Xiao-Jiang Li - Publications

Affiliations: 
Emory University, Atlanta, GA 
Area:
Molecular Biology, Neuroscience Biology, Genetics

115 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Liu Q, Pan Y, Li XJ, Li S. Molecular Mechanisms and Therapeutics for SCA17. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 31317427 DOI: 10.1007/s13311-019-00762-z  0.6
2019 Yan S, Li S, Li XJ. Use of large animal models to investigate Huntington's diseases. Cell Regeneration (London, England). 8: 9-11. PMID 31205683 DOI: 10.1016/j.cr.2019.01.001  0.6
2019 Ting LL, Lu HT, Yen SF, Ngo TH, Tu FY, Tsai IS, Tsai YH, Chang FY, Li XJ, Li S, Lee CK, Kao SH, Kuo YM, Lin YF. Expression of AHI1 Rescues Amyloidogenic Pathology in Alzheimer's Disease Model Cells. Molecular Neurobiology. PMID 31062249 DOI: 10.1007/s12035-019-1587-1  0.6
2019 Yang W, Li S, Li XJ. A CRISPR monkey model unravels a unique function of PINK1 in primate brains. Molecular Neurodegeneration. 14: 17. PMID 31046796 DOI: 10.1186/s13024-019-0321-9  0.6
2019 Zhu L, Chen L, Yan L, Perkins BD, Li S, Li B, Xu HA, Li XJ. Mutant Ahi1 Affects Retinal Axon Projection in Zebrafish Toxic Gain of Function. Frontiers in Cellular Neuroscience. 13: 81. PMID 30949029 DOI: 10.3389/fncel.2019.00081  0.6
2019 Yin P, Guo X, Yang W, Yan S, Yang S, Zhao T, Sun Q, Liu Y, Li S, Li XJ. Caspase-4 mediates cytoplasmic accumulation of TDP-43 in the primate brains. Acta Neuropathologica. PMID 30810811 DOI: 10.1007/s00401-019-01979-0  0.6
2019 Yang W, Liu Y, Tu Z, Xiao C, Yan S, Ma X, Guo X, Chen X, Yin P, Yang Z, Yang S, Jiang T, Li S, Qin C, Li XJ. CRISPR/Cas9-mediated PINK1 deletion leads to neurodegeneration in rhesus monkeys. Cell Research. PMID 30770867 DOI: 10.1038/s41422-019-0142-y  0.6
2019 Huang S, Zhu S, Li XJ, Li S. The Expanding Clinical Universe of Polyglutamine Disease. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 1073858418822993. PMID 30614396 DOI: 10.1177/1073858418822993  0.6
2018 Li T, Li S, Gao X, Cai Q, Li XJ. Expression and Localization of Huntingtin-Associated Protein 1 (HAP1) in the Human Digestive System. Digestive Diseases and Sciences. PMID 30560333 DOI: 10.1007/s10620-018-5425-5  0.6
2018 Yang S, Li S, Li XJ. MANF: A New Player in the Control of Energy Homeostasis, and Beyond. Frontiers in Physiology. 9: 1725. PMID 30555354 DOI: 10.3389/fphys.2018.01725  0.6
2018 Yang S, Li S, Li XJ. Shortening the Half-Life of Cas9 Maintains Its Gene Editing Ability and Reduces Neuronal Toxicity. Cell Reports. 25: 2653-2659.e3. PMID 30517854 DOI: 10.1016/j.celrep.2018.11.019  0.6
2018 Yan S, Tu Z, Liu Z, Fan N, Yang H, Yang S, Yang W, Zhao Y, Ouyang Z, Lai C, Yang H, Li L, Liu Q, Shi H, Xu G, ... ... Li XJ, et al. A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease. Cell. PMID 29606351 DOI: 10.1016/j.cell.2018.03.005  0.6
2018 Guo J, Cui Y, Liu Q, Yang Y, Li Y, Weng L, Tang B, Jin P, Li XJ, Yang S, Li S. Piperine ameliorates SCA17 neuropathology by reducing ER stress. Molecular Neurodegeneration. 13: 4. PMID 29378605 DOI: 10.1186/s13024-018-0236-x  0.6
2017 Yang S, Yang H, Chang R, Yin P, Yang Y, Yang W, Huang S, Gaertig MA, Li S, Li XJ. MANF regulates hypothalamic control of food intake and body weight. Nature Communications. 8: 579. PMID 28924165 DOI: 10.1038/s41467-017-00750-x  0.6
