Toshiharu Suzuki - Publications

Affiliations: 
The University of Tokyo, Bunkyō-ku, Tōkyō-to, Japan 

131 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Gotoh N, Saito Y, Hata S, Saito H, Ojima D, Murayama C, Shigeta M, Abe T, Konno D, Matsuzaki F, Suzuki T, Yamamoto T. Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of Alcadein α-deficient mice. The Journal of Biological Chemistry. PMID 32467230 DOI: 10.1074/Jbc.Ra119.012386  0.362
2020 Seita Y, Morimura T, Watanabe N, Iwatani C, Tsuchiya H, Nakamura S, Suzuki T, Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I. Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein. Journal of Alzheimer's Disease : Jad. PMID 32250299 DOI: 10.3233/Jad-191081  0.314
2020 Kakuda N, Yamaguchi H, Akazawa K, Hata S, Suzuki T, Hatsuta H, Murayama S, Funamoto S, Ihara Y. γ-Secretase activity is associated with Braak Senile Plaque stages. The American Journal of Pathology. PMID 32201261 DOI: 10.1016/J.Ajpath.2020.02.009  0.312
2019 Hata S, Hu A, Piao Y, Nakaya T, Taru H, Morishima-Kawashima M, Murayama S, Nishimura M, Suzuki T. Enhanced amyloid-β generation by γ-secretase complex in detergent-resistant membrane microdomains with reduced cholesterol levels. Human Molecular Genetics. PMID 31841137 DOI: 10.1093/Hmg/Ddz297  0.327
2019 Hata S, Omori C, Kimura A, Saito H, Kimura N, Gupta V, Pedrini S, Hone E, Chatterjee P, Taddei K, Kasuga K, Ikeuchi T, Waragai M, Nishimura M, Hu A, ... ... Suzuki T, et al. Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 5: 740-750. PMID 31754625 DOI: 10.1016/J.Trci.2019.09.015  0.35
2019 Saito H, Hata S, Suzuki T. P1-158: PREVENTION OF NEURON FROM TOXICITY INDUCED BY Aβ42 BY P3-ALCβ PEPTIDES AND THEIR PHARMACOKINETICS IN MICE Alzheimer's & Dementia. 15: P297-P297. DOI: 10.1016/J.Jalz.2019.06.713  0.311
2019 Hata S, Kimura A, Saito H, Waragai M, Ikeuchi T, Martins RN, Kimura N, Nishimura M, Suzuki T. P3-184: ALTERED LEVELS OF P3-ALCβ PEPTIDES IN THE CSF OF AGED MONKEYS AND ALZHEIMER'S DISEASE PATIENTS Alzheimer's & Dementia. 15: P1000-P1001. DOI: 10.1016/J.Jalz.2019.06.3213  0.305
2018 Cam M, Durieu E, Bodin M, Manousopoulou A, Koslowski S, Vasylieva N, Barnych B, Hammock BD, Bohl B, Koch P, Omori C, Yamamoto K, Hata S, Suzuki T, Karg F, et al. Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides. Journal of Alzheimer's Disease : Jad. PMID 29504531 DOI: 10.3233/Jad-170875  0.326
2017 Chiba K, Chien KY, Sobu Y, Hata S, Kato S, Nakaya T, Okada Y, Nairn AC, Kinjo M, Taru H, Wang R, Suzuki T. Phosphorylation of KLC1 modifies interaction with JIP1 and abolishes the enhanced fast velocity of APP transport by kinesin-1. Molecular Biology of the Cell. PMID 29093025 DOI: 10.1091/Mbc.E17-05-0303  0.315
2017 Sobu Y, Furukori K, Chiba K, Nairn AC, Kinjo M, Hata S, Suzuki T. Phosphorylation of multiple sites within an acidic region of Alcadein α is required for kinesin-1 association and Golgi exit of Alcadein α cargo. Molecular Biology of the Cell. PMID 29093024 DOI: 10.1091/Mbc.E17-05-0301  0.31
2017 Omori C, Hata S, Waragai M, Suzuki T, Yamamoto K. [P3-217]: NOVEL BIOMARKER P3-ALCα, PEPTIDES PRODUCED BY γ-SECRETASE CLEAVAGE, ALTERED IN AD PATIENTS Alzheimer's & Dementia. 13: P1021-P1021. DOI: 10.1016/J.Jalz.2017.06.1430  0.32
2017 Hata S, Kimura A, Waragai M, Ikeuchi T, Martins RN, Kimura N, Nishimura M, Suzuki T. [P3-202]: LEVEL OF P3-ALCβ PEPTIDES ALTER IN CSF OF AD PATIENTS Alzheimer's & Dementia. 13: P1013-P1013. DOI: 10.1016/J.Jalz.2017.06.1415  0.306
2017 Toyoda M, Nakaya T, Michikawa M, Suzuki T. [P3-093]: IDENTIFICATION OF APOE4-X11L REGULATED DOWNSTREAM GENES RELATED TO THE LATE-ONSET AD Alzheimer's & Dementia. 13: P969-P970. DOI: 10.1016/J.Jalz.2017.06.1303  0.3
2017 Saitoh H, Omori C, Kimura A, Waragai M, Maeda M, Hata S, Suzuki T. PROTECTIVE PROPERTY OF P3-ALCβ AGAINST A NEUROTOXICITY INDUCED BY Aβ OLIGOMER Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.019  0.304
2016 Kimura A, Hata S, Suzuki T. Alternative Selection of BACE1 Cleavage Sites in APP Harboring Protective And Pathogenic Mutations Within the Aβ Sequence. The Journal of Biological Chemistry. PMID 27687728 DOI: 10.1074/Jbc.M116.744722  0.314
