febs Journal. 276: 5832-40. PMID 19725872 DOI: 10.1111/j.1742-4658.2009.07264.x  1
2009 Hoshino T, Namba T, Takehara M, Nakaya T, Sugimoto Y, Araki W, Narumiya S, Suzuki T, Mizushima T. Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. The Journal of Biological Chemistry. 284: 18493-502. PMID 19407341 DOI: 10.1074/jbc.M109.003269  1
2009 Kume H, Murayama KS, Araki W. The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of beta-secretase BACE1. Journal of Neuroscience Research. 87: 2963-72. PMID 19405102 DOI: 10.1002/jnr.22112  1
2009 Kume H, Konishi Y, Murayama KS, Kametani F, Araki W. Expression of reticulon 3 in Alzheimer's disease brain. Neuropathology and Applied Neurobiology. 35: 178-88. PMID 19284479 DOI: 10.1111/j.1365-2990.2008.00974.x  1
2009 Araki W, Kume H, Oda A, Tamaoka A, Kametani F. IGF-1 promotes beta-amyloid production by a secretase-independent mechanism. Biochemical and Biophysical Research Communications. 380: 111-4. PMID 19167357 DOI: 10.1016/j.bbrc.2009.01.044  1
2008 Araki W, Takahashi-Sasaki N, Chui DH, Saito S, Takeda K, Shirotani K, Takahashi K, Murayama KS, Kametani F, Shiraishi H, Komano H, Tabira T. A family of membrane proteins associated with presenilin expression and gamma-secretase function. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 819-27. PMID 17928364 DOI: 10.1096/fj.07-9072com  1
2007 Hoshino T, Nakaya T, Homan T, Tanaka K, Sugimoto Y, Araki W, Narita M, Narumiya S, Suzuki T, Mizushima T. Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo. The Journal of Biological Chemistry. 282: 32676-88. PMID 17767011 DOI: 10.1074/jbc.M703087200  1
2007 Murayama KS, Kametani F, Tabira T, Araki W. A novel monoclonal antibody specific for the amino-truncated beta-amyloid Abeta5-40/42 produced from caspase-cleaved amyloid precursor protein. Journal of Neuroscience Methods. 161: 244-9. PMID 17207535 DOI: 10.1016/j.jneumeth.2006.11.010  1
2007 Hoshino T, Nakaya T, Araki W, Suzuki K, Suzuki T, Mizushima T. Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides. The Biochemical Journal. 402: 581-9. PMID 17132139 DOI: 10.1042/BJ20061318  1
2006 Murayama KS, Kametani F, Saito S, Kume H, Akiyama H, Araki W. Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein. The European Journal of Neuroscience. 24: 1237-44. PMID 16965550 DOI: 10.1111/j.1460-9568.2006.05005.x  1
2006 Araki W, Saito S, Takahashi-Sasaki N, Shiraishi H, Komano H, Murayama KS. Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif. Journal of Molecular Neuroscience : Mn. 29: 35-43. PMID 16757808 DOI: 10.1385/JMN:29:1:35  1
2006 Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, et al. Altered localization of amyloid precursor protein under endoplasmic reticulum stress. Biochemical and Biophysical Research Communications. 344: 525-30. PMID 16630560 DOI: 10.1016/j.bbrc.2006.03.173  1
2006 Shiraishi H, Marutani T, Wang HQ, Maeda Y, Kurono Y, Takashima A, Araki W, Nishimura M, Yanagisawa K, Komano H. Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 11: 83-93. PMID 16371134 DOI: 10.1111/j.1365-2443.2005.00914.x  1
2005 Murayama KS, Kametani F, Araki W. Extracellular release of BACE1 holoproteins from human neuronal cells. Biochemical and Biophysical Research Communications. 338: 800-7. PMID 16243299 DOI: 10.1016/j.bbrc.2005.10.015  1
2005 Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H. Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein. Brain Research. Molecular Brain Research. 137: 70-6. PMID 15950763 DOI: 10.1016/j.molbrainres.2005.02.018  1
