Charles Glabe, PhD - Publications

Affiliations: 
University of California, Irvine, Irvine, CA 
Area:
Fertilization, Alzheimer disease

123 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Rimal S, Li Y, Vartak R, Geng J, Tantray I, Li S, Huh S, Vogel H, Glabe C, Grinberg LT, Spina S, Seeley WW, Guo S, Lu B. Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease. Acta Neuropathologica Communications. 9: 169. PMID 34663454 DOI: 10.1186/s40478-021-01268-6  0.398
2020 Abskharon R, Seidler PM, Sawaya MR, Cascio D, Yang TP, Philipp S, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Felgner PL, Nakajima R, Glabe CG, et al. Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. The Journal of Biological Chemistry. PMID 32493775 DOI: 10.1074/Jbc.Ra120.013638  0.357
2019 Brewer GJ, Herrera RA, Philipp S, Sosna J, Reyes-Ruiz JM, Glabe CG. Age-Related Intraneuronal Aggregation of Amyloid-β in Endosomes, Mitochondria, Autophagosomes, and Lysosomes. Journal of Alzheimer's Disease : Jad. PMID 31771065 DOI: 10.3233/JAD-190835  0.381
2019 Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, ... ... Glabe CG, et al. Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus. Scientific Reports. 9: 15936. PMID 31685865 DOI: 10.1038/S41598-019-52324-0  0.331
2019 Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau. Elife. 8. PMID 31612856 DOI: 10.7554/Elife.46924  0.422
2019 Bilousova T, Melnik M, Miyoshi E, Gonzalez BL, Poon WW, Vinters HV, Miller CA, Corrada MM, Kawas C, Hatami A, Albay R, Glabe C, Gylys KH. Apolipoprotein E/Aβ Complex Accumulates in AD Cortical Synapses via apoE Receptors and Is Enhanced by APOE4. The American Journal of Pathology. PMID 31108099 DOI: 10.1016/J.Ajpath.2019.04.010  0.7
2018 Sosna J, Philipp S, Albay R, Reyes-Ruiz JM, Baglietto-Vargas D, LaFerla FM, Glabe CG. Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer's disease. Molecular Neurodegeneration. 13: 11. PMID 29490706 DOI: 10.1186/s13024-018-0244-x  0.414
2017 Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. Common fibrillar spines of amyloid-β and human Islet Amyloid Polypeptide revealed by Micro Electron Diffraction and inhibitors developed using structure-based design. The Journal of Biological Chemistry. PMID 29282295 DOI: 10.1074/Jbc.M117.806109  0.391
2017 Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME. Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. Acta Neuropathologica. PMID 28612290 DOI: 10.1007/S00401-017-1737-3  0.42
2017 Hatami A, Monjazeb S, Milton S, Glabe CG. Familial Alzheimer's disease mutations within the amyloid precursor protein alter the aggregation and conformation of the amyloid beta peptide. The Journal of Biological Chemistry. PMID 28049728 DOI: 10.1074/Jbc.M116.755264  0.723
2016 Wälti MA, Ravotti F, Arai H, Glabe CG, Wall JS, Böckmann A, Güntert P, Meier BH, Riek R. Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril. Proceedings of the National Academy of Sciences of the United States of America. PMID 27469165 DOI: 10.1073/Pnas.1600749113  0.67
2016 Breydo L, Kurouski D, Rasool S, Milton S, Wu JW, Uversky VN, Lednev IK, Glabe CG. Structural differences between amyloid beta oligomers. Biochemical and Biophysical Research Communications. PMID 27363332 DOI: 10.1016/J.Bbrc.2016.06.122  0.623
2016 Knight EM, Kim SH, Kottwitz JC, Hatami A, Albay R, Suzuki A, Lublin A, Alberini CM, Klein WL, Szabo P, Relkin NR, Ehrlich M, Glabe CG, Gandy S, Steele JW. Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes. Neurology® Neuroimmunology & Neuroinflammation. 3: e237. PMID 27218118 DOI: 10.1212/Nxi.0000000000000237  0.729
2016 Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S. Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1. Acta Neuropathologica Communications. 4: 16. PMID 26916443 DOI: 10.1186/S40478-016-0282-Y  0.381