2017 Hong Y, Zhao T, Li XJ, Li S. Mutant huntingtin inhibits αB-crystallin expression and impairs exosome secretion from astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28893927 DOI: 10.1523/JNEUROSCI.1418-17.2017  0.6
2017 Li XJ, Tu Z, Yang W, Li S. CRISPR: Established Editor of Human Embryos? Cell Stem Cell. 21: 295-296. PMID 28886363 DOI: 10.1016/j.stem.2017.08.007  0.6
2017 Zhao T, Hong Y, Yin P, Li S, Li XJ. Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 28847953 DOI: 10.1073/pnas.1710549114  0.6
2017 Yang Y, Yang S, Guo J, Cui Y, Tang B, Li XJ, Li S. Synergistic toxicity of polyglutamine-expanded TBP in glia and neuronal cells: therapeutic implications for SCA17. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28821675 DOI: 10.1523/JNEUROSCI.0111-17.2017  0.6
2017 Yang S, Chang R, Yang H, Zhao T, Hong Y, Kong HE, Sun X, Qin Z, Jin P, Li S, Li XJ. CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington's disease. The Journal of Clinical Investigation. PMID 28628038 DOI: 10.1172/JCI92087  0.6
2017 Yan S, Tu Z, Li S, Li XJ. Use of CRISPR/Cas9 to model brain diseases. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 28392484 DOI: 10.1016/j.pnpbp.2017.04.003  0.6
2017 Tu Z, Yang W, Yan S, Yin A, Gao J, Liu X, Zheng Y, Zheng J, Li Z, Yang S, Li S, Guo X, Li XJ. Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos. Scientific Reports. 7: 42081. PMID 28155910 DOI: 10.1038/srep42081  0.6
2017 Xiang J, Yang S, Xin N, Gaertig MA, Reeves RH, Li S, Li XJ. DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. PMID 28137862 DOI: 10.1073/pnas.1614893114  0.6
2016 Yang S, Li XJ, Li S. Molecular mechanisms underlying Spinocerebellar Ataxia 17 (SCA17) pathogenesis. Rare Diseases (Austin, Tex.). 4: e1223580. PMID 28032013 DOI: 10.1080/21675511.2016.1223580  0.6
2016 Cui Y, Yang S, Li XJ, Li S. Genetically modified rodent models of SCA17. Journal of Neuroscience Research. PMID 27859490 DOI: 10.1002/jnr.23984  0.6
2016 Hong Y, Zhao T, Li XJ, Li S. Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 8790-801. PMID 27559163 DOI: 10.1523/JNEUROSCI.0168-16.2016  0.6
2016 Zhao T, Hong Y, Li S, Li XJ. Compartment-Dependent Degradation of Mutant Huntingtin Accounts for Its Preferential Accumulation in Neuronal Processes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 8317-28. PMID 27511006 DOI: 10.1523/JNEUROSCI.0806-16.2016  0.6
2016 Liu X, Wang CE, Hong Y, Zhao T, Wang G, Gaertig MA, Sun M, Li S, Li XJ. N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy. Plos Genetics. 12: e1006083. PMID 27203582 DOI: 10.1371/journal.pgen.1006083  0.6
2016 Zhao T, Hong Y, Li XJ, Li SH. Subcellular Clearance and Accumulation of Huntington Disease Protein: A Mini-Review. Frontiers in Molecular Neuroscience. 9: 27. PMID 27147961 DOI: 10.3389/fnmol.2016.00027  0.64
2016 Wang G, Liu X, Gaertig MA, Li S, Li XJ. Ablation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26951659 DOI: 10.1073/pnas.1524575113  0.6
2015 Huang S, Yang S, Guo J, Yan S, Gaertig MA, Li S, Li XJ. Large Polyglutamine Repeats Cause Muscle Degeneration in SCA17 Mice. Cell Reports. PMID 26387956 DOI: 10.1016/j.celrep.2015.08.060  0.6
