| Year |
Citation |
Score |
| 2021 |
Coleman RC, Eguchi A, Lieu M, Roy R, Barr EW, Ibetti J, Lucchese AM, Peluzzo AM, Gresham K, Chuprun JK, Koch WJ. A peptide of the N terminus of GRK5 attenuates pressure-overload hypertrophy and heart failure. Science Signaling. 14. PMID 33785612 DOI: 10.1126/scisignal.abb5968 |
0.311 |
|
| 2021 |
Eguchi A, Coleman R, Gresham K, Gao E, Ibetti J, Chuprun JK, Koch WJ. GRK5 is a regulator of fibroblast activation and cardiac fibrosis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33500351 DOI: 10.1073/pnas.2012854118 |
0.318 |
|
| 2019 |
Cannavo A, Marzano F, Elia A, Liccardo D, Bencivenga L, Gambino G, Perna C, Rapacciuolo A, Cittadini A, Ferrara N, Paolocci N, Koch WJ, Rengo G. Aldosterone Jeopardizes Myocardial Insulin and β-Adrenergic Receptor Signaling G Protein-Coupled Receptor Kinase 2. Frontiers in Pharmacology. 10: 888. PMID 31447681 DOI: 10.3389/fphar.2019.00888 |
0.303 |
|
| 2019 |
Pfleger J, Gresham K, Koch WJ. G protein-coupled receptor kinases as therapeutic targets in the heart. Nature Reviews. Cardiology. PMID 31186538 DOI: 10.1038/s41569-019-0220-3 |
0.318 |
|
| 2019 |
Eguchi A, Koch WJ. Abstract 516: GRK5 Regulates Cardiac Fibroblast Differentiation and Fibrosis Circulation Research. 125. DOI: 10.1161/res.125.suppl_1.516 |
0.328 |
|
| 2017 |
McCrink KA, Maning J, Vu A, Jafferjee M, Marrero C, Brill A, Bathgate-Siryk A, Dabul S, Koch WJ, Lymperopoulos A. β-Arrestin2 Improves Post-Myocardial Infarction Heart Failure via Sarco[endo]plasmic Reticulum Ca(2+)-ATPase-Dependent Positive Inotropy in Cardiomyocytes. Hypertension (Dallas, Tex. : 1979). PMID 28874462 DOI: 10.1161/HYPERTENSIONAHA.117.09817 |
0.321 |
|
| 2017 |
Schlegel P, Reinkober J, Meinhardt E, Tscheschner H, Gao E, Schumacher SM, Yuan A, Backs J, Most P, Wieland T, Koch WJ, Katus HA, Raake PW. G protein-coupled receptor kinase 2 promotes cardiac hypertrophy. Plos One. 12: e0182110. PMID 28759639 DOI: 10.1371/Journal.Pone.0182110 |
0.327 |
|
| 2017 |
Cannavo A, Koch WJ. Targeting β3-Adrenergic Receptors in the Heart: Selective Agonism and β-Blockade. Journal of Cardiovascular Pharmacology. 69: 71-78. PMID 28170359 DOI: 10.1097/FJC.0000000000000444 |
0.302 |
|
| 2016 |
Cannavo A, Liccardo D, Eguchi A, Elliott KJ, Traynham CJ, Ibetti J, Eguchi S, Leosco D, Ferrara N, Rengo G, Koch WJ. Myocardial pathology induced by aldosterone is dependent on non-canonical activities of G protein-coupled receptor kinases. Nature Communications. 7: 10877. PMID 26932512 DOI: 10.1038/ncomms10877 |
0.319 |
|
| 2016 |
Schumacher SM, Koch WJ, VanHook AM. Science Signaling Podcast for 22 March 2016: Preventing heart failure with GRK2 Science Signaling. 9. DOI: 10.1126/Scisignal.Aaf6652 |
0.304 |
|
| 2016 |
Schumacher SM, Gao E, Cohen M, Lieu M, Chuprun JK, Koch WJ. A peptide of the RGS domain of GRK2 binds and inhibits Gαq to suppress pathological cardiac hypertrophy and dysfunction Science Signaling. 9. DOI: 10.1126/scisignal.aae0549 |
0.314 |
|
| 2015 |