2016 Bilousova T, Miller CA, Poon WW, Vinters HV, Corrada M, Kawas C, Hayden EY, Teplow DB, Glabe C, Albay R, Cole GM, Teng E, Gylys KH. Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. The American Journal of Pathology. 186: 185-98. PMID 26718979 DOI: 10.1016/J.Ajpath.2015.09.018  0.472
2015 Hatami A, Monjazeb S, Glabe C. The Anti-Amyloid-β Monoclonal Antibody 4G8 Recognizes a Generic Sequence-Independent Epitope Associated with α-Synuclein and Islet Amyloid Polypeptide Amyloid Fibrils. Journal of Alzheimer's Disease : Jad. PMID 26682688 DOI: 10.3233/Jad-150696  0.724
2015 Teng E, Taylor K, Bilousova T, Weiland D, Pham T, Zuo X, Yang F, Chen PP, Glabe CG, Takacs A, Hoffman DR, Frautschy SA, Cole GM. Dietary DHA supplementation in an APP/PS1 transgenic rat model of AD reduces behavioral and Aβ pathology and modulates Aβ oligomerization. Neurobiology of Disease. PMID 26369878 DOI: 10.1016/J.Nbd.2015.09.002  0.381
2015 Tan Z, Dai W, van Erp TG, Overman J, Demuro A, Digman MA, Hatami A, Albay R, Sontag EM, Potkin KT, Ling S, Macciardi F, Bunney WE, Long JD, Paulsen JS, ... ... Glabe C, et al. Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin. Molecular Psychiatry. PMID 26100538 DOI: 10.1038/Mp.2015.81  0.657
2014 Hatami A, Albay R, Monjazeb S, Milton S, Glabe C. Monoclonal antibodies against Aβ42 fibrils distinguish multiple aggregation state polymorphisms in vitro and in Alzheimer disease brain. The Journal of Biological Chemistry. 289: 32131-43. PMID 25281743 DOI: 10.1074/Jbc.M114.594846  0.738
2014 Kim SH, Steele JW, Lee SW, Clemenson GD, Carter TA, Treuner K, Gadient R, Wedel P, Glabe C, Barlow C, Ehrlich ME, Gage FH, Gandy S. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse. Molecular Psychiatry. 19: 1235-42. PMID 25113378 DOI: 10.1038/Mp.2014.87  0.386
2014 Pensalfini A, Albay R, Rasool S, Wu JW, Hatami A, Arai H, Margol L, Milton S, Poon WW, Corrada MM, Kawas CH, Glabe CG. Intracellular amyloid and the neuronal origin of Alzheimer neuritic plaques. Neurobiology of Disease. 71: 53-61. PMID 25092575 DOI: 10.1016/J.Nbd.2014.07.011  0.806
2014 Buhimschi IA, Nayeri UA, Zhao G, Shook LL, Pensalfini A, Funai EF, Bernstein IM, Glabe CG, Buhimschi CS. Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia. Science Translational Medicine. 6: 245ra92. PMID 25031267 DOI: 10.1126/scitranslmed.3008808  0.307
2013 Rasool S, Martinez-Coria H, Wu JW, LaFerla F, Glabe CG. Systemic vaccination with anti-oligomeric monoclonal antibodies improves cognitive function by reducing Aβ deposition and tau pathology in 3xTg-AD mice. Journal of Neurochemistry. 126: 473-82. PMID 23672786 DOI: 10.1111/Jnc.12305  0.646
2013 Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, et al. A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 6245-56. PMID 23575824 DOI: 10.1523/Jneurosci.3672-12.2013  0.364
2013 McLean D, Cooke MJ, Albay R, Glabe C, Shoichet MS. Positron emission tomography imaging of fibrillar parenchymal and vascular amyloid-β in TgCRND8 mice. Acs Chemical Neuroscience. 4: 613-23. PMID 23509918 DOI: 10.1021/Cn300226Q  0.361
2012 Sontag EM, Lotz GP, Yang G, Sontag CJ, Cummings BJ, Glabe CG, Muchowski PJ, Thompson LM. Detection of Mutant Huntingtin Aggregation Conformers and Modulation of SDS-Soluble Fibrillar Oligomers by Small Molecules. Journal of Huntington's Disease. 1: 127-40. PMID 24086178 DOI: 10.3233/Jhd-2012-129004  0.339
2012 Ringman JM, Tomic JL, Coppola G, Elashoff D, Gylys KH, Glabe CG. Conformation-dependent oligomers in cerebrospinal fluid of presymptomatic familial Alzheimer's disease mutation carriers. Dementia and Geriatric Cognitive Disorders Extra. 2: 652-7. PMID 23341831 DOI: 10.1159/000345771  0.331
2012 Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proceedings of the National Academy of Sciences of the United States of America. 109: 20913-8. PMID 23213214 DOI: 10.1073/Pnas.1218792109  0.374
2012 Arai H, Glabe C, Luecke H. Crystal structure of a conformation-dependent rabbit IgG Fab specific for amyloid prefibrillar oligomers. Biochimica Et Biophysica Acta. 1820: 1908-14. PMID 22940003 DOI: 10.1016/J.Bbagen.2012.08.016  0.649