2016 Portelius E, Durieu E, Bodin M, Cam M, Pannee J, Leuxe C, Mabondzo A, Oumata N, Galons H, Lee JY, Chang YT, Stϋber K, Koch P, Fontaine G, Potier MC, ... ... Suzuki T, et al. Specific Triazine Herbicides Induce Amyloid-β42 Production. Journal of Alzheimer's Disease : Jad. PMID 27589520 DOI: 10.3233/Jad-160310  0.322
2016 Omori C, Motodate R, Shiraki Y, Chiba K, Sobu Y, Kimura A, Nakaya T, Kondo H, Kurumiya S, Tanaka T, Yamamoto K, Nakajima M, Suzuki T, Hata S. Facilitation of brain mitochondrial activity by 5-aminolevulinic acid in a mouse model of Alzheimer's disease. Nutritional Neuroscience. 1-9. PMID 27329428 DOI: 10.1080/1028415X.2016.1199114  0.32
2016 Motodate R, Saito Y, Hata S, Suzuki T. Expression and localization of X11 family proteins in neurons. Brain Research. PMID 27268412 DOI: 10.1016/J.Brainres.2016.05.054  0.309
2016 Suzuki T, Kimura A, Hata S. P4-060: Alternative Cleavage Mechanism of Human App by Bace1 Alzheimer's & Dementia. 12: P1037-P1037. DOI: 10.1016/J.Jalz.2016.06.2150  0.303
2016 Omori C, Hata S, Waragai M, Yamamoto K, Suzuki T. P3-184: Increase of P3-ALCA38 to P3-ALCA35, Products by Γ-Secretase Cleavage, in CSF of Alzheimer's Disease Patients Alzheimer's & Dementia. 12: P891-P892. DOI: 10.1016/J.Jalz.2016.06.1844  0.316
2015 Hosono T, Mouri A, Nishitsuji K, Jung CG, Kontani M, Tokuda H, Kawashima H, Shibata H, Suzuki T, Nabehsima T, Michikawa M. Arachidonic or Docosahexaenoic Acid Diet Prevents Memory Impairment in Tg2576 Mice. Journal of Alzheimer's Disease : Jad. 48: 149-62. PMID 26401936 DOI: 10.3233/Jad-150341  0.32
2015 Kimura A, Hata S, Suzuki T. Stabilization of intracellular trafficking and metabolism of amyloid β-protein precursor and Alcadein β by apolipoprotein E. Febs Letters. 589: 2394-400. PMID 26213366 DOI: 10.1016/J.Febslet.2015.07.017  0.34
2015 Hosono T, Nishitsuji K, Nakamura T, Jung CG, Kontani M, Tokuda H, Kawashima H, Kiso Y, Suzuki T, Michikawa M. Arachidonic acid diet attenuates brain Aβ deposition in Tg2576 mice. Brain Research. 1613: 92-9. PMID 25881896 DOI: 10.1016/J.Brainres.2015.04.005  0.333
2015 Takei N, Sobu Y, Kimura A, Urano S, Piao Y, Araki Y, Taru H, Yamamoto T, Hata S, Nakaya T, Suzuki T. Cytoplasmic fragment of Alcadein α generated by regulated intramembrane proteolysis enhances amyloid β-protein precursor (APP) transport into the late secretory pathway and facilitates APP cleavage. The Journal of Biological Chemistry. 290: 987-95. PMID 25406318 DOI: 10.1074/Jbc.M114.599852  0.378
2014 Chiba K, Araseki M, Nozawa K, Furukori K, Araki Y, Matsushima T, Nakaya T, Hata S, Saito Y, Uchida S, Okada Y, Nairn AC, Davis RJ, Yamamoto T, Kinjo M, ... ... Suzuki T, et al. Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport. Molecular Biology of the Cell. 25: 3569-80. PMID 25165140 DOI: 10.1091/Mbc.E14-06-1111  0.301
2014 Tajes M, Eraso-Pichot A, Rubio-Moscardó F, Guivernau B, Ramos-Fernández E, Bosch-Morató M, Guix FX, Clarimón J, Miscione GP, Boada M, Gil-Gómez G, Suzuki T, Molina H, Villà-Freixa J, Vicente R, et al. Methylglyoxal produced by amyloid-β peptide-induced nitrotyrosination of triosephosphate isomerase triggers neuronal death in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 41: 273-88. PMID 24614897 DOI: 10.3233/Jad-131685  0.32
2014 Morihara T, Hayashi N, Yokokoji M, Akatsu H, Silverman MA, Kimura N, Sato M, Saito Y, Suzuki T, Yanagida K, Kodama TS, Tanaka T, Okochi M, Tagami S, Kazui H, et al. Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as an amyloid-β accumulation modifier. Proceedings of the National Academy of Sciences of the United States of America. 111: 2638-43. PMID 24497505 DOI: 10.1073/Pnas.1307345111  0.306
2014 Omori C, Kaneko M, Nakajima E, Akatsu H, Waragai M, Maeda M, Morishima-Kawashima M, Saito Y, Nakaya T, Taru H, Yamamoto T, Asada T, Hata S, Suzuki T. Increased levels of plasma p3-alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 39: 861-70. PMID 24305499 DOI: 10.3233/Jad-131610  0.339
2013 Hoshino T, Suzuki K, Matsushima T, Yamakawa N, Suzuki T, Mizushima T. Suppression of Alzheimer's disease-related phenotypes by geranylgeranylacetone in mice. Plos One. 8: e76306. PMID 24098472 DOI: 10.1371/Journal.Pone.0076306  0.328
2013 Piao Y, Kimura A, Urano S, Saito Y, Taru H, Yamamoto T, Hata S, Suzuki T. Mechanism of intramembrane cleavage of alcadeins by γ-secretase. Plos One. 8: e62431. PMID 23658629 DOI: 10.1371/Journal.Pone.0062431  0.317
