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Marcelo A. Nobrega - Publications

Affiliations: 
Human Genetics University of Chicago, Chicago, IL 
Area:
Genetics, Molecular Biology, Endocrinology Biology
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64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Glunk V, Laber S, Sinnott-Armstrong N, Sobreira DR, Strobel SM, Batista TM, Kubitz P, Moud BN, Ebert H, Huang Y, Brandl B, Garbo G, Honecker J, Stirling DR, Abdennur N, ... ... Nobrega MA, et al. A non-coding variant linked to metabolic obesity with normal weight affects actin remodelling in subcutaneous adipocytes. Nature Metabolism. 5: 861-879. PMID 37253881 DOI: 10.1038/s42255-023-00807-w  0.357
2023 Hansen GT, Sobreira DR, Weber ZT, Thornburg AG, Aneas I, Zhang L, Sakabe NJ, Joslin AC, Haddad GA, Strobel SM, Laber S, Sultana F, Sahebdel F, Khan K, Li YI, et al. Genetics of sexually dimorphic adipose distribution in humans. Nature Genetics. PMID 36797366 DOI: 10.1038/s41588-023-01306-0  0.713
2021 Joslin AC, Sobreira DR, Hansen GT, Sakabe NJ, Aneas I, Montefiori LE, Farris KM, Gu J, Lehman DM, Ober C, He X, Nóbrega MA. A functional genomics pipeline identifies pleiotropy and cross-tissue effects within obesity-associated GWAS loci. Nature Communications. 12: 5253. PMID 34489471 DOI: 10.1038/s41467-021-25614-3  0.34
2021 Sobreira DR, Joslin AC, Zhang Q, Williamson I, Hansen GT, Farris KM, Sakabe NJ, Sinnott-Armstrong N, Bozek G, Jensen-Cody SO, Flippo KH, Ober C, Bickmore WA, Potthoff M, Chen M, et al. Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of and . Science (New York, N.Y.). 372: 1085-1091. PMID 34083488 DOI: 10.1126/science.abf1008  0.35
2021 Gacita AM, Fullenkamp DE, Ohiri J, Pottinger T, Puckelwartz MJ, Nobrega MA, McNally EM. Genetic Variation in Enhancers Modifies Cardiomyopathy Gene Expression and Progression. Circulation. PMID 33478249 DOI: 10.1161/CIRCULATIONAHA.120.050432  0.595
2020 Gacita AM, Dellefave-Castillo L, Page PGT, Barefield DY, Wasserstrom JA, Puckelwartz MJ, Nobrega MA, McNally EM. Altered Enhancer and Promoter Usage Leads to Differential Gene Expression in the Normal and Failed Human Heart. Circulation. Heart Failure. CIRCHEARTFAILURE1200. PMID 32993371 DOI: 10.1161/CIRCHEARTFAILURE.120.006926  0.514
2020 Burnicka-Turek O, Broman MT, Steimle JD, Boukens BJ, Petrenko N, Ikegami K, Nadadur RD, Qiao Y, Arnolds DE, Yang XH, Patel VV, Nobrega MA, Efimov IR, Moskowitz IP. Transcriptional Patterning of the Ventricular Cardiac Conduction System. Circulation Research. PMID 32290757 DOI: 10.1161/Circresaha.118.314460  0.405
2019 van Ouwerkerk AF, Bosada FM, van Duijvenboden K, Hill MC, Montefiori LE, Scholman KT, Liu J, de Vries AAF, Boukens BJ, Ellinor PT, Goumans MJTH, Efimov IR, Nobrega MA, Barnett P, Martin JF, et al. Identification of atrial fibrillation associated genes and functional non-coding variants. Nature Communications. 10: 4755. PMID 31628324 DOI: 10.1038/S41467-019-12721-5  0.468
2019 El Khattabi L, Zhao H, Kalchschmidt J, Young N, Jung S, Van Blerkom P, Kieffer-Kwon P, Kieffer-Kwon KR, Park S, Wang X, Krebs J, Tripathi S, Sakabe N, Sobreira DR, Huang SC, et al. A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers. Cell. PMID 31402173 DOI: 10.1016/J.Cell.2019.07.011  0.355
2019 Montefiori LE, Nobrega MA. Gene therapy for pathologic gene expression. Science (New York, N.Y.). 363: 231-232. PMID 30655431 DOI: 10.1126/Science.Aaw0635  0.33