2015 Wang G, Yang H, Yan S, Wang CE, Liu X, Zhao B, Ouyang Z, Yin P, Liu Z, Zhao Y, Liu T, Fan N, Guo L, Li S, Li XJ, et al. Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain. Molecular Neurodegeneration. 10: 42. PMID 26334913 DOI: 10.1186/s13024-015-0036-5  0.36
2015 Jiang W, Wei W, Gaertig MA, Li S, Li XJ. Therapeutic Effect of Berberine on Huntington's Disease Transgenic Mouse Model. Plos One. 10: e0134142. PMID 26225560 DOI: 10.1371/journal.pone.0134142  0.6
2015 Yang W, Wang G, Wang CE, Guo X, Yin P, Gao J, Tu Z, Wang Z, Wu J, Hu X, Li S, Li XJ. Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8345-58. PMID 26019347 DOI: 10.1523/JNEUROSCI.0772-15.2015  0.36
2015 Chang R, Liu X, Li S, Li XJ. Transgenic animal models for study of the pathogenesis of Huntington's disease and therapy. Drug Design, Development and Therapy. 9: 2179-88. PMID 25931812 DOI: 10.2147/DDDT.S58470  0.6
2015 Xiang J, Yan S, Li SH, Li XJ. Postnatal loss of hap1 reduces hippocampal neurogenesis and causes adult depressive-like behavior in mice. Plos Genetics. 11: e1005175. PMID 25875952 DOI: 10.1371/journal.pgen.1005175  0.64
2015 Chen Y, Zheng Y, Kang Y, Yang W, Niu Y, Guo X, Tu Z, Si C, Wang H, Xing R, Pu X, Yang SH, Li S, Ji W, Li XJ. Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9. Human Molecular Genetics. 24: 3764-74. PMID 25859012 DOI: 10.1093/hmg/ddv120  0.6
2015 Huang B, Wei W, Wang G, Gaertig MA, Feng Y, Wang W, Li XJ, Li S. Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes. Neuron. 85: 1212-26. PMID 25789755 DOI: 10.1016/j.neuron.2015.02.026  0.6
2015 Niu Y, Guo X, Chen Y, Wang CE, Gao J, Yang W, Kang Y, Si W, Wang H, Yang SH, Li S, Ji W, Li XJ. Early Parkinson's disease symptoms in α-synuclein transgenic monkeys. Human Molecular Genetics. 24: 2308-17. PMID 25552648 DOI: 10.1093/hmg/ddu748  0.36
2015 Yin P, Tu Z, Yin A, Zhao T, Yan S, Guo X, Chang R, Zhang L, Hong Y, Huang X, Zhou J, Wang Y, Li S, Li XJ. Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin. Human Molecular Genetics. 24: 1350-62. PMID 25343992 DOI: 10.1093/hmg/ddu544  0.36
2015 Li XJ, Li S. Large Animal Models of Huntington's Disease. Current Topics in Behavioral Neurosciences. 22: 149-60. PMID 24048953 DOI: 10.1007/7854_2013_246  0.6
2014 Wade BE, Wang CE, Yan S, Bhat K, Huang B, Li S, Li XJ. Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8411-22. PMID 24948797 DOI: 10.1523/JNEUROSCI.0775-14.2014  0.36
2014 Bhat KP, Yan S, Wang CE, Li S, Li XJ. Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A. Proceedings of the National Academy of Sciences of the United States of America. 111: 5706-11. PMID 24706802 DOI: 10.1073/pnas.1402215111  0.36
2014 Yang H, Wang G, Sun H, Shu R, Liu T, Wang CE, Liu Z, Zhao Y, Zhao B, Ouyang Z, Yang D, Huang J, Zhou Y, Li S, Jiang X, ... ... Li XJ, et al. Species-dependent neuropathology in transgenic SOD1 pigs. Cell Research. 24: 464-81. PMID 24577199 DOI: 10.1038/cr.2014.25  0.6
2014 Yang S, Huang S, Gaertig MA, Li XJ, Li S. Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice. Neuron. 81: 349-65. PMID 24462098 DOI: 10.1016/j.neuron.2013.12.002  0.6
2014 Yan S, Wang CE, Wei W, Gaertig MA, Lai L, Li S, Li XJ. TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain. Human Molecular Genetics. 23: 2678-93. PMID 24381309 DOI: 10.1093/hmg/ddt662  0.36