2013 Kang S, Todokoro Y, Yumen I, Shen B, Iwasaki I, Suzuki T, Miyagi A, Yoshida M, Fujiwara T, Akutsu H. 3P100 The Active-Site Structure of Thermophilic F_oF_1-ATP Synthase c-Subunit Rings in Membranes(03. Membrane proteins,Poster) Seibutsu Butsuri. 53. DOI: 10.2142/Biophys.53.S228_4  0.322
2013 Hata S, Omori C, Kaneko M, Waragai M, Urakami K, Taniguchi M, Ikeuchi T, Akatsu H, Suzuki T. P1-135: Quantitative alteration of p3-Alc peptides in CSF of people with Alzheimer's disease Alzheimer's & Dementia. 9: P199-P199. DOI: 10.1016/J.Jalz.2013.05.357  0.31
2012 Maruta C, Saito Y, Hata S, Gotoh N, Suzuki T, Yamamoto T. Constitutive cleavage of the single-pass transmembrane protein alcadeinα prevents aberrant peripheral retention of Kinesin-1. Plos One. 7: e43058. PMID 22905201 DOI: 10.1371/Journal.Pone.0043058  0.315
2012 Kamogawa K, Kohara K, Tabara Y, Takita R, Miki T, Konno T, Hata S, Suzuki T. Potential utility of soluble p3-alcadein α plasma levels as a biomarker for sporadic Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 31: 421-8. PMID 22571980 DOI: 10.3233/Jad-2012-120601  0.319
2012 Hata S, Taniguchi M, Piao Y, Ikeuchi T, Fagan AM, Holtzman DM, Bateman R, Sohrabi HR, Martins RN, Gandy S, Urakami K, Suzuki T. Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects. Molecular Neurodegeneration. 7: 16. PMID 22534039 DOI: 10.1186/1750-1326-7-16  0.354
2012 Matsushima T, Saito Y, Elliott JI, Iijima-Ando K, Nishimura M, Kimura N, Hata S, Yamamoto T, Nakaya T, Suzuki T. Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue. The Journal of Biological Chemistry. 287: 19715-24. PMID 22511769 DOI: 10.1074/Jbc.M111.334847  0.353
2012 Kawano T, Araseki M, Araki Y, Kinjo M, Yamamoto T, Suzuki T. A small peptide sequence is sufficient for initiating kinesin-1 activation through part of TPR region of KLC1. Traffic (Copenhagen, Denmark). 13: 834-48. PMID 22404616 DOI: 10.1111/J.1600-0854.2012.01350.X  0.313
2012 Matsushima T, Saito Y, Nishimura M, Kimura N, Hata S, Suzuki T. P2-153: Membrane microdomain localization of APP c-terminal fragments regulated by the phosphorylation at cytoplasmic Thr668 residue Alzheimer's & Dementia. 8: P312-P312. DOI: 10.1016/J.Jalz.2012.05.859  0.328
2012 Kanada Y, Saito Y, Nishimura M, Kimura N, Suzuki T. P4-071: Involvement of X11/X11L in Alzheimer's-related beta-amyloid generation and epileptogenesis Alzheimer's & Dementia. 8: P658-P658. DOI: 10.1016/J.Jalz.2012.05.1773  0.347
2011 Konno T, Hata S, Hamada Y, Horikoshi-Sakuraba Y, Nakaya T, Saito Y, Yamamoto T, Yamamoto T, Maeda M, Ikeuchi T, Gandy S, Akatsu H, Suzuki T. Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system. Molecular Neurodegeneration. 6: 76. PMID 22067061 DOI: 10.1186/1750-1326-6-76  0.344
2011 Cui H, Hung AC, Klaver DW, Suzuki T, Freeman C, Narkowicz C, Jacobson GA, Small DH. Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice. Plos One. 6: e23007. PMID 21829577 DOI: 10.1371/Journal.Pone.0023007  0.337
2011 Saito Y, Akiyama M, Araki Y, Sumioka A, Shiono M, Taru H, Nakaya T, Yamamoto T, Suzuki T. Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like. Plos One. 6: e22108. PMID 21818298 DOI: 10.1371/Journal.Pone.0022108  0.368
2011 Hata S, Fujishige S, Araki Y, Taniguchi M, Urakami K, Peskind E, Akatsu H, Araseki M, Yamamoto K, Martins RN, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, ... ... Suzuki T, et al. Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction. Annals of Neurology. 69: 1026-31. PMID 21681798 DOI: 10.1002/Ana.22343  0.347
2011 Hoshino T, Murao N, Namba T, Takehara M, Adachi H, Katsuno M, Sobue G, Matsushima T, Suzuki T, Mizushima T. Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 5225-34. PMID 21471357 DOI: 10.1523/Jneurosci.5478-10.2011  0.323
2011 Suzuki T. P4-325: Intracellular trafficking and metabolism of APP regulated by novel function of X11L Alzheimer's & Dementia. 7: e24-e24. DOI: 10.1016/J.Jalz.2011.09.070  0.308
2011 Hata S, Urakami K, Taniguchi M, Akatsu H, Gandy S, Suzuki T. P3-189: Alternative gamma-secretase processing in sporadic Alzheimer's disease suggested by p3-Alc peptide, metabolic product of alcadein Alzheimer's & Dementia. 7: S577-S577. DOI: 10.1016/J.Jalz.2011.05.1630  0.325
