Year |
Citation |
Score |
2021 |
Komaki K, Takano T, Sato Y, Asada A, Ikeda S, Yamada K, Wei R, Huo A, Fukuchi A, Saito T, Ando K, Murayama S, Araki W, Kametani F, Hasegawa M, et al. Lemur tail kinase 1 (LMTK1) regulates the endosomal localization of β-secretase BACE1. Journal of Biochemistry. PMID 34523681 DOI: 10.1093/jb/mvab094 |
0.31 |
|
2019 |
Taniguchi K, Yamamoto F, Arai T, Yang J, Sakai Y, Itoh M, Mamada N, Sekiguchi M, Yamada D, Saitoh A, Kametani F, Tamaoka A, Araki YM, Wada K, Mizusawa H, ... Araki W, et al. Tyrosol Reduces Amyloid-β Oligomer Neurotoxicity and Alleviates Synaptic, Oxidative, and Cognitive Disturbances in Alzheimer's Disease Model Mice. Journal of Alzheimer's Disease : Jad. PMID 31227651 DOI: 10.3233/JAD-190098 |
0.387 |
|
2019 |
Yamamoto F, Taniguchi K, Mamada N, Tamaoka A, Kametani F, Lakshmana MK, Araki W. TFEB-mediated Enhancement of the Autophagy-lysosomal Pathway Dually Modulates the Process of Amyloid β-Protein Generation in Neurons. Neuroscience. 402: 11-22. PMID 30677488 DOI: 10.1016/j.neuroscience.2019.01.010 |
0.436 |
|
2017 |
Araki W, Hattori K, Kanemaru K, Yokoi Y, Omachi Y, Takano H, Sakata M, Yoshida S, Tsukamoto T, Murata M, Saito Y, Kunugi H, Goto YI, Nagaoka U, Nagao M, et al. Re-evaluation of soluble APP-α and APP-β in cerebrospinal fluid as potential biomarkers for early diagnosis of dementia disorders. Biomarker Research. 5: 28. PMID 29018524 DOI: 10.1186/S40364-017-0108-5 |
0.357 |
|
2017 |
Araki W. Reversibility of Aβ oligomer neurotoxicity. Oncotarget. 8: 50335-50336. PMID 28881565 DOI: 10.18632/oncotarget.19083 |
0.404 |
|
2017 |
Mamada N, Tanokashira D, Ishii K, Tamaoka A, Araki W. Mitochondria are devoid of amyloid β-protein (Aβ)-producing secretases: Evidence for unlikely occurrence within mitochondria of Aβ generation from amyloid precursor protein. Biochemical and Biophysical Research Communications. PMID 28302486 DOI: 10.1016/j.bbrc.2017.03.035 |
0.443 |
|
2017 |
Tanokashira D, Mamada N, Yamamoto F, Taniguchi K, Tamaoka A, Lakshmana MK, Araki W. The neurotoxicity of amyloid β-protein oligomers is reversible in a primary neuron model. Molecular Brain. 10: 4. PMID 28137266 DOI: 10.1186/s13041-016-0284-5 |
0.424 |
|
2016 |
Araki W. Post-translational regulation of the β-secretase BACE1. Brain Research Bulletin. PMID 27086128 DOI: 10.1016/j.brainresbull.2016.04.009 |
0.417 |
|
2015 |
Mamada N, Tanokashira D, Hosaka A, Kametani F, Tamaoka A, Araki W. Amyloid β-protein oligomers upregulate the β-secretase, BACE1, through a post-translational mechanism involving its altered subcellular distribution in neurons. Molecular Brain. 8: 73. PMID 26552445 DOI: 10.1186/s13041-015-0163-5 |
0.447 |
|
2015 |
Tanokashira D, Motoki K, Minegishi S, Hosaka A, Mamada N, Tamaoka A, Okada T, Lakshmana MK, Araki W. LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking(1,2,3). Eneuro. 2. PMID 26464978 DOI: 10.1523/ENEURO.0006-15.2015 |
0.379 |
|
2015 |
Araki W, Tamaoka A. Amyloid beta-protein and lipid rafts: focused on biogenesis and catabolism. Frontiers in Bioscience (Landmark Edition). 20: 314-24. PMID 25553453 DOI: 10.2741/4311 |
0.43 |
|
2014 |
Araki W, Minegishi S, Motoki K, Kume H, Hohjoh H, Araki YM, Tamaoka A. Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway. Molecular Neurobiology. 50: 1049-58. PMID 24477737 DOI: 10.1007/s12035-014-8644-6 |
0.376 |
|
2014 |
Ohno M, Hiraoka Y, Lichtenthaler SF, Nishi K, Saijo S, Matsuoka T, Tomimoto H, Araki W, Takahashi R, Kita T, Kimura T, Nishi E. Nardilysin prevents amyloid plaque formation by enhancing α-secretase activity in an Alzheimer's disease mouse model. Neurobiology of Aging. 35: 213-22. PMID 23954170 DOI: 10.1016/j.neurobiolaging.2013.07.014 |