2014 Xiang J, Yang H, Zhao T, Sun M, Xu X, Zhou XF, Li SH, Li XJ. Huntingtin-associated protein 1 regulates postnatal neurogenesis and neurotrophin receptor sorting. The Journal of Clinical Investigation. 124: 85-98. PMID 24355921 DOI: 10.1172/JCI69206  0.64
2013 Xu Q, Huang S, Song M, Wang CE, Yan S, Liu X, Gaertig MA, Yu SP, Li H, Li S, Li XJ. Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms. The Journal of Cell Biology. 202: 1123-38. PMID 24081492 DOI: 10.1083/jcb.201303146  0.6
2013 Kocerha J, Liu Y, Willoughby D, Chidamparam K, Benito J, Nelson K, Xu Y, Chi T, Engelhardt H, Moran S, Yang SH, Li SH, Li XJ, Larkin K, Neumann A, et al. Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington's disease monkeys. Bmc Neuroscience. 14: 88. PMID 23957861 DOI: 10.1186/1471-2202-14-88  0.64
2013 Weng L, Lin YF, Li AL, Wang CE, Yan S, Sun M, Gaertig MA, Mitha N, Kosaka J, Wakabayashi T, Xu X, Tang B, Li S, Li XJ. Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 8172-84. PMID 23658157 DOI: 10.1523/JNEUROSCI.0119-13.2013  0.6
2012 Li XJ, Li S. Influence of species differences on the neuropathology of transgenic Huntington's disease animal models. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 39: 239-45. PMID 22749010 DOI: 10.1016/j.jgg.2012.05.002  0.6
2012 Li S, Li XJ. A huntingtin-HAP1-PCM1 pathway in ciliogenesis. Expert Review of Proteomics. 9: 17-9. PMID 22292820 DOI: 10.1586/epr.11.72  0.6
2012 Wang H, Huang Z, Huang L, Niu S, Rao X, Xu J, Kong H, Yang J, Yang C, Wu D, Li S, Li XJ, Liu T, Sheng G. Hypothalamic Ahi1 mediates feeding behavior through interaction with 5-HT2C receptor. The Journal of Biological Chemistry. 287: 2237-46. PMID 22123816 DOI: 10.1074/jbc.M111.277871  0.6
2012 Cape A, Chen X, Wang CE, O'Neill A, Lin YF, He J, Xu XS, Yi H, Li H, Li S, Li XJ. Loss of huntingtin-associated protein 1 impairs insulin secretion from pancreatic β-cells. Cellular and Molecular Life Sciences : Cmls. 69: 1305-17. PMID 21544547 DOI: 10.1007/s00018-011-0692-8  0.6
2011 Mandal M, Wei J, Zhong P, Cheng J, Duffney LJ, Liu W, Yuen EY, Twelvetrees AE, Li S, Li XJ, Kittler JT, Yan Z. Impaired alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking and function by mutant huntingtin. The Journal of Biological Chemistry. 286: 33719-28. PMID 21832090 DOI: 10.1074/jbc.M111.236521  0.36
2011 Huang S, Ling JJ, Yang S, Li XJ, Li S. Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor. Brain : a Journal of Neurology. 134: 1943-58. PMID 21705419 DOI: 10.1093/brain/awr146  0.6
2011 Havel LS, Wang CE, Wade B, Huang B, Li S, Li XJ. Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation. Human Molecular Genetics. 20: 1424-37. PMID 21245084 DOI: 10.1093/hmg/ddr023  0.36
2011 Li XJ, Li S. Proteasomal dysfunction in aging and Huntington disease. Neurobiology of Disease. 43: 4-8. PMID 21145396 DOI: 10.1016/j.nbd.2010.11.018  0.6
2010 Wang CE, Li S, Li XJ. Lack of interleukin-1 type 1 receptor enhances the accumulation of mutant huntingtin in the striatum and exacerbates the neurological phenotypes of Huntington's disease mice. Molecular Brain. 3: 33. PMID 21044321 DOI: 10.1186/1756-6606-3-33  0.36
