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Marc Giulianotti - Publications

Affiliations: 
Chemistry University of South Florida, Tampa, FL, United States 
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ericson MD, Freeman KT, LaVoi TM, Donow HM, Santos RG, Giulianotti MA, Pinilla C, Houghten RA, Haskell-Luevano C. The Parallel Structure-Activity Relationship Screening of Three Compounds Identifies the Common Agonist Pharmacophore of Pyrrolidine Bis-Cyclic Guanidine Melanocortin-3 Receptor (MC3R) Small-Molecule Ligands. International Journal of Molecular Sciences. 24. PMID 37373293 DOI: 10.3390/ijms241210145  0.361
2023 Doering SR, Freeman K, Debevec G, Geer P, Santos RG, Lavoi TM, Giulianotti MA, Pinilla C, Appel JR, Houghten RA, Ericson MD, Haskell-Luevano C. Correction to "Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High Throughput 'Unbiased' Screening Campaign". Journal of Medicinal Chemistry. PMID 37155917 DOI: 10.1021/acs.jmedchem.3c00588  0.501
2021 Ericson MD, Doering SR, Larson CM, Freeman KT, LaVoi TM, Donow HM, Santos RG, Cho RH, Koerperich ZM, Giulianotti MA, Pinilla C, Houghten RA, Haskell-Luevano C. Functional Mixture-Based Positional Scan Identifies a Library of Antagonist Tetrapeptide Sequences (LAtTeS) with Nanomolar Potency for the Melanocortin-4 Receptor and Equipotent with the Endogenous AGRP(86-132) Antagonist. Journal of Medicinal Chemistry. PMID 34592820 DOI: 10.1021/acs.jmedchem.1c01417  0.403
2020 Zhang X, Santos R, Debevec G, Li D, Schutte R, Pham K, Liu C, Ostrov DA, Giulianotti M. Identification of small molecules by screening a mixture-based scaffold compound library for treatment of alpha-1 antitrypsin deficiency. Biochemical and Biophysical Research Communications. 527: 317-323. PMID 32446387 DOI: 10.1016/J.Bbrc.2020.04.037  0.523
2019 Sammons RM, Perry NA, Li Y, Cho EJ, Piserchio A, Zamora-Olivares DP, Ghose R, Kaoud TS, Debevec G, Bartholomeusz C, Gurevich VV, Iverson TM, Giulianotti M, Houghten RA, Dalby KN. A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation. Acs Chemical Biology. PMID 31058487 DOI: 10.1021/Acschembio.9B00093  0.317
2019 Fleming KA, Freeman KT, Powers MD, Santos RG, Debevec G, Giulianotti MA, Houghten RA, Doering SR, Pinilla C, Haskell-Luevano C. Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a µM MC4R Partial Agonist. Journal of Medicinal Chemistry. PMID 30741545 DOI: 10.1021/Acs.Jmedchem.9B00053  0.44
2017 Wu J, Cippitelli A, Zhang Y, Debevec G, Schoch J, Ozawa A, Yu Y, Liu H, Chen W, Houghten RA, Welmaker GS, Giulianotti MA, Toll L. Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats. Journal of Medicinal Chemistry. PMID 29178785 DOI: 10.1021/Acs.Jmedchem.7B01250  0.308
2017 Giulianotti MA, Vesely BA, Azhari A, Souza A, LaVoi T, Houghten RA, Kyle DE, Leahy JW. Identification of a Hit Series of Antileishmanial Compounds through the Use of Mixture-Based Libraries. Acs Medicinal Chemistry Letters. 8: 802-807. PMID 28835792 DOI: 10.1021/acsmedchemlett.7b00045  0.326
2017 Doering SR, Freeman KT, Schnell SM, Haslach EM, Dirain MLS, Ginamarie Debevec G, Geer P, Santos RG, Giulianotti MA, Pinilla C, Appel JR, Speth RC, Houghten RA, Haskell-Luevano C. Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa(1)-Arg-(pI)DPhe-Xaa((4))-NH2. Journal of Medicinal Chemistry. PMID 28453292 DOI: 10.1021/Acs.Jmedchem.7B00301  0.333
2016 Hamel LD, Lenhart BJ, Mitchell DA, Santos RG, Giulianotti MA, Deschenes RJ. Identification of Protein Palmitoylation Inhibitors from a Scaffold Ranking Library. Combinatorial Chemistry & High Throughput Screening. PMID 27009891 DOI: 10.2174/1386207319666160324123844  0.469
