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Robert J. Lefkowitz - Publications

Affiliations: 
Duke University, Durham, NC 
Area:
G protein-coupled receptors
Website:
http://cardiology.medicine.duke.edu/faculty/details/0096962
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Year Citation  Score
2024 Pakharukova N, Thomas BN, Bansia H, Li L, Abzalimov RR, Kim J, Kahsai AW, Pani B, Bassford DK, Liu S, Zhang X, des Georges A, Lefkowitz RJ. Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy. Biorxiv : the Preprint Server For Biology. PMID 39131402 DOI: 10.1101/2024.07.31.605623  0.86
2024 Liu S, Anderson PJ, Rajagopal S, Lefkowitz RJ, Rockman HA. G Protein-Coupled Receptors: A Century of Research and Discovery. Circulation Research. 135: 174-197. PMID 38900852 DOI: 10.1161/CIRCRESAHA.124.323067  0.647
2024 Casiraghi M, Wang H, Brennan P, Habrian C, Hübner H, Schmidt MF, Maul L, Pani B, Bahriz SMFM, Xu B, White E, Sunahara RK, Xiang YK, Lefkowitz RJ, Isacoff EY, et al. Molecular insights into G protein specificity and biased agonism at the β -adrenergic receptor. Biorxiv : the Preprint Server For Biology. PMID 38586060 DOI: 10.1101/2024.03.28.587240  0.844
2024 Rockman HA, Lefkowitz RJ. G protein-coupled receptors: from radioligand binding to cellular signaling. The Journal of Clinical Investigation. 134. PMID 38426490 DOI: 10.1172/JCI178109  0.412
2023 Lefkowitz RJ, Rockman HA, Shim PJ, Liu S, Ahn S, Pani B, Rajagopal S, Shenoy SK, Bouvier M, Benovic JL, Liggett SB, Ruffolo RR, Bristow MR, Packer M. How carvedilol does not activate β-adrenoceptors. Nature Communications. 14: 7866. PMID 38036531 DOI: 10.1038/s41467-023-42848-5  0.78
2023 Kahsai AW, Shah KS, Shim PJ, Lee MA, Shreiber BN, Schwalb AM, Zhang X, Kwon HY, Huang LY, Soderblom EJ, Ahn S, Lefkowitz RJ. Signal transduction at GPCRs: Allosteric activation of the ERK MAPK by β-arrestin. Proceedings of the National Academy of Sciences of the United States of America. 120: e2303794120. PMID 37844230 DOI: 10.1073/pnas.2303794120  0.828
2023 Ahn S, Maarsingh H, Walker JK, Liu SW, Hegde A, Sumajit HC, Kahsai AW, Lefkowitz RJ. Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models. The Journal of Clinical Investigation. PMID 37432742 DOI: 10.1172/JCI167337  0.774
2023 Li A, Liu S, Huang R, Ahn S, Lefkowitz RJ. Loss of biased signaling at a G protein-coupled receptor in overexpressed systems. Plos One. 18: e0283477. PMID 36961836 DOI: 10.1371/journal.pone.0283477  0.652
2022 Asher WB, Terry DS, Gregorio GGA, Kahsai AW, Borgia A, Xie B, Modak A, Zhu Y, Jang W, Govindaraju A, Huang LY, Inoue A, Lambert NA, Gurevich VV, Shi L, ... Lefkowitz RJ, et al. GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision. Cell. PMID 35483373 DOI: 10.1016/j.cell.2022.03.042  0.861
2022 Utz PJ, Jain MK, Cheung VG, Kobilka BK, Lefkowitz R, Yamada T, Dzau VJ. Translating science to medicine: The case for physician-scientists. Science Translational Medicine. 14: eabg7852. PMID 35171650 DOI: 10.1126/scitranslmed.abg7852  0.356
2021 Zang Y, Kahsai AW, Pakharukova N, Huang LY, Lefkowitz RJ. The GPCR-β-arrestin complex allosterically activates C-Raf by binding its amino-terminus. The Journal of Biological Chemistry. 101369. PMID 34757127 DOI: 10.1016/j.jbc.2021.101369  0.837
2021 Pani B, Ahn S, Rambarat PK, Vege S, Kahsai AW, Liu A, Valan BN, Staus DP, Costa T, Lefkowitz RJ. . Molecular Pharmacology. PMID 34580163 DOI: 10.1124/molpharm.121.000363  0.823
2021 Wang J, Pani B, Gokhan I, Xiong X, Kahsai AW, Jiang H, Ahn S, Lefkowitz RJ, Rockman HA. β-arrestin-biased allosteric modulator potentiates Carvedilol stimulated β adrenergic receptor cardioprotection. Molecular Pharmacology. PMID 34561298 DOI: 10.1124/molpharm.121.000359  0.832
2021 Nguyen AH, Lefkowitz RJ. Signaling at the endosome: cryo-EM structure of a GPCR-G protein-beta-arrestin megacomplex. The Febs Journal. PMID 33605032 DOI: 10.1111/febs.15773  0.693
2020 Pakharukova N, Masoudi A, Pani B, Staus DP, Lefkowitz RJ. Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes. The Journal of Biological Chemistry. 295: 16773-16784. PMID 33453910 DOI: 10.1074/jbc.RA120.015400  0.828
2020 Pakharukova N, Masoudi A, Pani B, Staus DP, Lefkowitz RJ. Allosteric activation of proto-oncogene kinase Src by GPCR-beta-arrestin complexes. The Journal of Biological Chemistry. PMID 32978252 DOI: 10.1074/jbc.RA120.015400  0.877
2020 Ahn S, Shenoy SK, Luttrell LM, Lefkowitz RJ. SnapShot: β-Arrestin Functions. Cell. 182: 1362-1362.e1. PMID 32888497 DOI: 10.1016/J.Cell.2020.07.034  0.831
2020 McMahon C, Staus DP, Wingler LM, Wang J, Skiba MA, Elgeti M, Hubbell WL, Rockman HA, Kruse AC, Lefkowitz RJ. Synthetic nanobodies as angiotensin receptor blockers. Proceedings of the National Academy of Sciences of the United States of America. PMID 32753386 DOI: 10.1073/Pnas.2009029117  0.845
2020 Wingler LM, Lefkowitz RJ. Conformational Basis of G Protein-Coupled Receptor Signaling Versatility. Trends in Cell Biology. PMID 32622699 DOI: 10.1016/J.Tcb.2020.06.002  0.801
2020 Kim J, Grotegut CA, Wisler JW, Mao L, Rosenberg PB, Rockman HA, Lefkowitz RJ. The β-arrestin-biased β-adrenergic receptor blocker carvedilol enhances skeletal muscle contractility. Proceedings of the National Academy of Sciences of the United States of America. PMID 32414934 DOI: 10.1073/Pnas.1920310117  0.55
2020 Manglik A, Wingler LM, Rockman HA, Lefkowitz RJ. β-Arrestin-Biased Angiotensin II Receptor Agonists for COVID-19. Circulation. PMID 32412788 DOI: 10.1161/Circulationaha.120.048723  0.831
2020 Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC. Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science (New York, N.Y.). 367: 888-892. PMID 32079768 DOI: 10.1126/Science.Aay9813  0.862
2020 Suomivuori CM, Latorraca NR, Wingler LM, Eismann S, King MC, Kleinhenz ALW, Skiba MA, Staus DP, Kruse AC, Lefkowitz RJ, Dror RO. Molecular mechanism of biased signaling in a prototypical G protein-coupled receptor. Science (New York, N.Y.). 367: 881-887. PMID 32079767 DOI: 10.1126/Science.Aaz0326  0.849
2020 Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G. Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc. Nature. PMID 31945772 DOI: 10.1038/S41586-020-1954-0  0.863
2020 McMahon C, Wingler L, Staus D, Lefkowitz R, Kruse A. So Long Llamas: Structure of Activated Angiotensin Receptor Stabilized by a Synthetic Nanobody The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.08990  0.831
2019 Nguyen AH, Thomsen ARB, Cahill TJ, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, ... ... Lefkowitz RJ, et al. Structure of an endosomal signaling GPCR-G protein-β-arrestin megacomplex. Nature Structural & Molecular Biology. PMID 31740855 DOI: 10.1038/S41594-019-0330-Y  0.841
2019 Jain MK, Cheung VG, Utz PJ, Kobilka BK, Yamada T, Lefkowitz R. Saving the Endangered Physician-Scientist - A Plan for Accelerating Medical Breakthroughs. The New England Journal of Medicine. 381: 399-402. PMID 31365796 DOI: 10.1056/Nejmp1904482  0.416
2019 Staus DP, Wingler LM, Pichugin D, Prosser RS, Lefkowitz RJ. Detergent- and phospholipid-based reconstitution systems have differential effects on constitutive activity of G protein-coupled receptors. The Journal of Biological Chemistry. PMID 31362983 DOI: 10.1074/Jbc.Ac119.009848  0.857
2019 Liu X, Masoudi A, Kahsai AW, Huang LY, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B. Mechanism of βAR regulation by an intracellular positive allosteric modulator. Science (New York, N.Y.). 364: 1283-1287. PMID 31249059 DOI: 10.1126/science.aaw8981  0.856
2019 Wingler LM, McMahon C, Staus DP, Lefkowitz RJ, Kruse AC. Distinctive Activation Mechanism for Angiotensin Receptor Revealed by a Synthetic Nanobody. Cell. PMID 30639100 DOI: 10.1016/J.Cell.2018.12.006  0.869
2019 Wingler LM, Elgeti M, Hilger D, Latorraca NR, Lerch MT, Staus DP, Dror RO, Kobilka BK, Hubbell WL, Lefkowitz RJ. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. PMID 30639099 DOI: 10.1016/J.Cell.2018.12.005  0.853
2019 Liu X, Masoudi A, Kahsai AW, Huang L, Pani B, Staus DP, Shim PJ, Hirata K, Simhal RK, Schwalb AM, Rambarat PK, Ahn S, Lefkowitz RJ, Kobilka B. Mechanism of beta2AR regulation by an intracellular positive allosteric modulator. Science. 364: 1283-1287. DOI: 10.2210/Pdb6N48/Pdb  0.853
2018 Kim J, Grotegut CA, Wisler JW, Li T, Mao L, Chen M, Chen W, Rosenberg PB, Rockman HA, Lefkowitz RJ. β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility. Skeletal Muscle. 8: 39. PMID 30591079 DOI: 10.1186/S13395-018-0184-8  0.669
2018 Luttrell LM, Wang J, Plouffe B, Smith JS, Yamani L, Kaur S, Jean-Charles PY, Gauthier C, Lee MH, Pani B, Kim J, Ahn S, Rajagopal S, Reiter E, Bouvier M, ... ... Lefkowitz RJ, et al. Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9. Science Signaling. 11. PMID 30254056 DOI: 10.1126/Scisignal.Aat7650  0.86
2018 Choi M, Staus DP, Wingler LM, Ahn S, Pani B, Capel WD, Lefkowitz RJ. G protein-coupled receptor kinases (GRKs) orchestrate biased agonism at the β-adrenergic receptor. Science Signaling. 11. PMID 30131371 DOI: 10.1126/Scisignal.Aar7084  0.858
2018 Kahsai AW, Pani B, Lefkowitz RJ. GPCR signaling: conformational activation of arrestins. Cell Research. PMID 30030517 DOI: 10.1038/S41422-018-0067-X  0.81
2018 Wisler JW, Rockman HA, Lefkowitz RJ. Biased G Protein-Coupled Receptor Signaling: Changing the Paradigm of Drug Discovery. Circulation. 137: 2315-2317. PMID 29844068 DOI: 10.1161/Circulationaha.117.028194  0.572
2018 Ahn S, Pani B, Kahsai AW, Olsen EK, Husemoen G, Vestrgaard M, Jin L, Zhao S, Wingler LM, Rambarat PK, Simhal RK, Xu TT, Sun LD, Shim PJ, Staus DP, ... ... Lefkowitz RJ, et al. Small Molecule Positive Allosteric Modulators of the β-Adrenoceptor Isolated from DNA Encoded Libraries. Molecular Pharmacology. PMID 29769246 DOI: 10.1124/Mol.118.111948  0.824
2018 Staus DP, Wingler LM, Choi M, Pani B, Manglik A, Kruse AC, Lefkowitz RJ. Sortase ligation enables homogeneous GPCR phosphorylation to reveal diversity in β-arrestin coupling. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581292 DOI: 10.1073/Pnas.1722336115  0.867
2018 Smith JS, Lefkowitz RJ, Rajagopal S. Biased signalling: from simple switches to allosteric microprocessors. Nature Reviews. Drug Discovery. PMID 29302067 DOI: 10.1038/Nrd.2017.229  0.822
2017 Rein LA, Wisler JW, Kim J, Theriot B, Huang L, Price T, Yang H, Chen M, Chen W, Sipkins D, Fedoriw Y, Walker JK, Premont RT, Lefkowitz RJ. β-Arrestin2 mediates progression of murine primary myelofibrosis. Jci Insight. 2. PMID 29263312 DOI: 10.1172/Jci.Insight.98094  0.783
2017 Liu X, Ahn S, Kahsai AW, Meng KC, Latorraca NR, Pani B, Venkatakrishnan AJ, Masoudi A, Weis WI, Dror RO, Chen X, Lefkowitz RJ, Kobilka BK. Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. Nature. PMID 28813418 DOI: 10.1038/Nature23652  0.865
2017 Stoppel LJ, Auerbach BD, Senter RK, Preza AR, Lefkowitz RJ, Bear MF. β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X. Cell Reports. 18: 2807-2814. PMID 28329674 DOI: 10.1016/J.Celrep.2017.02.075  0.413
2017 Cahill TJ, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J, ... ... Lefkowitz RJ, et al. Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28223524 DOI: 10.1073/Pnas.1701529114  0.851
2017 Ahn S, Kahsai AW, Pani B, Wang QT, Zhao S, Wall AL, Strachan RT, Staus DP, Wingler LM, Sun LD, Sinnaeve J, Choi M, Cho T, Xu TT, Hansen GM, ... ... Lefkowitz RJ, et al. Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library. Proceedings of the National Academy of Sciences of the United States of America. PMID 28130548 DOI: 10.1073/Pnas.1620645114  0.853
2017 Cahill T, Thomsen A, Plouffe B, Bouvier M, Lefkowitz R. LB987 New insights into gpcr-transducer coupling Journal of Investigative Dermatology. 137: B10. DOI: 10.1016/J.Jid.2017.07.067  0.79
2017 Smith J, Nicholson L, Suwanpradid J, Glenn R, Gundry J, Alagesan P, Knape N, Atwater A, Gunn M, MacLeod A, Lefkowitz R, Rajagopal S. 678 Biased CXCR3 ligands differentially alter allergic contact hypersensitivity and chemotaxis Journal of Investigative Dermatology. 137: S117. DOI: 10.1016/J.Jid.2017.02.701  0.659
2016 Thomsen AR, Plouffe B, Cahill TJ, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, ... ... Lefkowitz RJ, et al. GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling. Cell. PMID 27499021 DOI: 10.1016/J.Cell.2016.07.004  0.85
2016 Staus DP, Strachan RT, Manglik A, Pani B, Kahsai AW, Kim TH, Wingler LM, Ahn S, Chatterjee A, Masoudi A, Kruse AC, Pardon E, Steyaert J, Weis WI, Prosser RS, ... ... Lefkowitz RJ, et al. Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation. Nature. PMID 27409812 DOI: 10.1038/Nature18636  0.856
2016 Kahsai AW, Wisler JW, Lee J, Ahn S, Cahill Iii TJ, Dennison SM, Staus DP, Thomsen AR, Anasti KM, Pani B, Wingler LM, Desai H, Bompiani KM, Strachan RT, Qin X, ... ... Lefkowitz RJ, et al. Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor. Nature Chemical Biology. PMID 27398998 DOI: 10.1038/Nchembio.2126  0.849
2015 Wisler JW, Harris EM, Raisch M, Mao L, Kim J, Rockman HA, Lefkowitz RJ. The role of β-arrestin2-dependent signaling in thoracic aortic aneurysm formation in a murine model of Marfan syndrome. American Journal of Physiology. Heart and Circulatory Physiology. 309: H1516-27. PMID 26371162 DOI: 10.1152/Ajpheart.00291.2015  0.806
2015 Rein LA, Wisler JW, Theriot BS, Huang L, Premont RT, Lefkowitz RJ. β-arrestin2 Is Necessary for Development of MPLW515L Mutant Primary Myelofibrosis Blood. 126: 486-486. DOI: 10.1182/Blood.V126.23.486.486  0.785
2014 Tang W, Strachan RT, Lefkowitz RJ, Rockman HA. Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch. The Journal of Biological Chemistry. 289: 28271-83. PMID 25170081 DOI: 10.1074/Jbc.M114.585067  0.789
2014 Shukla AK, Westfield GH, Xiao K, Reis RI, Huang LY, Tripathi-Shukla P, Qian J, Li S, Blanc A, Oleskie AN, Dosey AM, Su M, Liang CR, Gu LL, Shan JM, ... ... Lefkowitz RJ, et al. Visualization of arrestin recruitment by a G-protein-coupled receptor. Nature. 512: 218-22. PMID 25043026 DOI: 10.1038/Nature13430  0.854
2014 Wisler JW, Xiao K, Thomsen AR, Lefkowitz RJ. Recent developments in biased agonism. Current Opinion in Cell Biology. 27: 18-24. PMID 24680426 DOI: 10.1016/J.Ceb.2013.10.008  0.797
2014 Strachan RT, Sun JP, Rominger DH, Violin JD, Ahn S, Rojas Bie Thomsen A, Zhu X, Kleist A, Costa T, Lefkowitz RJ. Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR). The Journal of Biological Chemistry. 289: 14211-24. PMID 24668815 DOI: 10.1074/Jbc.M114.548131  0.839
2014 Staus DP, Wingler LM, Strachan RT, Rasmussen SG, Pardon E, Ahn S, Steyaert J, Kobilka BK, Lefkowitz RJ. Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies. Molecular Pharmacology. 85: 472-81. PMID 24319111 DOI: 10.1124/Mol.113.089516  0.877