2010 Xu X, Yang H, Lin YF, Li X, Cape A, Ressler KJ, Li S, Li XJ. Neuronal Abelson helper integration site-1 (Ahi1) deficiency in mice alters TrkB signaling with a depressive phenotype. Proceedings of the National Academy of Sciences of the United States of America. 107: 19126-31. PMID 20956301 DOI: 10.1073/pnas.1013032107  0.6
2010 Yang D, Wang CE, Zhao B, Li W, Ouyang Z, Liu Z, Yang H, Fan P, O'Neill A, Gu W, Yi H, Li S, Lai L, Li XJ. Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs. Human Molecular Genetics. 19: 3983-94. PMID 20660116 DOI: 10.1093/hmg/ddq313  0.6
2010 Li XJ, Li H, Li S. Clearance of mutant huntingtin. Autophagy. 6: 663-4. PMID 20519964 DOI: 10.1093/hmg/ddq127  0.6
2010 Li X, Wang CE, Huang S, Xu X, Li XJ, Li H, Li S. Inhibiting the ubiquitin-proteasome system leads to preferential accumulation of toxic N-terminal mutant huntingtin fragments. Human Molecular Genetics. 19: 2445-55. PMID 20354076 DOI: 10.1093/hmg/ddq127  0.6
2010 Lin YF, Xu X, Cape A, Li S, Li XJ. Huntingtin-associated protein-1 deficiency in orexin-producing neurons impairs neuronal process extension and leads to abnormal behavior in mice. The Journal of Biological Chemistry. 285: 15941-9. PMID 20304926 DOI: 10.1074/jbc.M110.107318  0.6
2010 Bradford JW, Li S, Li XJ. Polyglutamine toxicity in non-neuronal cells. Cell Research. 20: 400-7. PMID 20231860 DOI: 10.1038/cr.2010.32  0.36
2010 Bradford J, Shin JY, Roberts M, Wang CE, Sheng G, Li S, Li XJ. Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease mice. The Journal of Biological Chemistry. 285: 10653-61. PMID 20145253 DOI: 10.1074/jbc.M109.083287  0.36
2010 Wu LL, Fan Y, Li S, Li XJ, Zhou XF. Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release. The Journal of Biological Chemistry. 285: 5614-23. PMID 19996106 DOI: 10.1074/jbc.M109.073197  0.6
2010 Li XJ, Orr AL, Li S. Impaired mitochondrial trafficking in Huntington's disease. Biochimica Et Biophysica Acta. 1802: 62-5. PMID 19591925 DOI: 10.1016/j.bbadis.2009.06.008  0.6
2009 Bradford J, Shin JY, Roberts M, Wang CE, Li XJ, Li S. Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms. Proceedings of the National Academy of Sciences of the United States of America. 106: 22480-5. PMID 20018729 DOI: 10.1073/pnas.0911503106  0.36
2009 Friedman MJ, Li S, Li XJ. Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protection. The Journal of Biological Chemistry. 284: 27944-51. PMID 19656944 DOI: 10.1074/jbc.M109.037937  0.6
2009 Shah AG, Friedman MJ, Huang S, Roberts M, Li XJ, Li S. Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17. Human Molecular Genetics. 18: 4141-52. PMID 19643914 DOI: 10.1093/hmg/ddp363  0.6
2009 Havel LS, Li S, Li XJ. Nuclear accumulation of polyglutamine disease proteins and neuropathology. Molecular Brain. 2: 21. PMID 19575804 DOI: 10.1186/1756-6606-2-21  0.6
2009 Orr AG, Orr AL, Li XJ, Gross RE, Traynelis SF. Adenosine A(2A) receptor mediates microglial process retraction. Nature Neuroscience. 12: 872-8. PMID 19525944 DOI: 10.1038/nn.2341  0.52
2008 Tydlacka S, Wang CE, Wang X, Li S, Li XJ. Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13285-95. PMID 19052220 DOI: 10.1523/JNEUROSCI.4393-08.2008  0.36
