Marc R. Freeman, Ph.D. - Publications

Neurobiology University of Massachusetts Medical School, Worcester, MA, United States 
 Oregon Health and Science University, Portland, OR 
Glia neurobiology and neurodegeneration

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Ackerman SD, Perez-Catalan NA, Freeman MR, Doe CQ. Astrocytes close a motor circuit critical period. Nature. PMID 33828296 DOI: 10.1038/s41586-021-03441-2  1
2019 Freeman M. Decision letter: Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1 Elife. DOI: 10.7554/Elife.44667.018  0.92
2016 He J, Zhou R, Wu Z, Carrasco MA, Kurshan PT, Farley JE, Simon DJ, Wang G, Han B, Hao J, Heller E, Freeman MR, Shen K, Maniatis T, Tessier-Lavigne M, et al. Prevalent presence of periodic actin-spectrin-based membrane skeleton in a broad range of neuronal cell types and animal species. Proceedings of the National Academy of Sciences of the United States of America. PMID 27162329 DOI: 10.1073/Pnas.1605707113  1
2016 Francis MM, Freeman MR. Dendrites actively restrain axon outgrowth and regeneration. Proceedings of the National Academy of Sciences of the United States of America. PMID 27147603 DOI: 10.1073/Pnas.1605215113  1
2016 Henninger N, Bouley J, Sikoglu EM, An J, Moore CM, King JA, Bowser R, Freeman MR, Brown RH. Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1. Brain : a Journal of Neurology. PMID 26912636 DOI: 10.1093/Brain/Aww001  1
2015 Farley JE, Freeman MR. Letting Go of JuNK by Disassembly of Adhesive Complexes. Neuron. 88: 848-50. PMID 26637791 DOI: 10.1016/J.Neuron.2015.11.015  1
2015 Gururajan M, Cavassani KA, Sievert M, Duan P, Lichterman J, Huang JM, Smith B, You S, Nandana S, Chu GC, Mink S, Josson S, Liu C, Morello M, Jones LW, ... ... Freeman MR, et al. SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer. Oncotarget. PMID 26624980 DOI: 10.18632/Oncotarget.6398  0.68
2015 Jeong P, Ha YS, Yun SJ, Yoon HY, Freeman MR, Kim J, Kim WJ. Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis. Bmc Urology. 15: 80. PMID 26250800 DOI: 10.1186/s12894-015-0074-x  0.84
2015 Sreedharan J, Neukomm LJ, Brown RH, Freeman MR. Age-Dependent TDP-43-Mediated Motor Neuron Degeneration Requires GSK3, hat-trick, and xmas-2. Current Biology : Cb. PMID 26234214 DOI: 10.1016/J.Cub.2015.06.045  1
2015 Morley S, You S, Pollan S, Choi J, Zhou B, Hager MH, Steadman K, Spinelli C, Rajendran K, Gertych A, Kim J, Adam RM, Yang W, Krishnan R, Knudsen BS, ... ... Freeman MR, et al. Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes. Scientific Reports. 5: 12136. PMID 26179371 DOI: 10.1038/srep12136  0.32
2015 Freeman MR. Drosophila Central Nervous System Glia. Cold Spring Harbor Perspectives in Biology. PMID 25722465 DOI: 10.1101/Cshperspect.A020552  1
2015 Wen H, Lee T, You S, Park SH, Song H, Eilber KS, Anger JT, Freeman MR, Park S, Kim J. Urinary metabolite profiling combined with computational analysis predicts interstitial cystitis-associated candidate biomarkers. Journal of Proteome Research. 14: 541-8. PMID 25353990 DOI: 10.1021/pr5007729  0.84
2015 Jeong P, Ha YS, Yun SJ, Yoon HY, Freeman MR, Kim J, Kim WJ. Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis Bmc Urology. 15. DOI: 10.1186/s12894-015-0074-x  0.32
2014 Doherty J, Sheehan AE, Bradshaw R, Fox AN, Lu TY, Freeman MR. PI3K signaling and Stat92E converge to modulate glial responsiveness to axonal injury. Plos Biology. 12: e1001985. PMID 25369313 DOI: 10.1371/Journal.Pbio.1001985  1