2014 Wisler J, Harris E, Raisch M, Mao L, Kim J, Rockman H, Lefkowitz R. NON-CANONICAL ANGIOTENSIN II TYPE 1A RECEPTOR-MEDIATED, BETA-ARRESTIN2-DEPENDENT SIGNALING CONTRIBUTES TO THORACIC AORTIC ANEURYSM FORMATION IN A MURINE MODEL OF MARFAN SYNDROME Journal of the American College of Cardiology. 63: A2148. DOI: 10.1016/S0735-1097(14)62151-3  0.831
2013 Aristotelous T, Ahn S, Shukla AK, Gawron S, Sassano MF, Kahsai AW, Wingler LM, Zhu X, Tripathi-Shukla P, Huang XP, Riley J, Besnard J, Read KD, Roth BL, Gilbert IH, ... ... Lefkowitz RJ, et al. Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor. Acs Medicinal Chemistry Letters. 4: 1005-1010. PMID 24454993 DOI: 10.1021/Ml400312J  0.825
2013 Simard E, Kovacs JJ, Miller WE, Kim J, Grandbois M, Lefkowitz RJ. β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration. Plos One. 8: e80532. PMID 24255721 DOI: 10.1371/Journal.Pone.0080532  0.836
2013 Lefkowitz RJ. Arrestins come of age: a personal historical perspective. Progress in Molecular Biology and Translational Science. 118: 3-18. PMID 23764048 DOI: 10.1016/B978-0-12-394440-5.00001-2  0.53
2013 Lefkowitz RJ. A brief history of G-protein coupled receptors (Nobel Lecture). Angewandte Chemie (International Ed. in English). 52: 6366-78. PMID 23650015 DOI: 10.1002/anie.201301924  0.506
2013 Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, ... ... Lefkowitz RJ, et al. Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide. Nature. 497: 137-41. PMID 23604254 DOI: 10.1038/Nature12120  0.875
2013 Weiss DR, Ahn S, Sassano MF, Kleist A, Zhu X, Strachan R, Roth BL, Lefkowitz RJ, Shoichet BK. Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. Acs Chemical Biology. 8: 1018-26. PMID 23485065 DOI: 10.1021/Cb400103F  0.86
2013 Hara MR, Sachs BD, Caron MG, Lefkowitz RJ. Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. Cell Cycle (Georgetown, Tex.). 12: 219-24. PMID 23287463 DOI: 10.4161/cc.23368  0.667
2013 Rein LA, Chen M, Theriot BS, Wisler JW, Wingler LM, Premont RT, Chen W, Walker JK, Lefkowitz RJ. Targeting β-arrestin2 Enhances Survival in a Murine Model of Chronic Myeloid Leukemia Blood. 122: 857-857. DOI: 10.1182/Blood.V122.21.857.857  0.794
2012 Fereshteh M, Ito T, Kovacs JJ, Zhao C, Kwon HY, Tornini V, Konuma T, Chen M, Lefkowitz RJ, Reya T. β-Arrestin2 mediates the initiation and progression of myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America. 109: 12532-7. PMID 22773819 DOI: 10.1073/Pnas.1209815109  0.816
2012 Heitzler D, Durand G, Gallay N, Rizk A, Ahn S, Kim J, Violin JD, Dupuy L, Gauthier C, Piketty V, Crépieux P, Poupon A, Clément F, Fages F, Lefkowitz RJ, et al. Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling. Molecular Systems Biology. 8: 590. PMID 22735336 DOI: 10.1038/Msb.2012.22  0.862
2012 Lefkowitz RJ. An interview with Robert J. Lefkowitz. Trends in Pharmacological Sciences. 33: 51-2. PMID 22403833 DOI: 10.1016/J.Tips.2011.10.009  0.553
2012 Reiter E, Ahn S, Shukla AK, Lefkowitz RJ. Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors. Annual Review of Pharmacology and Toxicology. 52: 179-97. PMID 21942629 DOI: 10.1146/Annurev.Pharmtox.010909.105800  0.836
2012 Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, ... ... Lefkowitz RJ, et al. Global phosphorylation analysis of β-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 34 (15299-15304) doi:10.1073/pnas.1008461107) Proceedings of the National Academy of Sciences of the United States of America. 109: 13464. DOI: 10.1073/Pnas.1211889109  0.831
2012 Lefkowitz R, Kobilka B. A signal honour Chemistry World. 9: 46-49.  0.415
2011 Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, Rajagopal S, Strachan RT, Huang TY, Bressler EA, Hara MR, Shenoy SK, Gygi SP, Lefkowitz RJ. Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. Science Signaling. 4: ra51. PMID 21868357 DOI: 10.1126/Scisignal.2001707  0.869
2011 Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, Shenoy SK, Gregory SG, Ahn S, Duckett DR, Lefkowitz RJ. A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature. 477: 349-53. PMID 21857681 DOI: 10.1038/Nature10368  0.783
2011 Kahsai AW, Xiao K, Rajagopal S, Ahn S, Shukla AK, Sun J, Oas TG, Lefkowitz RJ. Multiple ligand-specific conformations of the β2-adrenergic receptor. Nature Chemical Biology. 7: 692-700. PMID 21857662 DOI: 10.1038/Nchembio.634  0.865
2011 Shukla AK, Xiao K, Lefkowitz RJ. Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends in Biochemical Sciences. 36: 457-69. PMID 21764321 DOI: 10.1016/J.Tibs.2011.06.003  0.685
2011 Rockman HA, Lefkowitz RJ. Introduction to the series on novel aspects of cardiovascular G-protein-coupled receptor signaling. Circulation Research. 109: 202-4. PMID 21737815 DOI: 10.1161/Circresaha.110.231126  0.444
2011 Shenoy SK, Lefkowitz RJ. β-Arrestin-mediated receptor trafficking and signal transduction. Trends in Pharmacological Sciences. 32: 521-33. PMID 21680031 DOI: 10.1016/J.Tips.2011.05.002  0.74
2011 Rajagopal S, Ahn S, Rominger DH, Gowen-MacDonald W, Lam CM, Dewire SM, Violin JD, Lefkowitz RJ. Quantifying ligand bias at seven-transmembrane receptors. Molecular Pharmacology. 80: 367-77. PMID 21610196 DOI: 10.1124/Mol.111.072801  0.844
2011 Lovgren AK, Kovacs JJ, Xie T, Potts EN, Li Y, Foster WM, Liang J, Meltzer EB, Jiang D, Lefkowitz RJ, Noble PW. β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix. Science Translational Medicine. 3: 74ra23. PMID 21411739 DOI: 10.1126/scitranslmed.3001564  0.707
2011 Whalen EJ, Rajagopal S, Lefkowitz RJ. Therapeutic potential of β-arrestin- and G protein-biased agonists. Trends in Molecular Medicine. 17: 126-39. PMID 21183406 DOI: 10.1016/J.Molmed.2010.11.004  0.841
2011 Rajagopal S, Kovacs J, Badea C, Johnson GA, Rockman HA, Piantadosi CA, Lefkowitz RJ. BETA-ARRESTINS REGULATE SIGNALING BY BONE MORPHOGENETIC PROTEIN TYPE II RECEPTOR IN PULMONARY ARTERIAL HYPERTENSION Journal of the American College of Cardiology. 57: E2046. DOI: 10.1016/S0735-1097(11)62046-9  0.742
2010 Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, ... ... Lefkowitz RJ, et al. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proceedings of the National Academy of Sciences of the United States of America. 107: 15299-304. PMID 20686112 DOI: 10.1073/Pnas.1008461107  0.867
2010 Shukla AK, Kim J, Ahn S, Xiao K, Shenoy SK, Liedtke W, Lefkowitz RJ. Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. The Journal of Biological Chemistry. 285: 30115-25. PMID 20650893 DOI: 10.1074/Jbc.M110.141549  0.864
2010 Rajagopal S, Rajagopal K, Lefkowitz RJ. Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nature Reviews. Drug Discovery. 9: 373-86. PMID 20431569 DOI: 10.1038/Nrd3024  0.869
2010 Rajagopal S, Kim J, Ahn S, Craig S, Lam CM, Gerard NP, Gerard C, Lefkowitz RJ. Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. Proceedings of the National Academy of Sciences of the United States of America. 107: 628-32. PMID 20018651 DOI: 10.1073/Pnas.0912852107  0.878
2009 Gesty-Palmer D, Flannery P, Yuan L, Corsino L, Spurney R, Lefkowitz RJ, Luttrell LM. A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Science Translational Medicine. 1: 1ra1. PMID 20368153 DOI: 10.1126/Scitranslmed.3000071  0.829
2009 Kovacs JJ, Hara MR, Davenport CL, Kim J, Lefkowitz RJ. Arrestin development: emerging roles for beta-arrestins in developmental signaling pathways. Developmental Cell. 17: 443-58. PMID 19853559 DOI: 10.1016/J.Devcel.2009.09.011  0.854
2009 Chen M, Philipp M, Wang J, Premont RT, Garrison TR, Caron MG, Lefkowitz RJ, Chen W. G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. The Journal of Biological Chemistry. 284: 35040-8. PMID 19801552 DOI: 10.1074/Jbc.M109.047456  0.883
2009 Xie L, Xiao K, Whalen EJ, Forrester MT, Freeman RS, Fong G, Gygi SP, Lefkowitz RJ, Stamler JS. Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL. Science Signaling. 2: ra33. PMID 19584355 DOI: 10.1126/Scisignal.2000444  0.812
2009 Zidar DA, Violin JD, Whalen EJ, Lefkowitz RJ. Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proceedings of the National Academy of Sciences of the United States of America. 106: 9649-54. PMID 19497875 DOI: 10.1073/Pnas.0904361106  0.886
2009 Shenoy SK, Modi AS, Shukla AK, Xiao K, Berthouze M, Ahn S, Wilkinson KD, Miller WE, Lefkowitz RJ. Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proceedings of the National Academy of Sciences of the United States of America. 106: 6650-5. PMID 19363159 DOI: 10.1073/Pnas.0901083106  0.867
2009 Walters RW, Shukla AK, Kovacs JJ, Violin JD, DeWire SM, Lam CM, Chen JR, Muehlbauer MJ, Whalen EJ, Lefkowitz RJ. beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. The Journal of Clinical Investigation. 119: 1312-21. PMID 19349687 DOI: 10.1172/Jci36806  0.833
2009 Kim J, Ahn S, Rajagopal K, Lefkowitz RJ. Independent beta-arrestin2 and Gq/protein kinase Czeta pathways for ERK stimulated by angiotensin type 1A receptors in vascular smooth muscle cells converge on transactivation of the epidermal growth factor receptor. The Journal of Biological Chemistry. 284: 11953-62. PMID 19254952 DOI: 10.1074/Jbc.M808176200  0.854
2009 Ahn S, Kim J, Hara MR, Ren XR, Lefkowitz RJ. {beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation. The Journal of Biological Chemistry. 284: 8855-65. PMID 19171933 DOI: 10.1074/Jbc.M808463200  0.881
2009 Berthouze M, Lefkowitz R, Shenoy S. J018 The deubiquitinases USP33 and USP20 collaboratively regulate beta2 adrenergic receptor recycling and resensitization Archives of Cardiovascular Diseases. 102: S108-S109. DOI: 10.1016/S1875-2136(09)72393-9  0.749
2008 Ozawa K, Whalen EJ, Nelson CD, Mu Y, Hess DT, Lefkowitz RJ, Stamler JS. S-nitrosylation of beta-arrestin regulates beta-adrenergic receptor trafficking. Molecular Cell. 31: 395-405. PMID 18691971 DOI: 10.1016/J.Molcel.2008.05.024  0.847
2008 Tarrant TK, Rampersad RR, Esserman D, Rothlein LR, Liu P, Premont RT, Lefkowitz RJ, Lee DM, Patel DD. Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). Clinical Immunology (Orlando, Fla.). 129: 115-22. PMID 18662895 DOI: 10.1016/J.Clim.2008.06.008  0.646
2008 Shukla AK, Violin JD, Whalen EJ, Gesty-Palmer D, Shenoy SK, Lefkowitz RJ. Distinct conformational changes in beta-arrestin report biased agonism at seven-transmembrane receptors. Proceedings of the National Academy of Sciences of the United States of America. 105: 9988-93. PMID 18621717 DOI: 10.1073/Pnas.0804246105  0.886
2008 Nelson CD, Kovacs JJ, Nobles KN, Whalen EJ, Lefkowitz RJ. Beta-arrestin scaffolding of phosphatidylinositol 4-phosphate 5-kinase Ialpha promotes agonist-stimulated sequestration of the beta2-adrenergic receptor. The Journal of Biological Chemistry. 283: 21093-101. PMID 18534983 DOI: 10.1074/Jbc.M800431200  0.871
2008 Barak LS, Salahpour A, Zhang X, Masri B, Sotnikova TD, Ramsey AJ, Violin JD, Lefkowitz RJ, Caron MG, Gainetdinov RR. Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor. Molecular Pharmacology. 74: 585-94. PMID 18524885 DOI: 10.1124/Mol.108.048884  0.843
2008 Kim J, Zhang L, Peppel K, Wu JH, Zidar DA, Brian L, DeWire SM, Exum ST, Lefkowitz RJ, Freedman NJ. Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. Circulation Research. 103: 70-9. PMID 18519945 DOI: 10.1161/Circresaha.108.172338  0.839
2008 Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, Wang J, Chen W, Lefkowitz RJ. Beta-arrestin-mediated localization of smoothened to the primary cilium. Science (New York, N.Y.). 320: 1777-81. PMID 18497258 DOI: 10.1126/Science.1157983  0.846
2008 DeWire SM, Kim J, Whalen EJ, Ahn S, Chen M, Lefkowitz RJ. Beta-arrestin-mediated signaling regulates protein synthesis. The Journal of Biological Chemistry. 283: 10611-20. PMID 18276584 DOI: 10.1074/Jbc.M710515200  0.87
2008 Lefkowitz RJ, Sun JP, Shukla AK. A crystal clear view of the beta2-adrenergic receptor. Nature Biotechnology. 26: 189-91. PMID 18259173 DOI: 10.1038/Nbt0208-189  0.717
2008 Shukla AK, Sun JP, Lefkowitz RJ. Crystallizing thinking about the beta2-adrenergic receptor. Molecular Pharmacology. 73: 1333-8. PMID 18239031 DOI: 10.1124/Mol.108.045849  0.744
2008 Beaulieu JM, Marion S, Rodriguiz RM, Medvedev IO, Sotnikova TD, Ghisi V, Wetsel WC, Lefkowitz RJ, Gainetdinov RR, Caron MG. A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell. 132: 125-36. PMID 18191226 DOI: 10.1016/J.Cell.2007.11.041  0.732
2008 Drake MT, Violin JD, Whalen EJ, Wisler JW, Shenoy SK, Lefkowitz RJ. beta-arrestin-biased agonism at the beta2-adrenergic receptor. The Journal of Biological Chemistry. 283: 5669-76. PMID 18086673 DOI: 10.1074/Jbc.M708118200  0.872
2008 Violin JD, DiPilato LM, Yildirim N, Elston TC, Zhang J, Lefkowitz RJ. beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. The Journal of Biological Chemistry. 283: 2949-61. PMID 18045878 DOI: 10.1074/Jbc.M707009200  0.829
2007 Wisler JW, DeWire SM, Whalen EJ, Violin JD, Drake MT, Ahn S, Shenoy SK, Lefkowitz RJ. A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 16657-62. PMID 17925438 DOI: 10.1073/Pnas.0707936104  0.879
2007 Noma T, Lemaire A, Naga Prasad SV, Barki-Harrington L, Tilley DG, Chen J, Le Corvoisier P, Violin JD, Wei H, Lefkowitz RJ, Rockman HA. Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. The Journal of Clinical Investigation. 117: 2445-58. PMID 17786238 DOI: 10.1172/Jci31901  0.859
2007 Shenoy SK, Barak LS, Xiao K, Ahn S, Berthouze M, Shukla AK, Luttrell LM, Lefkowitz RJ. Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. The Journal of Biological Chemistry. 282: 29549-62. PMID 17666399 DOI: 10.1074/Jbc.M700852200  0.855
2007 Violin JD, Lefkowitz RJ. Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends in Pharmacological Sciences. 28: 416-22. PMID 17644195 DOI: 10.1016/j.tips.2007.06.006  0.782
2007 Xiao K, McClatchy DB, Shukla AK, Zhao Y, Chen M, Shenoy SK, Yates JR, Lefkowitz RJ. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proceedings of the National Academy of Sciences of the United States of America. 104: 12011-6. PMID 17620599 DOI: 10.1073/Pnas.0704849104  0.842
2007 Nobles KN, Guan Z, Xiao K, Oas TG, Lefkowitz RJ. The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. The Journal of Biological Chemistry. 282: 21370-81. PMID 17513300 DOI: 10.1074/Jbc.M611483200  0.846
2007 Whalen EJ, Foster MW, Matsumoto A, Ozawa K, Violin JD, Que LG, Nelson CD, Benhar M, Keys JR, Rockman HA, Koch WJ, Daaka Y, Lefkowitz RJ, Stamler JS. Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell. 129: 511-22. PMID 17482545 DOI: 10.1016/J.Cell.2007.02.046  0.891
2007 Lefkowitz RJ. Seven transmembrane receptors: something old, something new. Acta Physiologica (Oxford, England). 190: 9-19. PMID 17428228 DOI: 10.1111/j.1365-201X.2007.01693.x  0.602
2007 DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK. Beta-arrestins and cell signaling. Annual Review of Physiology. 69: 483-510. PMID 17305471 DOI: 10.1146/Annurev.Physiol.69.022405.154749  0.872