Traynham CJ, Cannavo A, Zhou Y, Vouga A, Woodall BP, Hullmann JE, Ibetti J, Gold JI, Chuprun JK, Gao E, Koch WJ. Differential Role of G Protein-Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy. Circulation Research. PMID 26515328 DOI: 10.1161/CIRCRESAHA.115.306961 |
0.315 |
|
| 2015 |
Sato PY, Chuprun JK, Schwartz M, Koch WJ. The evolving impact of g protein-coupled receptor kinases in cardiac health and disease. Physiological Reviews. 95: 377-404. PMID 25834229 DOI: 10.1152/physrev.00015.2014 |
0.304 |
|
| 2014 |
Hullmann JE, Grisanti LA, Makarewich CA, Gao E, Gold JI, Chuprun JK, Tilley DG, Houser SR, Koch WJ. GRK5-mediated exacerbation of pathological cardiac hypertrophy involves facilitation of nuclear NFAT activity. Circulation Research. 115: 976-85. PMID 25332207 DOI: 10.1161/Circresaha.116.304475 |
0.308 |
|
| 2014 |
Tilley DG, Zhu W, Myers VD, Barr LA, Gao E, Li X, Song J, Carter RL, Makarewich CA, Yu D, Troupes CD, Grisanti LA, Coleman RC, Koch WJ, Houser SR, et al. β-adrenergic receptor-mediated cardiac contractility is inhibited via vasopressin type 1A-receptor-dependent signaling. Circulation. 130: 1800-11. PMID 25205804 DOI: 10.1161/Circulationaha.114.010434 |
0.308 |
|
| 2014 |
Woodall MC, Ciccarelli M, Woodall BP, Koch WJ. G protein-coupled receptor kinase 2: a link between myocardial contractile function and cardiac metabolism. Circulation Research. 114: 1661-70. PMID 24812353 DOI: 10.1161/Circresaha.114.300513 |
0.302 |
|
| 2014 |
Bathgate-Siryk A, Dabul S, Pandya K, Walklett K, Rengo G, Cannavo A, De Lucia C, Liccardo D, Gao E, Leosco D, Koch WJ, Lymperopoulos A. Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms. Hypertension. 63: 404-12. PMID 24218435 DOI: 10.1161/HYPERTENSIONAHA.113.02043 |
0.316 |
|
| 2013 |
Cannavo A, Liccardo D, Koch WJ. Targeting cardiac β-adrenergic signaling via GRK2 inhibition for heart failure therapy. Frontiers in Physiology. 4: 264. PMID 24133451 DOI: 10.3389/fphys.2013.00264 |
0.336 |
|
| 2013 |
Salazar NC, Vallejos X, Siryk A, Rengo G, Cannavo A, Liccardo D, De Lucia C, Gao E, Leosco D, Koch WJ, Lymperopoulos A. GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility. Cell Communication and Signaling : Ccs. 11: 64. PMID 23984976 DOI: 10.1186/1478-811X-11-64 |
0.31 |
|
| 2012 |
Lymperopoulos A, Rengo G, Koch WJ. GRK2 inhibition in heart failure: something old, something new. Current Pharmaceutical Design. 18: 186-91. PMID 22229578 DOI: 10.2174/138161212799040510 |
0.351 |
|
| 2011 |
Huang ZM, Gold JI, Koch WJ. G protein-coupled receptor kinases in normal and failing myocardium. Frontiers in Bioscience (Landmark Edition). 16: 3047-60. PMID 21622221 DOI: 10.2741/3898 |
0.305 |
|
| 2011 |
Ciccarelli M, Chuprun JK, Rengo G, Gao E, Wei Z, Peroutka RJ, Gold JI, Gumpert A, Chen M, Otis NJ, Dorn GW, Trimarco B, Iaccarino G, Koch WJ. G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. Circulation. 123: 1953-62. PMID 21518983 DOI: 10.1161/Circulationaha.110.988642 |
0.312 |
|
| 2010 |
Brinks H, Koch WJ. βaRKct: A therapeutic approach for improved adrenergic signaling and function in heart disease Journal of Cardiovascular Translational Research. 3: 499-506. PMID 20623214 DOI: 10.1007/s12265-010-9206-6 |