2011 Chiba K, Nozawa K, Araseki M, Kinjo M, Taru H, Suzuki T. P3-145: Molecular mechanism of JIP1b-mediated APP association to kinesin-1 in APP transport and metabolic regulation Alzheimer's & Dementia. 7: S562-S562. DOI: 10.1016/J.Jalz.2011.05.1585  0.312
2010 Kondo M, Shiono M, Itoh G, Takei N, Matsushima T, Maeda M, Taru H, Hata S, Yamamoto T, Saito Y, Suzuki T. Increased amyloidogenic processing of transgenic human APP in X11-like deficient mouse brain. Molecular Neurodegeneration. 5: 35. PMID 20843325 DOI: 10.1186/1750-1326-5-35  0.313
2010 Mitsuishi Y, Hasegawa H, Matsuo A, Araki W, Suzuki T, Tagami S, Okochi M, Takeda M, Roepman R, Nishimura M. Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. The Journal of Biological Chemistry. 285: 14920-31. PMID 20299451 DOI: 10.1074/Jbc.M109.038760  0.341
2010 Kuruma Y, Suzuki T, Ueda T. Production of multi-subunit complexes on liposome through an E. coli cell-free expression system. Methods in Molecular Biology (Clifton, N.J.). 607: 161-71. PMID 20204856 DOI: 10.1007/978-1-60327-331-2_14  0.32
2010 Feniouk BA, Kato-Yamada Y, Yoshida M, Suzuki T. Conformational transitions of subunit epsilon in ATP synthase from thermophilic Bacillus PS3. Biophysical Journal. 98: 434-42. PMID 20141757 DOI: 10.1016/J.Bpj.2009.10.023  0.303
2010 Kawai T, Nakaya T, Suzuki T. Roles of the intramolecular regions of FE65 in its trans-accumulation and in p53 stabilization in the nuclear matrix of osmotically stressed cells. Febs Letters. 584: 765-9. PMID 20036665 DOI: 10.1016/J.Febslet.2009.12.040  0.314
2010 Suzuki T, Mizumaru C. P1-299: Regulation of APP α-secretase activity involved in protein palmitoylation by DHHC-12 Alzheimer's & Dementia. 6: S260-S260. DOI: 10.1016/J.Jalz.2010.05.851  0.331
2010 Hata S, Urakami K, Fagan A, Peskind E, Akatsu H, Maeda M, Levey A, Chung KA, Montine T, Leverenz J, Goate A, Bateman R, Holtzman DM, Gandy S, Suzuki T. P3-171: Gamma-secretase dysfunction in sporadic Alzhemer's disease suggested by p3-Alc peptide, metabolic product of Alcadein Alzheimer's & Dementia. 6: S499-S500. DOI: 10.1016/J.Jalz.2010.05.1669  0.31
2009 Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, ... ... Suzuki T, et al. Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. The Journal of Biological Chemistry. 284: 36024-33. PMID 19864413 DOI: 10.1074/Jbc.M109.057497  0.384
2009 Mizumaru C, Saito Y, Ishikawa T, Yoshida T, Yamamoto T, Nakaya T, Suzuki T. Suppression of APP-containing vesicle trafficking and production of beta-amyloid by AID/DHHC-12 protein. Journal of Neurochemistry. 111: 1213-24. PMID 19780898 DOI: 10.1111/J.1471-4159.2009.06399.X  0.37
2009 Taru H, Suzuki T. Regulation of the physiological function and metabolism of AbetaPP by AbetaPP binding proteins. Journal of Alzheimer's Disease : Jad. 18: 253-65. PMID 19584434 DOI: 10.3233/Jad-2009-1148  0.357
2009 Hoshino T, Namba T, Takehara M, Nakaya T, Sugimoto Y, Araki W, Narumiya S, Suzuki T, Mizushima T. Prostaglandin E2 stimulates the production of amyloid-beta peptides through internalization of the EP4 receptor. The Journal of Biological Chemistry. 284: 18493-502. PMID 19407341 DOI: 10.1074/Jbc.M109.003269  0.313
2009 Guix FX, Ill-Raga G, Bravo R, Nakaya T, de Fabritiis G, Coma M, Miscione GP, Villà-Freixa J, Suzuki T, Fernàndez-Busquets X, Valverde MA, de Strooper B, Muñoz FJ. Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain : a Journal of Neurology. 132: 1335-45. PMID 19251756 DOI: 10.1093/Brain/Awp023  0.361
2009 Sakuma M, Tanaka E, Taru H, Tomita S, Gandy S, Nairn AC, Nakaya T, Yamamoto T, Suzuki T. Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP. Journal of Neurochemistry. 109: 465-75. PMID 19222704 DOI: 10.1111/J.1471-4159.2009.05988.X  0.335
2009 Shiono M, Akiyama M, Saito Y, Yamamoto T, Suzuki T. P4-183: Regulation of intracellular APP transport by X11L Alzheimer's & Dementia. 5: P485-P485. DOI: 10.1016/J.Jalz.2009.04.750  0.303
2009 Hata S, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, Fagan A, Goate A, Bateman R, Holtzman DM, Nakaya T, Gandy S, Suzuki T. P2-190: p3-Alc peptides produced by covariant processing of Alcadein and APP implicate γ-secretase dysfunction in sporadic Alzheimer's disease Alzheimer's & Dementia. 5: P316-P317. DOI: 10.1016/J.Jalz.2009.04.502  0.33