2014 Muthukumar AK, Stork T, Freeman MR. Activity-dependent regulation of astrocyte GAT levels during synaptogenesis. Nature Neuroscience. 17: 1340-50. PMID 25151265 DOI: 10.1038/Nn.3791  1
2014 Lu TY, Doherty J, Freeman MR. DRK/DOS/SOS converge with Crk/Mbc/dCed-12 to activate Rac1 during glial engulfment of axonal debris. Proceedings of the National Academy of Sciences of the United States of America. 111: 12544-9. PMID 25099352 DOI: 10.1073/Pnas.1403450111  1
2014 Yang W, Ramachandran A, You S, Jeong H, Morley S, Mulone MD, Logvinenko T, Kim J, Hwang D, Freeman MR, Adam RM. Integration of proteomic and transcriptomic profiles identifies a novel PDGF-MYC network in human smooth muscle cells. Cell Communication and Signaling : Ccs. 12: 44. PMID 25080971 DOI: 10.1186/s12964-014-0044-z  0.32
2014 Burdett TC, Freeman MR. Neuroscience. Astrocytes eyeball axonal mitochondria. Science (New York, N.Y.). 345: 385-6. PMID 25061193 DOI: 10.1126/Science.1258295  1
2014 Stork T, Sheehan A, Tasdemir-Yilmaz OE, Freeman MR. Neuron-glia interactions through the Heartless FGF receptor signaling pathway mediate morphogenesis of Drosophila astrocytes. Neuron. 83: 388-403. PMID 25033182 DOI: 10.1016/J.Neuron.2014.06.026  1
2014 Neukomm LJ, Burdett TC, Gonzalez MA, Züchner S, Freeman MR. Rapid in vivo forward genetic approach for identifying axon death genes in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 111: 9965-70. PMID 24958874 DOI: 10.1073/Pnas.1406230111  1
2014 Freeman MR. Signaling mechanisms regulating Wallerian degeneration. Current Opinion in Neurobiology. 27: 224-31. PMID 24907513 DOI: 10.1016/J.Conb.2014.05.001  1
2014 Neukomm LJ, Freeman MR. Diverse cellular and molecular modes of axon degeneration. Trends in Cell Biology. 24: 515-23. PMID 24780172 DOI: 10.1016/J.Tcb.2014.04.003  1
2014 Rooney TM, Freeman MR. Drosophila models of neuronal injury. Ilar Journal / National Research Council, Institute of Laboratory Animal Resources. 54: 291-5. PMID 24615442 DOI: 10.1093/Ilar/Ilt057  1
2014 Kerr KS, Fuentes-Medel Y, Brewer C, Barria R, Ashley J, Abruzzi KC, Sheehan A, Tasdemir-Yilmaz OE, Freeman MR, Budnik V. Glial wingless/Wnt regulates glutamate receptor clustering and synaptic physiology at the Drosophila neuromuscular junction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 2910-20. PMID 24553932 DOI: 10.1523/Jneurosci.3714-13.2014  1
2014 Chu GC, Zhau HE, Wang R, Rogatko A, Feng X, Zayzafoon M, Liu Y, Farach-Carson MC, You S, Kim J, Freeman MR, Chung LW. RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization. Endocrine-Related Cancer. 21: 311-26. PMID 24478054 DOI: 10.1530/Erc-13-0548  0.68
2014 Tasdemir-Yilmaz OE, Freeman MR. Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons. Genes & Development. 28: 20-33. PMID 24361692 DOI: 10.1101/Gad.229518.113  1
2013 Corty MM, Freeman MR. Cell biology in neuroscience: Architects in neural circuit design: glia control neuron numbers and connectivity. The Journal of Cell Biology. 203: 395-405. PMID 24217617 DOI: 10.1083/Jcb.201306099  1
2013 Freeman MR, Rowitch DH. Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years. Neuron. 80: 613-23. PMID 24183014 DOI: 10.1016/J.Neuron.2013.10.034  1
2013 Milde S, Fox AN, Freeman MR, Coleman MP. Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo. Scientific Reports. 3: 2567. PMID 23995269 DOI: 10.1038/Srep02567  1
2013 Coutinho-Budd J, Freeman MR. Probing the enigma: unraveling glial cell biology in invertebrates. Current Opinion in Neurobiology. 23: 1073-9. PMID 23896311 DOI: 10.1016/J.Conb.2013.07.002  1