0.391 |
|
2013 |
Araki W. Potential repurposing of oncology drugs for the treatment of Alzheimer's disease. Bmc Medicine. 11: 82. PMID 23531187 DOI: 10.1186/1741-7015-11-82 |
0.339 |
|
2013 |
Hosaka A, Araki W, Oda A, Tomidokoro Y, Tamaoka A. Statins reduce amyloid β-peptide production by modulating amyloid precursor protein maturation and phosphorylation through a cholesterol-independent mechanism in cultured neurons. Neurochemical Research. 38: 589-600. PMID 23269484 DOI: 10.1007/s11064-012-0956-1 |
0.447 |
|
2013 |
Araki W, Oda A, Motoki K, Hattori K, Itoh M, Yuasa S, Konishi Y, Shin RW, Tamaoka A, Ogino K. Reduction of β-amyloid accumulation by reticulon 3 in transgenic mice. Current Alzheimer Research. 10: 135-42. PMID 22742855 DOI: 10.2174/1567205011310020003 |
0.407 |
|
2012 |
Hayes CD, Dey D, Palavicini JP, Wang H, Araki W, Lakshmana MK. Chronic cladribine administration increases amyloid beta peptide generation and plaque burden in mice. Plos One. 7: e45841. PMID 23056220 DOI: 10.1371/journal.pone.0045841 |
0.407 |
|
2012 |
Motoki K, Kume H, Oda A, Tamaoka A, Hosaka A, Kametani F, Araki W. Neuronal β-amyloid generation is independent of lipid raft association of β-secretase BACE1: analysis with a palmitoylation-deficient mutant. Brain and Behavior. 2: 270-82. PMID 22741101 DOI: 10.1002/brb3.52 |
0.443 |
|
2012 |
Mutoh T, Kawamura N, Hirabayashi Y, Shima S, Miyashita T, Ito S, Asakura K, Araki W, Cazzaniga E, Muto E, Masserini M. Abnormal cross-talk between mutant presenilin 1 (I143T, G384A) and glycosphingolipid biosynthesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3065-74. PMID 22508690 DOI: 10.1096/fj.11-198630 |
0.377 |
|
2012 |
Deng J, Hou H, Giunta B, Mori T, Wang YJ, Fernandez F, Weggen S, Araki W, Obregon D, Tan J. Autoreactive-Aβ antibodies promote APP β-secretase processing. Journal of Neurochemistry. 120: 732-40. PMID 22188568 DOI: 10.1111/J.1471-4159.2011.07629.X |
0.375 |
|
2011 |
Marutani T, Maeda T, Tanabe C, Zou K, Araki W, Kokame K, Michikawa M, Komano H. ER-stress-inducible Herp, facilitates the degradation of immature nicastrin. Biochimica Et Biophysica Acta. 1810: 790-8. PMID 21600962 DOI: 10.1016/j.bbagen.2011.04.017 |
0.355 |
|
2011 |
Araki W, Motoki K, Oda A, Kume H, Hohjoh H, Tamaoka A. Disease-associated mutations do not influence the subcellular localization of TDP-43 in neuronal cells Neuroscience Research. 71. DOI: 10.1016/J.Neures.2011.07.831 |
0.31 |
|
2011 |
Araki W, Oda A, Motoki K, Hattori K, Itoh M, Yuasa S, Konishi Y, Shin R, Tamaoka A, Ogino K. Reduction of beta-amyloid accumulation by reticulon 3 in transgenic mice Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1199 |
0.366 |
|
2010 |
Araki W, Kametani F, Oda A, Tamaoka A. MEK inhibitors suppress beta-amyloid production by altering the level of a beta-C-terminal fragment of amyloid precursor protein in neuronal cells. Febs Letters. 584: 3410-4. PMID 20600008 DOI: 10.1016/j.febslet.2010.06.038 |
0.447 |
|
2010 |
Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M. Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. The Journal of Biological Chemistry. 285: 14920-31. PMID 20299451 DOI: 10.1074/Jbc.M109.038760 |
0.42 |
|
2010 |
Oda A, Tamaoka A, Araki W. Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells. Journal of Neuroscience Research. 88: 1137-45. PMID 19885829 DOI: 10.1002/jnr.22271 |
0.431 |
|
2010 |
Araki W, Oda A, Motoki K, Hattori K, Itoh M, Yuasa S, Konishi Y, Shin R, Tamaoka A, Ogino K. Suppression of β-amyloid accumulation by reticulon 3 in Alzheimer's disease mouse model Neuroscience Research. 68: e303. DOI: 10.1016/j.neures.2010.07.1345 |
