| Year |
Citation |
Score |
| 2020 |
Apostol CR, Hay M, Polt R. Glycopeptide drugs: A pharmacological dimension between “Small Molecules” and “Biologics” Peptides. 131: 170369. PMID 32673700 DOI: 10.1016/J.Peptides.2020.170369 |
0.361 |
|
| 2020 |
Bartlett MJ, So LY, Szabò L, Skinner DP, Parent KL, Heien ML, Vanderah TW, Polt R, Sherman SJ, Falk T. Highly-selective µ-opioid receptor antagonism does not block L-DOPA-induced dyskinesia in a rodent model. Bmc Research Notes. 13: 149. PMID 32164786 DOI: 10.1186/S13104-020-04994-7 |
0.333 |
|
| 2020 |
Burgess GE, Polt R, Rice KC, Jutkiewicz EM. Characterization of Delta Opioid Receptor Activity of MMP2200, a Mixed Efficacy Mu and Delta Opioid Receptor Agonist The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05714 |
0.304 |
|
| 2017 |
Palos Pacheco R, Eismin RJ, Coss CS, Wang H, Maier RM, Polt R, Pemberton JE. Synthesis and Characterization of Four Diastereomers of Monorhamnolipids. Journal of the American Chemical Society. PMID 28301722 DOI: 10.1021/Jacs.7B00427 |
0.753 |
|
| 2016 |
Szabó LZ, Hanrahan DJ, Jones EM, Martin E, Pemberton JE, Polt R. Preparation of S-glycoside surfactants and cysteine thioglycosides using minimally competent Lewis acid catalysis. Carbohydrate Research. 422: 1-4. PMID 26795078 DOI: 10.1016/J.Carres.2015.12.008 |
0.333 |
|
| 2015 |
Jones EM, Polt R. CNS active O-linked glycopeptides. Frontiers in Chemistry. 3: 40. PMID 26157795 DOI: 10.3389/Fchem.2015.00040 |
0.375 |
|
| 2015 |
Lefever M, Li Y, Anglin B, Muthu D, Giuvelis D, Lowery JJ, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Structural Requirements for CNS Active Opioid Glycopeptides. Journal of Medicinal Chemistry. 58: 5728-41. PMID 26125201 DOI: 10.1021/Acs.Jmedchem.5B00014 |
0.78 |
|
| 2015 |
Stevenson GW, Luginbuhl A, Dunbar C, LaVigne J, Dutra J, Atherton P, Bell B, Cone K, Giuvelis D, Polt R, Streicher JM, Bilsky EJ. The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence. Pharmacology, Biochemistry, and Behavior. 132: 49-55. PMID 25735493 DOI: 10.1016/J.Pbb.2015.02.022 |
0.302 |
|
| 2014 |
Li Y, St Louis L, Knapp BI, Muthu D, Anglin B, Giuvelis D, Bidlack JM, Bilsky EJ, Polt R. Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to β-endorphin? Journal of Medicinal Chemistry. 57: 2237-46. PMID 24576160 DOI: 10.1021/Jm400879W |
0.793 |
|
| 2013 |
Wang H, Coss CS, Mudalige A, Polt RL, Pemberton JE. A PM-IRRAS investigation of monorhamnolipid orientation at the air-water interface. Langmuir : the Acs Journal of Surfaces and Colloids. 29: 4441-50. PMID 23406083 DOI: 10.1021/La3051725 |
0.749 |
|
| 2012 |
Mabrouk OS, Falk T, Sherman SJ, Kennedy RT, Polt R. CNS penetration of the opioid glycopeptide MMP-2200: a microdialysis study. Neuroscience Letters. 531: 99-103. PMID 23127847 DOI: 10.1016/J.Neulet.2012.10.029 |
0.364 |
|
| 2012 |
Lefever MR, Szabò LZ, Anglin B, Ferracane M, Hogan J, Cooney L, Polt R. Glycosylation of α-amino acids by sugar acetate donors with InBr3. Minimally competent Lewis acids. Carbohydrate Research. 351: 121-5. PMID 22342206 DOI: 10.1016/J.Carres.2012.01.008 |
0.77 |
|
| 2012 |
Li Y, Lefever MR, Muthu D, Bidlack JM, Bilsky EJ, Polt R. Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins. Future Medicinal Chemistry. 4: 205-26. PMID 22300099 DOI: 10.4155/Fmc.11.195 |
0.768 |
|
| 2012 |