2005 Lakshmana MK, Araki W, Tabira T. Amyloid beta peptide binds a novel death-inducing protein, AB-DIP. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1362-4. PMID 15923395 DOI: 10.1096/fj.05-3672fje  1
2005 Hasegawa T, Ukai W, Jo DG, Xu X, Mattson MP, Nakagawa M, Araki W, Saito T, Yamada T. Homocysteic acid induces intraneuronal accumulation of neurotoxic Abeta42: implications for the pathogenesis of Alzheimer's disease. Journal of Neuroscience Research. 80: 869-76. PMID 15898106 DOI: 10.1002/jnr.20514  1
2005 Saito S, Takahashi-Sasaki N, Araki W. Identification and characterization of a novel human APH-1b splice variant lacking exon 4. Biochemical and Biophysical Research Communications. 330: 1068-72. PMID 15823552 DOI: 10.1016/j.bbrc.2005.03.096  1
2005 Saito S, Araki W. Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes. Biochemical and Biophysical Research Communications. 327: 18-22. PMID 15629423 DOI: 10.1016/j.bbrc.2004.11.130  1
2004 Takeda K, Araki W, Akiyama H, Tabira T. Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1755-7. PMID 15364896 DOI: 10.1096/fj.03-1070fje  1
2004 Watanabe N, Araki W, Chui DH, Makifuchi T, Ihara Y, Tabira T. Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1013-5. PMID 15084524 DOI: 10.1096/fj.03-1040fje  1
2004 Takeda K, Araki W, Tabira T. Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2. The European Journal of Neuroscience. 19: 258-264. PMID 14725619 DOI: 10.1111/j.0953-816X.2003.03135.x  1
2002 Kowalska A, Hasegawa M, Miyamoto K, Akiguchi I, Ikemoto A, Takahashi K, Araki W, Tabira T. A novel mutation at position +11 in the intron following exon 10 of the tau gene in FTDP-17. Journal of Applied Genetics. 43: 535-43. PMID 12441638  1
2001 Araki W, Yuasa K, Takeda S, Takeda K, Shirotani K, Takahashi K, Tabira T. Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons. Journal of Neurochemistry. 79: 1161-8. PMID 11752057 DOI: 10.1046/j.1471-4159.2001.00638.x  1
2001 Miyamoto K, Kowalska A, Hasegawa M, Tabira T, Takahashi K, Araki W, Akiguchi I, Ikemoto A. Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10+11-splice site in the tau gene. Annals of Neurology. 50: 117-20. PMID 11456301 DOI: 10.1002/ana.1083  1
2001 Chui DH, Dobo E, Makifuchi T, Akiyama H, Kawakatsu S, Petit A, Checler F, Araki W, Takahashi K, Tabira T. Apoptotic neurons in Alzheimer's disease frequently show intracellular Aβ42 labeling Journal of Alzheimer's Disease. 3: 231-239.  1
2000 Araki W, Yuasa K, Takeda S, Shirotani K, Takahashi K, Tabira T. Overexpression of presenilin-2 enhances apoptotic death of cultured cortical neurons. Annals of the New York Academy of Sciences. 920: 241-4. PMID 11193157  1
2000 Shirotani K, Takahashi K, Araki W, Maruyama K, Tabira T. Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function. The Journal of Biological Chemistry. 275: 3681-6. PMID 10652366 DOI: 10.1074/jbc.275.5.3681  1
1999 Chui DH, Tanahashi H, Ozawa K, Ikeda S, Checler F, Ueda O, Suzuki H, Araki W, Inoue H, Shirotani K, Takahashi K, Gallyas F, Tabira T. Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nature Medicine. 5: 560-4. PMID 10229234 DOI: 10.1038/8438  1
1998 Araki W, Wurtman RJ. Increased expression of amyloid precursor protein and amyloid precursor-like protein 2 during trophic factor withdrawal-induced death of neuronal PC12 cells. Brain Research. Molecular Brain Research. 56: 169-77. PMID 9602112 DOI: 10.1016/S0169-328X(98)00050-3  1