2012 Rasool S, Albay R, Martinez-Coria H, Breydo L, Wu J, Milton S, Misra S, Tran A, Pensalfini A, Laferla F, Kayed R, Glabe CG. Vaccination with a non-human random sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition and micro hemorrhage in Tg2576 mice. Molecular Neurodegeneration. 7: 37. PMID 22866920 DOI: 10.1186/1750-1326-7-37  0.565
2012 Nussbaum JM, Schilling S, Cynis H, Silva A, Swanson E, Wangsanut T, Tayler K, Wiltgen B, Hatami A, Rönicke R, Reymann K, Hutter-Paier B, Alexandru A, Jagla W, Graubner S, ... Glabe CG, et al. Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β. Nature. 485: 651-5. PMID 22660329 DOI: 10.1038/Nature11060  0.723
2012 Lioudyno MI, Broccio M, Sokolov Y, Rasool S, Wu J, Alkire MT, Liu V, Kozak JA, Dennison PR, Glabe CG, Lösche M, Hall JE. Effect of synthetic aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance. Plos One. 7: e35090. PMID 22563377 DOI: 10.1371/Journal.Pone.0035090  0.529
2012 Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. Atomic view of a toxic amyloid small oligomer. Science (New York, N.Y.). 335: 1228-31. PMID 22403391 DOI: 10.1126/Science.1213151  0.493
2012 Colla E, Jensen PH, Pletnikova O, Troncoso JC, Glabe C, Lee MK. Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3301-5. PMID 22399752 DOI: 10.1523/Jneurosci.5368-11.2012  0.344
2011 Lasagna-Reeves CA, Glabe CG, Kayed R. Amyloid-β annular protofibrils evade fibrillar fate in Alzheimer disease brain. The Journal of Biological Chemistry. 286: 22122-30. PMID 21507938 DOI: 10.1074/Jbc.M111.236257  0.406
2011 Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello AC. Transgenic mice as a model of pre-clinical Alzheimer's disease. Current Alzheimer Research. 8: 4-23. PMID 21143159 DOI: 10.2174/156720511794604561  0.357
2011 Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ. Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 326-36. PMID 20876215 DOI: 10.1096/Fj.10-164624  0.32
2011 Rasool S, Coria HM, Breydo L, Wu J, Milton S, Tran A, Albay R, Glabe C. Vaccination with a non-human sequence amyloid oligomer mimic results in improved cognitive function and reduced plaque deposition in Tg2576 mice Neuroscience Research. 71: e85-e86. DOI: 10.1016/J.Neures.2011.07.365  0.592
2010 Kayed R, Canto I, Breydo L, Rasool S, Lukacsovich T, Wu J, Albay R, Pensalfini A, Yeung S, Head E, Marsh JL, Glabe C. Conformation dependent monoclonal antibodies distinguish different replicating strains or conformers of prefibrillar Aβ oligomers. Molecular Neurodegeneration. 5: 57. PMID 21144050 DOI: 10.1186/1750-1326-5-57  0.67
2010 Lotz GP, Legleiter J, Aron R, Mitchell EJ, Huang SY, Ng C, Glabe C, Thompson LM, Muchowski PJ. Hsp70 and Hsp40 functionally interact with soluble mutant huntingtin oligomers in a classic ATP-dependent reaction cycle. The Journal of Biological Chemistry. 285: 38183-93. PMID 20864533 DOI: 10.1074/Jbc.M110.160218  0.342
2010 Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Annals of Neurology. 68: 220-30. PMID 20641005 DOI: 10.1002/Ana.22052  0.432
2010 Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E. Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. The Febs Journal. 277: 3051-67. PMID 20573181 DOI: 10.1111/J.1742-4658.2010.07719.X  0.45
2010 Vasilevko V, Pop V, Kim HJ, Saing T, Glabe CC, Milton S, Barrett EG, Cotman CW, Cribbs DH, Head E. Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta. Neurobiology of Disease. 39: 301-10. PMID 20451612 DOI: 10.1016/j.nbd.2010.04.014  0.343
2010 Head E, Pop V, Sarsoza F, Kayed R, Beckett TL, Studzinski CM, Tomic JL, Glabe CG, Murphy MP. Amyloid-beta peptide and oligomers in the brain and cerebrospinal fluid of aged canines. Journal of Alzheimer's Disease : Jad. 20: 637-46. PMID 20164551 DOI: 10.3233/Jad-2010-1397  0.322
