Mohamed Chahine - Publications

Universite Laval (Canada) 
Medical Biophysics, General Biophysics, Neuroscience Biology

39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Poulin H, Mercier A, Djemai M, Pouliot V, Deschenes I, Boutjdir M, Puymirat J, Chahine M. iPSC-derived cardiomyocytes from patients with myotonic dystrophy type 1 have abnormal ion channel functions and slower conduction velocities. Scientific Reports. 11: 2500. PMID 33510259 DOI: 10.1038/s41598-021-82007-8  0.68
2020 Srivastava U, Jennings-Charles R, Qu YS, Sossalla S, Chahine M, Boutjdir M. Novel Re-expression of L-type Calcium Channel Ca1.3 in Left Ventricles of Failing Human Heart. Heart Rhythm. PMID 32113898 DOI: 10.1016/J.Hrthm.2020.02.025  0.68
2018 Aromolaran AS, Srivastava U, Alí A, Chahine M, Lazaro D, El-Sherif N, Capecchi PL, Laghi-Pasini F, Lazzerini PE, Boutjdir M. Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation. Plos One. 13: e0208321. PMID 30521586 DOI: 10.1371/Journal.Pone.0208321  0.68
2017 Aromolaran AS, Chahine M, Boutjdir M. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C. Handbook of Experimental Pharmacology. PMID 29032483 DOI: 10.1007/164_2017_53  0.68
2017 Moreau A, Boutjdir M, Chahine M. Induced Pluripotent Stem Cell-derived Cardiomyocytes: Cardiac Applications, Opportunities and Challenges. Canadian Journal of Physiology and Pharmacology. PMID 28350968 DOI: 10.1139/Cjpp-2016-0726  0.68
2016 Moreau A, Mercier A, Thériault O, Boutjdir M, Burger B, Keller DI, Chahine M. Biophysical, Molecular, and Pharmacological Characterization of Voltage-Dependent Sodium Channels From Induced Pluripotent Stem Cell-Derived Cardiomyocytes. The Canadian Journal of Cardiology. PMID 27998617 DOI: 10.1016/J.Cjca.2016.10.001  0.68
2016 Fabris F, Yue Y, Qu Y, Chahine M, Sobie E, Lee P, Wieczorek R, Jiang XC, Capecchi PL, Laghi-Pasini F, Lazzerini PE, Boutjdir M. Induction of autoimmune response to the extracellular loop of the HERG channel pore induces QTc prolongation in guinea pigs. The Journal of Physiology. PMID 27296897 DOI: 10.1113/Jp272151  0.68
2015 Moreau A, Gosselin-Badaroudine P, Boutjdir M, Chahine M. Mutations in the Voltage Sensors of Domains I and II of Nav1.5 that are Associated with Arrhythmias and Dilated Cardiomyopathy Generate Gating Pore Currents. Frontiers in Pharmacology. 6: 301. PMID 26733869 DOI: 10.3389/Fphar.2015.00301  0.68
2015 O'Leary ME, Chahine M. MTSET modification of D4S6 cysteines stabilize the fast inactivated state of Nav1.5 sodium channels. Frontiers in Pharmacology. 6: 118. PMID 26150789 DOI: 10.3389/Fphar.2015.00118  0.64
2015 Yue Y, Castrichini M, Srivastava U, Fabris F, Shah K, Li Z, Qu Y, El-Sherif N, Zhou Z, January C, Hussain MM, Jiang XC, Sobie EA, Wahren-Herlenius M, Chahine M, et al. Pathogenesis of the Novel Autoimmune-Associated Long QT Syndrome. Circulation. PMID 25995318 DOI: 10.1161/Circulationaha.115.009800  0.68
2014 Thériault O, Poulin H, Sculptoreanu A, de Groat WC, O'Leary ME, Chahine M. Modulation of peripheral Na(+) channels and neuronal firing by n-butyl-p-aminobenzoate. European Journal of Pharmacology. 727: 158-66. PMID 24486399 DOI: 10.1016/J.Ejphar.2014.01.036  0.64
2013 Moreau A, Krahn AD, Gosselin-Badaroudine P, Klein GJ, Christé G, Vincent Y, Boutjdir M, Chahine M. Sodium overload due to a persistent current that attenuates the arrhythmogenic potential of a novel LQT3 mutation. Frontiers in Pharmacology. 4: 126. PMID 24098284 DOI: 10.3389/Fphar.2013.00126  0.68
