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J. Ashot Kozak, Ph.D. - Publications

Affiliations: 
Neurosci., Cell Biol. and Physiol. Wright State University, Fairborn, OH, United States 
Area:
ion channel regulation
Website:
https://people.wright.edu/juliusz.kozak
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44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Liardo E, Pham AT, Ghilardi AF, Zhelay T, Szteyn K, Gandi NL, Ekkati A, Koerner S, Kozak JA, Sun L. Discovery of selective Orai channel blockers bearing an indazole or a pyrazole scaffold. European Journal of Medicinal Chemistry. 278: 116805. PMID 39232360 DOI: 10.1016/j.ejmech.2024.116805  0.831
2024 Holderby KG, Kozak JA. Use of tetraethylammonium (TEA) and Tris loading for blocking TRPM7 channels in intact cells Frontiers in Pharmacology. 15. DOI: 10.3389/fphar.2024.1341799  0.487
2024 Liardo E, Pham AT, Ghilardi AF, ZhelayT, Szteyn K, Gandi NL, Ekkati A, Koerner S, Kozak JA, Sun L. Discovery of selective Orai channel blockers bearing an indazole or a pyrazole scaffold European Journal of Medicinal Chemistry. 278. DOI: 10.1016/j.ejmech.2024.116805  0.355
2022 Kozak JA. Suppression of Store-operated Calcium Entry Channels and Cytokine Release by Cannabinoids. Function (Oxford, England). 3: zqac044. PMID 36168590 DOI: 10.1093/function/zqac044  0.42
2022 Kozak JA. Suppression of Store-operated Calcium Entry Channels and Cytokine Release by Cannabinoids Function (Oxf). 3. DOI: 10.1093/function/zqac044  0.306
2022 Kozak JA. Suppression of Store-operated Calcium Entry Channels and Cytokine Release by Cannabinoids Function (Oxf). 3. DOI: 10.1093/function/zqac044  0.306
2021 Chokshi R, Bennett O, Zhelay T, Kozak JA. NSAIDs Naproxen, Ibuprofen, Salicylate, and Aspirin Inhibit TRPM7 Channels by Cytosolic Acidification. Frontiers in Physiology. 12: 727549. PMID 34733174 DOI: 10.3389/fphys.2021.727549  0.825
2020 Beesetty P, Rockwood J, Kaitsuka T, Zhelay T, Hourani S, Matsushita M, Kozak JA. Phagocytic activity of splenic macrophages is enhanced and accompanied by cytosolic alkalinization in TRPM7 kinase-dead mice. The Febs Journal. PMID 33354894 DOI: 10.1111/febs.15683  0.777
2020 Mellott A, Rockwood J, Zhelay T, Luu CT, Kaitsuka T, Kozak JA. Correction to: TRPM7 channel activity in Jurkat T lymphocytes during magnesium depletion and loading: implications for divalent metal entry and cytotoxicity. Pflugers Archiv : European Journal of Physiology. PMID 33006640 DOI: 10.1007/s00424-020-02468-0  0.745
2020 Mellott A, Rockwood J, Zhelay T, Luu CT, Kaitsuka T, Kozak JA. TRPM7 channel activity in Jurkat T lymphocytes during magnesium depletion and loading: implications for divalent metal entry and cytotoxicity. Pflugers Archiv : European Journal of Physiology. PMID 32964285 DOI: 10.1007/s00424-020-02457-3  0.793
2020 Rockwood J, Beesetty P, Matsushita M, Kozak JA. Effects of TRPM7 Kinase Inactivation in Macrophages Biophysical Journal. 118: 415a. DOI: 10.1016/J.Bpj.2019.11.2343  0.773
2019 Zhelay T, Szteyn K, Liardo E, Eun Cheong J, Koerner S, Ekkati A, Sun L, Kozak JA. Initial Characterization of the Indole-3-Carboxamide Bic-154 as a Fast Onset and Reversible ORAI Channel Blocker Biophysical Journal. 116: 249a. DOI: 10.1016/J.Bpj.2018.11.1359  0.801
2018 Zhelay T, Wieczerzak KB, Beesetty P, Alter GM, Matsushita M, Kozak JA. Depletion of plasma membrane-associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg, spermine and pH. The Journal of Biological Chemistry. PMID 30305398 DOI: 10.1074/Jbc.Ra118.004066  0.819
