Kurt William Farrell - Publications

Affiliations: 
Mount Sinai School of Medicine, New York, NY 
Area:
Neural Stem Cells, neurofibrillary tangle, extracellular matrix, microglia, Amyloid beta, PART

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Goldberg D, Wadhwani AR, Dehghani N, Sreepada LP, Fu H, De Jager PL, Bennett DA, Wolk DA, Lee EB, Farrell K, Crary JF, Zhou W, McMillan CT. Epigenetic signatures of regional tau pathology and cognition in the aging and pathological brain. Medrxiv : the Preprint Server For Health Sciences. PMID 39606399 DOI: 10.1101/2024.11.07.24316933  0.658
2024 Farrell K, Humphrey J, Chang T, Zhao Y, Leung YY, Kuksa PP, Patil V, Lee WP, Kuzma AB, Valladares O, Cantwell LB, Wang H, Ravi A, De Sanctis C, Han N, et al. Author Correction: Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes. Nature Communications. 15: 9828. PMID 39537593 DOI: 10.1038/s41467-024-53617-3  0.494
2024 Wang H, Chang TS, Dombroski BA, Cheng PL, Patil V, Valiente-Banuet L, Farrell K, Mclean C, Molina-Porcel L, Rajput A, De Deyn PP, Le Bastard N, Gearing M, Kaat LD, Van Swieten JC, et al. Correction: Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy. Molecular Neurodegeneration. 19: 73. PMID 39402686 DOI: 10.1186/s13024-024-00763-3  0.486
2024 Farrell K, Humphrey J, Chang T, Zhao Y, Leung YY, Kuksa PP, Patil V, Lee WP, Kuzma AB, Valladares O, Cantwell LB, Wang H, Ravi A, De Sanctis C, Han N, et al. Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes. Nature Communications. 15: 7880. PMID 39251599 DOI: 10.1038/s41467-024-52025-x  0.603
2024 Ressler HW, Humphrey J, Vialle RA, Babrowicz B, Kandoi S, Raj T, Dickson DW, Ertekin-Taner N, Crary JF, Farrell K. MAPT haplotype-associated transcriptomic changes in progressive supranuclear palsy. Acta Neuropathologica Communications. 12: 135. PMID 39154163 DOI: 10.1186/s40478-024-01839-3  0.58
2024 Wang H, Chang TS, Dombroski BA, Cheng PL, Patil V, Valiente-Banuet L, Farrell K, Mclean C, Molina-Porcel L, Rajput A, De Deyn PP, Le Bastard N, Gearing M, Kaat LD, Van Swieten JC, et al. Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy. Molecular Neurodegeneration. 19: 61. PMID 39152475 DOI: 10.1186/s13024-024-00747-3  0.54
2024 McKenzie AT, Nnadi O, Slagell KD, Thorn EL, Farrell K, Crary JF. Fluid preservation in brain banking: a review. Free Neuropathology. 5. PMID 38690035 DOI: 10.17879/freeneuropathology-2024-5373  0.491
2024 Maldonado-Díaz C, Hiya S, Yokoda RT, Farrell K, Marx GA, Kauffman J, Daoud EV, Gonzales MM, Parker AS, Canbeldek L, Kulumani Mahadevan LS, Crary JF, White CL, Walker JM, Richardson TE. Disentangling and quantifying the relative cognitive impact of concurrent mixed neurodegenerative pathologies. Acta Neuropathologica. 147: 58. PMID 38520489 DOI: 10.1007/s00401-024-02716-y  0.783
2024 Wang H, Chang TS, Dombroski BA, Cheng PL, Si YQ, Tucci A, Patil V, Valiente-Banuet L, Farrell K, Mclean C, Molina-Porcel L, Alex R, Paul De Deyn P, Le Bastard N, Gearing M, et al. Association of Structural Forms of 17q21.31 with the Risk of Progressive Supranuclear Palsy and Sub-haplotypes. Medrxiv : the Preprint Server For Health Sciences. PMID 38464214 DOI: 10.1101/2024.02.26.24303379  0.478
2024 Wang Q, Wang M, Choi I, Sarrafha L, Liang M, Ho L, Farrell K, Beaumont KG, Sebra R, De Sanctis C, Crary JF, Ahfeldt T, Blanchard J, Neavin D, Powell J, et al. Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson's disease. Science Advances. 10: eadi8287. PMID 38198537 DOI: 10.1126/sciadv.adi8287  0.499
2023 Wang H, Chang TS, Dombroski BA, Cheng PL, Patil V, Valiente-Banuet L, Farrell K, Mclean C, Molina-Porcel L, Rajput A, Paul De Deyn P, Le Bastard N, Gearing M, Donker Kaat L, Van Swieten JC, et al. Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy. Medrxiv : the Preprint Server For Health Sciences. PMID 38234807 DOI: 10.1101/2023.12.28.23300612  0.58