2012 Ho C, Zhao J, Malinowski S, Chahine M, O'Leary ME. Differential expression of sodium channel β subunits in dorsal root ganglion sensory neurons. The Journal of Biological Chemistry. 287: 15044-53. PMID 22408255 DOI: 10.1074/Jbc.M111.333740  0.64
2011 Chahine M, O'Leary ME. Regulatory Role of Voltage-Gated Na Channel β Subunits in Sensory Neurons. Frontiers in Pharmacology. 2: 70. PMID 22125538 DOI: 10.3389/Fphar.2011.00070  0.64
2011 Zhao J, O'Leary ME, Chahine M. Regulation of Nav1.6 and Nav1.8 peripheral nerve Na+ channels by auxiliary β-subunits. Journal of Neurophysiology. 106: 608-19. PMID 21562192 DOI: 10.1152/Jn.00107.2011  0.64
2011 Qu Y, Karnabi E, Ramadan O, Yue Y, Chahine M, Boutjdir M. Perinatal and postnatal expression of Cav1.3 α1D Ca²⁺ channel in the rat heart. Pediatric Research. 69: 479-84. PMID 21378599 DOI: 10.1203/Pdr.0B013E318217A0Df  0.68
2011 Huang H, Priori SG, Napolitano C, O'Leary ME, Chahine M. Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels. American Journal of Physiology. Heart and Circulatory Physiology. 300: H288-99. PMID 21076026 DOI: 10.1152/Ajpheart.00539.2010  0.64
2010 Ziane R, Huang H, Moghadaszadeh B, Beggs AH, Levesque G, Chahine M. Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction. Biochemistry. 49: 166-78. PMID 19943616 DOI: 10.1021/Bi901086V  0.52
2010 Karnabi E, Qu Y, Wadgaonkar R, Mancarella S, Yue Y, Chahine M, Clancy RM, Buyon JP, Boutjdir M. Congenital heart block: identification of autoantibody binding site on the extracellular loop (domain I, S5-S6) of alpha(1D) L-type Ca channel. Journal of Autoimmunity. 34: 80-6. PMID 19640679 DOI: 10.1016/J.Jaut.2009.06.005  0.68
2009 Ramadan O, Qu Y, Wadgaonkar R, Baroudi G, Karnabi E, Chahine M, Boutjdir M. Phosphorylation of the consensus sites of protein kinase A on alpha1D L-type calcium channel. The Journal of Biological Chemistry. 284: 5042-9. PMID 19074150 DOI: 10.1074/Jbc.M809132200  0.68
2008 Hossain MI, Iwasaki H, Okochi Y, Chahine M, Higashijima S, Nagayama K, Okamura Y. Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish voltage-sensing phosphatases. The Journal of Biological Chemistry. 283: 18248-59. PMID 18375390 DOI: 10.1074/Jbc.M706184200  0.52
2008 Chahine M, Qu Y, Mancarella S, Boutjdir M. Protein kinase C activation inhibits α1D L-type Ca channel: A single-channel analysis Pflugers Archiv European Journal of Physiology. 455: 913-919. PMID 17909852 DOI: 10.1007/S00424-007-0342-Z  0.68
2007 Zhao J, Ziane R, Chatelier A, O'leary ME, Chahine M. Lidocaine promotes the trafficking and functional expression of Na(v)1.8 sodium channels in mammalian cells. Journal of Neurophysiology. 98: 467-77. PMID 17507497 DOI: 10.1152/Jn.00117.2007  0.64
2007 Qu Y, Karnabi E, Chahine M, Vassalle M, Boutjdir M. Expression of skeletal muscle Na(V)1.4 Na channel isoform in canine cardiac Purkinje myocytes. Biochemical and Biophysical Research Communications. 355: 28-33. PMID 17286959 DOI: 10.1016/J.Bbrc.2007.01.101  0.68
2006 Baroudi G, Qu Y, Ramadan O, Chahine M, Boutjdir M. Protein kinase C activation inhibits Cav1.3 calcium channel at NH2-terminal serine 81 phosphorylation site. American Journal of Physiology. Heart and Circulatory Physiology. 291: H1614-22. PMID 16973824 DOI: 10.1152/Ajpheart.00095.2006  0.68
2005 Chahine M, Ziane R, Vijayaragavan K, Okamura Y. Regulation of Na v channels in sensory neurons. Trends in Pharmacological Sciences. 26: 496-502. PMID 16125256 DOI: 10.1016/J.Tips.2005.08.002  0.68