2010 Gurlo T, Ryazantsev S, Huang CJ, Yeh MW, Reber HA, Hines OJ, O'Brien TD, Glabe CG, Butler PC. Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway. The American Journal of Pathology. 176: 861-9. PMID 20042670 DOI: 10.2353/ajpath.2010.090532  0.316
2010 Wu JW, Breydo L, Isas JM, Lee J, Kuznetsov YG, Langen R, Glabe C. Fibrillar oligomers nucleate the oligomerization of monomeric amyloid beta but do not seed fibril formation. The Journal of Biological Chemistry. 285: 6071-9. PMID 20018889 DOI: 10.1074/Jbc.M109.069542  0.683
2010 Isas JM, Luibl V, Johnson LV, Kayed R, Wetzel R, Glabe CG, Langen R, Chen J. Soluble and mature amyloid fibrils in drusen deposits. Investigative Ophthalmology & Visual Science. 51: 1304-10. PMID 19892876 DOI: 10.1167/Iovs.09-4207  0.404
2010 Steele JW, Simon AJ, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Glabe C, Bilker W, Abel T, Schmeidler J, Ehrlich ME, Gandy S. Evidence for dose-dependent neurotoxicity of amyloid-β oligomers/Aβ-derived diffusible ligands generated from physiological processing of transgenic human APP in situ in mouse brain Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.737  0.402
2010 Arai H, Luecke H, Glabe C. X-Ray Structure of an Amyloid-Oligomer-Specific Monoclonal Antibody Fab Biophysical Journal. 98: 177a. DOI: 10.1016/J.Bpj.2009.12.945  0.676
2009 Kokubo H, Kayed R, Glabe CG, Staufenbiel M, Saido TC, Iwata N, Yamaguchi H. Amyloid Beta annular protofibrils in cell processes and synapses accumulate with aging and Alzheimer-associated genetic modification. International Journal of Alzheimer's Disease. 2009. PMID 20798763 DOI: 10.4061/2009/689285  0.348
2009 Liu B, Rasool S, Yang Z, Glabe CG, Schreiber SS, Ge J, Tan Z. Amyloid-peptide vaccinations reduce {beta}-amyloid plaques but exacerbate vascular deposition and inflammation in the retina of Alzheimer's transgenic mice. The American Journal of Pathology. 175: 2099-110. PMID 19834067 DOI: 10.2353/ajpath.2009.090159  0.37
2009 Mina EW, Lasagna-Reeves C, Glabe CG, Kayed R. Poloxamer 188 copolymer membrane sealant rescues toxicity of amyloid oligomers in vitro. Journal of Molecular Biology. 391: 577-85. PMID 19524592 DOI: 10.1016/J.Jmb.2009.06.024  0.77
2009 Tomic JL, Pensalfini A, Head E, Glabe CG. Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiology of Disease. 35: 352-8. PMID 19523517 DOI: 10.1016/j.nbd.2009.05.024  0.374
2009 Shah SB, Nolan R, Davis E, Stokin GB, Niesman I, Canto I, Glabe C, Goldstein LS. Examination of potential mechanisms of amyloid-induced defects in neuronal transport. Neurobiology of Disease. 36: 11-25. PMID 19497367 DOI: 10.1016/J.Nbd.2009.05.016  0.444
2009 Sarsoza F, Saing T, Kayed R, Dahlin R, Dick M, Broadwater-Hollifield C, Mobley S, Lott I, Doran E, Gillen D, Anderson-Bergman C, Cribbs DH, Glabe C, Head E. A fibril-specific, conformation-dependent antibody recognizes a subset of Abeta plaques in Alzheimer disease, Down syndrome and Tg2576 transgenic mouse brain. Acta Neuropathologica. 118: 505-17. PMID 19360426 DOI: 10.1007/S00401-009-0530-3  0.508
2009 Kayed R, Pensalfini A, Margol L, Sokolov Y, Sarsoza F, Head E, Hall J, Glabe C. Annular protofibrils are a structurally and functionally distinct type of amyloid oligomer. The Journal of Biological Chemistry. 284: 4230-7. PMID 19098006 DOI: 10.1074/Jbc.M808591200  0.526
2009 Pham HM, Cartier A, Neild N, Hansen L, Adame A, Galasko D, Koo E, Glabe C, Masliah E. P4-233: Accumulation of Abeta oligomers in Alzheimer's disease is associated with cognitive impairment by disrupting scaffold dendritic spine proteins: Effects of immunotherapy Alzheimer's & Dementia. 5: P498-P499. DOI: 10.1016/J.Jalz.2009.04.699  0.401
2008 Shin TM, Isas JM, Hsieh CL, Kayed R, Glabe CG, Langen R, Chen J. Formation of soluble amyloid oligomers and amyloid fibrils by the multifunctional protein vitronectin. Molecular Neurodegeneration. 3: 16. PMID 18939994 DOI: 10.1186/1750-1326-3-16  0.456