2013 Macdonald JM, Doherty J, Hackett R, Freeman MR. The c-Jun kinase signaling cascade promotes glial engulfment activity through activation of draper and phagocytic function. Cell Death and Differentiation. 20: 1140-8. PMID 23618811 DOI: 10.1038/Cdd.2013.30  1
2013 Stork T, Freeman MR. Invertebrate Glia Comprehensive Developmental Neuroscience: Patterning and Cell Type Specification in the Developing Cns and Pns. 891-910. DOI: 10.1016/B978-0-12-397265-1.00090-3  1
2012 Gonzalez MA, Van Booven D, Hulme W, Ulloa RH, Lebrigio RF, Osterloh J, Logan M, Freeman M, Zuchner S. Whole Genome Sequencing and a New Bioinformatics Platform Allow for Rapid Gene Identification in D. melanogaster EMS Screens. Biology. 1: 766-77. PMID 24832518 DOI: 10.3390/Biology1030766  1
2012 Fuentes-Medel Y, Ashley J, Barria R, Maloney R, Freeman M, Budnik V. Integration of a retrograde signal during synapse formation by glia-secreted TGF-β ligand. Current Biology : Cb. 22: 1831-8. PMID 22959350 DOI: 10.1016/J.Cub.2012.07.063  1
2012 Wishart TM, Rooney TM, Lamont DJ, Wright AK, Morton AJ, Jackson M, Freeman MR, Gillingwater TH. Combining comparative proteomics and molecular genetics uncovers regulators of synaptic and axonal stability and degeneration in vivo. Plos Genetics. 8: e1002936. PMID 22952455 DOI: 10.1371/Journal.Pgen.1002936  1
2012 Ziegenfuss JS, Doherty J, Freeman MR. Distinct molecular pathways mediate glial activation and engulfment of axonal debris after axotomy. Nature Neuroscience. 15: 979-87. PMID 22706267 DOI: 10.1038/Nn.3135  1
2012 Osterloh JM, Yang J, Rooney TM, Fox AN, Adalbert R, Powell EH, Sheehan AE, Avery MA, Hackett R, Logan MA, MacDonald JM, Ziegenfuss JS, Milde S, Hou YJ, Nathan C, ... ... Freeman MR, et al. dSarm/Sarm1 is required for activation of an injury-induced axon death pathway. Science (New York, N.Y.). 337: 481-4. PMID 22678360 DOI: 10.1126/Science.1223899  1
2012 Logan MA, Hackett R, Doherty J, Sheehan A, Speese SD, Freeman MR. Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury. Nature Neuroscience. 15: 722-30. PMID 22426252 DOI: 10.1038/Nn.3066  1
2012 Avery MA, Rooney TM, Pandya JD, Wishart TM, Gillingwater TH, Geddes JW, Sullivan PG, Freeman MR. WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering. Current Biology : Cb. 22: 596-600. PMID 22425157 DOI: 10.1016/J.Cub.2012.02.043  1
2012 Stork T, Bernardos R, Freeman MR. Analysis of glial cell development and function in Drosophila. Cold Spring Harbor Protocols. 2012: 1-17. PMID 22194269 DOI: 10.1101/Pdb.Top067587  1
2011 Featherstone D, Freeman M. Introduction Glia. 59: 1213-1214. PMID 21732422 DOI: 10.1002/Glia.21197  1
2010 Freeman MR. Specification and morphogenesis of astrocytes. Science (New York, N.Y.). 330: 774-8. PMID 21051628 DOI: 10.1126/Science.1190928  1
2010 McPhee CK, Logan MA, Freeman MR, Baehrecke EH. Activation of autophagy during cell death requires the engulfment receptor Draper. Nature. 465: 1093-6. PMID 20577216 DOI: 10.1038/Nature09127  1
2010 Coleman MP, Freeman MR. Wallerian degeneration, wld(s), and nmnat. Annual Review of Neuroscience. 33: 245-67. PMID 20345246 DOI: 10.1146/Annurev-Neuro-060909-153248  1
2009 Osterloh JM, Freeman MR. Neuronal death or dismemberment mediated by Sox14. Nature Neuroscience. 12: 1479-80. PMID 19935724 DOI: 10.1038/Nn1209-1479  1