0.372 |
|
2009 |
Maeda T, Marutani T, Zou K, Araki W, Tanabe C, Yagishita N, Yamano Y, Amano T, Michikawa M, Nakajima T, Komano H. An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein. The Febs Journal. 276: 5832-40. PMID 19725872 DOI: 10.1111/j.1742-4658.2009.07264.x |
0.425 |
|
2009 |
Hoshino T, Namba T, Takehara M, Nakaya T, Sugimoto Y, Araki W, Narumiya S, Suzuki T, Mizushima T. Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. The Journal of Biological Chemistry. 284: 18493-502. PMID 19407341 DOI: 10.1074/Jbc.M109.003269 |
0.396 |
|
2009 |
Kume H, Murayama KS, Araki W. The two-hydrophobic domain tertiary structure of reticulon proteins is critical for modulation of beta-secretase BACE1. Journal of Neuroscience Research. 87: 2963-72. PMID 19405102 DOI: 10.1002/jnr.22112 |
0.437 |
|
2009 |
Kume H, Konishi Y, Murayama KS, Kametani F, Araki W. Expression of reticulon 3 in Alzheimer's disease brain. Neuropathology and Applied Neurobiology. 35: 178-88. PMID 19284479 DOI: 10.1111/j.1365-2990.2008.00974.x |
0.466 |
|
2009 |
Araki W, Kume H, Oda A, Tamaoka A, Kametani F. IGF-1 promotes beta-amyloid production by a secretase-independent mechanism. Biochemical and Biophysical Research Communications. 380: 111-4. PMID 19167357 DOI: 10.1016/j.bbrc.2009.01.044 |
0.452 |
|
2008 |
Araki W, Takahashi-Sasaki N, Chui DH, Saito S, Takeda K, Shirotani K, Takahashi K, Murayama KS, Kametani F, Shiraishi H, Komano H, Tabira T. A family of membrane proteins associated with presenilin expression and gamma-secretase function. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 819-27. PMID 17928364 DOI: 10.1096/fj.07-9072com |
0.463 |
|
2008 |
Hoshino T, Nakaya T, Sugimoto Y, Araki W, Narumiya S, Suzuki T, Mizushima T. O4-06-07: Involvement of the prostaglandin E2
receptors, EP2
and EP4
, in the production of amyloid-β peptides both in vitro and in vivo Alzheimer's & Dementia. 4: T198-T198. DOI: 10.1016/J.Jalz.2008.05.551 |
0.311 |
|
2007 |
Hoshino T, Nakaya T, Homan T, Tanaka K, Sugimoto Y, Araki W, Narita M, Narumiya S, Suzuki T, Mizushima T. Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo. The Journal of Biological Chemistry. 282: 32676-88. PMID 17767011 DOI: 10.1074/Jbc.M703087200 |
0.459 |
|
2007 |
Murayama KS, Kametani F, Tabira T, Araki W. A novel monoclonal antibody specific for the amino-truncated beta-amyloid Abeta5-40/42 produced from caspase-cleaved amyloid precursor protein. Journal of Neuroscience Methods. 161: 244-9. PMID 17207535 DOI: 10.1016/j.jneumeth.2006.11.010 |
0.447 |
|
2007 |
Hoshino T, Nakaya T, Araki W, Suzuki K, Suzuki T, Mizushima T. Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides. The Biochemical Journal. 402: 581-9. PMID 17132139 DOI: 10.1042/Bj20061318 |
0.404 |
|
2006 |
Murayama KS, Kametani F, Saito S, Kume H, Akiyama H, Araki W. Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein. The European Journal of Neuroscience. 24: 1237-44. PMID 16965550 DOI: 10.1111/j.1460-9568.2006.05005.x |
0.491 |
|
2006 |
Araki W, Saito S, Takahashi-Sasaki N, Shiraishi H, Komano H, Murayama KS. Characterization of APH-1 mutants with a disrupted transmembrane GxxxG motif. Journal of Molecular Neuroscience : Mn. 29: 35-43. PMID 16757808 DOI: 10.1385/JMN:29:1:35 |
0.326 |
|
2006 |
Kudo T, Okumura M, Imaizumi K, Araki W, Morihara T, Tanimukai H, Kamagata E, Tabuchi N, Kimura R, Kanayama D, Fukumori A, Tagami S, Okochi M, Kubo M, Tanii H, et al. Altered localization of amyloid precursor protein under endoplasmic reticulum stress. Biochemical and Biophysical Research Communications. 344: 525-30. PMID 16630560 DOI: 10.1016/j.bbrc.2006.03.173 |