2008 Bacher M, Dodel R, Aljabari B, Keyvani K, Marambaud P, Kayed R, Glabe C, Goertz N, Hoppmann A, Sachser N, Klotsche J, Schnell S, Lewejohann L, Al-Abed Y. CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease. The Journal of Experimental Medicine. 205: 1593-9. PMID 18573905 DOI: 10.1084/Jem.20060467  0.415
2008 Head E, Pop V, Vasilevko V, Hill M, Saing T, Sarsoza F, Nistor M, Christie LA, Milton S, Glabe C, Barrett E, Cribbs D. A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3555-66. PMID 18385314 DOI: 10.1523/JNEUROSCI.0208-08.2008  0.397
2008 Ferretti MT, Bruno M, Partridge V, Arvanitis D, Leon W, Ducatenzeiler A, Glabe C, Klein W, Cuello AC. P1-086: Intracellular accumulation of Aβ oligomers and inflammatory response precede plaque formation in a new transgenic model of the Alzheimer-like amyloid pathology Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.672  0.472
2008 Pham HE, Hansen L, Adame A, Salmon D, Galasko D, Glabe C, Masliah E. P4-279: Progressive accumulation of Abeta oligomers in the brains of patients with Alzheimer's disease is associated with selective alterations in synaptic proteins Alzheimer's & Dementia. 4: T753-T753. DOI: 10.1016/J.Jalz.2008.05.2348  0.407
2008 Bacher M, Dodel R, Aljabari B, Keyvani K, Marambaud P, Kayed R, Glabe C, Goertz N, Lewejohann L, Sachser N, Klotsche J, Al-Abed Y. P2-291: Administration of CNI-1493 inhibits Aβ accumulation, Amyloid plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1367  0.46
2007 Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG. Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Molecular Neurodegeneration. 2: 18. PMID 17897471 DOI: 10.1186/1750-1326-2-18  0.67
2007 Necula M, Breydo L, Milton S, Kayed R, van der Veer WE, Tone P, Glabe CG. Methylene blue inhibits amyloid Abeta oligomerization by promoting fibrillization. Biochemistry. 46: 8850-60. PMID 17595112 DOI: 10.1021/Bi700411K  0.382
2007 Mamikonyan G, Necula M, Mkrtichyan M, Ghochikyan A, Petrushina I, Movsesyan N, Mina E, Kiyatkin A, Glabe CG, Cribbs DH, Agadjanyan MG. Anti-A beta 1-11 antibody binds to different beta-amyloid species, inhibits fibril formation, and disaggregates preformed fibrils but not the most toxic oligomers. The Journal of Biological Chemistry. 282: 22376-86. PMID 17545160 DOI: 10.1074/Jbc.M700088200  0.777
2007 Necula M, Kayed R, Milton S, Glabe CG. Small molecule inhibitors of aggregation indicate that amyloid beta oligomerization and fibrillization pathways are independent and distinct. The Journal of Biological Chemistry. 282: 10311-24. PMID 17284452 DOI: 10.1074/Jbc.M608207200  0.372
2007 Zhou J, Fonseca MI, Billings-Luhr L, Kayed R, Glabe CG, LaFerla F, Tenner AJ. Effect of immunization with the oligomeric form of the Aβ peptide: Reduction of senile plaque area, decreased complement C3 deposition and synthesis, and decline in behavioral function in a murine model of Alzheimer's disease Molecular Immunology. 44: 264-265. DOI: 10.1016/J.Molimm.2006.07.277  0.305
2006 King ME, Kan HM, Baas PW, Erisir A, Glabe CG, Bloom GS. Tau-dependent microtubule disassembly initiated by prefibrillar beta-amyloid. The Journal of Cell Biology. 175: 541-6. PMID 17101697 DOI: 10.1083/Jcb.200605187  0.388
2006 Kayed R, Glabe CG. Conformation-dependent anti-amyloid oligomer antibodies. Methods in Enzymology. 413: 326-44. PMID 17046404 DOI: 10.1016/S0076-6879(06)13017-7  0.443
2006 Meier JJ, Kayed R, Lin CY, Gurlo T, Haataja L, Jayasinghe S, Langen R, Glabe CG, Butler PC. Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP. American Journal of Physiology. Endocrinology and Metabolism. 291: E1317-24. PMID 16849627 DOI: 10.1152/Ajpendo.00082.2006  0.312
2006 Chen YR, Glabe CG. Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42. The Journal of Biological Chemistry. 281: 24414-22. PMID 16809342 DOI: 10.1074/jbc.M602363200  0.378
2006 Deshpande A, Mina E, Glabe C, Busciglio J. Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6011-8. PMID 16738244 DOI: 10.1523/Jneurosci.1189-06.2006  0.791
