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Alessio Accardi, Ph.D. - Publications

Affiliations: 
Anesthesiology Weill Cornell Medical College, New York, NY, United States 
Area:
Chloride channels
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72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Kim ED, Wu X, Lee S, Tibbs GR, Cunningham KP, Di Zanni E, Perez ME, Goldstein PA, Accardi A, Larsson HP, Nimigean CM. Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature. PMID 39085604 DOI: 10.1038/s41586-024-07743-z  0.6
2024 Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftci HD, Falzone ME, Huysmans G, Robertson JL, Boudker O, Accardi A. Author Correction: Structural basis of pH-dependent activation in a CLC transporter. Nature Structural & Molecular Biology. PMID 38355726 DOI: 10.1038/s41594-024-01242-5  0.564
2024 Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftici D, Falzone ME, Huysmans G, Robertson JL, Boudker O, Accardi A. Structural basis of pH-dependent activation in a CLC transporter. Nature Structural & Molecular Biology. PMID 38279055 DOI: 10.1038/s41594-023-01210-5  0.633
2022 Leisle L, Lam K, Dehghani-Ghahnaviyeh S, Fortea E, Galpin JD, Ahern CA, Tajkhorshid E, Accardi A. Backbone amides are determinants of Cl selectivity in CLC ion channels. Nature Communications. 13: 7508. PMID 36473856 DOI: 10.1038/s41467-022-35279-1  0.323
2021 Fortea E, Accardi A. A quantitative flux assay for the study of reconstituted Cl channels and transporters. Methods in Enzymology. 652: 243-272. PMID 34059284 DOI: 10.1016/bs.mie.2021.01.026  0.47
2020 Leisle L, Xu Y, Fortea E, Lee S, Galpin JD, Vien M, Ahern CA, Accardi A, Bernèche S. Divergent Cland H pathways underlie transport coupling and gating in CLC exchangers and channels. Elife. 9. PMID 32343228 DOI: 10.7554/Elife.51224  0.56
2020 Falzone ME, Accardi A. Reconstitution of Proteoliposomes for Phospholipid Scrambling and Nonselective Channel Assays. Methods in Molecular Biology (Clifton, N.J.). 2127: 207-225. PMID 32112325 DOI: 10.1007/978-1-0716-0373-4_15  0.439
2020 Zajac M, Chakraborty K, Saha S, Mahadevan V, Infield DT, Accardi A, Qiu Z, Krishnan Y. What biologists want from their chloride reporters - a conversation between chemists and biologists. Journal of Cell Science. 133. PMID 31974277 DOI: 10.1242/Jcs.240390  0.418
2020 Leisle L, Xu Y, Fortea E, Lee S, Galpin JD, Vien M, Ahern CA, Accardi A, Bernèche S. Author response: Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels Elife. DOI: 10.7554/Elife.51224.Sa2  0.521
2020 Accardi A, Falzone M, Lee B, Cheng X, Khelashvili G, Weinstein H. Structural Basis of Lipid Scrambling and Ion Conduction by TMEM16 Scramblases The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00173  0.349
2020 Accardi A. Structural Basis of Lipid and Ion Transport by TMEM16 Scramblases Biophysical Journal. 118: 4a. DOI: 10.1016/J.Bpj.2019.11.213  0.477
2019 Khelashvili G, Cheng X, Falzone ME, Doktorova M, Accardi A, Weinstein H. Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins. Journal of Computational Chemistry. PMID 31750558 DOI: 10.1002/Jcc.26105  0.344
2019 Khelashvili G, Falzone ME, Cheng X, Lee BC, Accardi A, Weinstein H. Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca-bound nhTMEM16. Nature Communications. 10: 4972. PMID 31672969 DOI: 10.1038/S41467-019-12865-4  0.457
2019 Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, ... ... Accardi A, et al. The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Nature Communications. 10: 3956. PMID 31477691 DOI: 10.1038/S41467-019-11753-1  0.394
2019 Falzone ME, Rheinberger J, Lee BC, Peyear T, Sasset L, Raczkowski AM, Eng ET, Di Lorenzo A, Andersen OS, Nimigean CM, Accardi A. Structural basis of Ca-dependent activation and lipid transport by a TMEM16 scramblase. Elife. 8. PMID 30648972 DOI: 10.7554/Elife.43229  0.674