2007 Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Vasilcanu D, Girnita A, Lefkowitz RJ, Larsson O. Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. The Journal of Biological Chemistry. 282: 11329-38. PMID 17303558 DOI: 10.1074/Jbc.M611526200  0.748
2007 Nelson CD, Perry SJ, Regier DS, Prescott SM, Topham MK, Lefkowitz RJ. Targeting of diacylglycerol degradation to M1 muscarinic receptors by beta-arrestins. Science (New York, N.Y.). 315: 663-6. PMID 17272726 DOI: 10.1126/Science.1134562  0.772
2007 Lefkowitz RJ. Seven transmembrane receptors: a brief personal retrospective. Biochimica Et Biophysica Acta. 1768: 748-55. PMID 17173855 DOI: 10.1016/j.bbamem.2006.11.001  0.514
2006 Lefkowitz RJ, Rajagopal K, Whalen EJ. New roles for beta-arrestins in cell signaling: not just for seven-transmembrane receptors. Molecular Cell. 24: 643-52. PMID 17157248 DOI: 10.1016/J.Molcel.2006.11.007  0.874
2006 Rajagopal K, Whalen EJ, Violin JD, Stiber JA, Rosenberg PB, Premont RT, Coffman TM, Rockman HA, Lefkowitz RJ. Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 16284-9. PMID 17060617 DOI: 10.1073/Pnas.0607583103  0.861
2006 Violin JD, Dewire SM, Barnes WG, Lefkowitz RJ. G protein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics. The Journal of Biological Chemistry. 281: 36411-9. PMID 17008309 DOI: 10.1074/Jbc.M607956200  0.881
2006 Drake MT, Shenoy SK, Lefkowitz RJ. Trafficking of G protein-coupled receptors. Circulation Research. 99: 570-82. PMID 16973913 DOI: 10.1161/01.Res.0000242563.47507.Ce  0.813
2006 Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG. Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2. Molecular and Cellular Biology. 26: 7550-60. PMID 16908539 DOI: 10.1128/Mcb.00546-06  0.811
2006 Violin JD, Ren XR, Lefkowitz RJ. G-protein-coupled receptor kinase specificity for beta-arrestin recruitment to the beta2-adrenergic receptor revealed by fluorescence resonance energy transfer. The Journal of Biological Chemistry. 281: 20577-88. PMID 16687412 DOI: 10.1074/jbc.M513605200  0.883
2006 Reiter E, Lefkowitz RJ. GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends in Endocrinology and Metabolism: Tem. 17: 159-65. PMID 16595179 DOI: 10.1016/J.Tem.2006.03.008  0.779
2006 Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD, Wang S, Eckhardt AE, Cowan CL, Spurney RF, Luttrell LM, Lefkowitz RJ. Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. The Journal of Biological Chemistry. 281: 10856-64. PMID 16492667 DOI: 10.1074/Jbc.M513380200  0.854
2006 Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ. beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor. The Journal of Biological Chemistry. 281: 1261-73. PMID 16280323 DOI: 10.1074/Jbc.M506576200  0.872
2005 Shenoy SK, Lefkowitz RJ. Receptor regulation: beta-arrestin moves up a notch. Nature Cell Biology. 7: 1159-61. PMID 16319967 DOI: 10.1038/Ncb1205-1059  0.781
2005 Shenoy SK, Lefkowitz RJ. Angiotensin II-stimulated signaling through G proteins and beta-arrestin. Science's Stke : Signal Transduction Knowledge Environment. 2005: cm14. PMID 16304060 DOI: 10.1126/Stke.3112005Cm14  0.782
2005 Rajagopal K, Lefkowitz RJ, Rockman HA. When 7 transmembrane receptors are not G protein-coupled receptors. The Journal of Clinical Investigation. 115: 2971-4. PMID 16276410 DOI: 10.1172/Jci26950  0.725
2005 Shenoy SK, Lefkowitz RJ. Seven-transmembrane receptor signaling through beta-arrestin. Science's Stke : Signal Transduction Knowledge Environment. 2005: cm10. PMID 16267056 DOI: 10.1126/Stke.2005/308/Cm10  0.811
2005 Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell. 122: 261-73. PMID 16051150 DOI: 10.1016/j.cell.2005.05.012  0.726
2005 Lefkowitz RJ. Summary of Wenner-Gren international symposium receptor-receptor interactions among heptaspanning membrane receptors: from structure to function. Journal of Molecular Neuroscience : Mn. 26: 293-4. PMID 16012202 DOI: 10.1385/JMN:26:2-3:293  0.539
2005 Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Girnita A, Lefkowitz RJ, Larsson O. {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. The Journal of Biological Chemistry. 280: 24412-9. PMID 15878855 DOI: 10.1074/Jbc.M501129200  0.723
2005 Lefkowitz RJ, Shenoy SK. Transduction of receptor signals by beta-arrestins. Science (New York, N.Y.). 308: 512-7. PMID 15845844 DOI: 10.1126/Science.1109237  0.762
2005 Shenoy SK, Lefkowitz RJ. Receptor-specific ubiquitination of beta-arrestin directs assembly and targeting of seven-transmembrane receptor signalosomes. The Journal of Biological Chemistry. 280: 15315-24. PMID 15699045 DOI: 10.1074/Jbc.M412418200  0.761
2005 Milasta S, Evans NA, Ormiston L, Wilson S, Lefkowitz RJ, Milligan G. The sustainability of interactions between the orexin-1 receptor and beta-arrestin-2 is defined by a single C-terminal cluster of hydroxy amino acids and modulates the kinetics of ERK MAPK regulation. The Biochemical Journal. 387: 573-84. PMID 15683363 DOI: 10.1042/BJ20041745  0.588
2005 Kim J, Ahn S, Ren XR, Whalen EJ, Reiter E, Wei H, Lefkowitz RJ. Functional antagonism of different G protein-coupled receptor kinases for beta-arrestin-mediated angiotensin II receptor signaling. Proceedings of the National Academy of Sciences of the United States of America. 102: 1442-7. PMID 15671181 DOI: 10.1073/Pnas.0409532102  0.895
2005 Ren XR, Reiter E, Ahn S, Kim J, Chen W, Lefkowitz RJ. Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor. Proceedings of the National Academy of Sciences of the United States of America. 102: 1448-53. PMID 15671180 DOI: 10.1073/Pnas.0409534102  0.893
2005 Tachibana H, Naga Prasad SV, Lefkowitz RJ, Koch WJ, Rockman HA. Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure. Circulation. 111: 591-7. PMID 15668342 DOI: 10.1161/01.Cir.0000142291.70954.Df  0.597
2005 Hunton DL, Barnes WG, Kim J, Ren XR, Violin JD, Reiter E, Milligan G, Patel DD, Lefkowitz RJ. Beta-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. Molecular Pharmacology. 67: 1229-36. PMID 15635042 DOI: 10.1124/Mol.104.006270  0.848
2005 Barnes WG, Reiter E, Violin JD, Ren XR, Milligan G, Lefkowitz RJ. beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. The Journal of Biological Chemistry. 280: 8041-50. PMID 15611106 DOI: 10.1074/Jbc.M412924200  0.864
2005 Shenoy SK, Lefkowitz RJ. Receptor regulation: β-arrestin moves up a notch Nature Cell Biology. 7: 1159-1161. DOI: 10.1038/ncb1205-1159  0.68
2004 Shenoy SK, Lefkowitz RJ. Resonating to the music of ubiquitination. Nature Methods. 1: 191-3. PMID 15782194 DOI: 10.1038/Nmeth1204-191  0.607
2004 Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ. Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science (New York, N.Y.). 306: 2257-60. PMID 15618519 DOI: 10.1126/Science.1104135  0.876
2004 Xiao K, Shenoy SK, Nobles K, Lefkowitz RJ. Activation-dependent conformational changes in {beta}-arrestin 2. The Journal of Biological Chemistry. 279: 55744-53. PMID 15501822 DOI: 10.1074/Jbc.M409785200  0.846
2004 Ge L, Shenoy SK, Lefkowitz RJ, DeFea K. Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. The Journal of Biological Chemistry. 279: 55419-24. PMID 15489220 DOI: 10.1074/Jbc.M410312200  0.674
2004 Usui I, Imamura T, Huang J, Satoh H, Shenoy SK, Lefkowitz RJ, Hupfeld CJ, Olefsky JM. beta-arrestin-1 competitively inhibits insulin-induced ubiquitination and degradation of insulin receptor substrate 1. Molecular and Cellular Biology. 24: 8929-37. PMID 15456867 DOI: 10.1128/Mcb.24.20.8929-8937.2004  0.713
2004 Martin NP, Whalen EJ, Zamah MA, Pierce KL, Lefkowitz RJ. PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching. Cellular Signalling. 16: 1397-403. PMID 15381255 DOI: 10.1016/J.Cellsig.2004.05.002  0.858
2004 Wei H, Ahn S, Barnes WG, Lefkowitz RJ. Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. The Journal of Biological Chemistry. 279: 48255-61. PMID 15355986 DOI: 10.1074/Jbc.M406205200  0.877
2004 Dinudom A, Fotia AB, Lefkowitz RJ, Young JA, Kumar S, Cook DI. The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels. Proceedings of the National Academy of Sciences of the United States of America. 101: 11886-90. PMID 15284439 DOI: 10.1073/Pnas.0402178101  0.44
2004 Lefkowitz RJ. Historical review: a brief history and personal retrospective of seven-transmembrane receptors. Trends in Pharmacological Sciences. 25: 413-22. PMID 15276710 DOI: 10.1016/j.tips.2004.06.006  0.619
2004 Wang Q, Zhao J, Brady AE, Feng J, Allen PB, Lefkowitz RJ, Greengard P, Limbird LE. Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science (New York, N.Y.). 304: 1940-4. PMID 15218143 DOI: 10.1126/Science.1098274  0.874
2004 Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, Caron MG. Desensitization of G protein-coupled receptors and neuronal functions. Annual Review of Neuroscience. 27: 107-44. PMID 15217328 DOI: 10.1146/Annurev.Neuro.27.070203.144206  0.838
2004 Bohn LM, Dykstra LA, Lefkowitz RJ, Caron MG, Barak LS. Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery. Molecular Pharmacology. 66: 106-12. PMID 15213301 DOI: 10.1124/Mol.66.1.106  0.791
2004 Ahn S, Shenoy SK, Wei H, Lefkowitz RJ. Differential kinetic and spatial patterns of beta-arrestin and G protein-mediated ERK activation by the angiotensin II receptor. The Journal of Biological Chemistry. 279: 35518-25. PMID 15205453 DOI: 10.1074/Jbc.M405878200  0.852
2004 Lefkowitz RJ, Whalen EJ. beta-arrestins: traffic cops of cell signaling. Current Opinion in Cell Biology. 16: 162-8. PMID 15196559 DOI: 10.1016/J.Ceb.2004.01.001  0.81
2004 Witherow DS, Garrison TR, Miller WE, Lefkowitz RJ. beta-Arrestin inhibits NF-kappaB activity by means of its interaction with the NF-kappaB inhibitor IkappaBalpha. Proceedings of the National Academy of Sciences of the United States of America. 101: 8603-7. PMID 15173580 DOI: 10.1073/Pnas.0402851101  0.836
2004 Fukuto HS, Ferkey DM, Apicella AJ, Lans H, Sharmeen T, Chen W, Lefkowitz RJ, Jansen G, Schafer WR, Hart AC. G protein-coupled receptor kinase function is essential for chemosensation in C. elegans. Neuron. 42: 581-93. PMID 15157420 DOI: 10.1016/S0896-6273(04)00252-1  0.564
2004 Freedman NJ, Lefkowitz RJ. Anti-beta(1)-adrenergic receptor antibodies and heart failure: causation, not just correlation. The Journal of Clinical Investigation. 113: 1379-82. PMID 15146232 DOI: 10.1172/JCI21748  0.676
2004 Xu M, Petraschka M, McLaughlin JP, Westenbroek RE, Caron MG, Lefkowitz RJ, Czyzyk TA, Pintar JE, Terman GW, Chavkin C. Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4576-84. PMID 15140929 DOI: 10.1523/Jneurosci.5552-03.2004  0.496
2004 Galliera E, Jala VR, Trent JO, Bonecchi R, Signorelli P, Lefkowitz RJ, Mantovani A, Locati M, Haribabu B. beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. The Journal of Biological Chemistry. 279: 25590-7. PMID 15084596 DOI: 10.1074/jbc.M400363200  0.557
2004 Ahn S, Wei H, Garrison TR, Lefkowitz RJ. Reciprocal regulation of angiotensin receptor-activated extracellular signal-regulated kinases by beta-arrestins 1 and 2. The Journal of Biological Chemistry. 279: 7807-11. PMID 14711824 DOI: 10.1074/Jbc.C300443200  0.867
2004 Terman GW, Jin W, Cheong YP, Lowe J, Caron MG, Lefkowitz RJ, Chavkin C. G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. British Journal of Pharmacology. 141: 55-64. PMID 14662727 DOI: 10.1038/Sj.Bjp.0705595  0.571
2004 McLaughlin JP, Myers LC, Zarek PE, Caron MG, Lefkowitz RJ, Czyzyk TA, Pintar JE, Chavkin C. Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance. The Journal of Biological Chemistry. 279: 1810-8. PMID 14597630 DOI: 10.1074/Jbc.M305796200  0.549
2004 Walker JK, Gainetdinov RR, Feldman DS, McFawn PK, Caron MG, Lefkowitz RJ, Premont RT, Fisher JT. G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 286: L312-9. PMID 14565944 DOI: 10.1152/Ajplung.00255.2003  0.762
2003 Kavelaars A, Vroon A, Raatgever RP, Fong AM, Premont RT, Patel DD, Lefkowitz RJ, Heijnen CJ. Increased acute inflammation, leukotriene B4-induced chemotaxis, and signaling in mice deficient for G protein-coupled receptor kinase 6. Journal of Immunology (Baltimore, Md. : 1950). 171: 6128-34. PMID 14634128 DOI: 10.4049/Jimmunol.171.11.6128  0.716
2003 Bohn LM, Gainetdinov RR, Sotnikova TD, Medvedev IO, Lefkowitz RJ, Dykstra LA, Caron MG. Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10265-73. PMID 14614085  0.725
2003 Povsic TJ, Kohout TA, Lefkowitz RJ. Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis. The Journal of Biological Chemistry. 278: 51334-9. PMID 14534298 DOI: 10.1074/jbc.M309968200  0.877
2003 Martin NP, Lefkowitz RJ, Shenoy SK. Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. The Journal of Biological Chemistry. 278: 45954-9. PMID 12960162 DOI: 10.1074/Jbc.M308285200  0.867
2003 Shenoy SK, Lefkowitz RJ. Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. The Biochemical Journal. 375: 503-15. PMID 12959637 DOI: 10.1042/Bj20031076  0.804
2003 Chen W, Kirkbride KC, How T, Nelson CD, Mo J, Frederick JP, Wang XF, Lefkowitz RJ, Blobe GC. Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science (New York, N.Y.). 301: 1394-7. PMID 12958365 DOI: 10.1126/Science.1083195  0.796
2003 Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE, Caron MG, Barak LS, Nusse R, Lefkowitz RJ. Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science (New York, N.Y.). 301: 1391-4. PMID 12958364 DOI: 10.1126/Science.1082808  0.869
2003 Wei H, Ahn S, Shenoy SK, Karnik SS, Hunyady L, Luttrell LM, Lefkowitz RJ. Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. Proceedings of the National Academy of Sciences of the United States of America. 100: 10782-7. PMID 12949261 DOI: 10.1073/Pnas.1834556100  0.867
2003 Vines CM, Revankar CM, Maestas DC, LaRusch LL, Cimino DF, Kohout TA, Lefkowitz RJ, Prossnitz ER. N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. The Journal of Biological Chemistry. 278: 41581-4. PMID 12947104 DOI: 10.1074/Jbc.C300291200  0.804
2003 Walker JK, Fong AM, Lawson BL, Savov JD, Patel DD, Schwartz DA, Lefkowitz RJ. Beta-arrestin-2 regulates the development of allergic asthma. The Journal of Clinical Investigation. 112: 566-74. PMID 12925697 DOI: 10.1172/JCI17265  0.427
2003 Rapacciuolo A, Suvarna S, Barki-Harrington L, Luttrell LM, Cong M, Lefkowitz RJ, Rockman HA. Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways. The Journal of Biological Chemistry. 278: 35403-11. PMID 12821660 DOI: 10.1074/Jbc.M305675200  0.854
2003 Lodowski DT, Barnhill JF, Pitcher JA, Capel WD, Lefkowitz RJ, Tesmer JJ. Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gbeta1gamma2. Acta Crystallographica. Section D, Biological Crystallography. 59: 936-9. PMID 12777817 DOI: 10.1107/S0907444903002622  0.781
2003 Lodowski DT, Pitcher JA, Capel WD, Lefkowitz RJ, Tesmer JJ. Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. Science (New York, N.Y.). 300: 1256-62. PMID 12764189 DOI: 10.1126/Science.1082348  0.795