1998 Araki W, Wurtman RJ. How is membrane phospholipid biosynthesis controlled in neural tissues? Journal of Neuroscience Research. 51: 667-74. PMID 9545081 DOI: 10.1002/(SICI)1097-4547(19980315)51:6<667::AID-JNR1>3.0.CO;2-9  1
1997 Araki W, Wurtman RJ. Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 94: 11946-50. PMID 9342342 DOI: 10.1073/pnas.94.22.11946  1
1997 Lee RK, Araki W, Wurtman RJ. Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation. Proceedings of the National Academy of Sciences of the United States of America. 94: 5422-6. PMID 9144253 DOI: 10.1073/pnas.94.10.5422  1
1995 Araki W, Kunishita T, Takahashi K, Ikeda S, Tabira T. Secretion kinetics of Alzheimer's amyloid beta-protein differs from secreted beta-amyloid precursor protein. Biochemical and Biophysical Research Communications. 214: 490-5. PMID 7677756 DOI: 10.1006/bbrc.1995.2313  1
1995 Nakanishi T, Ishii K, Katayama M, Araki W, Iwata E, Ogawa N. Characterization of neurotrophic factors produced by immortalized mouse brain glial cells (VR-2g). Biochemistry and Molecular Biology International. 36: 991-9. PMID 7581016  1
1994 Araki W, Kunishita T, Takahashi K, Ikeda S, Tabira T. Demonstration of amyloid beta-protein secretion in a mouse neuronal cell line. Neuroscience Letters. 167: 125-7. PMID 8177510 DOI: 10.1016/0304-3940(94)91043-X  1
1994 Kunishita T, Ikeda S, Araki W, Tabira T. The decrement of muscarinic receptor-mediated calcium influx by overexpression of APP in a mouse cholinergic cell line. The Tohoku Journal of Experimental Medicine. 174: 225-39. PMID 7761988  1
1992 Ishii K, Inoue H, Hakura A, Araki W, Masuda T. Immortalization of fetal mouse brain glial cells by human papillomavirus type 16 E7 genes. Cell Structure and Function. 17: 197-202. PMID 1322802  1
1991 Araki W, Hirose S, Mimori Y, Nakamura S, Kimura J, Ohno K, Shimada T. Familial hypobetalipoproteinaemia complicated by cerebellar ataxia and steatocystoma multiplex. Journal of Internal Medicine. 229: 197-9. PMID 1997645  1
1991 Araki W, Kitaguchi N, Tokushima Y, Ishii K, Aratake H, Shimohama S, Nakamura S, Kimura J. Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture. Biochemical and Biophysical Research Communications. 181: 265-71. PMID 1958195 DOI: 10.1016/S0006-291X(05)81412-3  1
1991 Shimohama S, Homma Y, Suenaga T, Fujimoto S, Taniguchi T, Araki W, Yamaoka Y, Takenawa T, Kimura J. Aberrant accumulation of phospholipase C-delta in Alzheimer brains. The American Journal of Pathology. 139: 737-42. PMID 1928298  1
1991 Shimohama S, Suenaga T, Araki W, Yamaoaka Y, Shimizu K, Kimura J. Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease. Brain Research. 558: 105-8. PMID 1718565 DOI: 10.1016/0006-8993(91)90722-8  1
1991 Araki W, Nakamura S, Tanaka S, Kimura J, Ueda K. Separation of protease activity from acetylcholinesterase of the electric EEL Neurochemistry International. 19: 537-541. DOI: 10.1016/0197-0186(91)90073-M  1
1990 Nakamura S, Kawashima S, Nakano S, Tsuji T, Araki W. Subcellular distribution of acetylcholinesterase in Alzheimer's disease: abnormal localization and solubilization. Journal of Neural Transmission. Supplementum. 30: 13-23. PMID 2391513  1
1989 Araki W, Ohno K, Matsunaga K, Nakamura H, Sugimoto C, Shimada T. [Two sisters with pseudoidiopathic hypoparathyroidism presenting extensive intracranial calcification]. Nihon Naika Gakkai Zasshi. the Journal of the Japanese Society of Internal Medicine. 78: 81-2. PMID 2732579  1
Show low-probability matches.