2019 Falzone M, Rheinberger J, Lee B, Peyear T, Sasset L, Raczkowski A, Eng E, Di Lorenzo A, Anderson O, Nimigean C, Accardi A. Cryo-EM Structures Reveal Bilayer Remodeling during Ca2+ Activation of a TMEM16 Scramblase Biophysical Journal. 116: 26a. DOI: 10.1016/J.Bpj.2018.11.185  0.6
2018 Lee BC, Khelashvili G, Falzone M, Menon AK, Weinstein H, Accardi A. Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase. Nature Communications. 9: 3251. PMID 30108217 DOI: 10.1038/S41467-018-05724-1  0.387
2018 Malvezzi M, Andra KK, Pandey K, Lee BC, Falzone ME, Brown A, Iqbal R, Menon AK, Accardi A. Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases. Proceedings of the National Academy of Sciences of the United States of America. PMID 29925604 DOI: 10.1073/Pnas.1806721115  0.453
2018 Falzone ME, Malvezzi M, Lee BC, Accardi A. Known structures and unknown mechanisms of TMEM16 scramblases and channels. The Journal of General Physiology. PMID 29915161 DOI: 10.1085/Jgp.201711957  0.474
2018 Falzone ME, Rheinberger J, Lee B, Peyear T, Sasset L, Raczkowski AM, Eng ET, Lorenzo AD, Andersen OS, Nimigean CM, Accardi A. Author response: Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase Elife. DOI: 10.7554/Elife.43229.058  0.666
2018 Lee B, Kelashvili G, Falzone M, Weinstein H, Accardi A. Identification of the Extracellular Gate of a TMEM16 Scramblase Biophysical Journal. 114: 611a. DOI: 10.1016/J.Bpj.2017.11.3339  0.314
2017 Vien M, Basilio D, Leisle L, Accardi A. Probing the conformation of a conserved glutamic acid within the Cl(-) pathway of a CLC H(+)/Cl(-) exchanger. The Journal of General Physiology. PMID 28246117 DOI: 10.1085/Jgp.201611682  0.782
2017 Khelashvili G, Cheol Lee B, Falzone M, Menon AK, Accardi A, Weinstein H. Role of Hydrophilic Groove of the TMEM16 Protein in Lipid Scrambling Biophysical Journal. 112: 392a. DOI: 10.1016/J.Bpj.2016.11.2131  0.421
2017 Xu Y, Vien M, Liang C, Accardi A, Bernèche S. Molecular Mechanism of Cl − /H + Coupling in a CLC Antiporter Biophysical Journal. 112: 336a. DOI: 10.1016/J.Bpj.2016.11.1819  0.346
2017 Lee B, Falzone M, Menon A, Accardi A. Identification of Residues Important for Ion and Lipid Transport in a TMEM16 Scramblase Biophysical Journal. 112: 228a. DOI: 10.1016/J.Bpj.2016.11.1254  0.535
2016 Lee BC, Menon AK, Accardi A. The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel. Biophysical Journal. 111: 1919-1924. PMID 27806273 DOI: 10.1016/J.Bpj.2016.09.032  0.518
2016 Accardi A. Mechanisms of Ion and Lipid Transport by TMEM16 Scramblases Biophysical Journal. 110: 174a. DOI: 10.1016/J.Bpj.2015.11.968  0.458
2016 Malvezzi M, Iqbal R, Brown A, Menon A, Accardi A. Sizing up the Lipid Pathway in a TMEM16 Phospholipid Scramblase Biophysical Journal. 110: 291a. DOI: 10.1016/J.Bpj.2015.11.1573  0.355
2015 Accardi A. CELL SIGNALING. Lipids link ion channels and cancer. Science (New York, N.Y.). 349: 789-90. PMID 26293939 DOI: 10.1126/Science.Aad0874  0.376
2015 Accardi A. Structure and gating of CLC channels and exchangers. The Journal of Physiology. 593: 4129-38. PMID 26148215 DOI: 10.1113/Jp270575  0.547
2015 Basilio D, Accardi A. A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters. Journal of Visualized Experiments : Jove. PMID 25938223 DOI: 10.3791/52369  0.768
2015 Picollo A, Malvezzi M, Accardi A. TMEM16 proteins: unknown structure and confusing functions. Journal of Molecular Biology. 427: 94-105. PMID 25451786 DOI: 10.1016/J.Jmb.2014.09.028  0.491
2014 Accardi A. Unveiling the secret lives of glutamate transporters: VGLUTs engage in multiple transport modes. Neuron. 84: 1110-2. PMID 25521371 DOI: 10.1016/J.Neuron.2014.12.008  0.431
2014 Corral-Rodríguez MÁ, Stuiver M, Abascal-Palacios G, Diercks T, Oyenarte I, Ereño-Orbea J, de Opakua AI, Blanco FJ, Encinar JA, Spiwok V, Terashima H, Accardi A, Müller D, Martínez-Cruz LA. Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure. The Biochemical Journal. 464: 23-34. PMID 25184538 DOI: 10.1042/Bj20140409  0.367