2018 Srivastava R, Rolyan H, Xie Y, Li N, Bhat N, Hong L, Esteghamat F, Adeniran A, Geirsson A, Zhang J, Ge G, Nobrega M, Martin KA, Mani A. TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA118311830. PMID 30567484 DOI: 10.1161/Atvbaha.118.311830  0.326
2018 Montefiori LE, Sobreira DR, Sakabe NJ, Aneas I, Joslin AC, Hansen GT, Bozek G, Moskowitz IP, McNally EM, Nóbrega MA. A promoter interaction map for cardiovascular disease genetics. Elife. 7. PMID 29988018 DOI: 10.7554/Elife.35788  0.598
2018 Boogerd CJ, Zhu X, Aneas I, Sakabe NJ, Zhang L, Sobreira DR, Montefiori LE, Bogomolovas J, Joslin AC, Zhou B, Chen J, Nobrega M, Evans SM. Tbx20 Is Required in Mid-Gestation Cardiomyocytes and Plays a Central Role in Atrial Development. Circulation Research. PMID 29903739 DOI: 10.1161/Circresaha.118.311339  0.421
2018 Montefiori LE, Sobreira DR, Sakabe NJ, Aneas I, Joslin AC, Hansen GT, Bozek G, Moskowitz IP, McNally EM, Nóbrega MA. Author response: A promoter interaction map for cardiovascular disease genetics Elife. DOI: 10.7554/Elife.35788.103  0.503
2016 Nicodemus-Johnson J, Myers RA, Sakabe NJ, Sobreira DR, Hogarth DK, Naureckas ET, Sperling AI, Solway J, White SR, Nobrega MA, Nicolae DL, Gilad Y, Ober C. DNA methylation in lung cells is associated with asthma endotypes and genetic risk. Jci Insight. 1: e90151. PMID 27942592 DOI: 10.1172/Jci.Insight.90151  0.332
2016 Boogerd CJ, Aneas I, Sakabe N, Dirschinger RJ, Cheng QJ, Zhou B, Chen J, Nobrega MA, Evans SM. Probing chromatin landscape reveals roles of endocardial TBX20 in septation. The Journal of Clinical Investigation. PMID 27348591 DOI: 10.1172/Jci85350  0.43
2015 Gómez-Marín C, Tena JJ, Acemel RD, López-Mayorga M, Naranjo S, de la Calle-Mustienes E, Maeso I, Beccari L, Aneas I, Vielmas E, Bovolenta P, Nobrega MA, Carvajal J, Gómez-Skarmeta JL. Evolutionary comparison reveals that diverging CTCF sites are signatures of ancestral topological associating domains borders. Proceedings of the National Academy of Sciences of the United States of America. 112: 7542-7. PMID 26034287 DOI: 10.1073/Pnas.1505463112  0.395
2015 Guimarães-Camboa N, Stowe J, Aneas I, Sakabe N, Cattaneo P, Henderson L, Kilberg MS, Johnson RS, Chen J, McCulloch AD, Nobrega MA, Evans SM, Zambon AC. HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes. Developmental Cell. 33: 507-21. PMID 26028220 DOI: 10.1016/J.Devcel.2015.04.021  0.318
2015 Bailey KA, Savic D, Zielinski M, Park SY, Wang LJ, Witkowski P, Brady M, Hara M, Bell GI, Nobrega MA. Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice. Human Molecular Genetics. 24: 1646-54. PMID 25398947 DOI: 10.1093/Hmg/Ddu577  0.686
2014 Zhou Y, Park SY, Su J, Bailey K, Ottosson-Laakso E, Shcherbina L, Oskolkov N, Zhang E, Thevenin T, Fadista J, Bennet H, Vikman P, Wierup N, Fex M, Rung J, ... ... Nobrega M, et al. TCF7L2 is a master regulator of insulin production and processing. Human Molecular Genetics. 23: 6419-31. PMID 25015099 DOI: 10.1093/Hmg/Ddu359  0.428
2014 van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJ, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, ... ... Nobrega MA, et al. A common genetic variant within SCN10A modulates cardiac SCN5A expression. The Journal of Clinical Investigation. 124: 1844-52. PMID 24642470 DOI: 10.1172/Jci73140  0.381