2008 Sheng G, Xu X, Lin YF, Wang CE, Rong J, Cheng D, Peng J, Jiang X, Li SH, Li XJ. Huntingtin-associated protein 1 interacts with Ahi1 to regulate cerebellar and brainstem development in mice. The Journal of Clinical Investigation. 118: 2785-95. PMID 18636121 DOI: 10.1172/JCI35339  0.64
2008 Wang CE, Tydlacka S, Orr AL, Yang SH, Graham RK, Hayden MR, Li S, Chan AW, Li XJ. Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease. Human Molecular Genetics. 17: 2738-51. PMID 18558632 DOI: 10.1093/hmg/ddn175  0.6
2008 Gray M, Shirasaki DI, Cepeda C, André VM, Wilburn B, Lu XH, Tao J, Yamazaki I, Li SH, Sun YE, Li XJ, Levine MS, Yang XW. Full-length human mutant huntingtin with a stable polyglutamine repeat can elicit progressive and selective neuropathogenesis in BACHD mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6182-95. PMID 18550760 DOI: 10.1523/JNEUROSCI.0857-08.2008  0.36
2008 Wang CE, Zhou H, McGuire JR, Cerullo V, Lee B, Li SH, Li XJ. Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtin. The Journal of Cell Biology. 181: 803-16. PMID 18504298 DOI: 10.1083/jcb.200710158  0.64
2008 Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC, Snyder B, Larkin K, Liu J, Orkin J, Fang ZH, Smith Y, Bachevalier J, Zola SM, Li SH, ... Li XJ, et al. Towards a transgenic model of Huntington's disease in a non-human primate. Nature. 453: 921-4. PMID 18488016 DOI: 10.1038/nature06975  0.36
2008 Orr AL, Huang S, Roberts MA, Reed JC, Li S, Li XJ. Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice. The Journal of Biological Chemistry. 283: 16027-36. PMID 18400759 DOI: 10.1074/jbc.M710606200  0.36
2008 Wang J, Wang CE, Orr A, Tydlacka S, Li SH, Li XJ. Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice. The Journal of Cell Biology. 180: 1177-89. PMID 18362179 DOI: 10.1083/jcb.200709080  0.36
2008 Orr AL, Li S, Wang CE, Li H, Wang J, Rong J, Xu X, Mastroberardino PG, Greenamyre JT, Li XJ. N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2783-92. PMID 18337408 DOI: 10.1523/JNEUROSCI.0106-08.2008  0.36
2008 Friedman MJ, Wang CE, Li XJ, Li S. Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity. The Journal of Biological Chemistry. 283: 8283-90. PMID 18218637 DOI: 10.1074/jbc.M709674200  0.36
2008 Metzger S, Rong J, Nguyen HP, Cape A, Tomiuk J, Soehn AS, Propping P, Freudenberg-Hua Y, Freudenberg J, Tong L, Li SH, Li XJ, Riess O. Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease. Human Molecular Genetics. 17: 1137-46. PMID 18192679 DOI: 10.1093/hmg/ddn003  0.64
2007 Friedman MJ, Shah AG, Fang ZH, Ward EG, Warren ST, Li S, Li XJ. Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. Nature Neuroscience. 10: 1519-28. PMID 17994014 DOI: 10.1038/nn2011  0.36
2007 Li XJ, Friedman M, Li S. Interacting proteins as genetic modifiers of Huntington disease. Trends in Genetics : Tig. 23: 531-3. PMID 17961788 DOI: 10.1016/j.tig.2007.07.007  0.6
2007 Palfi S, Brouillet E, Jarraya B, Bloch J, Jan C, Shin M, Condé F, Li XJ, Aebischer P, Hantraye P, Déglon N. Expression of mutated huntingtin fragment in the putamen is sufficient to produce abnormal movement in non-human primates. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1444-51. PMID 17505477 DOI: 10.1038/sj.mt.6300185  0.36
2007 Rong J, Li SH, Li XJ. Regulation of intracellular HAP1 trafficking. Journal of Neuroscience Research. 85: 3025-9. PMID 17474105 DOI: 10.1002/jnr.21326  0.64