2006 Chong YH, Shin YJ, Lee EO, Kayed R, Glabe CG, Tenner AJ. ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures. The Journal of Biological Chemistry. 281: 20315-25. PMID 16714296 DOI: 10.1074/Jbc.M601016200  0.321
2006 Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH. A specific amyloid-beta protein assembly in the brain impairs memory. Nature. 440: 352-7. PMID 16541076 DOI: 10.1038/Nature04533  0.337
2006 Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 24: 2824-34. PMID 16460841 DOI: 10.1016/J.Vaccine.2005.12.058  0.317
2006 Luibl V, Isas JM, Kayed R, Glabe CG, Langen R, Chen J. Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers. The Journal of Clinical Investigation. 116: 378-85. PMID 16453022 DOI: 10.1172/Jci25843  0.381
2006 Glabe CG, Kayed R. Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis. Neurology. 66: S74-8. PMID 16432151 DOI: 10.1212/01.Wnl.0000192103.24796.42  0.37
2006 Ma QL, Lim GP, Harris-White ME, Yang F, Ambegaokar SS, Ubeda OJ, Glabe CG, Teter B, Frautschy SA, Cole GM. Antibodies against beta-amyloid reduce Abeta oligomers, glycogen synthase kinase-3beta activation and tau phosphorylation in vivo and in vitro. Journal of Neuroscience Research. 83: 374-84. PMID 16385556 DOI: 10.1002/Jnr.20734  0.414
2006 Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, LaFerla FM. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. The Journal of Biological Chemistry. 281: 1599-604. PMID 16282321 DOI: 10.1074/Jbc.M507892200  0.411
2006 Bacher M, Dodel R, Aljabari B, Keyvani K, Marambaud P, Kayed R, Glabe C, Goertz N, Schnell S, Al-Abed Y. P1-100: CNI-1493 inhibits Aβ production and prevents plaque formation in an animal model of Alzheimer’s disease Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.475  0.395
2006 Agadjanyan M, Mamikonyan G, Necula M, Mkrtichyan M, Ghochikyan A, Petrushina I, Movsesyan N, Mina E, Glabe C, Cribbs D. P4-329: Different susceptibilities of oligomeric and fibrillar forms of β-amyloid to antibodies specific to N-terminus of this peptide Alzheimer's & Dementia. 2: S613-S614. DOI: 10.1016/J.Jalz.2006.05.2070  0.768
2006 Deshpande A, Mina E, Glabe C, Busciglio J. P4-014: Divergent cytotoxic mechanisms of soluble and fibrillar forms of AAY in human cortical neurons Alzheimer's & Dementia. 2: S517-S518. DOI: 10.1016/J.Jalz.2006.05.1752  0.737
2005 Zhou J, Fonseca MI, Kayed R, Hernandez I, Webster SD, Yazan O, Cribbs DH, Glabe CG, Tenner AJ. Novel Abeta peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease. Journal of Neuroinflammation. 2: 28. PMID 16332263 DOI: 10.1186/1742-2094-2-28  0.396
2005 Lesné S, Ali C, Gabriel C, Croci N, MacKenzie ET, Glabe CG, Plotkine M, Marchand-Verrecchia C, Vivien D, Buisson A. NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9367-77. PMID 16221845 DOI: 10.1523/Jneurosci.0849-05.2005  0.317
2005 Sanbe A, Osinska H, Villa C, Gulick J, Klevitsky R, Glabe CG, Kayed R, Robbins J. Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 102: 13592-7. PMID 16155124 DOI: 10.1073/Pnas.0503324102  0.336
2005 Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. The Journal of Biological Chemistry. 280: 17294-300. PMID 15722360 DOI: 10.1074/Jbc.M500997200  0.763
2005 Kokubo H, Kayed R, Glabe CG, Yamaguchi H. Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimer's disease brain. Brain Research. 1031: 222-8. PMID 15649447 DOI: 10.1016/J.Brainres.2004.10.041  0.337
2005 Bloom GS, Ren K, Glabe CG. Cultured cell and transgenic mouse models for tau pathology linked to beta-amyloid. Biochimica Et Biophysica Acta. 1739: 116-24. PMID 15615631 DOI: 10.1016/J.Bbadis.2004.08.008  0.404
2005 Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. The Journal of Biological Chemistry. 280: 5892-901. PMID 15590663 DOI: 10.1074/Jbc.M404751200  0.414
2004 Kayed R, Sokolov Y, Edmonds B, McIntire TM, Milton SC, Hall JE, Glabe CG. Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. The Journal of Biological Chemistry. 279: 46363-6. PMID 15385542 DOI: 10.1074/Jbc.C400260200  0.412
