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Adam L. Orr, Ph.D. - Publications

Affiliations: 
2008 Emory University, Atlanta, GA 
Area:
Neuroscience Biology
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25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Barnett D, Zimmer TS, Booraem C, Palaguachi F, Meadows SM, Xiao H, Chouchani ET, Orr AG, Orr AL. Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology. Biorxiv : the Preprint Server For Biology. PMID 39229090 DOI: 10.1101/2024.08.19.608708  0.304
2019 Orr AL, Kim C, Jimenez-Morales D, Newton BW, Johnson JR, Krogan NJ, Swaney DL, Mahley RW. Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function. Journal of Alzheimer's Disease : Jad. PMID 30883359 DOI: 10.3233/Jad-181184  0.422
2018 Wong HS, Monternier PA, Orr AL, Brand MD. Plate-Based Measurement of Superoxide and Hydrogen Peroxide Production by Isolated Mitochondria. Methods in Molecular Biology (Clifton, N.J.). 1782: 287-299. PMID 29851006 DOI: 10.1007/978-1-4939-7831-1_16  0.308
2017 Pathak D, Berthet A, Bendor JT, Yu K, Sellnow RC, Orr AL, Nguyen MK, Edwards RH, Manfredsson FP, Nakamura K. Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. Eneuro. 4. PMID 28462393 DOI: 10.1523/ENEURO.0216-16.2017  0.342
2016 Brand MD, Goncalves RL, Orr AL, Vargas L, Gerencser AA, Borch Jensen M, Wang YT, Melov S, Turk CN, Matzen JT, Dardov VJ, Petrassi HM, Meeusen SL, Perevoshchikova IV, Jasper H, et al. Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury. Cell Metabolism. PMID 27667666 DOI: 10.1016/J.Cmet.2016.08.012  0.34
2015 Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RL, Perevoshchikova IV, Petrassi HM, Meeusen SL, Ainscow EK, Brand MD. Suppressors of superoxide production from mitochondrial complex III. Nature Chemical Biology. 11: 834-6. PMID 26368590 DOI: 10.1038/Nchembio.1910  0.302
2014 Orr AL, Ashok D, Sarantos MR, Ng R, Shi T, Gerencser AA, Hughes RE, Brand MD. Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase. Plos One. 9: e89938. PMID 24587137 DOI: 10.1371/Journal.Pone.0089938  0.327
2014 Brand MD, Quinlan CL, Goncalves RL, Perevoshchikova IV, Treberg JR, Hey-Mogensen M, Gerencser AA, Orr AL. Characterization and suppression of mitochondrial production of superoxide and hydrogen peroxide under near-physiological conditions Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1837: e57. DOI: 10.1016/J.Bbabio.2014.05.224  0.319
2013 Orr AL, Ashok D, Sarantos MR, Shi T, Hughes RE, Brand MD. Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening. Free Radical Biology & Medicine. 65: 1047-59. PMID 23994103 DOI: 10.1016/J.Freeradbiomed.2013.08.170  0.341
2013 Brand MD, Orr AL, Perevoshchikova IV, Quinlan CL. The role of mitochondrial function and cellular bioenergetics in ageing and disease. The British Journal of Dermatology. 169: 1-8. PMID 23786614 DOI: 10.1111/Bjd.12208  0.385
2012 Orr AL, Quinlan CL, Perevoshchikova IV, Brand MD. A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase. The Journal of Biological Chemistry. 287: 42921-35. PMID 23124204 DOI: 10.1074/Jbc.M112.397828  0.32
2012 Pranski EL, Van Sanford CD, Dalal NV, Orr AL, Karmali D, Cooper DS, Costa N, Heilman CJ, Gearing M, Lah JJ, Levey AI, Betarbet RS. Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain. Neuroscience Letters. 520: 104-9. PMID 22634524 DOI: 10.1016/J.Neulet.2012.05.043  0.319
2012 Pranski EL, Dalal NV, Herskowitz JH, Orr AL, Roesch LA, Fritz JJ, Heilman C, Lah JJ, Levey AI, Betarbet RS. Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling. Journal of Neuroinflammation. 9: 67. PMID 22507528 DOI: 10.1186/1742-2094-9-67  0.35
2012 Quinlan CL, Perevoshchikova IV, Orr AL, Hey-Morgensen M, Brand MD. Native Rates of Mitochondrial Superoxide Production: A Novel Method Utilizing Endogenous Reporters Free Radical Biology and Medicine. 53: S27. DOI: 10.1016/J.Freeradbiomed.2012.10.069  0.31
2012 Brand M, Quinlan C, Perevoshchikova I, Orr A, Hey-Mogensen M, Treberg J. Mitochondrial superoxide production under native conditions Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1817: S96. DOI: 10.1016/J.Bbabio.2012.06.260  0.306
2011 Birket MJ, Orr AL, Gerencser AA, Madden DT, Vitelli C, Swistowski A, Brand MD, Zeng X. A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells. Journal of Cell Science. 124: 348-58. PMID 21242311 DOI: 10.1242/Jcs.072272  0.326
2011 Orr AL, Quinlan CL, Perevoshchikova IV, Brand MD. A Refined Analysis of ROS Production from Mitochondrial sn-Glycerol-3-Phosphate Dehydrogenase (mGPDH) Free Radical Biology and Medicine. 51: S137-S138. DOI: 10.1016/J.Freeradbiomed.2011.10.291  0.302
2010 Li XJ, Orr AL, Li S. Impaired mitochondrial trafficking in Huntington's disease. Biochimica Et Biophysica Acta. 1802: 62-5. PMID 19591925 DOI: 10.1016/J.Bbadis.2009.06.008  0.617
2009 Orr AG, Orr AL, Li XJ, Gross RE, Traynelis SF. Adenosine A(2A) receptor mediates microglial process retraction. Nature Neuroscience. 12: 872-8. PMID 19525944 DOI: 10.1038/Nn.2341  0.509
2008 Mastroberardino PG, Orr AL, Hu X, Na HM, Greenamyre JT. A FRET-based method to study protein thiol oxidation in histological preparations. Free Radical Biology & Medicine. 45: 971-81. PMID 18620047 DOI: 10.1016/J.Freeradbiomed.2008.06.018  0.331
2008 Wang CE, Tydlacka S, Orr AL, Yang SH, Graham RK, Hayden MR, Li S, Chan AW, Li XJ. Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Human Molecular Genetics. 17: 2738-51. PMID 18558632 DOI: 10.1093/Hmg/Ddn175  0.618
2008 Orr AL, Huang S, Roberts MA, Reed JC, Li S, Li XJ. Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice. The Journal of Biological Chemistry. 283: 16027-36. PMID 18400759 DOI: 10.1074/Jbc.M710606200  0.632
2008 Wang J, Wang CE, Orr A, Tydlacka S, Li SH, Li XJ. Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice. The Journal of Cell Biology. 180: 1177-89. PMID 18362179 DOI: 10.1083/Jcb.200709080  0.61
2008 Orr AL, Li S, Wang CE, Li H, Wang J, Rong J, Xu X, Mastroberardino PG, Greenamyre JT, Li XJ. N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2783-92. PMID 18337408 DOI: 10.1523/Jneurosci.0106-08.2008  0.766
2008 Wang J, Wang C, Orr A, Tydlacka S, Li S, Li X. Impaired ubiquitin–proteasome system activity in the synapses of Huntington's disease mice The Journal of Experimental Medicine. 205: i9-i9. DOI: 10.1084/JEM2054OIA9  0.312
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