2009 Fuentes-Medel Y, Logan MA, Ashley J, Ataman B, Budnik V, Freeman MR. Glia and muscle sculpt neuromuscular arbors by engulfing destabilized synaptic boutons and shed presynaptic debris. Plos Biology. 7: e1000184. PMID 19707574 DOI: 10.1371/Journal.Pbio.1000184  1
2009 Freeman M. Marc Freeman: fishing for the function of fly glia. Interview by Ruth Williams. The Journal of Cell Biology. 186: 302-3. PMID 19667123 DOI: 10.1083/jcb.1863pi  0.36
2009 Doherty J, Logan MA, Ta?demir OE, Freeman MR. Ensheathing glia function as phagocytes in the adult Drosophila brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4768-81. PMID 19369546 DOI: 10.1523/Jneurosci.5951-08.2009  1
2009 Avery MA, Sheehan AE, Kerr KS, Wang J, Freeman MR. Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration. The Journal of Cell Biology. 184: 501-13. PMID 19237597 DOI: 10.1083/Jcb.200808042  1
2008 Ziegenfuss JS, Biswas R, Avery MA, Hong K, Sheehan AE, Yeung YG, Stanley ER, Freeman MR. Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling. Nature. 453: 935-9. PMID 18432193 DOI: 10.1038/Nature06901  1
2007 Freeman MR. A look inside. Neuron Glia Biology. 3: 1-3. PMID 18634573 DOI: 10.1017/S1740925X07000646  1
2007 Logan MA, Freeman MR. The scoop on the fly brain: glial engulfment functions in Drosophila. Neuron Glia Biology. 3: 63-74. PMID 18172512 DOI: 10.1017/S1740925X07000646  1
2007 Emery P, Freeman MR. Glia got rhythm. Neuron. 55: 337-9. PMID 17678846 DOI: 10.1016/J.Neuron.2007.07.014  1
2006 MacDonald JM, Beach MG, Porpiglia E, Sheehan AE, Watts RJ, Freeman MR. The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons. Neuron. 50: 869-81. PMID 16772169 DOI: 10.1016/J.Neuron.2006.04.028  1
2006 Freeman MR. Sculpting the nervous system: glial control of neuronal development. Current Opinion in Neurobiology. 16: 119-25. PMID 16387489 DOI: 10.1016/J.Conb.2005.12.004  1
2006 Freeman MR, Doherty J. Glial cell biology in Drosophila and vertebrates. Trends in Neurosciences. 29: 82-90. PMID 16377000 DOI: 10.1016/J.Tins.2005.12.002  1
2005 Freeman MR. Glial (and neuronal) cells missing. Neuron. 48: 163-5. PMID 16242394 DOI: 10.1016/J.Neuron.2005.10.002  1
2005 Freeman MR. Glial control of synaptogenesis. Cell. 120: 292-3. PMID 15707887 DOI: 10.1016/J.Cell.2005.01.021  1
2003 Freeman MR, Delrow J, Kim J, Johnson E, Doe CQ. Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function. Neuron. 38: 567-80. PMID 12765609 DOI: 10.1016/S0896-6273(03)00289-7  1
2001 Freeman MR, Doe CQ. Moving muscle. Jeb signaling in Drosophila. Developmental Cell. 1: 587-8. PMID 11709176 DOI: 10.1016/S1534-5807(01)00080-6  1
2001 Freeman MR, Doe CQ. Asymmetric Prospero localization is required to generate mixed neuronal/glial lineages in the Drosophila CNS. Development (Cambridge, England). 128: 4103-12. PMID 11641232  1
1999 Freeman MR, Dobritsa A, Gaines P, Segraves WA, Carlson JR. The dare gene: steroid hormone production, olfactory behavior, and neural degeneration in Drosophila. Development (Cambridge, England). 126: 4591-602. PMID 10498693  1
1999 Buszczak M, Freeman MR, Carlson JR, Bender M, Cooley L, Segraves WA. Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila. Development (Cambridge, England). 126: 4581-9. PMID 10498692  1
1999 Clyne PJ, Warr CG, Freeman MR, Lessing D, Kim J, Carlson JR. A novel family of divergent seven-transmembrane proteins: candidate odorant receptors in Drosophila. Neuron. 22: 327-38. PMID 10069338 DOI: 10.1016/S0896-6273(00)81093-4  1
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