Coss C, Carrocci T, Maier RM, Pemberton JE, Polt R. Minimally competent lewis acid catalysts: Indium(III) and bismuth(III) salts produce rhamnosides (=6-deoxymannosides) in high yield and purity Helvetica Chimica Acta. 95: 2652-2659. DOI: 10.1002/Hlca.201200528 |
0.763 |
|
| 2011 |
Yue X, Falk T, Zuniga LA, Szabò L, Porreca F, Polt R, Sherman SJ. Effects of the novel glycopeptide opioid agonist MMP-2200 in preclinical models of Parkinson's disease. Brain Research. 1413: 72-83. PMID 21840512 DOI: 10.1016/J.Brainres.2011.07.038 |
0.306 |
|
| 2011 |
Yeomans L, Muthu D, Lowery JJ, Martinez HN, Abrell L, Lin G, Strom K, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Phosphorylation of enkephalins: NMR and CD studies in aqueous and membrane-mimicking environments. Chemical Biology & Drug Design. 78: 749-56. PMID 21801311 DOI: 10.1111/J.1747-0285.2011.01203.X |
0.398 |
|
| 2011 |
Lowery JJ, Raymond TJ, Giuvelis D, Bidlack JM, Polt R, Bilsky EJ. In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice. The Journal of Pharmacology and Experimental Therapeutics. 336: 767-78. PMID 21118955 DOI: 10.1124/Jpet.110.172866 |
0.329 |
|
| 2010 |
Keyari CM, Polt R, Nichol GS. (S)-Methyl 2-{(S)-2-[bis-(4-meth-oxy-phen-yl)methyl-idene-amino]-3-hy-droxy-propanamido}-3-methyl-butano-ate. Acta Crystallographica. Section E, Structure Reports Online. 67: o13-4. PMID 21522640 DOI: 10.1107/S1600536810049032 |
0.77 |
|
| 2010 |
Keyari CM, Polt R. Serine and threonine Schiff base esters react with β-anomeric peracetates in the presence of BF3·Et2O to produce β-glycosides Journal of Carbohydrate Chemistry. 29: 181-206. DOI: 10.1080/07328303.2010.508295 |
0.77 |
|
| 2010 |
SAMES D, POLT R. ChemInform Abstract: Piperidine Triols via Enantioselective Alkylation and Osmylation of Alanine Schiff Base Esters. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199540222 |
0.542 |
|
| 2009 |
Keyari CM, Knapp BI, Bidlack JM, Lowey J, Bilsky EJ, Polt R. Glycosyl-enkephalins: synthesis and binding at the mu, delta & kappa opioid receptors. Antinociception in mice. Advances in Experimental Medicine and Biology. 611: 495-6. PMID 19400281 DOI: 10.1007/978-0-387-73657-0_214 |
0.774 |
|
| 2008 |
Do Carmo GP, Polt R, Bilsky EJ, Rice KC, Negus SS. Behavioral pharmacology of the mu/delta opioid glycopeptide MMP2200 in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 326: 939-48. PMID 18511649 DOI: 10.1124/Jpet.108.138180 |
0.307 |
|
| 2007 |
Lowery JJ, Yeomans L, Keyari CM, Davis P, Porreca F, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Glycosylation improves the central effects of DAMGO. Chemical Biology & Drug Design. 69: 41-7. PMID 17313456 DOI: 10.1111/J.1747-0285.2007.00462.X |
0.792 |
|
| 2005 |
Dhanasekaran M, Polt R. New prospects for glycopeptide based analgesia: glycoside-induced penetration of the blood-brain barrier. Current Drug Delivery. 2: 59-73. PMID 16305409 DOI: 10.2174/1567201052772843 |
0.378 |
|
| 2005 |
Polt R, Dhanasekaran M, Keyari CM. Glycosylated neuropeptides: a new vista for neuropsychopharmacology? Medicinal Research Reviews. 25: 557-85. PMID 16075406 DOI: 10.1002/Med.20039 |
0.787 |
|
| 2005 |