2003 Hu LA, Chen W, Martin NP, Whalen EJ, Premont RT, Lefkowitz RJ. GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. The Journal of Biological Chemistry. 278: 26295-301. PMID 12724327 DOI: 10.1074/Jbc.M212352200  0.887
2003 Gainetdinov RR, Bohn LM, Sotnikova TD, Cyr M, Laakso A, Macrae AD, Torres GE, Kim KM, Lefkowitz RJ, Caron MG, Premont RT. Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. Neuron. 38: 291-303. PMID 12718862 DOI: 10.1016/S0896-6273(03)00192-2  0.801
2003 Miller WE, Houtz DA, Nelson CD, Kolattukudy PE, Lefkowitz RJ. G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR. The Journal of Biological Chemistry. 278: 21663-71. PMID 12668664 DOI: 10.1074/Jbc.M303219200  0.842
2003 Lefkowitz RJ. A magnificent time with the "magnificent seven" transmembrane spanning receptors. Circulation Research. 92: 342-4. PMID 12623870 DOI: 10.1161/01.RES.0000061771.61280.B8  0.534
2003 Ahn S, Nelson CD, Garrison TR, Miller WE, Lefkowitz RJ. Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. Proceedings of the National Academy of Sciences of the United States of America. 100: 1740-4. PMID 12582207 DOI: 10.1073/Pnas.262789099  0.885
2003 Shenoy SK, Lefkowitz RJ. Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. The Journal of Biological Chemistry. 278: 14498-506. PMID 12574160 DOI: 10.1074/Jbc.M209626200  0.775
2003 Baillie GS, Sood A, McPhee I, Gall I, Perry SJ, Lefkowitz RJ, Houslay MD. beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi. Proceedings of the National Academy of Sciences of the United States of America. 100: 940-5. PMID 12552097 DOI: 10.1073/pnas.262787199  0.576
2003 Kohout TA, Lefkowitz RJ. Regulation of G protein-coupled receptor kinases and arrestins during receptor desensitization. Molecular Pharmacology. 63: 9-18. PMID 12488531 DOI: 10.1124/mol.63.1.9  0.814
2003 Tohgo A, Choy EW, Gesty-Palmer D, Pierce KL, Laporte S, Oakley RH, Caron MG, Lefkowitz RJ, Luttrell LM. The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation. The Journal of Biological Chemistry. 278: 6258-67. PMID 12473660 DOI: 10.1074/jbc.M212231200  0.882
2002 Bohn LM, Lefkowitz RJ, Caron MG. Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10494-500. PMID 12451149 DOI: 10.1523/Jneurosci.22-23-10494.2002  0.739
2002 Perry SJ, Baillie GS, Kohout TA, McPhee I, Magiera MM, Ang KL, Miller WE, McLean AJ, Conti M, Houslay MD, Lefkowitz RJ. Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins. Science (New York, N.Y.). 298: 834-6. PMID 12399592 DOI: 10.1126/Science.1074683  0.865
2002 Hanyaloglu AC, Seeber RM, Kohout TA, Lefkowitz RJ, Eidne KA. Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2. The Journal of Biological Chemistry. 277: 50422-30. PMID 12393857 DOI: 10.1074/jbc.M209340200  0.795
2002 Lefkowitz RJ, Pierce KL, Luttrell LM. Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity. Molecular Pharmacology. 62: 971-4. PMID 12391258 DOI: 10.1124/mol.62.5.971  0.711
2002 Hall RA, Lefkowitz RJ. Regulation of G protein-coupled receptor signaling by scaffold proteins. Circulation Research. 91: 672-80. PMID 12386143 DOI: 10.1161/01.RES.0000037000.74258.03  0.691
2002 Freeman JL, Gonzalo P, Pitcher JA, Claing A, Lavergne JP, Reboud JP, Lefkowitz RJ. Beta 2-adrenergic receptor stimulated, G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2. Biochemistry. 41: 12850-7. PMID 12379128 DOI: 10.1021/Bi020145D  0.847
2002 Pierce KL, Premont RT, Lefkowitz RJ. Seven-transmembrane receptors. Nature Reviews. Molecular Cell Biology. 3: 639-50. PMID 12209124 DOI: 10.1038/nrm908  0.671
2002 Lin FT, Chen W, Shenoy S, Cong M, Exum ST, Lefkowitz RJ. Phosphorylation of beta-arrestin2 regulates its function in internalization of beta(2)-adrenergic receptors. Biochemistry. 41: 10692-9. PMID 12186555 DOI: 10.1021/Bi025705N  0.875
2002 Zamah AM, Delahunty M, Luttrell LM, Lefkowitz RJ. Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system. The Journal of Biological Chemistry. 277: 31249-56. PMID 12063255 DOI: 10.1074/jbc.M202753200  0.853
2002 Eckhart AD, Fentzke RC, Lepore J, Lang R, Lin H, Lefkowitz RJ, Koch WJ, Leiden JM. Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy. Journal of Molecular and Cellular Cardiology. 34: 669-77. PMID 12054854 DOI: 10.1006/jmcc.2002.2007  0.623
2002 Fong AM, Premont RT, Richardson RM, Yu YR, Lefkowitz RJ, Patel DD. Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 7478-83. PMID 12032308 DOI: 10.1073/Pnas.112198299  0.714
2002 Ahn S, Kim J, Lucaveche CL, Reedy MC, Luttrell LM, Lefkowitz RJ, Daaka Y. Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. The Journal of Biological Chemistry. 277: 26642-51. PMID 12011079 DOI: 10.1074/Jbc.M201499200  0.836
2002 Claing A, Laporte SA, Caron MG, Lefkowitz RJ. Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Progress in Neurobiology. 66: 61-79. PMID 11900882 DOI: 10.1016/S0301-0082(01)00023-5  0.876
2002 Luttrell LM, Lefkowitz RJ. The role of beta-arrestins in the termination and transduction of G-protein-coupled receptor signals. Journal of Cell Science. 115: 455-65. PMID 11861753  0.759
2002 Perry SJ, Lefkowitz RJ. Arresting developments in heptahelical receptor signaling and regulation. Trends in Cell Biology. 12: 130-8. PMID 11859025 DOI: 10.1016/S0962-8924(01)02239-5  0.56
2002 Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature. 415: 206-12. PMID 11805844 DOI: 10.1038/415206A  0.701
2002 Tohgo A, Pierce KL, Choy EW, Lefkowitz RJ, Luttrell LM. beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation. The Journal of Biological Chemistry. 277: 9429-36. PMID 11777902 DOI: 10.1074/jbc.M106457200  0.869
2002 Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ. G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95. The Journal of Biological Chemistry. 277: 1607-13. PMID 11700307 DOI: 10.1074/Jbc.M107297200  0.877
2002 Paing MM, Stutts AB, Kohout TA, Lefkowitz RJ, Trejo J. beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation. The Journal of Biological Chemistry. 277: 1292-300. PMID 11694535 DOI: 10.1074/Jbc.M109160200  0.817
2001 Miller WE, Lefkowitz RJ. Arrestins as signaling molecules involved in apoptotic pathways: a real eye opener. Science's Stke : Signal Transduction Knowledge Environment. 2001: pe1. PMID 11752639 DOI: 10.1126/Stke.2001.69.Pe1  0.679
2001 Chen W, Hu LA, Semenov MV, Yanagawa S, Kikuchi A, Lefkowitz RJ, Miller WE. beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Proceedings of the National Academy of Sciences of the United States of America. 98: 14889-94. PMID 11742073 DOI: 10.1073/Pnas.211572798  0.857
2001 Kohout TA, Takaoka H, McDonald PH, Perry SJ, Mao L, Lefkowitz RJ, Rockman HA. Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. Circulation. 104: 2485-91. PMID 11705829 DOI: 10.1161/Hc4501.098933  0.779
2001 McDonald PH, Lefkowitz RJ. Beta-Arrestins: new roles in regulating heptahelical receptors' functions. Cellular Signalling. 13: 683-9. PMID 11602178 DOI: 10.1016/S0898-6568(01)00203-0  0.578
2001 Shenoy SK, McDonald PH, Kohout TA, Lefkowitz RJ. Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Science (New York, N.Y.). 294: 1307-13. PMID 11588219 DOI: 10.1126/Science.1063866  0.885
2001 Pierce KL, Lefkowitz RJ. Classical and new roles of beta-arrestins in the regulation of G-protein-coupled receptors. Nature Reviews. Neuroscience. 2: 727-33. PMID 11584310 DOI: 10.1038/35094577  0.624
2001 Cong M, Perry SJ, Hu LA, Hanson PI, Claing A, Lefkowitz RJ. Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling. The Journal of Biological Chemistry. 276: 45145-52. PMID 11577089 DOI: 10.1074/Jbc.M106087200  0.871
2001 Imamura T, Huang J, Dalle S, Ugi S, Usui I, Luttrell LM, Miller WE, Lefkowitz RJ, Olefsky JM. beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. The Journal of Biological Chemistry. 276: 43663-7. PMID 11546805 DOI: 10.1074/Jbc.M105364200  0.758
2001 Claing A, Chen W, Miller WE, Vitale N, Moss J, Premont RT, Lefkowitz RJ. beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. The Journal of Biological Chemistry. 276: 42509-13. PMID 11533043 DOI: 10.1074/Jbc.M108399200  0.884
2001 Iaccarino G, Keys JR, Rapacciuolo A, Shotwell KF, Lefkowitz RJ, Rockman HA, Koch WJ. Regulation of myocardial betaARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing alpha1B-adrenergic receptors. Journal of the American College of Cardiology. 38: 534-40. PMID 11499749 DOI: 10.1016/S0735-1097(01)01396-1  0.778
2001 Miller WE, McDonald PH, Cai SF, Field ME, Davis RJ, Lefkowitz RJ. Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. The Journal of Biological Chemistry. 276: 27770-7. PMID 11356842 DOI: 10.1074/Jbc.M102264200  0.716
2001 Harding VB, Jones LR, Lefkowitz RJ, Koch WJ, Rockman HA. Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. Proceedings of the National Academy of Sciences of the United States of America. 98: 5809-14. PMID 11331748 DOI: 10.1073/Pnas.091102398  0.608
2001 Pierce KL, Luttrell LM, Lefkowitz RJ. New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene. 20: 1532-9. PMID 11313899 DOI: 10.1038/sj.onc.1204184  0.737
2001 Freeman K, Lerman I, Kranias EG, Bohlmeyer T, Bristow MR, Lefkowitz RJ, Iaccarino G, Koch WJ, Leinwand LA. Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. The Journal of Clinical Investigation. 107: 967-74. PMID 11306600 DOI: 10.1172/Jci12083  0.783
2001 Pierce KL, Tohgo A, Ahn S, Field ME, Luttrell LM, Lefkowitz RJ. Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding. The Journal of Biological Chemistry. 276: 23155-60. PMID 11290747 DOI: 10.1074/Jbc.M101303200  0.84
2001 Cong M, Perry SJ, Lin FT, Fraser ID, Hu LA, Chen W, Pitcher JA, Scott JD, Lefkowitz RJ. Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. The Journal of Biological Chemistry. 276: 15192-9. PMID 11278469 DOI: 10.1074/jbc.M009130200  0.863
2001 Miller WE, Lefkowitz RJ. Expanding roles for beta-arrestins as scaffolds and adapters in GPCR signaling and trafficking. Current Opinion in Cell Biology. 13: 139-45. PMID 11248546 DOI: 10.1016/S0955-0674(00)00190-3  0.763
2001 Shah AS, White DC, Emani S, Kypson AP, Lilly RE, Wilson K, Glower DD, Lefkowitz RJ, Koch WJ. In vivo ventricular gene delivery of a beta-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. Circulation. 103: 1311-6. PMID 11238278 DOI: 10.1161/01.Cir.103.9.1311  0.626
2001 Luttrell LM, Roudabush FL, Choy EW, Miller WE, Field ME, Pierce KL, Lefkowitz RJ. Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds. Proceedings of the National Academy of Sciences of the United States of America. 98: 2449-54. PMID 11226259 DOI: 10.1073/Pnas.041604898  0.833
2001 Zhu WZ, Zheng M, Koch WJ, Lefkowitz RJ, Kobilka BK, Xiao RP. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 98: 1607-12. PMID 11171998 DOI: 10.1073/Pnas.98.4.1607  0.756
2001 Kohout TA, Lin FS, Perry SJ, Conner DA, Lefkowitz RJ. beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Proceedings of the National Academy of Sciences of the United States of America. 98: 1601-6. PMID 11171997 DOI: 10.1073/pnas.041608198  0.793
2000 Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, Caron MG. Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature. 408: 720-3. PMID 11130073 DOI: 10.1038/35047086  0.765
2000 McDonald PH, Chow CW, Miller WE, Laporte SA, Field ME, Lin FT, Davis RJ, Lefkowitz RJ. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science (New York, N.Y.). 290: 1574-7. PMID 11090355 DOI: 10.1126/Science.290.5496.1574  0.819
2000 Gainetdinov RR, Premont RT, Caron MG, Lefkowitz RJ. Reply: receptor specificity of G-protein-coupled receptor kinases Trends in Pharmacological Sciences. 21: 366-7. PMID 11050311 DOI: 10.1016/S0165-6147(00)01538-8  0.736
2000 Maudsley S, Zamah AM, Rahman N, Blitzer JT, Luttrell LM, Lefkowitz RJ, Hall RA. Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity. Molecular and Cellular Biology. 20: 8352-63. PMID 11046132 DOI: 10.1128/Mcb.20.22.8352-8363.2000  0.861
2000 Cao W, Luttrell LM, Medvedev AV, Pierce KL, Daniel KW, Dixon TM, Lefkowitz RJ, Collins S. Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation. The Journal of Biological Chemistry. 275: 38131-4. PMID 11013230 DOI: 10.1074/Jbc.C000592200  0.809
2000 Hu LA, Tang Y, Miller WE, Cong M, Lau AG, Lefkowitz RJ, Hall RA. beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors. The Journal of Biological Chemistry. 275: 38659-66. PMID 10995758 DOI: 10.1074/Jbc.M005938200  0.854
2000 Shah AS, White DC, Tai O, Hata JA, Wilson KH, Pippen A, Kypson AP, Glower DD, Lefkowitz RJ, Koch WJ. Adenovirus-mediated genetic manipulation of the myocardial beta-adrenergic signaling system in transplanted hearts. The Journal of Thoracic and Cardiovascular Surgery. 120: 581-8. PMID 10962422 DOI: 10.1067/Mtc.2000.107519  0.715
2000 Premont RT, Claing A, Vitale N, Perry SJ, Lefkowitz RJ. The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. The Journal of Biological Chemistry. 275: 22373-80. PMID 10896954 DOI: 10.1074/Jbc.275.29.22373  0.798
2000 Lefkowitz RJ. The superfamily of heptahelical receptors. Nature Cell Biology. 2: E133-6. PMID 10878827 DOI: 10.1038/35017152  0.483
2000 Koch WJ, Lefkowitz RJ, Rockman HA. Functional consequences of altering myocardial adrenergic receptor signaling. Annual Review of Physiology. 62: 237-60. PMID 10845091 DOI: 10.1146/Annurev.Physiol.62.1.237  0.65
2000 Freeman JL, Pitcher JA, Li X, Bennett V, Lefkowitz RJ. alpha-Actinin is a potent regulator of G protein-coupled receptor kinase activity and substrate specificity in vitro. Febs Letters. 473: 280-4. PMID 10818226 DOI: 10.1016/S0014-5793(00)01543-X  0.766
2000 Vitale N, Patton WA, Moss J, Vaughan M, Lefkowitz RJ, Premont RT. GIT proteins, A novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6. The Journal of Biological Chemistry. 275: 13901-6. PMID 10788515 DOI: 10.1074/Jbc.275.18.13901  0.629
2000 Zhang SJ, Cheng H, Zhou YY, Wang DJ, Zhu W, Ziman B, Spurgoen H, Lefkowitz RJ, Lakatta EG, Koch WJ, Xiao RP. Inhibition of spontaneous beta 2-adrenergic activation rescues beta 1-adrenergic contractile response in cardiomyocytes overexpressing beta 2-adrenoceptor. The Journal of Biological Chemistry. 275: 21773-9. PMID 10787424 DOI: 10.1074/Jbc.M909484199  0.722
2000 White DC, Hata JA, Shah AS, Glower DD, Lefkowitz RJ, Koch WJ. Preservation of myocardial beta-adrenergic receptor signaling delays the development of heart failure after myocardial infarction. Proceedings of the National Academy of Sciences of the United States of America. 97: 5428-33. PMID 10779554 DOI: 10.1073/pnas.090091197  0.61
2000 Lefkowitz RJ, Rockman HA, Koch WJ. Catecholamines, cardiac beta-adrenergic receptors, and heart failure. Circulation. 101: 1634-7. PMID 10758041 DOI: 10.1161/01.Cir.101.14.1634  0.6
2000 Miller WE, Maudsley S, Ahn S, Khan KD, Luttrell LM, Lefkowitz RJ. beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis. The Journal of Biological Chemistry. 275: 11312-9. PMID 10753943 DOI: 10.1074/Jbc.275.15.11312  0.87