2015 Houghten RA, Ganno ML, McLaughlin JP, Dooley CT, Eans SO, Santos RG, LaVoi T, Nefzi A, Welmaker G, Giulianotti MA, Toll L. Direct High Throughput In Vivo Screening: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734,821 Pyrrolidine bis-Piperazines. Acs Combinatorial Science. PMID 26651386 DOI: 10.1021/Acscombsci.5B00126  0.54
2015 Knapinska AM, Dreymuller D, Ludwig A, Smith L, Golubkov V, Sohail A, Fridman R, Giulianotti M, LaVoi TM, Houghten RA, Fields GB, Minond D. SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes. Journal of Medicinal Chemistry. 58: 5808-24. PMID 26192023 DOI: 10.1021/Acs.Jmedchem.5B00354  0.418
2015 Fleeman R, LaVoi TM, Santos RG, Morales A, Nefzi A, Welmaker GS, Medina-Franco JL, Giulianotti MA, Houghten RA, Shaw LN. Combinatorial Libraries As a Tool for the Discovery of Novel, Broad-Spectrum Antibacterial Agents Targeting the ESKAPE Pathogens. Journal of Medicinal Chemistry. 58: 3340-55. PMID 25780985 DOI: 10.1021/jm501628s  0.526
2014 Onwuha-Ekpete L, Tack L, Knapinska A, Smith L, Kaushik G, Lavoi T, Giulianotti M, Houghten RA, Fields GB, Minond D. Novel pyrrolidine diketopiperazines selectively inhibit melanoma cells via induction of late-onset apoptosis. Journal of Medicinal Chemistry. 57: 1599-608. PMID 24471466 DOI: 10.1021/Jm4019542  0.373
2013 Debevec G, Chen W, Yu Y, Houghten RA, Giulianotti MA. Libraries from Libraries: A Series of Sulfonamide Linked Heterocycles Derived from the Same Scaffold. Tetrahedron Letters. 54. PMID 24363466 DOI: 10.1016/j.tetlet.2013.06.003  0.398
2013 Wu J, Zhang Y, Maida LE, Santos RG, Welmaker GS, LaVoi TM, Nefzi A, Yu Y, Houghten RA, Toll L, Giulianotti MA. Scaffold ranking and positional scanning utilized in the discovery of nAChR-selective compounds suitable for optimization studies. Journal of Medicinal Chemistry. 56: 10103-17. PMID 24274400 DOI: 10.1021/Jm401543H  0.447
2013 Santos RG, Giulianotti MA, Houghten RA, Medina-Franco JL. Conditional probabilistic analysis for prediction of the activity landscape and relative compound activities. Journal of Chemical Information and Modeling. 53: 2613-25. PMID 23971977 DOI: 10.1021/ci400243e  0.433
2013 Pinilla C, Edwards BS, Appel JR, Yates-Gibbins T, Giulianotti MA, Medina-Franco JL, Young SM, Santos RG, Sklar LA, Houghten RA. Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries. Molecular Pharmacology. 84: 314-24. PMID 23788657 DOI: 10.1124/Mol.113.086595  0.424
2013 Santos RG, Appel JR, Giulianotti MA, Edwards BS, Sklar LA, Houghten RA, Pinilla C. The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors. Molecules (Basel, Switzerland). 18: 6408-24. PMID 23722730 DOI: 10.3390/Molecules18066408  0.439
2013 Medina-Franco JL, Edwards BS, Pinilla C, Appel JR, Giulianotti MA, Santos RG, Yongye AB, Sklar LA, Houghten RA. Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches. Journal of Chemical Information and Modeling. 53: 1475-85. PMID 23705689 DOI: 10.1021/Ci400192Y  0.314
2013 Wu B, Zhang Z, Noberini R, Barile E, Giulianotti M, Pinilla C, Houghten RA, Pasquale EB, Pellecchia M. HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery. Chemistry & Biology. 20: 19-33. PMID 23352136 DOI: 10.1016/j.chembiol.2012.10.015  0.379
2013 Medina-Franco JL, Giulianotti MA, Welmaker GS, Houghten RA. Shifting from the single to the multitarget paradigm in drug discovery. Drug Discovery Today. 18: 495-501. PMID 23340113 DOI: 10.1016/j.drudis.2013.01.008  0.311
2012 Minond D, Cudic M, Bionda N, Giulianotti M, Maida L, Houghten RA, Fields GB. Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates. The Journal of Biological Chemistry. 287: 36473-87. PMID 22927435 DOI: 10.1074/Jbc.M112.389114  0.32