0.432 |
|
2006 |
Shiraishi H, Marutani T, Wang HQ, Maeda Y, Kurono Y, Takashima A, Araki W, Nishimura M, Yanagisawa K, Komano H. Reconstitution of gamma-secretase by truncated presenilin (PS) fragments revealed that PS C-terminal transmembrane domain is critical for formation of gamma-secretase complex. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 11: 83-93. PMID 16371134 DOI: 10.1111/j.1365-2443.2005.00914.x |
0.33 |
|
2005 |
Murayama KS, Kametani F, Araki W. Extracellular release of BACE1 holoproteins from human neuronal cells. Biochemical and Biophysical Research Communications. 338: 800-7. PMID 16243299 DOI: 10.1016/j.bbrc.2005.10.015 |
0.393 |
|
2005 |
Hamano T, Mutoh T, Tabira T, Araki W, Kuriyama M, Mihara T, Yano S, Yamamoto H. Abnormal intracellular trafficking of high affinity nerve growth factor receptor, Trk, in stable transfectants expressing presenilin 1 protein. Brain Research. Molecular Brain Research. 137: 70-6. PMID 15950763 DOI: 10.1016/j.molbrainres.2005.02.018 |
0.429 |
|
2005 |
Lakshmana MK, Araki W, Tabira T. Amyloid beta peptide binds a novel death-inducing protein, AB-DIP. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 1362-4. PMID 15923395 DOI: 10.1096/fj.05-3672fje |
0.477 |
|
2005 |
Hasegawa T, Ukai W, Jo DG, Xu X, Mattson MP, Nakagawa M, Araki W, Saito T, Yamada T. Homocysteic acid induces intraneuronal accumulation of neurotoxic Abeta42: implications for the pathogenesis of Alzheimer's disease. Journal of Neuroscience Research. 80: 869-76. PMID 15898106 DOI: 10.1002/Jnr.20514 |
0.464 |
|
2005 |
Saito S, Takahashi-Sasaki N, Araki W. Identification and characterization of a novel human APH-1b splice variant lacking exon 4. Biochemical and Biophysical Research Communications. 330: 1068-72. PMID 15823552 DOI: 10.1016/j.bbrc.2005.03.096 |
0.334 |
|
2004 |
Takeda K, Araki W, Akiyama H, Tabira T. Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1755-7. PMID 15364896 DOI: 10.1096/fj.03-1070fje |
0.498 |
|
2004 |
Watanabe N, Araki W, Chui DH, Makifuchi T, Ihara Y, Tabira T. Glypican-1 as an Abeta binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1013-5. PMID 15084524 DOI: 10.1096/fj.03-1040fje |
0.483 |
|
2004 |
Takeda K, Araki W, Tabira T. Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2. The European Journal of Neuroscience. 19: 258-264. PMID 14725619 DOI: 10.1111/j.0953-816X.2003.03135.x |
0.475 |
|
2004 |
Murayama K, Kametani F, Takahashi N, Saito S, Araki W. P4-196 Analysis of the secretion mechanism of beta-secretases Neurobiology of Aging. 25: S531. DOI: 10.1016/S0197-4580(04)81754-8 |
0.308 |
|
2001 |
Chui DH, Dobo E, Makifuchi T, Akiyama H, Kawakatsu S, Petit A, Checler F, Araki W, Takahashi K, Tabira T. Apoptotic neurons in Alzheimer's disease frequently show intracellular Abeta42 labeling. Journal of Alzheimer's Disease : Jad. 3: 231-239. PMID 12214064 DOI: 10.3233/Jad-2001-3208 |
0.471 |
|
2001 |
Araki W, Yuasa K, Takeda S, Takeda K, Shirotani K, Takahashi K, Tabira T. Pro-apoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons. Journal of Neurochemistry. 79: 1161-8. PMID 11752057 DOI: 10.1046/j.1471-4159.2001.00638.x |
0.447 |
|
2001 |
Miyamoto K, Kowalska A, Hasegawa M, Tabira T, Takahashi K, Araki W, Akiguchi I, Ikemoto A. Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10+11-splice site in the tau gene. Annals of Neurology. 50: 117-20. PMID 11456301 DOI: 10.1002/Ana.1083 |
0.301 |
|
2000 |
Araki W, Yuasa K, Takeda S, Shirotani K, Takahashi K, Tabira T. Overexpression of presenilin-2 enhances apoptotic death of cultured cortical neurons. Annals of the New York Academy of Sciences. 920: 241-4. PMID 11193157 DOI: 10.1111/J.1749-6632.2000.Tb06929.X |