2000 Fraser ID, Cong M, Kim J, Rollins EN, Daaka Y, Lefkowitz RJ, Scott JD. Assembly of an A kinase-anchoring protein-beta(2)-adrenergic receptor complex facilitates receptor phosphorylation and signaling. Current Biology : Cb. 10: 409-12. PMID 10753752 DOI: 10.1016/S0960-9822(00)00419-X  0.886
2000 Maudsley S, Pierce KL, Zamah AM, Miller WE, Ahn S, Daaka Y, Lefkowitz RJ, Luttrell LM. The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor. The Journal of Biological Chemistry. 275: 9572-80. PMID 10734107 DOI: 10.1074/Jbc.275.13.9572  0.869
2000 Pierce KL, Maudsley S, Daaka Y, Luttrell LM, Lefkowitz RJ. Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. Proceedings of the National Academy of Sciences of the United States of America. 97: 1489-94. PMID 10677489 DOI: 10.1073/PNAS.97.4.1489  0.86
2000 Claing A, Perry SJ, Achiriloaie M, Walker JK, Albanesi JP, Lefkowitz RJ, Premont RT. Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity. Proceedings of the National Academy of Sciences of the United States of America. 97: 1119-24. PMID 10655494 DOI: 10.1073/Pnas.97.3.1119  0.845
2000 Shah AS, Lilly RE, Kypson AP, Tai O, Hata JA, Pippen A, Silvestry SC, Lefkowitz RJ, Glower DD, Koch WJ. Intracoronary adenovirus-mediated delivery and overexpression of the beta(2)-adrenergic receptor in the heart : prospects for molecular ventricular assistance. Circulation. 101: 408-14. PMID 10653833 DOI: 10.1161/01.Cir.101.4.408  0.694
2000 Eckhart AD, Duncan SJ, Penn RB, Benovic JL, Lefkowitz RJ, Koch WJ. Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. Circulation Research. 86: 43-50. PMID 10625304 DOI: 10.1161/01.Res.86.1.43  0.732
1999 Walker JKL, Peppel K, Lefkowitz RJ, Caron MG, Fisher JT. Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 276: R1214-R1221. PMID 29592499 DOI: 10.1152/ajpregu.1999.276.4.R1214  0.754
1999 Gainetdinov RR, Bohn LM, Walker JK, Laporte SA, Macrae AD, Caron MG, Lefkowitz RJ, Premont RT. Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice. Neuron. 24: 1029-36. PMID 10624964 DOI: 10.1016/S0896-6273(00)81048-X  0.833
1999 Bohn LM, Lefkowitz RJ, Gainetdinov RR, Peppel K, Caron MG, Lin FT. Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science (New York, N.Y.). 286: 2495-8. PMID 10617462 DOI: 10.1126/Science.286.5449.2495  0.867
1999 Pitcher JA, Tesmer JJ, Freeman JL, Capel WD, Stone WC, Lefkowitz RJ. Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. The Journal of Biological Chemistry. 274: 34531-4. PMID 10574913 DOI: 10.1074/Jbc.274.49.34531  0.824
1999 Cross HR, Steenbergen C, Lefkowitz RJ, Koch WJ, Murphy E. Overexpression of the cardiac beta(2)-adrenergic receptor and expression of a beta-adrenergic receptor kinase-1 (betaARK1) inhibitor both increase myocardial contractility but have differential effects on susceptibility to ischemic injury. Circulation Research. 85: 1077-84. PMID 10571539 DOI: 10.1161/01.RES.85.11.1077  0.654
1999 Tang Y, Hu LA, Miller WE, Ringstad N, Hall RA, Pitcher JA, DeCamilli P, Lefkowitz RJ. Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 96: 12559-64. PMID 10535961 DOI: 10.1073/Pnas.96.22.12559  0.865
1999 Iaccarino G, Lefkowitz RJ, Koch WJ. Myocardial G protein-coupled receptor kinases: implications for heart failure therapy. Proceedings of the Association of American Physicians. 111: 399-405. PMID 10519160  0.774
1999 Premont RT, Macrae AD, Aparicio SA, Kendall HE, Welch JE, Lefkowitz RJ. The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. The Journal of Biological Chemistry. 274: 29381-9. PMID 10506199 DOI: 10.1074/Jbc.274.41.29381  0.667
1999 Kypson AP, Hendrickson SC, Akhter SA, Wilson K, McDonald PH, Lilly RE, Dolber PC, Glower DD, Lefkowitz RJ, Koch WJ. Adenovirus-mediated gene transfer of the β2-adrenergic receptor to donor hearts enhances cardiac function Gene Therapy. 6: 1298-1304. PMID 10455439 DOI: 10.1038/sj.gt.3300940  0.722
1999 Hall RA, Spurney RF, Premont RT, Rahman N, Blitzer JT, Pitcher JA, Lefkowitz RJ. G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. The Journal of Biological Chemistry. 274: 24328-34. PMID 10446210 DOI: 10.1074/Jbc.274.34.24328  0.824
1999 Akhter SA, Eckhart AD, Rockman HA, Shotwell K, Lefkowitz RJ, Koch WJ. In vivo inhibition of elevated myocardial beta-adrenergic receptor kinase activity in hybrid transgenic mice restores normal beta-adrenergic signaling and function. Circulation. 100: 648-53. PMID 10441103 DOI: 10.1161/01.Cir.100.6.648  0.777
1999 Maurice JP, Hata JA, Shah AS, White DC, McDonald PH, Dolber PC, Wilson KH, Lefkowitz RJ, Glower DD, Koch WJ. Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary beta2-adrenergic receptor gene delivery. The Journal of Clinical Investigation. 104: 21-9. PMID 10393695 DOI: 10.1172/JCI6026  0.663
1999 Hall RA, Premont RT, Lefkowitz RJ. Heptahelical receptor signaling: beyond the G protein paradigm. The Journal of Cell Biology. 145: 927-32. PMID 10352011 DOI: 10.1083/Jcb.145.5.927  0.745
1999 Lin FT, Miller WE, Luttrell LM, Lefkowitz RJ. Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases. The Journal of Biological Chemistry. 274: 15971-4. PMID 10347142 DOI: 10.1074/Jbc.274.23.15971  0.804
1999 Della Rocca GJ, Maudsley S, Daaka Y, Lefkowitz RJ, Luttrell LM. Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. The Journal of Biological Chemistry. 274: 13978-84. PMID 10318809 DOI: 10.1074/Jbc.274.20.13978  0.845
1999 Luttrell LM, Daaka Y, Lefkowitz RJ. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Current Opinion in Cell Biology. 11: 177-83. PMID 10209148 DOI: 10.1016/S0955-0674(99)80023-4  0.816
1999 Walker JK, Peppel K, Lefkowitz RJ, Caron MG, Fisher JT. Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. The American Journal of Physiology. 276: R1214-21. PMID 10198406 DOI: 10.1152/Ajpregu.1999.276.4.R1214  0.734
1999 McDonald PH, Cote NL, Lin FT, Premont RT, Pitcher JA, Lefkowitz RJ. Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation. The Journal of Biological Chemistry. 274: 10677-80. PMID 10196135 DOI: 10.1074/Jbc.274.16.10677  0.863
1999 Iaccarino G, Smithwick LA, Lefkowitz RJ, Koch WJ. Targeting Gbeta gamma signaling in arterial vascular smooth muscle proliferation: a novel strategy to limit restenosis. Proceedings of the National Academy of Sciences of the United States of America. 96: 3945-50. PMID 10097143 DOI: 10.1073/Pnas.96.7.3945  0.806
1999 Della Rocca GJ, Mukhin YV, Garnovskaya MN, Daaka Y, Clark GJ, Luttrell LM, Lefkowitz RJ, Raymond JR. Serotonin 5-HT1A receptor-mediated Erk activation requires calcium/calmodulin-dependent receptor endocytosis. The Journal of Biological Chemistry. 274: 4749-53. PMID 9988712 DOI: 10.1074/jbc.274.8.4749  0.825
1999 Iaccarino G, Dolber PC, Lefkowitz RJ, Koch WJ. Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. Hypertension. 33: 396-401. PMID 9931136 DOI: 10.1161/01.Hyp.33.1.396  0.869
1999 Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ. Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science (New York, N.Y.). 283: 655-61. PMID 9924018 DOI: 10.1126/Science.283.5402.655  0.895
1999 Xiao RP, Avdonin P, Zhou YY, Cheng H, Akhter SA, Eschenhagen T, Lefkowitz RJ, Koch WJ, Lakatta EG. Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. Circulation Research. 84: 43-52. PMID 9915773 DOI: 10.1161/01.Res.84.1.43  0.799
1999 Ahn S, Maudsley S, Luttrell LM, Lefkowitz RJ, Daaka Y. Src-mediated tyrosine phosphorylation of dynamin is required for beta2-adrenergic receptor internalization and mitogen-activated protein kinase signaling. The Journal of Biological Chemistry. 274: 1185-8. PMID 9880482 DOI: 10.1074/Jbc.274.3.1185  0.89
1998 Premont RT, Claing A, Vitale N, Freeman JL, Pitcher JA, Patton WA, Moss J, Vaughan M, Lefkowitz RJ. beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proceedings of the National Academy of Sciences of the United States of America. 95: 14082-7. PMID 9826657 DOI: 10.1073/Pnas.95.24.14082  0.89
1998 Lin FT, Daaka Y, Lefkowitz RJ. beta-arrestins regulate mitogenic signaling and clathrin-mediated endocytosis of the insulin-like growth factor I receptor. The Journal of Biological Chemistry. 273: 31640-3. PMID 9822622 DOI: 10.1074/Jbc.273.48.31640  0.798
1998 Stoffel RH, Inglese J, Macrae AD, Lefkowitz RJ, Premont RT. Palmitoylation increases the kinase activity of the G protein-coupled receptor kinase, GRK6. Biochemistry. 37: 16053-9. PMID 9819198 DOI: 10.1021/Bi981432D  0.69
1998 Iaccarino G, Tomhave ED, Lefkowitz RJ, Koch WJ. Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. Circulation. 98: 1783-9. PMID 9788834 DOI: 10.1161/01.Cir.98.17.1783  0.865
1998 Pitcher JA, Freedman NJ, Lefkowitz RJ. G protein-coupled receptor kinases. Annual Review of Biochemistry. 67: 653-92. PMID 9759500 DOI: 10.1146/annurev.biochem.67.1.653  0.87
1998 Davies MG, Huynh TT, Fulton GJ, Lefkowitz RJ, Svendsen E, Hagen PO, Koch WJ. G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development. Arteriosclerosis, Thrombosis, and Vascular Biology. 18: 1275-80. PMID 9714134 DOI: 10.1161/01.ATV.18.8.1275  0.671
1998 Freeman JL, De La Cruz EM, Pollard TD, Lefkowitz RJ, Pitcher JA. Regulation of G protein-coupled receptor kinase 5 (GRK5) by actin. The Journal of Biological Chemistry. 273: 20653-7. PMID 9685424 DOI: 10.1074/Jbc.273.32.20653  0.772
1998 Hall RA, Ostedgaard LS, Premont RT, Blitzer JT, Rahman N, Welsh MJ, Lefkowitz RJ. A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins. Proceedings of the National Academy of Sciences of the United States of America. 95: 8496-501. PMID 9671706 DOI: 10.1073/Pnas.95.15.8496  0.853
1998 Lefkowitz RJ. G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. The Journal of Biological Chemistry. 273: 18677-80. PMID 9668034 DOI: 10.1074/jbc.273.30.18677  0.648
1998 Rockman HA, Choi DJ, Akhter SA, Jaber M, Giros B, Lefkowitz RJ, Caron MG, Koch WJ. Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice. The Journal of Biological Chemistry. 273: 18180-4. PMID 9660778 DOI: 10.1074/Jbc.273.29.18180  0.833
1998 Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP. GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. The Journal of Biological Chemistry. 273: 17749-55. PMID 9651375 DOI: 10.1074/Jbc.273.28.17749  0.605
1998 Rockman HA, Chien KR, Choi DJ, Iaccarino G, Hunter JJ, Ross J, Lefkowitz RJ, Koch WJ. Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. Proceedings of the National Academy of Sciences of the United States of America. 95: 7000-5. PMID 9618528 DOI: 10.1073/Pnas.95.12.7000  0.808
1998 Gaballa MA, Peppel K, Lefkowitz RJ, Aguirre M, Dolber PC, Pennock GD, Koch WJ, Goldman S. Enhanced vasorelaxation by overexpression of beta 2-adrenergic receptors in large arteries. Journal of Molecular and Cellular Cardiology. 30: 1037-45. PMID 9618244 DOI: 10.1006/jmcc.1998.0668  0.801
1998 Ford CE, Skiba NP, Bae H, Daaka Y, Reuveny E, Shekter LR, Rosal R, Weng G, Yang CS, Iyengar R, Miller RJ, Jan LY, Lefkowitz RJ, Hamm HE. Molecular basis for interactions of G protein betagamma subunits with effectors. Science (New York, N.Y.). 280: 1271-4. PMID 9596582 DOI: 10.1126/Science.280.5367.1271  0.786
1998 Pitcher JA, Hall RA, Daaka Y, Zhang J, Ferguson SS, Hester S, Miller S, Caron MG, Lefkowitz RJ, Barak LS. The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin. The Journal of Biological Chemistry. 273: 12316-24. PMID 9575184 DOI: 10.1074/Jbc.273.20.12316  0.862
1998 Hall RA, Premont RT, Chow CW, Blitzer JT, Pitcher JA, Claing A, Stoffel RH, Barak LS, Shenolikar S, Weinman EJ, Grinstein S, Lefkowitz RJ. The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature. 392: 626-30. PMID 9560162 DOI: 10.1038/33458  0.88
1998 Akhter SA, Luttrell LM, Rockman HA, Iaccarino G, Lefkowitz RJ, Koch WJ. Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy. Science (New York, N.Y.). 280: 574-7. PMID 9554846 DOI: 10.1126/Science.280.5363.574  0.846
1998 Kypson AP, Peppel K, Akhter SA, Lilly RE, Glower DD, Lefkowitz RJ, Koch WJ. Ex vivo adenovirus-mediated gene transfer to the adult rat heart. The Journal of Thoracic and Cardiovascular Surgery. 115: 623-30. PMID 9535450 DOI: 10.1016/S0022-5223(98)70327-7  0.829
1998 Daaka Y, Luttrell LM, Ahn S, Della Rocca GJ, Ferguson SS, Caron MG, Lefkowitz RJ. Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. The Journal of Biological Chemistry. 273: 685-8. PMID 9422717 DOI: 10.1074/Jbc.273.2.685  0.881
1998 Koch WJ, Lefkowitz RJ, Milano CA, Akhter SA, Rockman HA. Myocardial overexpression of adrenergic receptors and receptor kinases. Advances in Pharmacology (San Diego, Calif.). 42: 502-6. PMID 9327950  0.46
1998 Luttrell LM, van Biesen T, Hawes BE, Della Rocca GJ, Luttrell DK, Lefkowitz RJ. Regulation of mitogen-activated protein kinase pathways by catecholamine receptors. Advances in Pharmacology (San Diego, Calif.). 42: 466-70. PMID 9327940 DOI: 10.1016/S1054-3589(08)60789-9  0.729
1998 Lefkowitz RJ, Pitcher J, Krueger K, Daaka Y. Mechanisms of beta-adrenergic receptor desensitization and resensitization. Advances in Pharmacology (San Diego, Calif.). 42: 416-20. PMID 9327928 DOI: 10.1016/S1054-3589(08)60777-2  0.886
1997 Peppel K, Koch WJ, Lefkowitz RJ. Gene transfer strategies for augmenting cardiac function. Trends in Cardiovascular Medicine. 7: 145-50. PMID 21235878 DOI: 10.1016/S1050-1738(97)00028-5  0.725
1997 Zhang J, Ferguson SS, Barak LS, Aber MJ, Giros B, Lefkowitz RJ, Caron MG. Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization. Receptors & Channels. 5: 193-9. PMID 9606723  0.843
1997 Ishizaka N, Alexander RW, Laursen JB, Kai H, Fukui T, Oppermann M, Lefkowitz RJ, Lyons PR, Griendling KK. G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. Regulation by angiotensin II and hypertension. The Journal of Biological Chemistry. 272: 32482-8. PMID 9405459 DOI: 10.1074/Jbc.272.51.32482  0.443
1997 Luttrell LM, Daaka Y, Della Rocca GJ, Lefkowitz RJ. G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases. The Journal of Biological Chemistry. 272: 31648-56. PMID 9395506 DOI: 10.1074/Jbc.272.50.31648  0.794
1997 Lin FT, Krueger KM, Kendall HE, Daaka Y, Fredericks ZL, Pitcher JA, Lefkowitz RJ. Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. The Journal of Biological Chemistry. 272: 31051-7. PMID 9388255 DOI: 10.1074/Jbc.272.49.31051  0.883
1997 Daaka Y, Luttrell LM, Lefkowitz RJ. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature. 390: 88-91. PMID 9363896 DOI: 10.1038/36362  0.864
1997 Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Krueger KM, Touhara K, Lefkowitz RJ. G-protein-coupled receptors and their regulation: activation of the MAP kinase signaling pathway by G-protein-coupled receptors. Advances in Second Messenger and Phosphoprotein Research. 31: 263-77. PMID 9344257  0.684
1997 Akhter SA, Skaer CA, Kypson AP, McDonald PH, Peppel KC, Glower DD, Lefkowitz RJ, Koch WJ. Restoration of beta-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proceedings of the National Academy of Sciences of the United States of America. 94: 12100-5. PMID 9342369 DOI: 10.1073/pnas.94.22.12100  0.84