2014 Zhou J, Wu J, Li B, Liu D, Yu J, Yan X, Zheng S, Wang J, Zhang L, Zhang L, He F, Li Q, Chen A, Zhang Y, Zhao X, ... ... Nobrega MA, et al. PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway. Leukemia. 28: 1436-48. PMID 24445817 DOI: 10.1038/Leu.2013.384  0.41
2013 Sakabe NJ, Nobrega MA. Beyond the ENCODE project: using genomics and epigenomics strategies to study enhancer evolution. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20130022. PMID 24218635 DOI: 10.1098/Rstb.2013.0022  0.453
2013 Pennacchio LA, Bickmore W, Dean A, Nobrega MA, Bejerano G. Enhancers: five essential questions. Nature Reviews. Genetics. 14: 288-95. PMID 23503198 DOI: 10.1038/Nrg3458  0.378
2013 Nobrega MA. TCF7L2 and glucose metabolism: time to look beyond the pancreas. Diabetes. 62: 706-8. PMID 23431017 DOI: 10.2337/Db12-1418  0.401
2013 Savic D, Park SY, Bailey KA, Bell GI, Nobrega MA. In vitro scan for enhancers at the TCF7L2 locus. Diabetologia. 56: 121-5. PMID 23011354 DOI: 10.1007/S00125-012-2730-Y  0.728
2013 Zhou J, Wu J, Li B, Liu D, Yu J, Yan X, Zheng S, Wang J, Zhang L, Zhang L, He F, Li Q, Chen A, Zhang Y, Zhao X, ... ... Nobrega M, et al. PU.1 Is Essential For MLL Leukemia Via Activation Of The Meis/HOX Pathway and A Monocytic Cytokine Mediated Anti-Apoptotic Inflammatory Program Blood. 122: 1276-1276. DOI: 10.1182/Blood.V122.21.1276.1276  0.398
2012 Arnolds DE, Liu F, Fahrenbach JP, Kim GH, Schillinger KJ, Smemo S, McNally EM, Nobrega MA, Patel VV, Moskowitz IP. TBX5 drives Scn5a expression to regulate cardiac conduction system function. The Journal of Clinical Investigation. 122: 2509-18. PMID 22728936 DOI: 10.1172/Jci62617  0.579
2012 Savic D, Bell GI, Nobrega MA. An in vivo cis-regulatory screen at the type 2 diabetes associated TCF7L2 locus identifies multiple tissue-specific enhancers. Plos One. 7: e36501. PMID 22590553 DOI: 10.1371/Journal.Pone.0036501  0.741
2012 Smemo S, Campos LC, Moskowitz IP, Krieger JE, Pereira AC, Nobrega MA. Regulatory variation in a TBX5 enhancer leads to isolated congenital heart disease. Human Molecular Genetics. 21: 3255-63. PMID 22543974 DOI: 10.1093/Hmg/Dds165  0.396
2012 Auton A, Fledel-Alon A, Pfeifer S, Venn O, Ségurel L, Street T, Leffler EM, Bowden R, Aneas I, Broxholme J, Humburg P, Iqbal Z, Lunter G, Maller J, Hernandez RD, ... ... Nobrega MA, et al. A fine-scale chimpanzee genetic map from population sequencing. Science (New York, N.Y.). 336: 193-8. PMID 22422862 DOI: 10.1126/Science.1216872  0.342
2012 Sakabe NJ, Aneas I, Shen T, Shokri L, Park SY, Bulyk ML, Evans SM, Nobrega MA. Dual transcriptional activator and repressor roles of TBX20 regulate adult cardiac structure and function. Human Molecular Genetics. 21: 2194-204. PMID 22328084 DOI: 10.1093/Hmg/Dds034  0.378
2012 Sakabe NJ, Savic D, Nobrega MA. Transcriptional enhancers in development and disease. Genome Biology. 13: 238. PMID 22269347 DOI: 10.1186/Gb-2012-13-1-238  0.717
2011 Shen T, Aneas I, Sakabe N, Dirschinger RJ, Wang G, Smemo S, Westlund JM, Cheng H, Dalton N, Gu Y, Boogerd CJ, Cai CL, Peterson K, Chen J, Nobrega MA, et al. Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. The Journal of Clinical Investigation. 121: 4640-54. PMID 22080862 DOI: 10.1172/Jci59472  0.404
2011 Savic D, Distler MG, Sokoloff G, Shanahan NA, Dulawa SC, Palmer AA, Nobrega MA. Modulation ofTcf7l2 expression alters behavior in mice. Plos One. 6: e26897. PMID 22046400 DOI: 10.1371/Journal.Pone.0026897  0.699