2004 Sanbe A, Osinska H, Saffitz JE, Glabe CG, Kayed R, Maloyan A, Robbins J. Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proceedings of the National Academy of Sciences of the United States of America. 101: 10132-6. PMID 15220483 DOI: 10.1073/Pnas.0401900101  0.307
2004 Zhang Q, Powers ET, Nieva J, Huff ME, Dendle MA, Bieschke J, Glabe CG, Eschenmoser A, Wentworth P, Lerner RA, Kelly JW. Metabolite-initiated protein misfolding may trigger Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 4752-7. PMID 15034169 DOI: 10.1073/Pnas.0400924101  0.354
2004 Kayed R, Glabe C. P1-172 Annular protofibrils, formation, stability and toxicity: new insights into the pore-like mechanism for amyloid toxicity Neurobiology of Aging. 25: S144. DOI: 10.1016/S0197-4580(04)80485-8  0.394
2004 Glabe C, Kayed R, Sokolov Y, Hall J. O4-02-02 Common structure and mechanism of soluble amyloid oligomer pathogenesis in degenerative diseases Neurobiology of Aging. 25: S75-S76. DOI: 10.1016/S0197-4580(04)80257-4  0.394
2003 Yoburn JC, Tian W, Brower JO, Nowick JS, Glabe CG, Van Vranken DL. Dityrosine cross-linked Abeta peptides: fibrillar beta-structure in Abeta(1-40) is conducive to formation of dityrosine cross-links but a dityrosine cross-link in Abeta(8-14) does not induce beta-structure. Chemical Research in Toxicology. 16: 531-5. PMID 12703970 DOI: 10.1021/Tx025666G  0.308
2003 Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science (New York, N.Y.). 300: 486-9. PMID 12702875 DOI: 10.1126/Science.1079469  0.466
2002 Török M, Milton S, Kayed R, Wu P, McIntire T, Glabe CG, Langen R. Structural and dynamic features of Alzheimer's Abeta peptide in amyloid fibrils studied by site-directed spin labeling. The Journal of Biological Chemistry. 277: 40810-5. PMID 12181315 DOI: 10.1074/Jbc.M205659200  0.375
2002 Soreghan B, Pike C, Kayed R, Tian W, Milton S, Cotman C, Glabe CG. The influence of the carboxyl terminus of the Alzheimer Abeta peptide on its conformation, aggregation, and neurotoxic properties. Neuromolecular Medicine. 1: 81-94. PMID 12025818 DOI: 10.1385/Nmm:1:1:81  0.397
2001 Head E, Garzon-Rodriguez W, Johnson JK, Lott IT, Cotman CW, Glabe C. Oxidation of Abeta and plaque biogenesis in Alzheimer's disease and Down syndrome. Neurobiology of Disease. 8: 792-806. PMID 11592849 DOI: 10.1006/nbdi.2001.0431  0.443
2001 Webster SD, Galvan MD, Ferran E, Garzon-Rodriguez W, Glabe CG, Tenner AJ. Antibody-mediated phagocytosis of the amyloid beta-peptide in microglia is differentially modulated by C1q. Journal of Immunology (Baltimore, Md. : 1950). 166: 7496-503. PMID 11390503 DOI: 10.4049/Jimmunol.166.12.7496  0.399
2000 Webster SD, Yang AJ, Margol L, Garzon-Rodriguez W, Glabe CG, Tenner AJ. Complement component C1q modulates the phagocytosis of Abeta by microglia. Experimental Neurology. 161: 127-38. PMID 10683279 DOI: 10.1006/Exnr.1999.7260  0.34
1999 Huang X, Cuajungco MP, Atwood CS, Hartshorn MA, Tyndall JD, Hanson GR, Stokes KC, Leopold M, Multhaup G, Goldstein LE, Scarpa RC, Saunders AJ, Lim J, Moir RD, Glabe C, et al. Cu(II) potentiation of alzheimer abeta neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. The Journal of Biological Chemistry. 274: 37111-6. PMID 10601271 DOI: 10.1074/Jbc.274.52.37111  0.402
1999 Yang AJ, Chandswangbhuvana D, Shu T, Henschen A, Glabe CG. Intracellular accumulation of insoluble, newly synthesized abetan-42 in amyloid precursor protein-transfected cells that have been treated with Abeta1-42. The Journal of Biological Chemistry. 274: 20650-6. PMID 10400697 DOI: 10.1074/Jbc.274.29.20650  0.369
1999 Milton SCF, De Lisle Milton RC, Kates SA, Glabe C. Improved synthesis and purification of Alzheimer's Aβ 1-42 and analogs International Journal of Peptide Research and Therapeutics. 6: 151-156. DOI: 10.1007/Bf02443630  0.366