2014 Basilio D, Noack K, Picollo A, Accardi A. Conformational changes required for H(+)/Cl(-) exchange mediated by a CLC transporter. Nature Structural & Molecular Biology. 21: 456-63. PMID 24747941 DOI: 10.1038/Nsmb.2814  0.778
2014 Malvezzi M, Janjusevic R, Menon A, Accardi A. Lipid Modulation of a Dual Function TMEM16 Channel/Scramblase Biophysical Journal. 106: 155a. DOI: 10.1016/J.Bpj.2013.11.890  0.442
2014 Xu Y, Liang C, Basilio D, Accardi A, Bernèche S. Conformational Changes Required for Chloride Ion Permeation in the CLC-ec1 Exchanger Biophysical Journal. 106: 145a-146a. DOI: 10.1016/J.Bpj.2013.11.841  0.761
2014 Basilio D, Vera A, Accardi A. Testing the Limits of Stoichiometric Exchange in a CLC-Type Transporter Biophysical Journal. 106: 145a. DOI: 10.1016/J.Bpj.2013.11.840  0.776
2013 Terashima H, Picollo A, Accardi A. Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels. Proceedings of the National Academy of Sciences of the United States of America. 110: 19354-9. PMID 24167264 DOI: 10.1073/Pnas.1312014110  0.435
2013 Malvezzi M, Chalat M, Janjusevic R, Picollo A, Terashima H, Menon AK, Accardi A. Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel. Nature Communications. 4: 2367. PMID 23996062 DOI: 10.1038/Ncomms3367  0.415
2013 Terashima H, Picollo A, Accardi A. Purification and Functional Reconstitution of the TMEM16A Ca2+ Activated Cl− Channel Biophysical Journal. 104: 628a. DOI: 10.1016/J.Bpj.2012.11.3476  0.412
2013 Basilio D, Noack K, Picollo A, Accardi A. Conformational Changes Outside the Ion Pathway are required for Transport in a CLC-Type Cl−/H+ Exchanger Biophysical Journal. 104: 627a. DOI: 10.1016/J.Bpj.2012.11.3468  0.793
2013 Malvezzi M, Chalat M, Terashima H, Janjusevic R, Menon A, Accardi A. Ca2+-Dependent Ion and Lipid Transport Mediated by a Fungal TMEM16 Homologue Biophysical Journal. 104: 366a. DOI: 10.1016/J.Bpj.2012.11.2034  0.485
2012 Picollo A, Xu Y, Johner N, Bernèche S, Accardi A. Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+)/Cl(-) exchanger. Nature Structural & Molecular Biology. 19: 525-31, S1. PMID 22484316 DOI: 10.1038/Nsmb.2277  0.515
2011 Ying SW, Tibbs GR, Picollo A, Abbas SY, Sanford RL, Accardi A, Hofmann F, Ludwig A, Goldstein PA. PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10412-23. PMID 21753018 DOI: 10.1523/Jneurosci.0021-11.2011  0.359
2011 Picollo A, Accardi A. Synergistic Substrate binding in the CLC-Ec1 Exchanger Biophysical Journal. 100: 246a. DOI: 10.1016/J.Bpj.2010.12.1559  0.509
2011 Malvezzi M, Picollo A, Accardi A. Proton Transport and Conformational Changes in H+/CL- Exchangers Biophysical Journal. 100: 245a. DOI: 10.1016/J.Bpj.2010.12.1555  0.56
2010 Picollo A, Malvezzi M, Accardi A. Proton block of the CLC-5 Cl-/H+ exchanger. The Journal of General Physiology. 135: 653-9. PMID 20513761 DOI: 10.1085/Jgp.201010428  0.505
2010 Accardi A, Picollo A. CLC channels and transporters: proteins with borderline personalities. Biochimica Et Biophysica Acta. 1798: 1457-64. PMID 20188062 DOI: 10.1016/J.Bbamem.2010.02.022  0.549
2010 Picollo A, Malvezzi M, Accardi A. Proton Block of Human CLC-5 Cl-/H+ Exchanger Biophysical Journal. 98: 320a. DOI: 10.1016/J.Bpj.2009.12.1737  0.467
2010 Hills C, Bruce S, Accardi A. Role of the Q-R Linker in H+/Cl- Coupling in a CLC Exchanger Biophysical Journal. 98: 320a. DOI: 10.1016/J.Bpj.2009.12.1736  0.534
2009 Picollo A, Malvezzi M, Houtman JC, Accardi A. Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters. Nature Structural & Molecular Biology. 16: 1294-301. PMID 19898476 DOI: 10.1038/Nsmb.1704  0.564
2009 Malvezzi M, Picollo A, Accardi A. Cooperative Ion Binding and Transport Mediated by a CLC-Type H+/Cl− Exchanger Biophysical Journal. 96: 471a. DOI: 10.1016/J.Bpj.2008.12.2423  0.447
2009 Picollo A, Accardi A. Molecular Mechanisms of Cl−/H+ Coupling in CLC-ec1 Biophysical Journal. 96: 269a-270a. DOI: 10.1016/J.Bpj.2008.12.1333  0.459