1997 Peppel K, Boekhoff I, McDonald P, Breer H, Caron MG, Lefkowitz RJ. G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. The Journal of Biological Chemistry. 272: 25425-8. PMID 9325250 DOI: 10.1074/jbc.272.41.25425  0.809
1997 Akhter SA, Milano CA, Shotwell KF, Cho MC, Rockman HA, Lefkowitz RJ, Koch WJ. Transgenic mice with cardiac overexpression of alpha1B-adrenergic receptors. In vivo alpha1-adrenergic receptor-mediated regulation of beta-adrenergic signaling. The Journal of Biological Chemistry. 272: 21253-9. PMID 9261135 DOI: 10.1074/Jbc.272.34.21253  0.81
1997 Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ. Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase. The Journal of Biological Chemistry. 272: 19125-32. PMID 9235901 DOI: 10.1074/jbc.272.31.19125  0.807
1997 Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST, Lefkowitz RJ. Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity. The Journal of Biological Chemistry. 272: 17734-43. PMID 9211925 DOI: 10.1074/jbc.272.28.17734  0.726
1997 Drazner MH, Koch WJ, Lefkowitz RJ. Potentiation of beta-adrenergic signaling by gene transfer. Proceedings of the Association of American Physicians. 109: 220-7. PMID 9154638  0.401
1997 Bittner HB, Chen EP, Milano CA, Lefkowitz RJ, Van Trigt P. Functional analysis of myocardial performance in murine hearts overexpressing the human beta 2-adrenergic receptor. Journal of Molecular and Cellular Cardiology. 29: 961-7. PMID 9152857 DOI: 10.1006/jmcc.1996.0339  0.361
1997 Ménard L, Ferguson SS, Zhang J, Lin FT, Lefkowitz RJ, Caron MG, Barak LS. Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. Molecular Pharmacology. 51: 800-8. PMID 9145918  0.692
1997 Stoffel RH, Pitcher JA, Lefkowitz RJ. Targeting G protein-coupled receptor kinases to their receptor substrates. The Journal of Membrane Biology. 157: 1-8. PMID 9141353 DOI: 10.1007/S002329900210  0.772
1997 Rockman HA, Koch WJ, Lefkowitz RJ. Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. The American Journal of Physiology. 272: H1553-9. PMID 9139936 DOI: 10.1152/Ajpheart.1997.272.4.H1553  0.707
1997 Daaka Y, Pitcher JA, Richardson M, Stoffel RH, Robishaw JD, Lefkowitz RJ. Receptor and G betagamma isoform-specific interactions with G protein-coupled receptor kinases. Proceedings of the National Academy of Sciences of the United States of America. 94: 2180-5. PMID 9122168 DOI: 10.1073/Pnas.94.6.2180  0.864
1997 Korzick DH, Xiao RP, Ziman BD, Koch WJ, Lefkowitz RJ, Lakatta EG. Transgenic manipulation of beta-adrenergic receptor kinase modifies cardiac myocyte contraction to norepinephrine. The American Journal of Physiology. 272: H590-6. PMID 9038983 DOI: 10.1152/Ajpheart.1997.272.1.H590  0.681
1997 Luttrell LM, Della Rocca GJ, van Biesen T, Luttrell DK, Lefkowitz RJ. Gbetagamma subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor. A scaffold for G protein-coupled receptor-mediated Ras activation. The Journal of Biological Chemistry. 272: 4637-44. PMID 9020193 DOI: 10.1074/jbc.272.7.4637  0.748
1997 Boekhoff I, Touhara K, Danner S, Inglese J, Lohse MJ, Breer H, Lefkowitz RJ. Phosducin, potential role in modulation of olfactory signaling. The Journal of Biological Chemistry. 272: 4606-12. PMID 9020189 DOI: 10.1074/Jbc.272.7.4606  0.741
1997 Drazner MH, Peppel KC, Dyer S, Grant AO, Koch WJ, Lefkowitz RJ. Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes. The Journal of Clinical Investigation. 99: 288-96. PMID 9005997 DOI: 10.1172/JCI119157  0.826
1997 Krueger KM, Daaka Y, Pitcher JA, Lefkowitz RJ. The role of sequestration in G protein-coupled receptor resensitization. Regulation of beta2-adrenergic receptor dephosphorylation by vesicular acidification. The Journal of Biological Chemistry. 272: 5-8. PMID 8995214 DOI: 10.1074/Jbc.272.1.5  0.869
1997 Samama P, Bond RA, Rockman HA, Milano CA, Lefkowitz RJ. Ligand-induced overexpression of a constitutively active beta2-adrenergic receptor: pharmacological creation of a phenotype in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 94: 137-41. PMID 8990174 DOI: 10.1073/Pnas.94.1.137  0.877
1997 Ledent C, Denef JF, Cottecchia S, Lefkowitz R, Dumont J, Vassart G, Parmentier M. Costimulation of adenylyl cyclase and phospholipase C by a mutant alpha 1B-adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells. Endocrinology. 138: 369-78. PMID 8977426 DOI: 10.1210/endo.138.1.4861  0.421
1997 Ménard L, Ferguson SSG, Zhang J, Lin F, Lefkowitz RJ, Caron MG, Barak LS. Synergistic Regulation of β2-Adrenergic Receptor Sequestration: Intracellular Complement of β-Adrenergic Receptor Kinase and β-Arrestin Determine Kinetics of Internalization Molecular Pharmacology. 51: 800-808. DOI: 10.1124/MOL.51.5.800  0.612
1997 Koch WJ, Lefkowitz RJ, Milano CA, Akhter SA, Rockmad HA. Myocarondial Overexpression of Adrenergic Receptors and Receptor Kinases Advances in Pharmacology. 42: 502-506. DOI: 10.1016/S1054-3589(08)60799-1  0.806
1997 Lefkowitz RJ, Pitcher J, Krueger K, Daaka Y. Mechanisms of β-Adrenergic Receptor Desensitization and Resensitization Advances in Pharmacology. 42: 416-420. DOI: 10.1016/S1054-3589(08)60777-2  0.841
1996 Lefkowitz RJ. G protein-coupled receptors and receptor kinases: from molecular biology to potential therapeutic applications. Nature Biotechnology. 14: 283-6. PMID 9630887 DOI: 10.1038/nbt0396-283  0.541
1996 Sizmann D, Kuusinen H, Keränen S, Lomasney J, Caron MG, Lefkowitz RJ, Keinänen K. Production of adrenergic receptors in yeast. Receptors & Channels. 4: 197-203. PMID 9014242  0.444
1996 Macrae AD, Premont RT, Jaber M, Peterson AS, Lefkowitz RJ. Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. Brain Research. Molecular Brain Research. 42: 245-54. PMID 9013780 DOI: 10.1016/S0169-328X(96)00128-3  0.646
1996 van Biesen T, Luttrell LM, Hawes BE, Lefkowitz RJ. Mitogenic signaling via G protein-coupled receptors. Endocrine Reviews. 17: 698-714. PMID 8969974 DOI: 10.1210/Edrv-17-6-698  0.861
1996 Jaber M, Koch WJ, Rockman H, Smith B, Bond RA, Sulik KK, Ross J, Lefkowitz RJ, Caron MG, Giros B. Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proceedings of the National Academy of Sciences of the United States of America. 93: 12974-9. PMID 8917529 DOI: 10.1073/Pnas.93.23.12974  0.854
1996 Garnovskaya MN, van Biesen T, Hawe B, Casañas Ramos S, Lefkowitz RJ, Raymond JR. Ras-dependent activation of fibroblast mitogen-activated protein kinase by 5-HT1A receptor via a G protein beta gamma-subunit-initiated pathway. Biochemistry. 35: 13716-22. PMID 8901512 DOI: 10.1021/bi961764n  0.458
1996 Rockman HA, Koch WJ, Milano CA, Lefkowitz RJ. Myocardial beta-adrenergic receptor signaling in vivo: insights from transgenic mice. Journal of Molecular Medicine (Berlin, Germany). 74: 489-95. PMID 8892053 DOI: 10.1007/Bf00204974  0.766
1996 Pitcher JA, Fredericks ZL, Stone WC, Premont RT, Stoffel RH, Koch WJ, Lefkowitz RJ. Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. The Journal of Biological Chemistry. 271: 24907-13. PMID 8798768 DOI: 10.1074/Jbc.271.40.24907  0.872
1996 Rockman HA, Choi DJ, Rahman NU, Akhter SA, Lefkowitz RJ, Koch WJ. Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 93: 9954-9. PMID 8790438 DOI: 10.1073/Pnas.93.18.9954  0.833
1996 Diverse-Pierluissi M, Inglese J, Stoffel RH, Lefkowitz RJ, Dunlap K. G protein-coupled receptor kinase mediates desensitization of norepinephrine-induced Ca2+ channel inhibition. Neuron. 16: 579-85. PMID 8785055 DOI: 10.1016/S0896-6273(00)80077-X  0.532
1996 Bond RA, Lefkowitz RJ. The third beta is not the charm. The Journal of Clinical Investigation. 98: 241. PMID 8755628 DOI: 10.1172/JCI118783  0.405
1996 Oppermann M, Diversé-Pierluissi M, Drazner MH, Dyer SL, Freedman NJ, Peppel KC, Lefkowitz RJ. Monoclonal antibodies reveal receptor specificity among G-protein-coupled receptor kinases. Proceedings of the National Academy of Sciences of the United States of America. 93: 7649-54. PMID 8755530 DOI: 10.1073/Pnas.93.15.7649  0.877
1996 Luttrell LM, Hawes BE, van Biesen T, Luttrell DK, Lansing TJ, Lefkowitz RJ. Role of c-Src tyrosine kinase in G protein-coupled receptor- and Gbetagamma subunit-mediated activation of mitogen-activated protein kinases. The Journal of Biological Chemistry. 271: 19443-50. PMID 8702633 DOI: 10.1074/jbc.271.32.19443  0.671
1996 Freedman NJ, Lefkowitz RJ. Desensitization of G protein-coupled receptors. Recent Progress in Hormone Research. 51: 319-51; discussion 3. PMID 8701085  0.539
1996 Ménard L, Ferguson SS, Barak LS, Bertrand L, Premont RT, Colapietro AM, Lefkowitz RJ, Caron MG. Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration. Biochemistry. 35: 4155-60. PMID 8672451 DOI: 10.1021/Bi952961+  0.822
1996 Fredericks ZL, Pitcher JA, Lefkowitz RJ. Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor. The Journal of Biological Chemistry. 271: 13796-803. PMID 8662852 DOI: 10.1074/Jbc.271.23.13796  0.781
1996 Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ. Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C. The Journal of Biological Chemistry. 271: 13266-72. PMID 8662816  0.775
1996 Hawes BE, Luttrell LM, van Biesen T, Lefkowitz RJ. Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway. The Journal of Biological Chemistry. 271: 12133-6. PMID 8647803 DOI: 10.1074/jbc.271.21.12133  0.69
1996 Koch WJ, Milano CA, Lefkowitz RJ. Transgenic manipulation of myocardial G protein-coupled receptors and receptor kinases. Circulation Research. 78: 511-6. PMID 8635207 DOI: 10.1161/01.Res.78.4.511  0.693
1996 Tiberi M, Nash SR, Bertrand L, Lefkowitz RJ, Caron MG. Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. The Journal of Biological Chemistry. 271: 3771-8. PMID 8631993 DOI: 10.1074/JBC.271.7.3771  0.662
1996 Premont RT, Macrae AD, Stoffel RH, Chung N, Pitcher JA, Ambrose C, Inglese J, MacDonald ME, Lefkowitz RJ. Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants. The Journal of Biological Chemistry. 271: 6403-10. PMID 8626439 DOI: 10.1074/Jbc.271.11.6403  0.814
1996 Rockman HA, Hamilton RA, Jones LR, Milano CA, Mao L, Lefkowitz RJ. Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein. The Journal of Clinical Investigation. 97: 1618-23. PMID 8601626 DOI: 10.1172/Jci118587  0.436
1996 van Biesen T, Hawes BE, Raymond JR, Luttrell LM, Koch WJ, Lefkowitz RJ. G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. The Journal of Biological Chemistry. 271: 1266-9. PMID 8576109 DOI: 10.1074/jbc.271.3.1266  0.807
1996 Silvestry SC, Peppel K, Lilly R, Heintz G, Koch WJ, Milano C, Glower DD, Lefkowitz RJ. Adenoviral mediated overexpression of human β2 adrenergic receptor after direct delivery into canine myocardium Journal of the American College of Cardiology. 27: 289. DOI: 10.1016/S0735-1097(96)82047-X  0.786
1995 Kwatra MM, Schreurs J, Schwinn DA, Innis MA, Caron MG, Lefkowitz RJ. Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity. Protein Expression and Purification. 6: 717-21. PMID 8746622 DOI: 10.1006/Prep.1995.0001  0.79
1995 Walensky LD, Roskams AJ, Lefkowitz RJ, Snyder SH, Ronnett GV. Odorant receptors and desensitization proteins colocalize in mammalian sperm. Molecular Medicine (Cambridge, Mass.). 1: 130-41. PMID 8529092 DOI: 10.1007/Bf03401561  0.56
1995 Bond RA, Leff P, Johnson TD, Milano CA, Rockman HA, McMinn TR, Apparsundaram S, Hyek MF, Kenakin TP, Allen LF, Lefkowitz RJ. Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor Nature. 374: 272-276. PMID 7885448 DOI: 10.1038/374272A0  0.608
1995 Milano CA, Allen LF, Dolber PC, Johnson TD, Rockman HA, Bond RA, Lefkowitz RJ. Marked enhancement in myocardial function resulting from overexpression of a human β-adrenergic receptor gene The Journal of Thoracic and Cardiovascular Surgery. 109: 236-241. PMID 7853876 DOI: 10.1016/S0022-5223(95)70384-5  0.583
1995 Koch WJ, Hawes BE, Allen LF, Lefkowitz RJ. Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. Proceedings of the National Academy of Sciences of the United States of America. 91: 12706-10. PMID 7809106 DOI: 10.1073/PNAS.91.26.12706  0.748
1995 Lefkowitz RJ. G proteins in medicine. The New England Journal of Medicine. 332: 186-7. PMID 7800014 DOI: 10.1056/NEJM199501193320312  0.357
1995 Premont RT, Inglese J, Lefkowitz RJ. Protein kinases that phosphorylate activated G protein-coupled receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 9: 175-82. PMID 7781920 DOI: 10.1096/Fasebj.9.2.7781920  0.76
1995 Inglese J, Koch WJ, Touhara K, Lefkowitz RJ. G beta gamma interactions with PH domains and Ras-MAPK signaling pathways. Trends in Biochemical Sciences. 20: 151-6. PMID 7770915 DOI: 10.1016/S0968-0004(00)88992-6  0.802
1995 Luttrell LM, Hawes BE, Touhara K, van Biesen T, Koch WJ, Lefkowitz RJ. Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling. The Journal of Biological Chemistry. 270: 12984-9. PMID 7768889 DOI: 10.1074/JBC.270.22.12984  0.824
1995 Koch WJ, Rockman HA, Samama P, Hamilton RA, Bond RA, Milano CA, Lefkowitz RJ. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science (New York, N.Y.). 268: 1350-3. PMID 7761854 DOI: 10.1126/Science.7761854  0.845
1995 Pitcher JA, Touhara K, Payne ES, Lefkowitz RJ. Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. The Journal of Biological Chemistry. 270: 11707-10. PMID 7744811 DOI: 10.1074/JBC.270.20.11707  0.817
1995 Nair LA, Inglese J, Stoffel R, Koch WJ, Lefkowitz RJ, Kwatra MM, Grant AO. Cardiac muscarinic potassium channel activity is attenuated by inhibitors of G beta gamma. Circulation Research. 76: 832-8. PMID 7729000 DOI: 10.1161/01.Res.76.5.832  0.838
1995 Pitcher JA, Payne ES, Csortos C, DePaoli-Roach AA, Lefkowitz RJ. The G-protein-coupled receptor phosphatase: a protein phosphatase type 2A with a distinct subcellular distribution and substrate specificity. Proceedings of the National Academy of Sciences of the United States of America. 92: 8343-7. PMID 7667292 DOI: 10.1073/Pnas.92.18.8343  0.771
1995 van Biesen T, Hawes BE, Luttrell DK, Krueger KM, Touhara K, Porfiri E, Sakaue M, Luttrell LM, Lefkowitz RJ. Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. Nature. 376: 781-4. PMID 7651538 DOI: 10.1038/376781a0  0.795
1995 Pei G, Kieffer BL, Lefkowitz RJ, Freedman NJ. Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C. Molecular Pharmacology. 48: 173-7. PMID 7651349  0.53
1995 Chen CK, Inglese J, Lefkowitz RJ, Hurley JB. Ca(2+)-dependent interaction of recoverin with rhodopsin kinase. The Journal of Biological Chemistry. 270: 18060-6. PMID 7629115 DOI: 10.1074/JBC.270.30.18060  0.435
1995 Freedman NJ, Liggett SB, Drachman DE, Pei G, Caron MG, Lefkowitz RJ. Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase. The Journal of Biological Chemistry. 270: 17953-61. PMID 7629102 DOI: 10.1074/Jbc.270.30.17953  0.856