Dhanasekaran M, Palian MM, Alves I, Yeomans L, Keyari CM, Davis P, Bilsky EJ, Egleton RD, Yamamura HI, Jacobsen NE, Tollin G, Hruby VJ, Porreca F, Polt R. Glycopeptides related to beta-endorphin adopt helical amphipathic conformations in the presence of lipid bilayers. Journal of the American Chemical Society. 127: 5435-48. PMID 15826181 DOI: 10.1021/Ja0432158 |
0.757 |
|
| 2005 |
Egleton RD, Bilsky EJ, Tollin G, Dhanasekaran M, Lowery J, Alves I, Davis P, Porreca F, Yamamura HI, Yeomans L, Keyari CM, Polt R. Biousian glycopeptides penetrate the blood-brain barrier Tetrahedron Asymmetry. 16: 65-75. DOI: 10.1016/J.Tetasy.2004.11.038 |
0.793 |
|
| 2004 |
Elmagbari NO, Egleton RD, Palian MM, Lowery JJ, Schmid WR, Davis P, Navratilova E, Dhanasekaran M, Keyari CM, Yamamura HI, Porreca F, Hruby VJ, Polt R, Bilsky EJ. Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides. The Journal of Pharmacology and Experimental Therapeutics. 311: 290-7. PMID 15166257 DOI: 10.1124/Jpet.104.069393 |
0.78 |
|
| 2004 |
Slavish JP, Friel DK, Oland LA, Polt R. New PDMP analogues inhibit process outgrowth in an insect cell line. Bioorganic & Medicinal Chemistry Letters. 14: 1487-90. PMID 15006387 DOI: 10.1016/J.Bmcl.2004.01.013 |
0.732 |
|
| 2003 |
Palian MM, Boguslavsky VI, O'Brien DF, Polt R. Glycopeptide-membrane interactions: glycosyl enkephalin analogues adopt turn conformations by NMR and CD in amphipathic media. Journal of the American Chemical Society. 125: 5823-31. PMID 12733923 DOI: 10.1021/Ja0268635 |
0.798 |
|
| 2003 |
Polt R, Kelly BD, Dangel BD, Tadikonda UB, Ross RE, Raitsimring AM, Astashkin AV. Optically active 4- and 5-coordinate transition metal complexes of bifurcated dipeptide Schiff bases. Inorganic Chemistry. 42: 566-74. PMID 12693240 DOI: 10.1021/Ic025996O |
0.702 |
|
| 2001 |
Egleton RD, Mitchell SA, Huber JD, Palian MM, Polt R, Davis TP. Improved blood-brain barrier penetration and enhanced analgesia of an opioid peptide by glycosylation. The Journal of Pharmacology and Experimental Therapeutics. 299: 967-72. PMID 11714884 |
0.786 |
|
| 2001 |
Palian MM, Polt R. Lipo alpha-amino-beta-hydroxy acids and O-linked glycosides: building blocks for ceramyl and glycosphingoyl peptides. The Journal of Organic Chemistry. 66: 7178-83. PMID 11597248 DOI: 10.1021/Jo015844V |
0.778 |
|
| 2001 |
Palian MM, Jacobsen NE, Polt R. O-Linked glycopeptides retain helicity in water. The Journal of Peptide Research : Official Journal of the American Peptide Society. 58: 180-9. PMID 11532077 DOI: 10.1034/J.1399-3011.2001.00906.X |
0.785 |
|
| 2001 |
Mitchell SA, Pratt MR, Hruby VJ, Polt R. Solid-phase synthesis of O-linked glycopeptide analogues of enkephalin Journal of Organic Chemistry. 66: 2327-2342. PMID 11281773 DOI: 10.1021/Jo005712M |
0.399 |
|
| 2001 |
Polt R, Palian MM. Glycopeptide analgesics Drugs of the Future. 26: 561-576. DOI: 10.1358/dof.2001.026.06.668342 |
0.765 |
|
| 2000 |
Egleton RD, Mitchell SA, Huber JD, Janders J, Stropova D, Polt R, Yamamura HI, Hruby VJ, Davis TP. Improved bioavailability to the brain of glycosylated Met-enkephalin analogs. Brain Research. 881: 37-46. PMID 11033091 DOI: 10.1016/S0006-8993(00)02794-3 |
0.393 |
|
| 2000 |
Dangel BD, Polt R. Catalysis by amino acid-derived tetracoordinate complexes: enantioselective addition of dialkylzincs to aliphatic and aromatic aldehydes. Organic Letters. 2: 3003-6. PMID 10986093 DOI: 10.1021/Ol0063151 |
0.769 |
|
| 2000 |