2018 Beesetty P, Wieczerzak KB, Gibson JN, Kaitsuka T, Luu CT, Matsushita M, Kozak JA. Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry. Scientific Reports. 8: 3023. PMID 29445164 DOI: 10.1038/S41598-018-21004-W  0.758
2017 Kursan S, McMillen TS, Beesetty P, Dias-Junior E, Almutairi MM, Sajib AA, Kozak JA, Aguilar-Bryan L, Di Fulvio M. The neuronal K(+)Cl(-) co-transporter 2 (Slc12a5) modulates insulin secretion. Scientific Reports. 7: 1732. PMID 28496181 DOI: 10.1038/S41598-017-01814-0  0.77
2017 Beesetty P, Wieczerzak K, Zhelay T, Kaitsuka T, Matsushita M, Kozak JA. Regulation of TRPM7 by Cytosolic Mg 2+ and pH: Insights from VSP Expression Biophysical Journal. 112: 251a. DOI: 10.1016/J.Bpj.2016.11.1369  0.77
2016 Gibson JN, Beesetty P, Sulentic C, Kozak JA. Rapid Quantification of Mitogen-induced Blastogenesis in T Lymphocytes for Identifying Immunomodulatory Drugs. Journal of Visualized Experiments : Jove. PMID 28060354 DOI: 10.3791/55212  0.786
2016 Beesetty P, Matsushita M, Kozak JA. Mitogenic Activation and Proliferation of T Lymphocytes in TRPM7 Kinase-Dead Mutant Mice Biophysical Journal. 110: 605a. DOI: 10.1016/J.Bpj.2015.11.3233  0.847
2015 Kaitsuka T, Katagiri C, Beesetty P, Nakamura K, Hourani S, Tomizawa K, Kozak JA, Matsushita M. Effects of Inactivation of TRPM7 Kinase Activity on its Channel Activity in Mice Biophysical Journal. 108: 37a. DOI: 10.1016/J.Bpj.2014.11.232  0.852
2014 Kaitsuka T, Katagiri C, Beesetty P, Nakamura K, Hourani S, Tomizawa K, Kozak JA, Matsushita M. Inactivation of TRPM7 kinase activity does not impair its channel function in mice. Scientific Reports. 4: 5718. PMID 25030553 DOI: 10.1038/Srep05718  0.825
2014 Hourani S, Beesetty P, Matsushita M, Kozak JA. Single-Cell Na+ Flux Assay for Measurement of TRPM7 Channel Activity Biophysical Journal. 106: 335a. DOI: 10.1016/J.Bpj.2013.11.1919  0.841
2013 Chokshi R, Kozak JA. Mechanism of TRPM7 Channel Inhibition by 2-Aminoethyl Diphenyl Borinate (2-APB) Biophysical Journal. 104: 455a-456a. DOI: 10.1016/J.Bpj.2012.11.2520  0.59
2012 Chokshi R, Fruasaha P, Kozak JA. 2-aminoethyl diphenyl borinate (2-APB) inhibits TRPM7 channels through an intracellular acidification mechanism. Channels (Austin, Tex.). 6: 362-9. PMID 22922232 DOI: 10.4161/Chan.21628  0.845
2012 Lioudyno MI, Broccio M, Sokolov Y, Rasool S, Wu J, Alkire MT, Liu V, Kozak JA, Dennison PR, Glabe CG, Lösche M, Hall JE. Effect of synthetic aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance. Plos One. 7: e35090. PMID 22563377 DOI: 10.1371/Journal.Pone.0035090  0.434
2012 Chokshi R, Matsushita M, Kozak JA. Sensitivity of TRPM7 channels to Mg2+ characterized in cell-free patches of Jurkat T lymphocytes. American Journal of Physiology. Cell Physiology. 302: C1642-51. PMID 22460708 DOI: 10.1152/Ajpcell.00037.2012  0.847
2012 Chokshi R, Matsushita M, Kozak JA. Detailed examination of Mg2+ and pH sensitivity of human TRPM7 channels. American Journal of Physiology. Cell Physiology. 302: C1004-11. PMID 22301056 DOI: 10.1152/Ajpcell.00422.2011  0.852
2012 Chokshi R, Matsushita M, Kozak JA. Detailed Examination of TRPM7 Channel Mg2+ Dependence Biophysical Journal. 102: 132a. DOI: 10.1016/J.Bpj.2011.11.734  0.585
2009 Lioudyno MI, Sokolov Y, Kozak JA, Cahalan MD, Hall JE. Soluble β-amyloid oligomers alter biophysical properties of Kv1.3 channels Biophysical Journal. 96: 482a-483a. DOI: 10.1016/J.Bpj.2008.12.2488  0.602
2008 Zhang SL, Kozak JA, Jiang W, Yeromin AV, Chen J, Yu Y, Penna A, Shen W, Chi V, Cahalan MD. Store-dependent and -independent modes regulating Ca2+ release-activated Ca2+ channel activity of human Orai1 and Orai3. The Journal of Biological Chemistry. 283: 17662-71. PMID 18420579 DOI: 10.1074/Jbc.M801536200  0.718