2008 Jayaram H, Accardi A, Wu F, Williams C, Miller C. Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger. Proceedings of the National Academy of Sciences of the United States of America. 105: 11194-9. PMID 18678918 DOI: 10.1073/Pnas.0804503105  0.68
2007 Walden M, Accardi A, Wu F, Xu C, Williams C, Miller C. Uncoupling and turnover in a Cl-/H+ exchange transporter. The Journal of General Physiology. 129: 317-29. PMID 17389248 DOI: 10.1085/Jgp.200709756  0.791
2006 Accardi A, Lobet S, Williams C, Miller C, Dutzler R. Synergism between halide binding and proton transport in a CLC-type exchanger. Journal of Molecular Biology. 362: 691-9. PMID 16949616 DOI: 10.1016/J.Jmb.2006.07.081  0.613
2006 Accardi A. Structure and Function of CLC Chloride Channels and Transporters Advances in Molecular and Cell Biology. 38: 59-82. DOI: 10.1016/S1569-2558(06)38003-4  0.401
2005 Accardi A, Walden M, Nguitragool W, Jayaram H, Williams C, Miller C. Separate ion pathways in a Cl-/H+ exchanger. The Journal of General Physiology. 126: 563-70. PMID 16316975 DOI: 10.1085/Jgp.200509417  0.787
2004 Accardi A, Miller C. Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels. Nature. 427: 803-7. PMID 14985752 DOI: 10.1038/Nature02314  0.622
2004 Accardi A, Kolmakova-Partensky L, Williams C, Miller C. Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels. The Journal of General Physiology. 123: 109-19. PMID 14718478 DOI: 10.1085/Jgp.200308935  0.539
2003 Sokolova O, Accardi A, Gutierrez D, Lau A, Rigney M, Grigorieff N. Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit. Proceedings of the National Academy of Sciences of the United States of America. 100: 12607-12. PMID 14569011 DOI: 10.1073/Pnas.2235650100  0.326
2003 Accardi A, Pusch M. Conformational changes in the pore of CLC-0. The Journal of General Physiology. 122: 277-93. PMID 12913090 DOI: 10.1085/Jgp.200308834  0.424
2003 Estévez R, Schroeder BC, Accardi A, Jentsch TJ, Pusch M. Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1. Neuron. 38: 47-59. PMID 12691663 DOI: 10.1016/S0896-6273(03)00168-5  0.406
2002 Pusch M, Accardi A, Liantonio A, Guida P, Traverso S, Camerino DC, Conti F. Mechanisms of block of muscle type CLC chloride channels (Review). Molecular Membrane Biology. 19: 285-92. PMID 12512775 DOI: 10.1080/09687680210166938  0.406
2002 Iyer R, Iverson TM, Accardi A, Miller C. A biological role for prokaryotic ClC chloride channels. Nature. 419: 715-8. PMID 12384697 DOI: 10.1038/Nature01000  0.505
2002 Liantonio A, Accardi A, Carbonara G, Fracchiolla G, Loiodice F, Tortorella P, Traverso S, Guida P, Pierno S, De Luca A, Camerino DC, Pusch M. Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid. Molecular Pharmacology. 62: 265-71. PMID 12130677 DOI: 10.1124/Mol.62.2.265  0.351
2001 Accardi A, Ferrera L, Pusch M. Drastic reduction of the slow gate of human muscle chloride channel (ClC-1) by mutation C277S. The Journal of Physiology. 534: 745-52. PMID 11483705 DOI: 10.1111/J.1469-7793.2001.00745.X  0.355
2001 Pusch M, Accardi A, Liantonio A, Ferrera L, De Luca A, Camerino DC, Conti F. Mechanism of block of single protopores of the Torpedo chloride channel ClC-0 by 2-(p-chlorophenoxy)butyric acid (CPB). The Journal of General Physiology. 118: 45-62. PMID 11432801 DOI: 10.1085/Jgp.118.1.45  0.392
2000 Accardi A, Pusch M. Fast and slow gating relaxations in the muscle chloride channel CLC-1. The Journal of General Physiology. 116: 433-44. PMID 10962018 DOI: 10.1085/Jgp.116.3.433  0.339
2000 Pusch M, Liantonio A, Bertorello L, Accardi A, De Luca A, Pierno S, Tortorella V, Camerino DC. Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives. Molecular Pharmacology. 58: 498-507. PMID 10953042 DOI: 10.1124/Mol.58.3.498  0.389
1999 Carpaneto A, Accardi A, Pisciotta M, Gambale F. Chloride channels activated by hypotonicity in N2A neuroblastoma cell line. Experimental Brain Research. 124: 193-9. PMID 9928842 DOI: 10.1007/S002210050614  0.428
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