0.309 |
|
| 2010 |
Lymperopoulos A, Rengo G, Gao E, Ebert SN, Dorn GW, Koch WJ. Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction Journal of Biological Chemistry. 285: 16378-16386. PMID 20351116 DOI: 10.1074/Jbc.M109.077859 |
0.304 |
|
| 2009 |
Rengo G, Lymperopoulos A, Zincarelli C, Donniacuo M, Soltys S, Rabinowitz JE, Koch WJ. Myocardial adeno-associated virus serotype 6-βARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure Circulation. 119: 89-98. PMID 19103992 DOI: 10.1161/CIRCULATIONAHA.108.803999 |
0.308 |
|
| 2008 |
Martini JS, Raake P, Vinge LE, DeGeorge BR, DeGeorge B, Chuprun JK, Harris DM, Gao E, Eckhart AD, Pitcher JA, Koch WJ. Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America. 105: 12457-62. PMID 18711143 DOI: 10.1073/pnas.0803153105 |
0.303 |
|
| 2008 |
Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, Degeorge BR, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW, Koch WJ. G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure Circulation Research. 103: 413-422. PMID 18635825 DOI: 10.1161/Circresaha.107.168336 |
0.331 |
|
| 2006 |
Matkovich SJ, Diwan A, Klanke JL, Hammer DJ, Marreez Y, Odley AM, Brunskill EW, Koch WJ, Schwartz RJ, Dorn GW. Cardiac-specific ablation of G-protein receptor kinase 2 redefines its roles in heart development and beta-adrenergic signaling. Circulation Research. 99: 996-1003. PMID 17008600 DOI: 10.1161/01.Res.0000247932.71270.2C |
0.339 |
|
| 2006 |
Hata JA, Williams ML, Schroder JN, Lima B, Keys JR, Blaxall BC, Petrofski JA, Jakoi A, Milano CA, Koch WJ. Lymphocyte levels of GRK2 (betaARK1) mirror changes in the LVAD-supported failing human heart: lower GRK2 associated with improved beta-adrenergic signaling after mechanical unloading. Journal of Cardiac Failure. 12: 360-8. PMID 16762799 DOI: 10.1016/j.cardfail.2006.02.011 |
0.3 |
|
| 2005 |
Tachibana H, Naga Prasad SV, Lefkowitz RJ, Koch WJ, Rockman HA. Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. Circulation. 111: 591-7. PMID 15668342 DOI: 10.1161/01.Cir.0000142291.70954.Df |
0.302 |
|
| 2005 |
Tevaearai HT, Koch WJ. Molecular restoration of beta-adrenergic receptor signaling improves contractile function of failing hearts. Trends in Cardiovascular Medicine. 14: 252-6. PMID 15451518 DOI: 10.1016/J.TCM.2004.07.002 |
0.312 |
|
| 2004 |
Hata JA, Koch WJ. Phosphorylation of G protein-coupled receptors: GPCR kinases in heart disease. Molecular Interventions. 3: 264-72. PMID 14993440 DOI: 10.1124/MI.3.5.264 |
0.325 |
|
| 2004 |
Keys JR, Koch WJ. The adrenergic pathway and heart failure Recent Progress in Hormone Research. 59: 13-30. PMID 14749495 DOI: 10.1210/rp.59.1.13 |
0.312 |
|
| 2004 |
Petrofski JA, Koch WJ. The beta-adrenergic receptor kinase in heart failure. Journal of Molecular and Cellular Cardiology. 35: 1167-74. PMID 14519424 DOI: 10.1016/S0022-2828(03)00243-8 |
0.312 |
|
| 2003 |