2007 Gu X, André VM, Cepeda C, Li SH, Li XJ, Levine MS, Yang XW. Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease. Molecular Neurodegeneration. 2: 8. PMID 17470275 DOI: 10.1186/1750-1326-2-8  0.64
2007 Rong J, Li S, Sheng G, Wu M, Coblitz B, Li M, Fu H, Li XJ. 14-3-3 protein interacts with Huntingtin-associated protein 1 and regulates its trafficking. The Journal of Biological Chemistry. 282: 4748-56. PMID 17166838 DOI: 10.1074/jbc.M609057200  0.36
2006 Bi GQ, Bolshakov V, Bu G, Cahill CM, Chen ZF, Collingridge GL, Cooper RL, Coorssen JR, El-Husseini A, Galhardo V, Gan WB, Gu J, Inoue K, Isaac J, Iwata K, ... ... Li XJ, et al. Recent advances in basic neurosciences and brain disease: from synapses to behavior. Molecular Pain. 2: 38. PMID 17196111 DOI: 10.1186/1744-8069-2-38  0.36
2006 Li S, Li XJ. Multiple pathways contribute to the pathogenesis of Huntington disease. Molecular Neurodegeneration. 1: 19. PMID 17173700 DOI: 10.1186/1750-1326-1-19  0.6
2006 Cornett J, Smith L, Friedman M, Shin JY, Li XJ, Li SH. Context-dependent dysregulation of transcription by mutant huntingtin. The Journal of Biological Chemistry. 281: 36198-204. PMID 17012230 DOI: 10.1074/jbc.M607839200  0.36
2006 Rong J, McGuire JR, Fang ZH, Sheng G, Shin JY, Li SH, Li XJ. Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6019-30. PMID 16738245 DOI: 10.1523/JNEUROSCI.1251-06.2006  0.64
2006 Sheng G, Chang GQ, Lin JY, Yu ZX, Fang ZH, Rong J, Lipton SA, Li SH, Tong G, Leibowitz SF, Li XJ. Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nature Medicine. 12: 526-33. PMID 16604089 DOI: 10.1038/nm1382  0.36
2006 Bae BI, Hara MR, Cascio MB, Wellington CL, Hayden MR, Ross CA, Ha HC, Li XJ, Snyder SH, Sawa A. Mutant huntingtin: nuclear translocation and cytotoxicity mediated by GAPDH. Proceedings of the National Academy of Sciences of the United States of America. 103: 3405-9. PMID 16492755 DOI: 10.1073/pnas.0511316103  0.36
2006 McGuire JR, Rong J, Li SH, Li XJ. Interaction of Huntingtin-associated protein-1 with kinesin light chain: implications in intracellular trafficking in neurons. The Journal of Biological Chemistry. 281: 3552-9. PMID 16339760 DOI: 10.1074/jbc.M509806200  0.64
2005 Shin JY, Fang ZH, Yu ZX, Wang CE, Li SH, Li XJ. Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity. The Journal of Cell Biology. 171: 1001-12. PMID 16365166 DOI: 10.1083/jcb.200508072  0.64
2005 Benn CL, Landles C, Li H, Strand AD, Woodman B, Sathasivam K, Li SH, Ghazi-Noori S, Hockly E, Faruque SM, Cha JH, Sharpe PT, Olson JM, Li XJ, Bates GP. Contribution of nuclear and extranuclear polyQ to neurological phenotypes in mouse models of Huntington's disease. Human Molecular Genetics. 14: 3065-78. PMID 16183657 DOI: 10.1093/hmg/ddi340  0.36
2005 Liao M, Shen J, Zhang Y, Li SH, Li XJ, Li H. Immunohistochemical localization of huntingtin-associated protein 1 in endocrine system of the rat. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 1517-24. PMID 16087704 DOI: 10.1369/jhc.5A6662.2005  0.64
2005 Gu X, Li C, Wei W, Lo V, Gong S, Li SH, Iwasato T, Itohara S, Li XJ, Mody I, Heintz N, Yang XW. Pathological cell-cell interactions elicited by a neuropathogenic form of mutant Huntingtin contribute to cortical pathogenesis in HD mice. Neuron. 46: 433-44. PMID 15882643 DOI: 10.1016/j.neuron.2005.03.025  0.36