2008 Lioudyno MI, Kozak JA, Penna A, Safrina O, Zhang SL, Sen D, Roos J, Stauderman KA, Cahalan MD. Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation. Proceedings of the National Academy of Sciences of the United States of America. 105: 2011-6. PMID 18250319 DOI: 10.1073/Pnas.0706122105  0.789
2005 Kozak JA, Matsushita M, Nairn AC, Cahalan MD. Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels. The Journal of General Physiology. 126: 499-514. PMID 16260839 DOI: 10.1085/Jgp.200509324  0.699
2005 Zhang SL, Yu Y, Roos J, Kozak JA, Deerinck TJ, Ellisman MH, Stauderman KA, Cahalan MD. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature. 437: 902-5. PMID 16208375 DOI: 10.1038/Nature04147  0.76
2005 Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA, Wagner SL, Cahalan MD, Veliçelebi G, Stauderman KA. STIM1, an essential and conserved component of store-operated Ca2+ channel function. The Journal of Cell Biology. 169: 435-45. PMID 15866891 DOI: 10.1083/Jcb.200502019  0.743
2005 Matsushita M, Kozak JA, Shimizu Y, McLachlin DT, Yamaguchi H, Wei FY, Tomizawa K, Matsui H, Chait BT, Cahalan MD, Nairn AC. Channel function is dissociated from the intrinsic kinase activity and autophosphorylation of TRPM7/ChaK1. The Journal of Biological Chemistry. 280: 20793-803. PMID 15781465 DOI: 10.1074/Jbc.M413671200  0.708
2004 Akbari Y, Dagher N, Murphy MP, Kozak JA, Hitt B, Oddo S, Tseng B, Golde TE, Cahalan M, Leissring MA, M. LaFerla F. P1-206 Capacitative and non-capacitative Ca2+ entry modulate Aβ levels Neurobiology of Aging. 25: S154-S155. DOI: 10.1016/S0197-4580(04)80519-0  0.528
2003 Kerschbaum HH, Kozak JA, Cahalan MD. Polyvalent cations as permeant probes of MIC and TRPM7 pores. Biophysical Journal. 84: 2293-305. PMID 12668438 DOI: 10.1016/S0006-3495(03)75035-8  0.722
2003 Kozak JA, Cahalan MD. MIC channels are inhibited by internal divalent cations but not ATP. Biophysical Journal. 84: 922-7. PMID 12547774 DOI: 10.1016/S0006-3495(03)74909-1  0.703
2002 Pérez CA, Huang L, Rong M, Kozak JA, Preuss AK, Zhang H, Max M, Margolskee RF. A transient receptor potential channel expressed in taste receptor cells. Nature Neuroscience. 5: 1169-76. PMID 12368808 DOI: 10.1038/nn952  0.81
2002 Kozak JA, Kerschbaum HH, Cahalan MD. Distinct properties of CRAC and MIC channels in RBL cells. The Journal of General Physiology. 120: 221-35. PMID 12149283 DOI: 10.1085/Jgp.20028601  0.71
2000 Fomina AF, Fanger CM, Kozak JA, Cahalan MD. Single channel properties and regulated expression of Ca(2+) release-activated Ca(2+) (CRAC) channels in human T cells. The Journal of Cell Biology. 150: 1435-44. PMID 10995447 DOI: 10.1083/Jcb.150.6.1435  0.713
1998 Kozak JA, Misler S, Logothetis DE. Characterization of a Ca2+-activated K+ current in insulin-secreting murine betaTC-3 cells. The Journal of Physiology. 509: 355-70. PMID 9575286 DOI: 10.1111/J.1469-7793.1998.355Bn.X  0.604
1998 Kozak JA, Misler S, Logothetis DE. Characterization of a Ca2+-activated K+ current in insulin-secreting murine βTC-3 cells Journal of Physiology. 509: 355-370. DOI: 10.1111/j.1469-7793.1998.355bn.x  0.51
1997 Kozak JA, Logothetis DE. A calcium-dependent chloride current in insulin-secreting beta TC-3 cells. Pflã¼Gers Archiv : European Journal of Physiology. 433: 679-90. PMID 9049157 DOI: 10.1007/S004240050332  0.564
1996 Chan KW, Langan MN, Sui JL, Kozak JA, Pabon A, Ladias JA, Logothetis DE. A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins. The Journal of General Physiology. 107: 381-97. PMID 8868049 DOI: 10.1085/jgp.107.3.381  0.611
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