2011 Schneider I, Aneas I, Gehrke AR, Dahn RD, Nobrega MA, Shubin NH. Appendage expression driven by the Hoxd Global Control Region is an ancient gnathostome feature. Proceedings of the National Academy of Sciences of the United States of America. 108: 12782-6. PMID 21765002 DOI: 10.1073/Pnas.1109993108  0.457
2011 Savic D, Ye H, Aneas I, Park SY, Bell GI, Nobrega MA. Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism. Genome Research. 21: 1417-25. PMID 21673050 DOI: 10.1101/Gr.123745.111  0.747
2011 Taher L, McGaughey DM, Maragh S, Aneas I, Bessling SL, Miller W, Nobrega MA, McCallion AS, Ovcharenko I. Genome-wide identification of conserved regulatory function in diverged sequences. Genome Research. 21: 1139-49. PMID 21628450 DOI: 10.1101/Gr.119016.110  0.413
2011 Arnolds DE, Chu A, McNally EM, Nobrega MA, Moskowitz IP. The emerging genetic landscape underlying cardiac conduction system function. Birth Defects Research. Part a, Clinical and Molecular Teratology. 91: 578-85. PMID 21538814 DOI: 10.1002/Bdra.20800  0.558
2011 Zhou J, Li B, Wu J, He F, Li Q, Yan X, Zhang Y, Zhang L, Zhao X, Yan J, Nobrega M, Tenen DG, Huang G, Wang Q. Essential Role for PU.1 in MEIS1 Activation and MLL Fusion Leukemia, Blood. 118: 3466-3466. DOI: 10.1182/Blood.V118.21.3466.3466  0.361
2010 Sakabe NJ, Nobrega MA. Genome-wide maps of transcription regulatory elements. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 2: 422-37. PMID 20836039 DOI: 10.1002/Wsbm.70  0.471
2010 Wasserman NF, Aneas I, Nobrega MA. An 8q24 gene desert variant associated with prostate cancer risk confers differential in vivo activity to a MYC enhancer. Genome Research. 20: 1191-7. PMID 20627891 DOI: 10.1101/Gr.105361.110  0.705
2010 Nobrega MA. Journal club. A human geneticist explores the ways that genes are regulated. Nature. 466: 11. PMID 20595974 DOI: 10.1038/466011E  0.371
2010 Gotea V, Visel A, Westlund JM, Nobrega MA, Pennacchio LA, Ovcharenko I. Homotypic clusters of transcription factor binding sites are a key component of human promoters and enhancers. Genome Research. 20: 565-77. PMID 20363979 DOI: 10.1101/Gr.104471.109  0.42
2010 Narlikar L, Sakabe NJ, Blanski AA, Arimura FE, Westlund JM, Nobrega MA, Ovcharenko I. Genome-wide discovery of human heart enhancers. Genome Research. 20: 381-92. PMID 20075146 DOI: 10.1101/Gr.098657.109  0.46
2009 van Bon BW, Mefford HC, Menten B, Koolen DA, Sharp AJ, Nillesen WM, Innis JW, de Ravel TJ, Mercer CL, Fichera M, Stewart H, Connell LE, Ounap K, Lachlan K, Castle B, ... ... Nobrega MA, et al. Further delineation of the 15q13 microdeletion and duplication syndromes: a clinical spectrum varying from non-pathogenic to a severe outcome. Journal of Medical Genetics. 46: 511-23. PMID 19372089 DOI: 10.1136/Jmg.2008.063412  0.308
2008 Wang Q, Dong J, Mattison R, Prabhakar S, Arimura FE, Kaberlein J, Wang C, Wang Q, Nobrega M, Thirman M. Autoregulation of MEIS1 through a Distal Enhancer in Acute Leukemia Blood. 112: 745-745. DOI: 10.1182/Blood.V112.11.745.745  0.462
2007 Moskowitz IP, Kim JB, Moore ML, Wolf CM, Peterson MA, Shendure J, Nobrega MA, Yokota Y, Berul C, Izumo S, Seidman JG, Seidman CE. A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development. Cell. 129: 1365-76. PMID 17604724 DOI: 10.1016/J.Cell.2007.04.036  0.382
2007 Pennacchio LA, Loots GG, Nobrega MA, Ovcharenko I. Predicting tissue-specific enhancers in the human genome. Genome Research. 17: 201-11. PMID 17210927 DOI: 10.1101/Gr.5972507  0.448