2005 Cornett J, Cao F, Wang CE, Ross CA, Bates GP, Li SH, Li XJ. Polyglutamine expansion of huntingtin impairs its nuclear export. Nature Genetics. 37: 198-204. PMID 15654337 DOI: 10.1038/ng1503  0.36
2005 Li XJ, Li SH. HAP1 and intracellular trafficking. Trends in Pharmacological Sciences. 26: 1-3. PMID 15629196 DOI: 10.1016/j.tips.2004.11.001  0.64
2004 Li SH, Li XJ. Huntingtin and its role in neuronal degeneration. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 10: 467-75. PMID 15359012 DOI: 10.1177/1073858404266777  0.64
2004 Li SH, Li XJ. Huntingtin-protein interactions and the pathogenesis of Huntington's disease. Trends in Genetics : Tig. 20: 146-54. PMID 15036808 DOI: 10.1016/j.tig.2004.01.008  0.64
2003 Zhou H, Cao F, Wang Z, Yu ZX, Nguyen HP, Evans J, Li SH, Li XJ. Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity. The Journal of Cell Biology. 163: 109-18. PMID 14557250 DOI: 10.1083/jcb.200306038  0.64
2003 Li H, Wyman T, Yu ZX, Li SH, Li XJ. Abnormal association of mutant huntingtin with synaptic vesicles inhibits glutamate release. Human Molecular Genetics. 12: 2021-30. PMID 12913073  0.64
2003 Li SH, Yu ZX, Li CL, Nguyen HP, Zhou YX, Deng C, Li XJ. Lack of huntingtin-associated protein-1 causes neuronal death resembling hypothalamic degeneration in Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 6956-64. PMID 12890790  0.64
2003 Slow EJ, van Raamsdonk J, Rogers D, Coleman SH, Graham RK, Deng Y, Oh R, Bissada N, Hossain SM, Yang YZ, Li XJ, Simpson EM, Gutekunst CA, Leavitt BR, Hayden MR. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease. Human Molecular Genetics. 12: 1555-67. PMID 12812983 DOI: 10.1093/hmg/ddg169  0.36
2003 Yu ZX, Li SH, Evans J, Pillarisetti A, Li H, Li XJ. Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 2193-202. PMID 12657678  0.36
2003 von Hörsten S, Schmitt I, Nguyen HP, Holzmann C, Schmidt T, Walther T, Bader M, Pabst R, Kobbe P, Krotova J, Stiller D, Kask A, Vaarmann A, Rathke-Hartlieb S, Schulz JB, ... ... Li XJ, et al. Transgenic rat model of Huntington's disease. Human Molecular Genetics. 12: 617-24. PMID 12620967 DOI: 10.1093/hmg/12.6.617  0.36
2003 Li SH, Li XJ. In vitro expression systems for the Huntington protein. Methods in Molecular Biology (Clifton, N.J.). 217: 277-84. PMID 12491940  0.64
2002 Menalled LB, Sison JD, Wu Y, Olivieri M, Li XJ, Li H, Zeitlin S, Chesselet MF. Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8266-76. PMID 12223581  0.36
2002 Yu ZX, Li SH, Nguyen HP, Li XJ. Huntingtin inclusions do not deplete polyglutamine-containing transcription factors in HD mice. Human Molecular Genetics. 11: 905-14. PMID 11971872  0.64
2002 Chuang JZ, Zhou H, Zhu M, Li SH, Li XJ, Sung CH. Characterization of a brain-enriched chaperone, MRJ, that inhibits Huntingtin aggregation and toxicity independently. The Journal of Biological Chemistry. 277: 19831-8. PMID 11896048 DOI: 10.1074/jbc.M109613200  0.64
2002 Li SH, Cheng AL, Zhou H, Lam S, Rao M, Li H, Li XJ. Interaction of Huntington disease protein with transcriptional activator Sp1. Molecular and Cellular Biology. 22: 1277-87. PMID 11839795  0.64
Show low-probability matches.