2012 López-Vallejo F, Giulianotti MA, Houghten RA, Medina-Franco JL. Expanding the medicinally relevant chemical space with compound libraries. Drug Discovery Today. 17: 718-26. PMID 22515962 DOI: 10.1016/j.drudis.2012.04.001  0.372
2011 Zou H, Zhang L, Ouyang J, Giulianotti MA, Yu Y. Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents. European Journal of Medicinal Chemistry. 46: 5970-7. PMID 22019188 DOI: 10.1016/j.ejmech.2011.10.009  0.385
2011 Rideout MC, Boldt JL, Vahi-Ferguson G, Salamon P, Nefzi A, Ostresh JM, Giulianotti M, Pinilla C, Segall AM. Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes. Molecular Diversity. 15: 989-1005. PMID 21938393 DOI: 10.1007/S11030-011-9333-2  0.345
2011 López-Vallejo F, Caulfield T, Martínez-Mayorga K, Giulianotti MA, Nefzi A, Houghten RA, Medina-Franco JL. Integrating virtual screening and combinatorial chemistry for accelerated drug discovery. Combinatorial Chemistry & High Throughput Screening. 14: 475-87. PMID 21521151  0.336
2011 Yongye AB, Pinilla C, Medina-Franco JL, Giulianotti MA, Dooley CT, Appel JR, Nefzi A, Scior T, Houghten RA, Martínez-Mayorga K. Integrating computational and mixture-based screening of combinatorial libraries. Journal of Molecular Modeling. 17: 1473-82. PMID 20853183 DOI: 10.1007/s00894-010-0850-1  0.451
2010 Pérez-Villanueva J, Santos R, Hernández-Campos A, Giulianotti MA, Castillo R, Medina-Franco JL. Towards a systematic characterization of the antiprotozoal activity landscape of benzimidazole derivatives. Bioorganic & Medicinal Chemistry. 18: 7380-91. PMID 20888242 DOI: 10.1016/j.bmc.2010.09.019  0.371
2010 Hernández-Campos A, Velázquez-Martínez I, Castillo R, López-Vallejo F, Jia P, Yu Y, Giulianotti MA, Medina-Franco JL. Docking of protein kinase B inhibitors: implications in the structure-based optimization of a novel scaffold. Chemical Biology & Drug Design. 76: 269-76. PMID 20572809 DOI: 10.1111/j.1747-0285.2010.01002.x  0.406
2010 Reilley KJ, Giulianotti M, Dooley CT, Nefzi A, McLaughlin JP, Houghten RA. Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library. The Aaps Journal. 12: 318-29. PMID 20422341 DOI: 10.1208/S12248-010-9191-3  0.532
2009 Medina-Franco JL, Giulianotti MA, Yu Y, Shen L, Yao L, Singh N. Discovery of a novel protein kinase B inhibitor by structure-based virtual screening. Bioorganic & Medicinal Chemistry Letters. 19: 4634-8. PMID 19604696 DOI: 10.1016/j.bmcl.2009.06.078  0.326
2009 Yongye AB, Appel JR, Giulianotti MA, Dooley CT, Medina-Franco JL, Nefzi A, Houghten RA, Martínez-Mayorga K. Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands. Bioorganic & Medicinal Chemistry. 17: 5583-97. PMID 19576786 DOI: 10.1016/j.bmc.2009.06.026  0.316
2009 Medina-Franco JL, Martínez-Mayorga K, Bender A, Marín RM, Giulianotti MA, Pinilla C, Houghten RA. Characterization of activity landscapes using 2D and 3D similarity methods: consensus activity cliffs. Journal of Chemical Information and Modeling. 49: 477-91. PMID 19434846 DOI: 10.1021/Ci800379Q  0.329
2008 Houghten RA, Pinilla C, Giulianotti MA, Appel JR, Dooley CT, Nefzi A, Ostresh JM, Yu Y, Maggiora GM, Medina-Franco JL, Brunner D, Schneider J. Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods. Journal of Combinatorial Chemistry. 10: 3-19. PMID 18067268 DOI: 10.1021/Cc7001205  0.544
2007 Medina-Franco JL, Maggiora GM, Giulianotti MA, Pinilla C, Houghten RA. A similarity-based data-fusion approach to the visual characterization and comparison of compound databases. Chemical Biology & Drug Design. 70: 393-412. PMID 17927720 DOI: 10.1111/j.1747-0285.2007.00579.x  0.411
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