2007 Castillo HA, Cravo RM, Nóbrega M, Xavier-Neto J. Identification of a conserved roof plate enhancer in the RALDH2 gene Developmental Biology. 306: 349-350. DOI: 10.1016/J.Ydbio.2007.03.213  0.345
2007 Cravo R, Castillo H, Simoes-Costa M, Nobrega M, Gonzalez J, Slonimsky E, Rosenthal N, Xavier-Neto J. Regulatory enhancers in the RALDH2 gene Developmental Biology. 306: 349. DOI: 10.1016/J.Ydbio.2007.03.212  0.371
2006 Pennacchio LA, Ahituv N, Moses AM, Prabhakar S, Nobrega MA, Shoukry M, Minovitsky S, Dubchak I, Holt A, Lewis KD, Plajzer-Frick I, Akiyama J, De Val S, Afzal V, Black BL, et al. In vivo enhancer analysis of human conserved non-coding sequences. Nature. 444: 499-502. PMID 17086198 DOI: 10.1038/Nature05295  0.437
2005 Ovcharenko I, Nobrega MA. Identifying synonymous regulatory elements in vertebrate genomes. Nucleic Acids Research. 33: W403-7. PMID 15980499 DOI: 10.1093/Nar/Gki466  0.44
2005 Poulin F, Nobrega MA, Plajzer-Frick I, Holt A, Afzal V, Rubin EM, Pennacchio LA. In vivo characterization of a vertebrate ultraconserved enhancer. Genomics. 85: 774-81. PMID 15885503 DOI: 10.1016/J.Ygeno.2005.03.003  0.367
2005 Ovcharenko I, Loots GG, Nobrega MA, Hardison RC, Miller W, Stubbs L. Evolution and functional classification of vertebrate gene deserts. Genome Research. 15: 137-45. PMID 15590943 DOI: 10.1101/Gr.3015505  0.407
2004 Nóbrega MA, Zhu Y, Plajzer-Frick I, Afzal V, Rubin EM. Megabase deletions of gene deserts result in viable mice. Nature. 431: 988-93. PMID 15496924 DOI: 10.1038/Nature03022  0.403
2004 Ahituv N, Rubin EM, Nobrega MA. Exploiting human - Fish genome comparisons for deciphering gene regulation Human Molecular Genetics. 13: R261-R266. PMID 15358733 DOI: 10.1093/Hmg/Ddh229  0.392
2004 Ovcharenko I, Nobrega MA, Loots GG, Stubbs L. ECR Browser: a tool for visualizing and accessing data from comparisons of multiple vertebrate genomes. Nucleic Acids Research. 32: W280-6. PMID 15215395 DOI: 10.1093/Nar/Gkh355  0.359
2004 Boffelli D, Nobrega MA, Rubin EM. Comparative genomics at the vertebrate extremes. Nature Reviews. Genetics. 5: 456-65. PMID 15153998 DOI: 10.1038/Nrg1350  0.35
2004 Nobrega MA, Pennacchio LA. Comparative genomic analysis as a tool for biological discovery. The Journal of Physiology. 554: 31-9. PMID 14678488 DOI: 10.1113/Jphysiol.2003.050948  0.407
2003 Nobrega MA, Ovcharenko I, Afzal V, Rubin EM. Scanning human gene deserts for long-range enhancers. Science (New York, N.Y.). 302: 413. PMID 14563999 DOI: 10.1126/Science.1088328  0.408
2002 Yoon JW, Kita Y, Frank DJ, Majewski RR, Konicek BA, Nobrega MA, Jacob H, Walterhouse D, Iannaccone P. Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation. The Journal of Biological Chemistry. 277: 5548-55. PMID 11719506 DOI: 10.1074/Jbc.M105708200  0.392
2001 Kwitek AE, Tonellato PJ, Chen D, Gullings-Handley J, Cheng YS, Twigger S, Scheetz TE, Casavant TL, Stoll M, Nobrega MA, Shiozawa M, Soares MB, Sheffield VC, Jacob HJ. Automated construction of high-density comparative maps between rat, human, and mouse Genome Research. 11: 1935-1943. PMID 11691858 DOI: 10.1101/Gr.173701  0.331
2000 Nobrega MA, Shiozawa M, Koike G, Jacob HJ, Miano JM. Gene structure and chromosomal mapping of the rat smooth muscle calponin gene. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 11: 115-9. PMID 10656925 DOI: 10.1007/S003350010023  0.425
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