Bilsky EJ, Egleton RD, Mitchell SA, Palian MM, Davis P, Huber JD, Jones H, Yamamura HI, Janders J, Davis TP, Porreca F, Hruby VJ, Polt R. Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability. Journal of Medicinal Chemistry. 43: 2586-90. PMID 10891118 DOI: 10.1021/Jm000077Y |
0.792 |
|
| 2000 |
Kriss CT, Lou BS, Szabò LZ, Mitchell SA, Hruby VJ, Polt R. Enkephalin-based drug design: Conformational analysis of O-linked glycopeptides by NMR and molecular modeling Tetrahedron Asymmetry. 11: 9-25. DOI: 10.1016/S0957-4166(99)00544-3 |
0.381 |
|
| 1999 |
Polt R, Sames D, Chruma J. Glycosidase inhibitors: Synthesis of enantiomerically pure aza-sugars from Schiff base amino esters via tandem reduction-alkenylation and osmylation Journal of Organic Chemistry. 64: 6147-6158. DOI: 10.1021/Jo9820115 |
0.757 |
|
| 1998 |
Mitchell SA, Oates BD, Razavi H, Polt R. Glycosyltransferase inhibitors: Synthesis of D-threo-PDMP, L-threo- PDMP, and other brain glucosylceramide synthase inhibitors from D- or L- serine Journal of Organic Chemistry. 63: 8837-8842. DOI: 10.1021/Jo980951J |
0.326 |
|
| 1998 |
Razavi H, Polt R. Syntheses of iminolyxitols via tandem reduction-alkenylation of O'Donnell's Schiff bases Tetrahedron Letters. 39: 3371-3374. DOI: 10.1016/S0040-4039(98)00495-X |
0.351 |
|
| 1997 |
Dangel B, Clarke M, Haley J, Sames D, Polt R. Amino acid-derived ligands for transition metals: Catalysis via a minimalist interpretation of a metalloprotein Journal of the American Chemical Society. 119: 10865-10866. DOI: 10.1021/Ja972135J |
0.767 |
|
| 1997 |
Chruma JJ, Sames D, Polt R. General method for the synthesis of N-methyl amino acids and N-alkyl amino esters from O'Donnell's Schiff bases Tetrahedron Letters. 38: 5085-5086. DOI: 10.1016/S0040-4039(97)01132-5 |
0.762 |
|
| 1995 |
Szabó L, Ramza J, Langdon C, Polt R. Stereoselective synthesis of O-serinyl/threoninyl-2-acetamido-2-deoxy-α- or β-glycosides Carbohydrate Research. 274: 11-28. PMID 7585702 DOI: 10.1016/0008-6215(95)00016-M |
0.338 |
|
| 1995 |
Sames D, Polt R. Piperidine Triols via Enantioselective Alkylation and Osmylation of Alanine Schiff Base Esters Synlett. 1995: 552-554. DOI: 10.1055/S-1995-5282 |
0.592 |
|
| 1995 |
Sames D, Liu Y, DeYoung L, Polt R. Preparation of monosilyl acetals from esters via iBu2AlH reduction and trapping with N-(trimethylsilyl)imidazole. Addition of allyltrimethylsilane to yield homoallylic alcohols or ethers Journal of Organic Chemistry. 60: 2153-2159. DOI: 10.1021/Jo00112A039 |
0.552 |
|
| 1994 |
Polt R, Porreca F, Szabò LZ, Bilsky EJ, Davis P, Abbruscato TJ, Davis TP, Harvath R, Yamamura HI, Hruby VJ. Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America. 91: 7114-8. PMID 8041755 DOI: 10.1073/Pnas.91.15.7114 |
0.373 |
|
| 1994 |
Sames D, Polt R. An enantioselective synthesis of N-methylfucosamine via tandem C-C/C-O bond formation Journal of Organic Chemistry. 59: 4596-4601. DOI: 10.1021/Jo00095A039 |
0.597 |
|
| 1994 |
Hruby VJ, Misicka A, Lipkowski AW, Haaseth R, Bartosz H, Qian X, Collins N, Meyer JP, Szabo L, Polt R, Porreca F, Davis T, Yamamura HI. New opioid compounds in analgesia Regulatory Peptides. 53: S71-S72. DOI: 10.1016/0167-0115(94)90246-1 |
0.359 |
|
| 1993 |
Peterson MA, Polt R. N-diphenylmethylene-protected glycosyl acceptors. Selective β-O-glycosylation to form lactosyl-threo-ceramides Journal of Organic Chemistry. 58: 4309-4314. DOI: 10.1021/Jo00068A028 |