1998 Bahr BA, Hoffman KB, Yang AJ, Hess US, Glabe CG, Lynch G. Amyloid beta protein is internalized selectively by hippocampal field CA1 and causes neurons to accumulate amyloidogenic carboxyterminal fragments of the amyloid precursor protein. The Journal of Comparative Neurology. 397: 139-47. PMID 9671284 DOI: 10.1002/(Sici)1096-9861(19980720)397:1<139::Aid-Cne10>3.0.Co;2-K  0.371
1998 Yang AJ, Chandswangbhuvana D, Margol L, Glabe CG. Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis. Journal of Neuroscience Research. 52: 691-8. PMID 9669318 DOI: 10.1002/(Sici)1097-4547(19980615)52:6<691::Aid-Jnr8>3.0.Co;2-3  0.35
1997 Weber LL, Leissring MA, Yang AJ, Glabe CG, Cribbs DH, LaFerla FM. Presenilin-1 immunoreactivity is localized intracellularly in Alzheimer's disease brain, but not detected in amyloid plaques. Experimental Neurology. 143: 37-44. PMID 9000444 DOI: 10.1006/Exnr.1996.6348  0.335
1997 Milton SCF, de Lisle Milton RC, Kates SA, Glabe C. Synthesis of Alzheimer's (1-42) Aβ-amyloid peptide with preformed Fmoc-aminoacyl fluorides Techniques in Protein Chemistry. 8: 865-873. DOI: 10.1016/S1080-8914(97)80083-X  0.377
1996 Knauer MF, Orlando RA, Glabe CG. Cell surface APP751 forms complexes with protease nexin 2 ligands and is internalized via the low density lipoprotein receptor-related protein (LRP). Brain Research. 740: 6-14. PMID 8973792 DOI: 10.1016/S0006-8993(96)00711-1  0.341
1996 Moy GW, Mendoza LM, Schulz JR, Swanson WJ, Glabe CG, Vacquier VD. The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1. The Journal of Cell Biology. 133: 809-17. PMID 8666666 DOI: 10.1083/jcb.133.4.809  0.503
1995 Pike CJ, Walencewicz-Wasserman AJ, Kosmoski J, Cribbs DH, Glabe CG, Cotman CW. Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity. Journal of Neurochemistry. 64: 253-65. PMID 7798921 DOI: 10.1046/J.1471-4159.1995.64010253.X  0.336
1995 Yang AJ, Knauer M, Burdick DA, Glabe C. Intracellular A beta 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells. The Journal of Biological Chemistry. 270: 14786-92. PMID 7782344 DOI: 10.1074/Jbc.270.24.14786  0.382
1995 Korotzer AR, Watt J, Cribbs D, Tenner AJ, Burdick D, Glabe C, Cotman CW. Cultured rat microglia express C1q and receptor for C1q: implications for amyloid effects on microglia. Experimental Neurology. 134: 214-21. PMID 7556541 DOI: 10.1006/Exnr.1995.1051  0.444
1993 Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 1676-87. PMID 8463843 DOI: 10.1523/Jneurosci.13-04-01676.1993  0.327
1991 Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW. In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. Brain Research. 563: 311-4. PMID 1786545 DOI: 10.1016/0006-8993(91)91553-D  0.363
1982 Glabe CG, Grabel LB, Vacquier VD, Rosen SD. Carbohydrate specificity of sea urchin sperm bindin: a cell surface lectin mediating sperm-egg adhesion. The Journal of Cell Biology. 94: 123-8. PMID 7119010 DOI: 10.1083/jcb.94.1.123  0.468
1982 Lopo AC, Glabe CG, Lennarz WJ, Vacquier VD. Sperm-egg binding events during sea urchin fertilization. Annals of the New York Academy of Sciences. 383: 405-25. PMID 6283995  0.42
1979 VACQUIER VD, BRANDRIFF B, GLABE CG. THE EFFECT OF SOLUBLE EGG JELLY ON THE FERTILIZABILITY OF ACID-DEJELLIED SEA URCHIN EGGS* Development, Growth and Differentiation. 21: 47-60. DOI: 10.1111/j.1440-169X.1979.00047.x  0.428
1978 Glabe CG, Vacquier VD. Egg surface glycoprotein receptor for sea urchin sperm bindin. Proceedings of the National Academy of Sciences of the United States of America. 75: 881-5. PMID 273249  0.458
1977 Glabe CG, Vacquier VD. Species specific agglutination of eggs by bindin isolated from sea urchin sperm. Nature. 267: 836-8. PMID 561310  0.434
1977 Glabe CG, Vacquier VD. Isolation and characterization of the vitelline layer of sea urchin eggs. The Journal of Cell Biology. 75: 410-21. PMID 264118  0.436
1977 Glabe CG, Vacquier VD. The surface of sea urchin eggs possess a species-specific receptor for bindin Journal of Cell Biology. 75: 56A.  0.428
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