0.345 |
|
2000 |
Shirotani K, Takahashi K, Araki W, Maruyama K, Tabira T. Mutational analysis of intrinsic regions of presenilin 2 that determine its endoproteolytic cleavage and pathological function. The Journal of Biological Chemistry. 275: 3681-6. PMID 10652366 DOI: 10.1074/jbc.275.5.3681 |
0.396 |
|
1999 |
Chui DH, Tanahashi H, Ozawa K, Ikeda S, Checler F, Ueda O, Suzuki H, Araki W, Inoue H, Shirotani K, Takahashi K, Gallyas F, Tabira T. Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nature Medicine. 5: 560-4. PMID 10229234 DOI: 10.1038/8438 |
0.411 |
|
1998 |
Araki W, Wurtman RJ. Increased expression of amyloid precursor protein and amyloid precursor-like protein 2 during trophic factor withdrawal-induced death of neuronal PC12 cells. Brain Research. Molecular Brain Research. 56: 169-77. PMID 9602112 DOI: 10.1016/S0169-328X(98)00050-3 |
0.558 |
|
1998 |
Araki W, Wurtman RJ. How is membrane phospholipid biosynthesis controlled in neural tissues? Journal of Neuroscience Research. 51: 667-74. PMID 9545081 DOI: 10.1002/(SICI)1097-4547(19980315)51:6<667::AID-JNR1>3.0.CO;2-9 |
0.423 |
|
1997 |
Araki W, Wurtman RJ. Control of membrane phosphatidylcholine biosynthesis by diacylglycerol levels in neuronal cells undergoing neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 94: 11946-50. PMID 9342342 DOI: 10.1073/pnas.94.22.11946 |
0.47 |
|
1997 |
Lee RK, Araki W, Wurtman RJ. Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation. Proceedings of the National Academy of Sciences of the United States of America. 94: 5422-6. PMID 9144253 DOI: 10.1073/pnas.94.10.5422 |
0.589 |
|
1996 |
Lees RK, Araki W, Wurtman RJ. 808 Regulation of amyloid precursor protein processing and synthesis by receptor-mediated signal transduction Neurobiology of Aging. 17: S201. DOI: 10.1016/S0197-4580(96)80810-4 |
0.484 |
|
1995 |
Araki W, Kunishita T, Takahashi K, Ikeda S, Tabira T. Secretion kinetics of Alzheimer's amyloid beta-protein differs from secreted beta-amyloid precursor protein. Biochemical and Biophysical Research Communications. 214: 490-5. PMID 7677756 DOI: 10.1006/bbrc.1995.2313 |
0.407 |
|
1994 |
Araki W, Kunishita T, Takahashi K, Ikeda S, Tabira T. Demonstration of amyloid beta-protein secretion in a mouse neuronal cell line. Neuroscience Letters. 167: 125-7. PMID 8177510 DOI: 10.1016/0304-3940(94)91043-X |
0.411 |
|
1994 |
Kunishita T, Ikeda S, Araki W, Tabira T. The decrement of muscarinic receptor-mediated calcium influx by overexpression of APP in a mouse cholinergic cell line. The Tohoku Journal of Experimental Medicine. 174: 225-39. PMID 7761988 DOI: 10.1620/Tjem.174.225 |
0.403 |
|
1991 |
Araki W, Kitaguchi N, Tokushima Y, Ishii K, Aratake H, Shimohama S, Nakamura S, Kimura J. Trophic effect of beta-amyloid precursor protein on cerebral cortical neurons in culture. Biochemical and Biophysical Research Communications. 181: 265-71. PMID 1958195 DOI: 10.1016/S0006-291X(05)81412-3 |
0.451 |
|
1991 |
Shimohama S, Suenaga T, Araki W, Yamaoaka Y, Shimizu K, Kimura J. Presence of calpain II immunoreactivity in senile plaques in Alzheimer's disease. Brain Research. 558: 105-8. PMID 1718565 DOI: 10.1016/0006-8993(91)90722-8 |
0.358 |
|
1990 |
Nakamura S, Kawashima S, Nakano S, Tsuji T, Araki W. Subcellular distribution of acetylcholinesterase in Alzheimer's disease: abnormal localization and solubilization. Journal of Neural Transmission. Supplementum. 30: 13-23. PMID 2391513 DOI: 10.1007/978-3-7091-3345-3_2 |
0.336 |
|
Show low-probability matches. |