Iaccarino G, Koch WJ. Transgenic mice targeting the heart unveil G protein-coupled receptor kinases as therapeutic targets Assay Drug Dev Technol. 1: 347-355. PMID 15090200 DOI: 10.1089/154065803321204484 |
0.327 |
|
| 2001 |
Chen EP, Bittner HB, Akhter SA, Koch WJ, Davis RD. Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5. The Annals of Thoracic Surgery. 71: 1320-4. PMID 11308180 DOI: 10.1016/S0003-4975(00)01754-9 |
0.314 |
|
| 2001 |
Freeman K, Lerman I, Kranias EG, Bohlmeyer T, Bristow MR, Lefkowitz RJ, Iaccarino G, Koch WJ, Leinwand LA. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. The Journal of Clinical Investigation. 107: 967-74. PMID 11306600 DOI: 10.1172/Jci12083 |
0.312 |
|
| 2000 |
White DC, Hata JA, Shah AS, Glower DD, Lefkowitz RJ, Koch WJ. Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. Proceedings of the National Academy of Sciences of the United States of America. 97: 5428-33. PMID 10779554 DOI: 10.1073/pnas.090091197 |
0.326 |
|
| 1999 |
Koch WJ, Rockman HA. Exploring the role of the β-adrenergic receptor kinase in cardiac disease using gene-targeted mice Trends in Cardiovascular Medicine. 9: 77-81. PMID 10578521 DOI: 10.1016/S1050-1738(99)00009-2 |
0.31 |
|
| 1999 |
Akhter SA, Eckhart AD, Rockman HA, Shotwell K, Lefkowitz RJ, Koch WJ. In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. Circulation. 100: 648-53. PMID 10441103 DOI: 10.1161/01.Cir.100.6.648 |
0.305 |
|
| 1999 |
Dorn GW, Tepe NM, Lorenz JN, Koch WJ, Liggett SB. Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 6400-5. PMID 10339599 DOI: 10.1073/Pnas.96.11.6400 |
0.301 |
|
| 1999 |
Iaccarino G, Koch WJ. Therapeutic potential of G-protein coupled receptor kinases in the heart Expert Opinion On Investigational Drugs. 8: 545-554. DOI: 10.1517/13543784.8.5.545 |
0.334 |
|
| 1998 |
Iaccarino G, Tomhave ED, Lefkowitz RJ, Koch WJ. Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. Circulation. 98: 1783-9. PMID 9788834 DOI: 10.1161/01.Cir.98.17.1783 |
0.316 |
|
| 1998 |
Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J, Lefkowitz RJ, Koch WJ. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proceedings of the National Academy of Sciences of the United States of America. 95: 7000-5. PMID 9618528 DOI: 10.1073/Pnas.95.12.7000 |
0.33 |
|
| 1997 |
Rockman HA, Koch WJ, Lefkowitz RJ. Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. The American Journal of Physiology. 272: H1553-9. PMID 9139936 DOI: 10.1152/Ajpheart.1997.272.4.H1553 |
0.306 |
|
| 1996 |
Rockman HA, Koch WJ, Milano CA, Lefkowitz RJ. Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. Journal of Molecular Medicine (Berlin, Germany). 74: 489-95. PMID 8892053 DOI: 10.1007/Bf00204974 |
0.304 |
|
| 1977 |
Powell MJ, Koch WJ. Morphological variations in a new species of Entophlyctis. II. Influence of growth conditions on morphology Canadian Journal of Botany. 55: 1686-1695. DOI: 10.1139/B77-196 |
0.44 |
|
| 1977 |
Powell MJ, Koch WJ. Morphological variations in a new species of Entophlyctis. I. The species concept Canadian Journal of Botany. 55: 1668-1685. DOI: 10.1139/B77-195 |
0.442 |
|
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