0.311 |
|
| 1992 |
Polt R, Peterson MA, Deyoung L. Aluminoxy acetals from α-amino esters: Chirality transfer via sequential addition of hydride and C-nucleophiles. 2-Amino alcohols and sphingosines Journal of Organic Chemistry. 57: 5469-5480. DOI: 10.1021/Jo00046A032 |
0.319 |
|
| 1992 |
Polt R, Szabo L, Treiberg J, Li Y, Hruby VJ. General methods for .alpha.- or .beta.-O-Ser/Thr glycosides and glycopeptides. Solid-phase synthesis of O-glycosyl cyclic enkephalin analogs Journal of the American Chemical Society. 114: 10249-10258. DOI: 10.1021/Ja00052A022 |
0.355 |
|
| 1992 |
Polt R, Li Y, Fernando Q, Rivera M. A synthetic method for unsymmetrical disulfides of cysteine: the bis-cysteine disulfide of meso-2,3-dimercaptosuccinic acid. Tetrahedron Letters. 33: 2961-2964. DOI: 10.1016/S0040-4039(00)79572-4 |
0.32 |
|
| 1990 |
Polt R, Peterson MA. β-Amino alcohols from amino acids: Chelation control via schiff bases Tetrahedron Letters. 31: 4985-4986. DOI: 10.1016/S0040-4039(00)97784-0 |
0.321 |
|
| 1989 |
Polt R, Seebach D. Stereoselective alkylation of glycine units in dipeptide derivatives. "Chirality transfer" via a pivalaldehyde N,N-acetal center Journal of the American Chemical Society. 111: 2622-2632. DOI: 10.1021/Ja00189A042 |
0.419 |
|
| 1988 |
Stork G, Polt RL, Li Y, Houk KN. Theoretical studies of the lithiation of enamines Journal of the American Chemical Society. 110: 8360-8367. DOI: 10.1021/Ja00233A013 |
0.443 |
|
| 1987 |
Polt R, Seebach D. Alkylation of Imidazolidinone Dipeptide Derivatives: Preparation of Enantiomerically Pure Di- and Tripeptides by ?Chirality Transfer?via a Pivalaldehyde N,N-Acetal Center. Preliminary Communication Helvetica Chimica Acta. 70: 1930-1936. DOI: 10.1002/Hlca.19870700727 |
0.438 |
|
| 1986 |
Stork G, Shiner CS, Cheng CW, Polt RL. Deprotonation of chelating enamines. Direct formation of .beta.-lithio enamines Journal of the American Chemical Society. 108: 304-305. DOI: 10.1021/ja00262a025 |
0.402 |
|
| 1986 |
Stork G, Shiner CS, Cheng CW, Polt RL. Deprotonation of chelating enamines. Direct formation of β-lithio enamines Journal of the American Chemical Society. 108: 304-305. DOI: 10.1021/Ja00262A025 |
0.476 |
|
| 1985 |
O'Donnell MJ, Bennett WD, Polt RL. Preparation of an electrophilic glycine cation equivalent and its reaction with heteroatom nucleophiles Tetrahedron Letters. 26: 695-698. DOI: 10.1016/S0040-4039(00)89111-X |
0.306 |
|
| 1985 |
O'DONNELL MJ, BENNETT WD, POLT RL, FALMAGNE J. ChemInform Abstract: Preparation of an Electrophilic Glycine Cation Equivalent and Its Reaction with Heteroatom Nucleophiles. The Synthesis of Amino Acids by Reaction of an Electrophilic Glycine Cation Equivalent with Carbon Nucleophiles. Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198525356 |
0.303 |
|
| 1984 |
Polt RL, Stork G, Carpenter GB, Williard PG. X-ray crystal structure of N-(2-lithiocyclohexenyl)-N,N′,N′-trimethyl-1,3-propanediamine: A pentavalent lithium? Journal of the American Chemical Society. 106: 4276-4277. DOI: 10.1002/Chin.198445057 |
0.605 |
|
| 1982 |
O'Donnell MJ, Polt RL. A mild and efficient route to Schiff base derivatives of amino acids Journal of Organic Chemistry. 47: 2663-2666. DOI: 10.1002/Chin.198251347 |
0.33 |
|
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