2009 Matsushima T, Nakaya T, Suzuki T. P1-155: Exclusion of phosporylated APP CTFs from membrane region rich in active γ-secretase Alzheimer's & Dementia. 5: P223-P223. DOI: 10.1016/J.Jalz.2009.04.161  0.306
2009 Saito Y, Nakaya T, Suzuki T. P1-007: Aberrant localization of amyloid precursor protein in X11 and X11L- deficient mice brain Alzheimer's & Dementia. 5: P173-P174. DOI: 10.1016/J.Jalz.2009.04.010  0.329
2008 Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T. X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain. The Journal of Biological Chemistry. 283: 35763-71. PMID 18845544 DOI: 10.1074/Jbc.M801353200  0.359
2008 Suzuki T, Nakaya T. Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions. The Journal of Biological Chemistry. 283: 29633-7. PMID 18650433 DOI: 10.1074/Jbc.R800003200  0.371
2008 Sumioka A, Saito Y, Sakuma M, Araki Y, Yamamoto T, Suzuki T. The X11L/X11beta/MINT2 and X11L2/X11gamma/MINT3 scaffold proteins shuttle between the nucleus and cytoplasm. Experimental Cell Research. 314: 1155-62. PMID 18201694 DOI: 10.1016/J.Yexcr.2007.12.006  0.323
2008 Ozaki Y, Suzuki T, Kuruma Y, Ueda T, Yoshida M. UncI protein can mediate ring-assembly of c-subunits of FoF1-ATP synthase in vitro. Biochemical and Biophysical Research Communications. 367: 663-6. PMID 18182163 DOI: 10.1016/J.Bbrc.2007.12.170  0.306
2008 Suzuki T. S3-04-04: Regulation of APP trafficking and processing in neurons Alzheimer's & Dementia. 4: T155-T155. DOI: 10.1016/J.Jalz.2008.05.395  0.358
2008 Hata S, Araki Y, Urakami K, Akatsu H, Nishimura M, Gandy S, Nakaya T, Suzuki T. P3-072: Analysis of β-Alc; Alcadein processing yields fragment homologous to APP P3 peptide Alzheimer's & Dementia. 4: T539-T539. DOI: 10.1016/J.Jalz.2008.05.1636  0.302
2008 Matsushima T, Suzuki T, Nakaya T. P1-453: APP metabolism in brain of Thr668 residue mutant mice Alzheimer's & Dementia. 4: T352-T352. DOI: 10.1016/J.Jalz.2008.05.1036  0.307
2007 Suzuki T, Ozaki Y, Sone N, Feniouk BA, Yoshida M. The product of uncI gene in F1Fo-ATP synthase operon plays a chaperone-like role to assist c-ring assembly. Proceedings of the National Academy of Sciences of the United States of America. 104: 20776-81. PMID 18083842 DOI: 10.1073/Pnas.0708075105  0.306
2007 Ikin AF, Causevic M, Pedrini S, Benson LS, Buxbaum JD, Suzuki T, Lovestone S, Higashiyama S, Mustelin T, Burgoyne RD, Gandy S. Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding. Molecular Neurodegeneration. 2: 23. PMID 18067682 DOI: 10.1186/1750-1326-2-23  0.362
2007 Hoshino T, Nakaya T, Homan T, Tanaka K, Sugimoto Y, Araki W, Narita M, Narumiya S, Suzuki T, Mizushima T. Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo. The Journal of Biological Chemistry. 282: 32676-88. PMID 17767011 DOI: 10.1074/Jbc.M703087200  0.335
2007 Araki Y, Kawano T, Taru H, Saito Y, Wada S, Miyamoto K, Kobayashi H, Ishikawa HO, Ohsugi Y, Yamamoto T, Matsuno K, Kinjo M, Suzuki T. The novel cargo Alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. The Embo Journal. 26: 1475-86. PMID 17332754 DOI: 10.1038/Sj.Emboj.7601609  0.325
2007 Hoshino T, Nakaya T, Araki W, Suzuki K, Suzuki T, Mizushima T. Endoplasmic reticulum chaperones inhibit the production of amyloid-beta peptides. The Biochemical Journal. 402: 581-9. PMID 17132139 DOI: 10.1042/Bj20061318  0.353
2007 Feniouk BA, Suzuki T, Yoshida M. Regulatory interplay between proton motive force, ADP, phosphate, and subunit epsilon in bacterial ATP synthase. The Journal of Biological Chemistry. 282: 764-72. PMID 17092944 DOI: 10.1074/Jbc.M606321200  0.316
2006 Sano Y, Nakaya T, Pedrini S, Takeda S, Iijima-Ando K, Iijima K, Mathews PM, Itohara S, Gandy S, Suzuki T. Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP. Plos One. 1: e51. PMID 17183681 DOI: 10.1371/Journal.Pone.0000051  0.346
2006 Sano Y, Syuzo-Takabatake A, Nakaya T, Saito Y, Tomita S, Itohara S, Suzuki T. Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain. The Journal of Biological Chemistry. 281: 37853-60. PMID 17032642 DOI: 10.1074/Jbc.M609312200  0.35
2006 Suzuki T, Araki Y, Yamamoto T, Nakaya T. Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. Journal of Biochemistry. 139: 949-55. PMID 16788045 DOI: 10.1093/Jb/Mvj121  0.343