2004 Chang CC, Acharfi S, Wu MH, Chiang FT, Wang JK, Sung TC, Chahine M. A novel SCN5A mutation manifests as a malignant form of long QT syndrome with perinatal onset of tachycardia/bradycardia. Cardiovascular Research. 64: 268-78. PMID 15485686 DOI: 10.1016/J.Cardiores.2004.07.007  0.64
2004 Vijayaragavan K, Powell AJ, Kinghorn IJ, Chahine M. Role of auxiliary beta1-, beta2-, and beta3-subunits and their interaction with Na(v)1.8 voltage-gated sodium channel. Biochemical and Biophysical Research Communications. 319: 531-40. PMID 15178439 DOI: 10.1016/J.Bbrc.2004.05.026  0.68
2004 Chevrier P, Vijayaragavan K, Chahine M. Differential modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by the local anesthetic lidocaine. British Journal of Pharmacology. 142: 576-84. PMID 15148257 DOI: 10.1038/Sj.Bjp.0705796  0.68
2004 Vijayaragavan K, Acharfi S, Chahine M. The C-terminal region as a modulator of rNa(v)1.7 and rNa(v)1.8 expression levels. Febs Letters. 559: 39-44. PMID 14960304 DOI: 10.1016/S0014-5793(04)00019-5  0.68
2004 Vijayaragavan K, Boutjdir M, Chahine M. Modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by protein kinase A and protein kinase C. Journal of Neurophysiology. 91: 1556-69. PMID 14657190 DOI: 10.1152/Jn.00676.2003  0.68
2003 Keller DI, Acharfi S, Delacrétaz E, Benammar N, Rotter M, Pfammatter JP, Fressart V, Guicheney P, Chahine M. A novel mutation in SCN5A, delQKP 1507-1509, causing long QT syndrome: role of Q1507 residue in sodium channel inactivation. Journal of Molecular and Cellular Cardiology. 35: 1513-21. PMID 14654377 DOI: 10.1016/J.Yjmcc.2003.08.007  0.64
2003 O'Leary ME, Digregorio M, Chahine M. Closing and inactivation potentiate the cocaethylene inhibition of cardiac sodium channels by distinct mechanisms. Molecular Pharmacology. 64: 1575-1585. PMID 14645689 DOI: 10.1124/Mol.64.6.1575  0.64
2003 Deschênes D, Acharfi S, Pouliot V, Hegele R, Krahn A, Daleau P, Chahine M. Biophysical characteristics of a new mutation on the KCNQ1 potassium channel (L251P) causing long QT syndrome. Canadian Journal of Physiology and Pharmacology. 81: 129-34. PMID 12710526 DOI: 10.1139/Y02-162  0.64
2002 Carbonneau E, Vijayaragavan K, Chahine M. A tryptophan residue (W736) in the amino-terminus of the P-segment of domain II is involved in pore formation in Na(v)1.4 voltage-gated sodium channels. PflüGers Archiv : European Journal of Physiology. 445: 18-24. PMID 12397382 DOI: 10.1007/S00424-002-0887-9  0.68
2002 O'Leary ME, Chahine M. Cocaine binds to a common site on open and inactivated human heart (Nav1.5) sodium channels The Journal of Physiology. 541: 701-716. PMID 12068034 DOI: 10.1113/Jphysiol.2001.016139  0.64
2002 Baroudi G, Acharfi S, Larouche C, Chahine M. Expression and intracellular localization of an SCN5A double mutant R1232W/T1620M implicated in Brugada syndrome. Circulation Research. 90: E11-6. PMID 11786529 DOI: 10.1161/Hh0102.102977  0.64
2001 Vijayaragavan K, O'Leary ME, Chahine M. Gating properties of Na(v)1.7 and Na(v)1.8 peripheral nerve sodium channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 7909-18. PMID 11588164 DOI: 10.1523/Jneurosci.21-20-07909.2001  0.68
2000 Baroudi G, Carbonneau E, Pouliot V, Chahine M. SCN5A mutation (T1620M) causing Brugada syndrome exhibits different phenotypes when expressed in Xenopus oocytes and mammalian cells. Febs Letters. 467: 12-16. PMID 10664447 DOI: 10.1016/S0014-5793(00)01099-1  0.56
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