1995 Touhara K, Koch WJ, Hawes BE, Lefkowitz RJ. Mutational analysis of the pleckstrin homology domain of the beta-adrenergic receptor kinase. Differential effects on G beta gamma and phosphatidylinositol 4,5-bisphosphate binding. The Journal of Biological Chemistry. 270: 17000-5. PMID 7622521 DOI: 10.1074/JBC.270.28.17000  0.772
1995 Luttrell LM, van Biesen T, Hawes BE, Koch WJ, Touhara K, Lefkowitz RJ. G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. The Journal of Biological Chemistry. 270: 16495-8. PMID 7622449 DOI: 10.1074/JBC.270.28.16495  0.859
1995 Hawes BE, van Biesen T, Koch WJ, Luttrell LM, Lefkowitz RJ. Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation. The Journal of Biological Chemistry. 270: 17148-53. PMID 7615510 DOI: 10.1074/JBC.270.29.17148  0.82
1995 Kingsmore SF, Peppel K, Suh D, Caron MG, Lefkowitz RJ, Seldin MF. Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 6: 306-7. PMID 7613043 DOI: 10.1007/BF00352426  0.727
1995 Touhara K, Hawes BE, van Biesen T, Lefkowitz RJ. G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein. Proceedings of the National Academy of Sciences of the United States of America. 92: 9284-7. PMID 7568118 DOI: 10.1073/pnas.92.20.9284  0.732
1995 Rockman HA, Hamilton R, Milano CA, Mao L, Lefkowitz RJ, Koch WJ. 718-3 Cardiac Overexpression of βARK in Transgenic Mice Inhibits Isoproterenol Stimulated Contractility In Vivo Journal of the American College of Cardiology. 25: 91A. DOI: 10.1016/0735-1097(95)91830-Q  0.604
1994 Inglese J, Luttrell LM, Iñiguez-Lluhi JA, Touhara K, Koch WJ, Lefkowitz RJ. Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. Proceedings of the National Academy of Sciences of the United States of America. 91: 3637-41. PMID 8170960 DOI: 10.1073/PNAS.91.9.3637  0.853
1994 Pei G, Tiberi M, Caron MG, Lefkowitz RJ. An approach to the study of G-protein-coupled receptor kinases: An in vitro-purified membrane assay reveals differential receptor specificity and regulation by Gβγ subunits Proceedings of the National Academy of Sciences of the United States of America. 91: 3633-3636. PMID 8170959 DOI: 10.1073/Pnas.91.9.3633  0.764
1994 Scheinin M, Lomasney JW, Hayden-Hixson DM, Schambra UB, Caron MG, Lefkowitz RJ, Fremeau RT. Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain. Brain Research. Molecular Brain Research. 21: 133-49. PMID 8164514 DOI: 10.1016/0169-328X(94)90386-7  0.745
1994 Milano CA, Allen LF, Rockman HA, Dolber PC, McMinn TR, Chien KR, Johnson TD, Bond RA, Lefkowitz RJ. Enhanced myocardial function in transgenic mice overexpressing the β2-adrenergic receptor Science. 264: 582-586. PMID 8160017 DOI: 10.1126/Science.8160017  0.745
1994 Reuveny E, Slesinger PA, Inglese J, Morales JM, Iñiguez-Lluhi JA, Lefkowitz RJ, Bourne HR, Jan YN, Jan LY. Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature. 370: 143-6. PMID 8022483 DOI: 10.1038/370143A0  0.465
1994 Milano CA, Dolber PC, Rockman HA, Bond RA, Venable ME, Allen LF, Lefkowitz RJ. Myocardial expression of a constitutively active α1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy Proceedings of the National Academy of Sciences of the United States of America. 91: 10109-10113. PMID 7937846 DOI: 10.1073/Pnas.91.21.10109  0.528
1994 Pei G, Samama P, Lohse M, Wang M, Codina J, Lefkowitz RJ. A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated. Proceedings of the National Academy of Sciences of the United States of America. 91: 2699-702. PMID 7908440 DOI: 10.1073/Pnas.91.7.2699  0.883
1994 Kwatra MM, Lefkowitz RJ, Caron MG. Partially Purified and Reconstituted G-Protein Coupled Receptors as Substrates of Specific Receptor Kinases Methods. 6: 11-17. DOI: 10.1006/METH.1994.1003  0.702
1993 Lefkowitz RJ. G-protein-coupled receptors. Turned on to ill effect. Nature. 365: 603-4. PMID 8413622 DOI: 10.1038/365603A0  0.502
1993 Lefkowitz RJ. G protein—coupled receptor kinases Cell. 74: 409-412. PMID 8394218 DOI: 10.1016/0092-8674(93)80042-D  0.578
1993 Liggett SB, Freedman NJ, Schwinn DA, Lefkowitz RJ. Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 90: 3665-9. PMID 8386380 DOI: 10.1073/Pnas.90.8.3665  0.848
1993 Luttrell LM, Ostrowski J, Cotecchia S, Kendall H, Lefkowitz RJ. Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. Science (New York, N.Y.). 259: 1453-7. PMID 8383880 DOI: 10.1126/SCIENCE.8383880  0.826
1993 Collins S, Ostrowski J, Lefkowitz RJ. Cloning and sequence analysis of the human beta 1-adrenergic receptor 5'-flanking promoter region. Biochimica Et Biophysica Acta. 1172: 171-4. PMID 8382527 DOI: 10.1016/0167-4781(93)90287-N  0.719
1993 Schleicher S, Boekhoff I, Arriza J, Lefkowitz RJ, Breer H. A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. Proceedings of the National Academy of Sciences of the United States of America. 90: 1420-4. PMID 8381966 DOI: 10.1073/PNAS.90.4.1420  0.519
1993 Dawson TM, Arriza JL, Jaworsky DE, Borisy FF, Attramadal H, Lefkowitz RJ, Ronnett GV. β-adrenergic receptor kinase-2 and β-arrestin-2 as mediators of odorant-induced desensitization Science. 259: 825-829. PMID 8381559 DOI: 10.1126/Science.8381559  0.714
1993 Pippig S, Andexinger S, Daniel K, Puzicha M, Caron MG, Lefkowitz RJ, Lohse MJ. Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors. The Journal of Biological Chemistry. 268: 3201-8. PMID 8381421  0.667
1993 Lefkowitz RJ, Cotecchia S, Samama P, Costa T. Constitutive activity of receptors coupled to guanine nucleotide regulatory proteins. Trends in Pharmacological Sciences. 14: 303-7. PMID 8249148 DOI: 10.1016/0165-6147(93)90048-O  0.869
1993 Lefkowitz RJ, Premont RT. Diseased G protein-coupled receptors. The Journal of Clinical Investigation. 92: 2089. PMID 8227321 DOI: 10.1172/Jci116806  0.678
1993 Price DT, Schwinn DA, Lomasney JW, Allen LF, Caron MG, Lefkowitz RJ. Identification, quantification, and localization of mRNA for three distinct alpha 1 adrenergic receptor subtypes in human prostate. The Journal of Urology. 150: 546-51. PMID 7686987 DOI: 10.1016/S0022-5347(17)35544-1  0.752
1993 Lefkowitz RJ, Inglese J, Koch WJ, Pitcher J, Attramadal H, Caron MG. G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. Cold Spring Harbor Symposia On Quantitative Biology. 57: 127-33. PMID 1339651 DOI: 10.1101/Sqb.1992.057.01.016  0.868
1992 Roth NS, Lefkowitz RJ, Caron MG. Structure and function of the adrenergic receptor family. Advances in Experimental Medicine and Biology. 308: 223-38. PMID 1801586 DOI: 10.1007/978-1-4684-6015-5_20  0.685
1992 Allen LF, Lefkowitz RJ, Caron MG, Cotecchia S. G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. Proceedings of the National Academy of Sciences of the United States of America. 88: 11354-8. PMID 1662393 DOI: 10.1073/PNAS.88.24.11354  0.748
1992 Inglese J, Koch WJ, Caron MG, Lefkowitz RJ. Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases. Nature. 359: 147-50. PMID 1522899 DOI: 10.1038/359147A0  0.794
1992 Arriza JL, Dawson TM, Simerly RB, Martin LJ, Caron MG, Snyder SH, Lefkowitz RJ. The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 4045-55. PMID 1403099 DOI: 10.1523/Jneurosci.12-10-04045.1992  0.56
1992 Luttrell DK, Hausdorff WP, Moyers JE, Gilmer TM, Parsons SJ, Caron MG, Lefkowitz RJ. Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase Cellular Signalling. 4: 531-541. PMID 1384635 DOI: 10.1016/0898-6568(92)90022-Z  0.603
1992 Hausdorff WP, Pitcher JA, Luttrell DK, Linder ME, Kurose H, Parsons SJ, Caron MG, Lefkowitz RJ. Tyrosine phosphorylation of G protein α subunits by pp60c-src Proceedings of the National Academy of Sciences of the United States of America. 89: 5720-5724. PMID 1378615 DOI: 10.1073/Pnas.89.13.5720  0.83
1992 Lohse MJ, Andexinger S, Pitcher J, Trukawinski S, Codina J, Faure JP, Caron MG, Lefkowitz RJ. Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems. The Journal of Biological Chemistry. 267: 8558-64. PMID 1349018  0.848
1992 Pitcher J, Lohse MJ, Codina J, Caron MG, Lefkowitz RJ. Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms. Biochemistry. 31: 3193-7. PMID 1348186 DOI: 10.1021/Bi00127A021  0.861
1992 Pitcher JA, Inglese J, Higgins JB, Arriza JL, Casey PJ, Kim C, Benovic JL, Kwatra MM, Caron MG, Lefkowitz RJ. Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors. Science (New York, N.Y.). 257: 1264-7. PMID 1325672 DOI: 10.1126/Science.1325672  0.854
1992 Lefkowitz RJ. G proteins. The subunit story thickens. Nature. 358: 372. PMID 1322498 DOI: 10.1038/358372A0  0.365
1992 Ostrowski J, Kjelsberg MA, Caron MG, Lefkowitz RJ. Mutagenesis of the beta 2-adrenergic receptor: how structure elucidates function. Annual Review of Pharmacology and Toxicology. 32: 167-83. PMID 1318669 DOI: 10.1146/ANNUREV.PA.32.040192.001123  0.693
1992 Collins S, Caron MG, Lefkowitz RJ. From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors. Trends in Biochemical Sciences. 17: 37-9. PMID 1316650 DOI: 10.1016/0968-0004(92)90425-9  0.791
1991 Collins S, Caron MG, Lefkowitz RJ. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Annual Review of Physiology. 53: 497-508. PMID 2042970 DOI: 10.1146/Annurev.Ph.53.030191.002433  0.786
1991 Benovic JL, Stone WC, Huebner K, Croce C, Caron MG, Lefkowitz RJ. cDNA cloning and chromosomal localization of the human α-adrenergic receptor kinase Febs Letters. 283: 122-126. PMID 2037065 DOI: 10.1016/0014-5793(91)80568-N  0.671
1991 Lefkowitz RJ. Thrombin receptor. Variations on a theme. Nature. 351: 353-4. PMID 1851963 DOI: 10.1038/351353A0  0.495
1991 Hausdorff WP, Campbell PT, Ostrowski J, Yu SS, Caron MG, Lefkowitz RJ. A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation. Proceedings of the National Academy of Sciences of the United States of America. 88: 2979-83. PMID 1849641 DOI: 10.1073/PNAS.88.8.2979  0.84
1991 Kurose H, Regan JW, Caron MG, Lefkowitz RJ. Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles. Biochemistry. 30: 3335-41. PMID 1849000 DOI: 10.1021/Bi00227A024  0.787
1991 Fargin A, Yamamoto K, Cotecchia S, Goldsmith PK, Spiegel AM, Lapetina EG, Caron MG, Lefkowitz RJ. Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein. Cellular Signalling. 3: 547-57. PMID 1786205 DOI: 10.1016/0898-6568(91)90031-O  0.784
1991 Oakey RJ, Caron MG, Lefkowitz RJ, Seldin MF. Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. Genomics. 10: 338-44. PMID 1676978 DOI: 10.1016/0888-7543(91)90317-8  0.507
1991 Collins S, Lohse MJ, O'Dowd B, Caron MG, Lefkowitz RJ. Structure and regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a model. Vitamins and Hormones. 46: 1-39. PMID 1660639 DOI: 10.1016/S0083-6729(08)60681-0  0.87
1991 Lomasney JW, Cotecchia S, Lefkowitz RJ, Caron MG. Molecular biology of alpha-adrenergic receptors: implications for receptor classification and for structure-function relationships. Biochimica Et Biophysica Acta. 1095: 127-39. PMID 1657194 DOI: 10.1016/0167-4889(91)90075-9  0.828
1991 Lorenz W, Inglese J, Palczewski K, Onorato JJ, Caron MG, Lefkowitz RJ. The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. Proceedings of the National Academy of Sciences of the United States of America. 88: 8715-9. PMID 1656454 DOI: 10.1073/Pnas.88.19.8715  0.7
1991 Dohlman HG, Thorner J, Caron MG, Lefkowitz RJ. Model systems for the study of seven-transmembrane-segment receptors. Annual Review of Biochemistry. 60: 653-88. PMID 1652922 DOI: 10.1146/annurev.bi.60.070191.003253  0.781
1991 Yang SD, Benovic JL, Fong YL, Caron MG, Lefkowitz RJ. Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase) Biochemical and Biophysical Research Communications. 178: 1306-1311. PMID 1651717 DOI: 10.1016/0006-291X(91)91036-C  0.651
1991 Roth NS, Campbell PT, Caron MG, Lefkowitz RJ, Lohse MJ. Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 88: 6201-4. PMID 1648731 DOI: 10.1073/Pnas.88.14.6201  0.776
1991 Onorato JJ, Palczewski K, Regan JW, Caron MG, Lefkowitz RJ, Benovic JL. Role of acidic amino acids in peptide substrates of the β-adrenergic receptor kinase and rhodopsin kinase Biochemistry®. 30: 5118-5125. PMID 1645191 DOI: 10.1021/Bi00235A002  0.749
1991 Schwinn D, Page S, Cotecchia S, Caron M, Lefkowitz R. THE α1-ADRENERGIC RECEPTOR SUBTYPE COUPLES TO PHOSPHOLIPASE C Anesthesiology. 75: A629-A629. DOI: 10.1097/00000542-199109001-00628  0.78
1990 Lefkowitz RJ, Hausdorff WP, Caron MG. Role of phosphorylation in desensitization of the beta-adrenoceptor. Trends in Pharmacological Sciences. 11: 190-4. PMID 2188401 DOI: 10.1016/0165-6147(90)90113-M  0.692
1990 Collins S, Bouvier M, Lohse MJ, Benovic JL, Caron MG, Lefkowitz RJ. Mechanisms involved in adrenergic receptor desensitization. Biochemical Society Transactions. 18: 541-4. PMID 2177406 DOI: 10.1042/Bst0180541  0.884
1990 Benovic JL, Onorato J, Lohse MJ, Dohlman HG, Staniszewski C, Caron MG, Lefkowitz RJ. Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase. British Journal of Clinical Pharmacology. 30: 3S-12S. PMID 2176526 DOI: 10.1111/J.1365-2125.1990.Tb05462.X  0.836
1990 King K, Dohlman HG, Thorner J, Caron MG, Lefkowitz RJ. Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit. Science (New York, N.Y.). 250: 121-3. PMID 2171146 DOI: 10.1126/Science.2171146  0.872
1990 Lomasney JW, Lorenz W, Allen LF, Klng K, Regan JW, Yang-Fengh TL, Caron MG, Lefkowitz RJ. Expansion of the α2-adrenergic receptor family: Cloning and characterization of a human α2-adrenergic receptor subtype, the gene for which is located on chromosome 2 Proceedings of the National Academy of Sciences of the United States of America. 87: 5094-5098. PMID 2164221 DOI: 10.1073/Pnas.87.13.5094  0.816
1990 Valiquette M, Bonin H, Hnatowich M, Caron MG, Lefkowitz RJ, Bouvier M. Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor. Proceedings of the National Academy of Sciences of the United States of America. 87: 5089-93. PMID 2164220 DOI: 10.1073/Pnas.87.13.5089  0.878
1990 Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ. beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science (New York, N.Y.). 248: 1547-50. PMID 2163110 DOI: 10.1126/Science.2163110  0.811
1990 Dohlman HG, Caron MG, DeBlasi A, Frielle T, Lefkowitz RJ. Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor. Biochemistry. 29: 2335-42. PMID 2159799 DOI: 10.1021/Bi00461A018  0.842
1990 Cotecchia S, Exum S, Caron MG, Lefkowitz RJ. Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function. Proceedings of the National Academy of Sciences of the United States of America. 87: 2896-900. PMID 2158097 DOI: 10.1073/PNAS.87.8.2896  0.779
1990 Yang-Feng TL, Xue F, Zhong W, Cotecchia S, Frielle T, Caron MG, Lefkowitz RJ, Francke U. Chromosomal organization of adrenergic receptor genes Proceedings of the National Academy of Sciences of the United States of America. 87: 1516-1520. PMID 2154750 DOI: 10.1073/Pnas.87.4.1516  0.824
1990 Lohse MJ, Benovic JL, Caron MG, Lefkowitz RJ. Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors. The Journal of Biological Chemistry. 265: 3202-11. PMID 2154473  0.76