2006 Feniouk BA, Suzuki T, Yoshida M. The role of subunit epsilon in the catalysis and regulation of FOF1-ATP synthase. Biochimica Et Biophysica Acta. 1757: 326-38. PMID 16701076 DOI: 10.1016/J.Bbabio.2006.03.022  0.306
2006 Masaike T, Suzuki T, Tsunoda SP, Konno H, Yoshida M. Probing conformations of the beta subunit of F0F1-ATP synthase in catalysis. Biochemical and Biophysical Research Communications. 342: 800-7. PMID 16517239 DOI: 10.1016/J.Bbrc.2006.02.017  0.315
2006 Suzuki T, Sano Y, Itohara S, Nakaya T. P1-060: APP metabolism in the brain of X11-like null mutant mouse Alzheimer's & Dementia. 2: S112-S112. DOI: 10.1016/J.Jalz.2006.05.435  0.306
2006 Hoshino T, Nakaya T, Suzuki T, Mizushima T. P4-029: Inhibition of amyloid-B production by endoplasmic reticulum chaperones Alzheimer's & Dementia. 2: S521-S522. DOI: 10.1016/J.Jalz.2006.05.1767  0.307
2006 Fujishige S, Yamamoto K, Suenaga N, Seiki M, Saftig P, Hartmann D, Nakaya T, Gandy S, Suzuki T. P4-025: Characterization of primary secretase-like cleavages of Alcadein Alzheimer's & Dementia. 2: S520-S521. DOI: 10.1016/J.Jalz.2006.05.1763  0.304
2006 Mizumaru C, Kihara A, Suzuki T. P4-012: Molecular mechanism of DHHC family proteins on the suppression of Aβ generation Alzheimer's & Dementia. 2: S517-S517. DOI: 10.1016/J.Jalz.2006.05.1750  0.311
2005 Iino R, Murakami T, Iizuka S, Kato-Yamada Y, Suzuki T, Yoshida M. Real-time monitoring of conformational dynamics of the epsilon subunit in F1-ATPase. The Journal of Biological Chemistry. 280: 40130-4. PMID 16203732 DOI: 10.1074/Jbc.M506160200  0.306
2005 Asaumi M, Iijima K, Sumioka A, Iijima-Ando K, Kirino Y, Nakaya T, Suzuki T. Interaction of N-terminal acetyltransferase with the cytoplasmic domain of beta-amyloid precursor protein and its effect on A beta secretion. Journal of Biochemistry. 137: 147-55. PMID 15749829 DOI: 10.1093/Jb/Mvi014  0.353
2004 von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM, Konietzko U. The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. Journal of Cell Science. 117: 4435-48. PMID 15331662 DOI: 10.1242/Jcs.01323  0.342
2004 Taru H, Yoshikawa K, Suzuki T. Suppression of the caspase cleavage of beta-amyloid precursor protein by its cytoplasmic phosphorylation. Febs Letters. 567: 248-52. PMID 15178331 DOI: 10.1016/J.Febslet.2004.04.077  0.352
2004 Tabuchi A, Ishii A, Fukuchi M, Kobayashi S, Suzuki T, Tsuda M. Activity-dependent increase in beta-amyloid precursor protein mRNA expression in neurons. Neuroreport. 15: 1329-33. PMID 15167560 DOI: 10.1097/01.Wnr.0000127140.54853.04  0.302
2004 Konno H, Suzuki T, Bald D, Yoshida M, Hisabori T. Significance of the epsilon subunit in the thiol modulation of chloroplast ATP synthase. Biochemical and Biophysical Research Communications. 318: 17-24. PMID 15110747 DOI: 10.1016/J.Bbrc.2004.03.179  0.305
2004 Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T. Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation. The Journal of Biological Chemistry. 279: 24343-54. PMID 15037614 DOI: 10.1074/Jbc.M401925200  0.356
2004 Taru H, Suzuki T. Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein. The Journal of Biological Chemistry. 279: 21628-36. PMID 14970211 DOI: 10.1074/Jbc.M312007200  0.363
2004 Sawamura N, Ko M, Yu W, Zou K, Hanada K, Suzuki T, Gong JS, Yanagisawa K, Michikawa M. Modulation of amyloid precursor protein cleavage by cellular sphingolipids. The Journal of Biological Chemistry. 279: 11984-91. PMID 14715666 DOI: 10.1074/Jbc.M309832200  0.35
2004 Araki Y, Miyagi N, Kato N, Yoshida T, Suzuki T. P4-299 Presenilin-dependent gamma-secretase cleavage of alcadein and amyloid precursor protein: their coordinative metabolism and cooperative regulation on FE65-dependent gene transactivation Neurobiology of Aging. 25: S560. DOI: 10.1016/S0197-4580(04)81857-8  0.347
2004 Nakaya T, Kawaguchi E, Suzuki T. P1-285 Phosphorylation of APP at THR668 regulates the function of APP intracellular domain fragment Neurobiology of Aging. 25: S177. DOI: 10.1016/S0197-4580(04)80598-0  0.339
2004 Sumioka A, Miura M, Suzuki T. P1-282 14-3-3 modulates gene transactivation of AICD through it's interaction between C-terminal region of APP Neurobiology of Aging. 25: S176. DOI: 10.1016/S0197-4580(04)80595-5  0.302
2004 Taru H, Suzuki T. P1-229 Stress-induced phosphorylation of beta-amyloid precursor protein by JNK and its facilitation by X11-like/mint2 protein Neurobiology of Aging. 25: S161. DOI: 10.1016/S0197-4580(04)80542-6  0.337
2004 Miyagi N, Sakuma M, Araki Y, Suzuki T. P1-225 X11L and Alcadein form a tripartite comprex with APP and suppress the γ-cleavage of CTFβ Neurobiology of Aging. 25: S160. DOI: 10.1016/S0197-4580(04)80538-4  0.326
2003 Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T. Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. The Journal of Biological Chemistry. 278: 49448-58. PMID 12972431 DOI: 10.1074/Jbc.M306024200  0.376
2003 Sumioka A, Imoto S, Martins RN, Kirino Y, Suzuki T. XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms. The Biochemical Journal. 374: 261-8. PMID 12780348 DOI: 10.1042/Bj20030489  0.387
2003 Inomata H, Nakamura Y, Hayakawa A, Takata H, Suzuki T, Miyazawa K, Kitamura N. A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. The Journal of Biological Chemistry. 278: 22946-55. PMID 12665528 DOI: 10.1074/Jbc.M212160200  0.335
2002 Hase M, Yagi Y, Taru H, Tomita S, Sumioka A, Hori K, Miyamoto K, Sasamura T, Nakamura M, Matsuno K, Suzuki T. Expression and characterization of the Drosophila X11-like/Mint protein during neural development. Journal of Neurochemistry. 81: 1223-32. PMID 12068070 DOI: 10.1046/J.1471-4159.2002.00911.X  0.339
2002 Taru H, Kirino Y, Suzuki T. Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. The Journal of Biological Chemistry. 277: 27567-74. PMID 12023290 DOI: 10.1074/Jbc.M203713200  0.355
2002 Taru H, Iijima K, Hase M, Kirino Y, Yagi Y, Suzuki T. Interaction of Alzheimer's beta -amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. The Journal of Biological Chemistry. 277: 20070-8. PMID 11912189 DOI: 10.1074/Jbc.M108372200  0.349
2002 Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki R, Suzuki T, Kawaichi M, Miyata T, Kitamura T, De Strooper B, Yanagisawa K, Komano H. Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. The Journal of Biological Chemistry. 277: 12915-20. PMID 11799129 DOI: 10.1074/Jbc.M112372200  0.365
2001 Ando K, Iijima KI, Elliott JI, Kirino Y, Suzuki T. Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. The Journal of Biological Chemistry. 276: 40353-61. PMID 11517218 DOI: 10.1074/Jbc.M104059200  0.335
2001 Hisabori T, Bald D, Noji H, Yoshida M, Suzuki T, Konno H. Thiol modulation of the chimeric ATP synthase complex of bacterial F1 containing the regulatory region of the gamma subunit of chloroplast ATP synthase Science Access. 3. DOI: 10.1071/Sa0403305  0.304
2000 Suzuki T, Ando K, Iijima K, Oguchi S, Takeda S. Phosphorylation of Amyloid Precursor Protein (APP) Family Proteins. Methods in Molecular Medicine. 32: 271-82. PMID 21318525 DOI: 10.1385/1-59259-195-7:271  0.352
2000 Yagi Y, Tomita S, Nakamura M, Suzuki T. Overexpression of human amyloid precursor protein in Drosophila. Molecular Cell Biology Research Communications : McBrc. 4: 43-9. PMID 11152627 DOI: 10.1006/Mcbr.2000.0248  0.358
2000 Suzuki T, Suzuki J, Mitome N, Ueno H, Yoshida M. Second Stalk of ATP Synthase: CROSS-LINKING OF γ SUBUNIT IN F1TO TRUNCATED FobSUBUNIT PREVENTS ATP HYDROLYSIS Journal of Biological Chemistry. 275: 37902-37906. PMID 10970900 DOI: 10.1074/Jbc.M007075200  0.3
2000 Iijima K, Ando K, Takeda S, Satoh Y, Seki T, Itohara S, Greengard P, Kirino Y, Nairn AC, Suzuki T. Neuron-specific phosphorylation of Alzheimer's beta-amyloid precursor protein by cyclin-dependent kinase 5. Journal of Neurochemistry. 75: 1085-91. PMID 10936190 DOI: 10.1046/J.1471-4159.2000.0751085.X  0.321
2000 Lee DS, Tomita S, Kirino Y, Suzuki T. Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. The Journal of Biological Chemistry. 275: 23134-8. PMID 10833507 DOI: 10.1074/Jbc.C000302200  0.367
2000 Tomita S, Fujita T, Kirino Y, Suzuki T. PDZ domain-dependent suppression of NF-kappaB/p65-induced Abeta42 production by a neuron-specific X11-like protein. The Journal of Biological Chemistry. 275: 13056-60. PMID 10777610 DOI: 10.1074/Jbc.C000019200  0.365