1990 Cotecchia S, Kobilka BK, Daniel KW, Nolan RD, Lapetina EY, Caron MG, Lefkowitz RJ, Regan JW. Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells. The Journal of Biological Chemistry. 265: 63-9. PMID 2152928  0.7
1990 Raymond JR, Hnatowich M, Lefkowitz RJ, Caron MG. Adrenergic receptors. Models for regulation of signal transduction processes. Hypertension (Dallas, Tex. : 1979). 15: 119-31. PMID 2105909 DOI: 10.1161/01.HYP.15.2.119  0.699
1990 Hausdorff WP, Lohse MJ, Bouvier M, Liggett SB, Caron MG, Lefkowitz RJ. Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor. Symposia of the Society For Experimental Biology. 44: 225-40. PMID 1983369  0.74
1990 Seuwen K, Magnaldo I, Kobilka BK, Caron MG, Regan JW, Lefkowitz RJ, Pouysségur J. Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. Cell Regulation. 1: 445-51. PMID 1981685 DOI: 10.1091/Mbc.1.6.445  0.767
1990 Schwinn DA, Cotecchia S, Lomasney J, Caron M, Lefkowitz RJ. MOLECULAR CLONING AND EXPRESSION OF A NEW ALPHA-1-ADRENERGIC RECEPTOR SUBTYPE Anesthesia & Analgesia. 70: S359. DOI: 10.1213/00000539-199002001-00359  0.823
1990 Hausdorff WP, Caron MG, Lefkowitz RJ. Turning off the signal: desensitization of β‐adrenergic receptor function The Faseb Journal. 4: 2881-2889. DOI: 10.1096/fasebj.4.11.2165947  0.707
1990 COTECCHIA S, CARON M, LEFKOWITZ R. The molecular basis of adrenergic receptor function Cell Biology International Reports. 14: 34. DOI: 10.1016/0309-1651(90)90244-S  0.758
1990 Lefkowitz R. The adrenergic receptors: structure/function and regulation European Journal of Pharmacology. 183: 53. DOI: 10.1016/0014-2999(90)91303-S  0.494
1989 Frielle T, Daniel KW, Caron MG, Lefkowitz RJ. Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors. Proceedings of the National Academy of Sciences of the United States of America. 85: 9494-8. PMID 2849109 DOI: 10.1073/PNAS.85.24.9494  0.862
1989 Kwatra MM, Benovic JL, Caron MG, Lefkowitz RJ, Hosey MM. Phosphorylation of chick heart muscarinic cholinergic receptors by the β-adrenergic receptor kinase Biochemistry. 28: 4543-4547. PMID 2765501 DOI: 10.1021/Bi00437A005  0.751
1989 O'Dowd BF, Lefkowitz RJ, Caron MG. Structure of the adrenergic and related receptors. Annual Review of Neuroscience. 12: 67-83. PMID 2648960 DOI: 10.1146/ANNUREV.NE.12.030189.000435  0.677
1989 Liggett SB, Bouvier M, O'Dowd BF, Caron MG, Lefkowitz RJ, DeBlasi A. Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization. Biochemical and Biophysical Research Communications. 165: 257-63. PMID 2556136 DOI: 10.1016/0006-291X(89)91063-2  0.873
1989 Liggett SB, Bouvier M, Hausdorff WP, O'Dowd B, Caron MG, Lefkowitz RJ. Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites. Molecular Pharmacology. 36: 641-6. PMID 2554115  0.664
1989 Benovic JL, DeBlasi A, Stone WC, Caron MG, Lefkowitz RJ. Β-adrenergic receptor kinase: Primary structure delineates a multigene family Science. 246: 235-240. PMID 2552582 DOI: 10.1126/Science.2552582  0.72
1989 Lefkowitz RJ, Kobilka BK, Caron MG. The new biology of drug receptors. Biochemical Pharmacology. 38: 2941-8. PMID 2551299 DOI: 10.1016/0006-2952(89)90001-4  0.661
1989 Matsui H, Lefkowitz RJ, Caron MG, Regan JW. Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet α2-adrenergic receptor Biochemistry. 28: 4125-4130. PMID 2546589 DOI: 10.1021/Bi00435A075  0.805
1989 Palacios JM, O'Dowd BF, Cotecchia S, Hnatowich M, Caron MG, Lefkowitz RJ. Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization. Life Sciences. 44: 2057-65. PMID 2545987 DOI: 10.1016/0024-3205(89)90352-4  0.843
1989 Hausdorff WP, Bouvier M, O'Dowd BF, Irons GP, Caron MG, Lefkowitz RJ. Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization. The Journal of Biological Chemistry. 264: 12657-65. PMID 2545714  0.653
1989 Lohse MJ, Lefkowitz RJ, Caron MG, Benovic JL. Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors. Proceedings of the National Academy of Sciences of the United States of America. 86: 3011-5. PMID 2541428 DOI: 10.1073/Pnas.86.9.3011  0.795
1989 Collins S, Bolanowski MA, Caron MG, Lefkowitz RJ. Genetic regulation of beta-adrenergic receptors. Annual Review of Physiology. 51: 203-15. PMID 2540696 DOI: 10.1146/Annurev.Ph.51.030189.001223  0.867
1989 O'Dowd BF, Hnatowich M, Caron MG, Lefkowitz RJ, Bouvier M. Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. The Journal of Biological Chemistry. 264: 7564-9. PMID 2540197  0.667
1989 Raymond JR, Fargin A, Lohse MJ, Regan JW, Senogles SE, Lefkowitz RJ, Caron MG. Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe. Molecular Pharmacology. 36: 15-21. PMID 2526292  0.71
1989 Bouvier M, Collins S, O'Dowd BF, Campbell PT, de Blasi A, Kobilka BK, MacGregor C, Irons GP, Caron MG, Lefkowitz RJ. Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level. The Journal of Biological Chemistry. 264: 16786-92. PMID 2476447  0.734
1989 Collins S, Bouvier M, Bolanowski MA, Caron MG, Lefkowitz RJ. cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure. Proceedings of the National Academy of Sciences of the United States of America. 86: 4853-7. PMID 2472635 DOI: 10.1073/Pnas.86.13.4853  0.843
1989 Frielle T, Kobilka B, Lefkowitz RJ, Caron MG. Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes. Trends in Neurosciences. 11: 321-4. PMID 2465637 DOI: 10.1016/0166-2236(88)90095-1  0.877
1989 Kobilka BK, Kobilka TS, Daniels KW, Regan JW, Caran MG, Lefkowitz RJ. Response:Analysis of ligand binding specificity of receptor chimeras Science. 243: 237-237. DOI: 10.1126/Science.243.4888.237  0.723
1989 Frielle T, Caron MG, Lefkowitz RJ. Properties of the beta 1- and beta 2-adrenergic receptor subtypes revealed by molecular cloning. Clinical Chemistry. 35: 721-725. DOI: 10.1093/CLINCHEM/35.5.721  0.864
1989 Matsui H, Lefkowitz RJ, Caron MG, Regan JW. Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet .alpha.2-adrenergic receptor [Erratum to document cited in CA110(21):187980z] Biochemistry. 28: 5702-5702. DOI: 10.1021/Bi00439A054  0.773
1989 Caron MG, Kobilka BK, Bouvier M, Hausdorff WP, Benovic JL, Lohse M, Cotecchia S, Regan JW, Fargin A, Raymond JR, Lefkowitz RJ. Catecholamine Receptors: Structure, Function, and Regulation Recent Progress in Hormone Research. 48: 195-200. DOI: 10.1007/978-3-642-75022-9_21  0.846
1988 Fargin A, Raymond JR, Lohse MJ, Kobilka BK, Caron MG, Lefkowitz RJ. The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. Nature. 335: 358-60. PMID 3138543 DOI: 10.1038/335358A0  0.813
1988 Lefkowitz RJ, Kobilka BK, Benovic JL, Bouvier M, Cotecchia S, Hausdorff WP, Dohlman HG, Regan JW, Caron MG. Molecular biology of adrenergic receptors. Cold Spring Harbor Symposia On Quantitative Biology. 53: 507-14. PMID 2855490 DOI: 10.1101/Sqb.1988.053.01.058  0.85
1988 Benovic JL, Bouvier M, Caron MG, Lefkowitz RJ. Regulation of adenylyl cyclase-coupled beta-adrenergic receptors. Annual Review of Cell Biology. 4: 405-28. PMID 2848553 DOI: 10.1146/Annurev.Cb.04.110188.002201  0.82
1988 Cotecchia S, Schwinn DA, Randall RR, Lefkowitz RJ, Caron MG, Kobilka BK. Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 85: 7159-63. PMID 2845398 DOI: 10.1073/Pnas.85.19.7159  0.832
1988 Strasser RH, Benovic JL, Lefkowitz RJ, Caron MG. The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells Advances in Experimental Medicine and Biology. 231: 503-517. PMID 2843012 DOI: 10.1007/978-1-4684-9042-8_43  0.799
1988 Regan JW, Kobilka TS, Yang-Feng TL, Caron MG, Lefkowitz RJ, Kobilka BK. Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype. Proceedings of the National Academy of Sciences of the United States of America. 85: 6301-5. PMID 2842764 DOI: 10.1073/Pnas.85.17.6301  0.771
1988 Caron MG, Kobilka BK, Frielle T, Bolanowski MA, Benovic JL, Lefkowitz RJ. Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors. Journal of Receptor Research. 8: 7-21. PMID 2838630 DOI: 10.3109/10799898809048975  0.869
1988 Collins S, Quarmby VE, French FS, Lefkowitz RJ, Caron MG. Regulation of the beta 2-adrenergic receptor and its mRNA in the rat ventral prostate by testosterone. Febs Letters. 233: 173-6. PMID 2838324 DOI: 10.1016/0014-5793(88)81378-4  0.732
1988 Yang SD, Fong YL, Benovic JL, Sibley DR, Caron MG, Lefkowitz RJ. Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2. The Journal of Biological Chemistry. 263: 8856-8. PMID 2837466  0.714
1988 Dohlman HG, Caron MG, Strader CD, Amlaiky N, Lefkowitz RJ. Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor. Biochemistry. 27: 1813-7. PMID 2837273 DOI: 10.1021/Bi00406A002  0.785
1988 Kobilka BK, Kobilka TS, Daniel K, Regan JW, Caron MG, Lefkowitz RJ. Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity. Science (New York, N.Y.). 240: 1310-6. PMID 2836950 DOI: 10.1126/Science.2836950  0.826
1988 Bouvier M, Hausdorff WP, De Blasi A, O'Dowd BF, Kobilka BK, Caron MG, Lefkowitz RJ. Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization. Nature. 333: 370-3. PMID 2836733 DOI: 10.1038/333370A0  0.823
1988 Sibley DR, Benovic JL, Caron MG, Lefkowitz RJ. Phosphorylation of cell surface receptors: a mechanism for regulating signal transduction pathways. Endocrine Reviews. 9: 38-56. PMID 2836188 DOI: 10.1210/Edrv-9-1-38  0.797
1988 Bouvier M, Hnatowich M, Collins S, Kobilka BK, Deblasi A, Lefkowitz RJ, Caron MG. Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors. Molecular Pharmacology. 33: 133-9. PMID 2828911  0.732
1988 Dohlman HG, Caron MG, Strader CD, Amlaiky N, Lefkowitz RJ. Identification and sequence of a binding site peptide of the .beta.2-adrenergic receptor [Erratum to document cited in CA108(15):126956h] Biochemistry. 27: 8508-8508. DOI: 10.1021/Bi00422A034  0.724
1988 Sibley DR, Lefkowitz RJ. β-Adrenergic Receptor-Coupled Adenylate Cyclase Molecular Neurobiology. 1: 121-154. DOI: 10.1007/978-1-4612-4604-6_6  0.583
1987 Kobilka BK, Frielle T, Collins S, Yang-Feng T, Kobilka TS, Francke U, Lefkowitz RJ, Caron MG. An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature. 329: 75-9. PMID 3041227 DOI: 10.1038/329075A0  0.873
1987 Dohlman HG, Caron MG, Lefkowitz RJ. A family of receptors coupled to guanine nucleotide regulatory proteins. Biochemistry. 26: 2657-64. PMID 3038163 DOI: 10.1021/Bi00384A001  0.738
1987 Kobilka BK, Frielle T, Dohlman HG, Bolanowski MA, Dixon RA, Keller P, Caron MG, Lefkowitz RJ. Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions. The Journal of Biological Chemistry. 262: 7321-7. PMID 3034889  0.857
1987 Yoshimasa T, Sibley DR, Bouvier M, Lefkowitz RJ, Caron MG. Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation. Nature. 327: 67-70. PMID 3033513 DOI: 10.1038/327067A0  0.824
1987 Cerione RA, Gierschik P, Staniszewski C, Benovic JL, Codina J, Somers R, Birnbaumer L, Spiegel AM, Lefkowitz RJ, Caron MG. Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein. Biochemistry. 26: 1485-91. PMID 3032251 DOI: 10.1021/Bi00379A041  0.742
1987 Sibley DR, Benovic JL, Caron MG, Lefkowitz RJ. Regulation of transmembrane signaling by receptor phosphorylation. Cell. 48: 913-22. PMID 3030559 DOI: 10.1016/0092-8674(87)90700-8  0.828
1987 Bouvier M, Leeb-Lundberg LM, Benovic JL, Caron MG, Lefkowitz RJ. Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase. The Journal of Biological Chemistry. 262: 3106-13. PMID 3029101  0.823
1987 Kobilka BK, Dixon RA, Frielle T, Dohlman HG, Bolanowski MA, Sigal IS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ. cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor. Proceedings of the National Academy of Sciences of the United States of America. 84: 46-50. PMID 3025863 DOI: 10.1073/Pnas.84.1.46  0.853
1987 Lefkowitz RJ, Caron MG. Regulation of adrenergic receptor function by phosphorylation. Current Topics in Cellular Regulation. 28: 209-31. PMID 3024910 DOI: 10.1016/B978-0-12-152828-7.50007-X  0.71
1987 Benovic JL, Staniszewski C, Cerione RA, Codina J, Lefkowitz RJ, Caron MG. The mammalian βadrenergic receptor: Structural and functional characterization of the carbohydrate moiety Journal of Receptors and Signal Transduction. 7: 257-281. PMID 2887651 DOI: 10.3109/10799898709054989  0.771
1987 Sibley DR, Lefkowitz RJ. Beta-adrenergic receptor-coupled adenylate cyclase. Biochemical mechanisms of regulation. Molecular Neurobiology. 1: 121-54. PMID 2855789 DOI: 10.1007/BF02935266  0.737
1987 Dohlman HG, Caron MG, Lefkowitz RJ. Structure and function of the beta 2-adrenergic receptor--homology with rhodopsin. Kidney International. Supplement. 23: S2-13. PMID 2831423  0.709
1987 Sibley DR, Benovic JL, Caron MG, Lefkowitz RJ. Molecular mechanisms of beta-adrenergic receptor desensitization. Advances in Experimental Medicine and Biology. 221: 253-73. PMID 2829583 DOI: 10.1007/978-1-4684-7618-7_19  0.83
1987 Benovic JL, Kühn H, Weyand I, Codina J, Caron MG, Lefkowitz RJ. Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein) Proceedings of the National Academy of Sciences of the United States of America. 84: 8879-8882. PMID 2827157 DOI: 10.1073/Pnas.84.24.8879  0.79
1987 Frielle T, Collins S, Daniel KW, Caron MG, Lefkowitz RJ, Kobilka BK. Cloning of the cDNA for the human beta 1-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 84: 7920-4. PMID 2825170 DOI: 10.1073/Pnas.84.22.7920  0.85
1987 Kobilka BK, MacGregor C, Daniel K, Kobilka TS, Caron MG, Lefkowitz RJ. Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes. The Journal of Biological Chemistry. 262: 15796-802. PMID 2824467  0.685
1987 Kobilka BK, Matsui H, Kobilka TS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ, Regan JW. Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor. Science (New York, N.Y.). 238: 650-6. PMID 2823383 DOI: 10.1126/Science.2823383  0.838
1987 Dohlman HG, Bouvier M, Benovic JL, Caron MG, Lefkowitz RJ. The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis. The Journal of Biological Chemistry. 262: 14282-8. PMID 2821000  0.802
1987 Lefkowitz RJ, Caron MG. Molecular and regulatory properties of adrenergic receptors. Recent Progress in Hormone Research. 43: 469-97. PMID 2819998 DOI: 10.1016/B978-0-12-571143-2.50018-6  0.662
1987 Sibley DR, Daniel K, Strader CD, Lefkowitz RJ. Phosphorylation of the beta-adrenergic receptor in intact cells: relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization. Archives of Biochemistry and Biophysics. 258: 24-32. PMID 2444163 DOI: 10.1016/0003-9861(87)90318-3  0.741
1987 Benovic JL, Lefkowitz RJ. 10 Regulation of Receptor Function Enzymes. 18: 319-333. DOI: 10.1016/S1874-6047(08)60261-9  0.7
1986 Sibley DR, Jeffs RA, Daniel K, Nambi P, Lefkowitz RJ. Phorbol diester treatment promotes enhanced adenylate cyclase activity in frog erythrocytes. Archives of Biochemistry and Biophysics. 244: 373-81. PMID 3484932 DOI: 10.1016/0003-9861(86)90126-8  0.772
1986 Sibley DR, Lefkowitz RJ. Adenylate cyclase coupled beta-adrenergic receptors: biochemical mechanisms of desensitization. Clinical Neuropharmacology. 9: 3-5. PMID 3032428  0.68
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