1999 Isohara T, Horiuchi A, Watanabe T, Ando K, Czernik AJ, Uno I, Greengard P, Nairn AC, Suzuki T. Phosphorylation of the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein at Ser655 by a novel protein kinase. Biochemical and Biophysical Research Communications. 258: 300-5. PMID 10329382 DOI: 10.1006/Bbrc.1999.0637  0.321
1999 Watanabe T, Sukegawa J, Sukegawa I, Tomita S, Iijima K, Oguchi S, Suzuki T, Nairn AC, Greengard P. A 127-kDa protein (UV-DDB) binds to the cytoplasmic domain of the Alzheimer's amyloid precursor protein. Journal of Neurochemistry. 72: 549-56. PMID 9930726 DOI: 10.1046/J.1471-4159.1999.0720549.X  0.376
1999 Tomita S, Ozaki T, Taru H, Oguchi S, Takeda S, Yagi Y, Sakiyama S, Kirino Y, Suzuki T. Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein. The Journal of Biological Chemistry. 274: 2243-54. PMID 9890987 DOI: 10.1074/Jbc.274.4.2243  0.338
1999 Ando K, Oishi M, Takeda S, Iijima K, Isohara T, Nairn AC, Kirino Y, Greengard P, Suzuki T. Role of Phosphorylation of Alzheimer’s Amyloid Precursor Protein during Neuronal Differentiation The Journal of Neuroscience. 19: 4421-4427. DOI: 10.1523/Jneurosci.19-11-04421.1999  0.328
1998 Tomita S, Kirino Y, Suzuki T. A basic amino acid in the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein (APP) is essential for cleavage of APP at the alpha-site. The Journal of Biological Chemistry. 273: 19304-10. PMID 9668120 DOI: 10.1074/Jbc.273.30.19304  0.358
1998 Tomita S, Kirino Y, Suzuki T. Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism. The Journal of Biological Chemistry. 273: 6277-84. PMID 9497354 DOI: 10.1074/Jbc.273.11.6277  0.364
1998 Iijima K, Lee DS, Okutsu J, Tomita S, Hirashima N, Kirino Y, Suzuki T. cDNA isolation of Alzheimer's amyloid precursor protein from cholinergic nerve terminals of the electric organ of the electric ray. The Biochemical Journal. 330: 29-33. PMID 9461486 DOI: 10.1042/Bj3300029  0.331
1997 Itoh T, Ikeda T, Gomi H, Nakao S, Suzuki T, Itohara S. Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice. The Journal of Biological Chemistry. 272: 22389-92. PMID 9278386 DOI: 10.1074/Jbc.272.36.22389  0.334
1997 Suzuki T, Ando K, Isohara T, Oishi M, Lim GS, Satoh Y, Wasco W, Tanzi RE, Nairn AC, Greengard P, Gandy SE, Kirino Y. Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. Biochemistry. 36: 4643-9. PMID 9109675 DOI: 10.1021/Bi962618K  0.325
1997 Oishi M, Nairn AC, Czernik AJ, Lim GS, Isohara T, Gandy SE, Greengard P, Suzuki T. The Cytoplasmic Domain of Alzheimer’s Amyloid Precursor Protein Is Phosphorylated at Thr654, Ser655, and Thr668 in Adult Rat Brain and Cultured Cells Molecular Medicine. 3: 111-123. DOI: 10.1007/Bf03401803  0.313
1996 Watanabe T, Suzuki T, Sukegawa J, Sukegawa I, Nairn A, Greengard P. 387 Identification of a protein which interacts with the cytoplasmic domain of the Alzheimer amyloid protein Precursor Neurobiology of Aging. 17: S97. DOI: 10.1016/S0197-4580(96)80389-7  0.331
1995 Fukuda I, Suzuki T, Munakata H, Hayashi N, Katayama E, Yoshikawa M, Sasakawa C. Cleavage of Shigella surface protein VirG occurs at a specific site, but the secretion is not essential for intracellular spreading. Journal of Bacteriology. 177: 1719-1726. PMID 7896693 DOI: 10.1128/Jb.177.7.1719-1726.1995  0.316
1994 Suzuki T, Oishi M, Marshak D, Czernik A, Nairn A, Greengard P. Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein. The Embo Journal. 13: 1114-1122. DOI: 10.1002/J.1460-2075.1994.Tb06360.X  0.378
1992 Suzuki T, Nairn AC, Gandy SE, Greengard P. Phosphorylation of Alzheimer amyloid precursor protein by protein kinase C. Neuroscience. 48: 755-61. PMID 1630623 DOI: 10.1016/0306-4522(92)90264-3  0.325
1992 Gandy SE, Buxbaum JD, Suzuki T, Ramabhadran TV, Caporaso GL, Nairn AC, Greengard P. The nature and metabolism of potentially amyloidogenic carboxyl-terminal fragments of the Alzheimer beta/A4-amyloid precursor protein: some technical notes. Neurobiology of Aging. 13: 601-3. PMID 1461349 DOI: 10.1016/0197-4580(92)90063-4  0.341
1992 Gandy SE, Caporaso GL, Ramabhadran TV, Suzuki T, Buxbaum JD, Nordstedt C, Iverfeldt K, Czernik AJ, Nairn AC, Greengard P. Characterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine. Annals of the New York Academy of Sciences. 674: 203-17. PMID 1363189 DOI: 10.1111/J.1749-6632.1992.Tb27489.X  0.302
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