2023 Vizcarra JC, Pearce TM, Dugger BN, Keiser MJ, Gearing M, Crary JF, Kiely EJ, Morris M, White B, Glass JD, Farrell K, Gutman DA. Toward a generalizable machine learning workflow for neurodegenerative disease staging with focus on neurofibrillary tangles. Acta Neuropathologica Communications. 11: 202. PMID 38110981 DOI: 10.1186/s40478-023-01691-x  0.549
2023 Whitney K, Song WM, Sharma A, Dangoor DK, Farrell K, Krassner MM, Ressler HW, Christie TD, Walker RH, Nirenberg MJ, Zhang B, Frucht SJ, Riboldi GM, Crary JF, Pereira AC. Single-cell transcriptomic and neuropathologic analysis reveals dysregulation of the integrated stress response in progressive supranuclear palsy. Biorxiv : the Preprint Server For Biology. PMID 38014079 DOI: 10.1101/2023.11.17.567587  0.582
2023 Marx GA, Kauffman J, McKenzie AT, Koenigsberg DG, McMillan CT, Morgello S, Karlovich E, Insausti R, Richardson TE, Walker JM, White CL, Babrowicz BM, Shen L, McKee AC, Stein TD, ... Farrell K, et al. Histopathologic brain age estimation via multiple instance learning. Acta Neuropathologica. PMID 37815677 DOI: 10.1007/s00401-023-02636-3  0.764
2023 Walker JM, Orr ME, Orr TC, Thorn EL, Christie TD, Yokoda RT, Vij M, Ehrenberg AJ, Marx GA, McKenzie AT, Kauffman J, Selmanovic E, Wisniewski T, Drummond E, White CL, ... ... Farrell K, et al. Spatial proteomics of hippocampal subfield-specific pathology in Alzheimer's disease and primary age-related tauopathy. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 37777848 DOI: 10.1002/alz.13484  0.778
2023 Ditzel RM, Walker RH, Nirenberg MJ, Tetlow AM, Farrell K, Lind-Watson KJ, Thorn EL, Dangoor DK, Gordon R, De Sanctis C, Barton B, Karp BI, Kirby A, Lett DJ, Mente K, et al. An Autopsy Series of Seven Cases of VPS13A Disease (Chorea-Acanthocytosis). Movement Disorders : Official Journal of the Movement Disorder Society. PMID 37670483 DOI: 10.1002/mds.29589  0.536
2023 Krassner MM, Kauffman J, Sowa A, Cialowicz K, Walsh S, Farrell K, Crary JF, McKenzie AT. Postmortem changes in brain cell structure: a review. Free Neuropathology. 4. PMID 37384330 DOI: 10.17879/freeneuropathology-2023-4790  0.535
2023 Miltenberger-Miltenyi G, Jones A, Tetlow AM, Conceição VA, Crary JF, Ditzel RM, Farrell K, Nandakumar R, Barton B, Karp BI, Kirby A, Lett DJ, Mente K, Morgello S, Simon DK, et al. Sphingolipid and Phospholipid Levels Are Altered in Human Brain in Chorea-Acanthocytosis. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 37307400 DOI: 10.1002/mds.29445  0.494
2023 Zhou X, Cao J, Zhu L, Farrell K, Wang M, Guo L, Yang J, McKenzie A, Crary JF, Cai D, Tu Z, Zhang B. Molecular differences in brain regional vulnerability to aging between males and females. Frontiers in Aging Neuroscience. 15: 1153251. PMID 37284017 DOI: 10.3389/fnagi.2023.1153251  0.592
2023 Ghanem A, Berry DS, Farrell K, Cosentino S, Crary JF, Louis ED. Cognitive Performance as a Function of MAPT Haplotype: A Prospective Longitudinal Study of an Essential Tremor Cohort. Tremor and Other Hyperkinetic Movements (New York, N.Y.). 13: 19. PMID 37214541 DOI: 10.5334/tohm.768  0.568
2023 Walker JM, Gonzales MM, Goette W, Farrell K, White Iii CL, Crary JF, Richardson TE. Cognitive and Neuropsychological Profiles in Alzheimer's Disease and Primary Age-Related Tauopathy and the Influence of Comorbid Neuropathologies. Journal of Alzheimer's Disease : Jad. PMID 36847012 DOI: 10.3233/JAD-230022  0.647
2023 McKee AC, Stein TD, Huber BR, Crary JF, Bieniek K, Dickson D, Alvarez VE, Cherry JD, Farrell K, Butler M, Uretsky M, Abdolmohammadi B, Alosco ML, Tripodis Y, Mez J, et al. Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts. Acta Neuropathologica. PMID 36759368 DOI: 10.1007/s00401-023-02540-w  0.581
2023 Walker JM, Goette W, Farrell K, Iida MA, Karlovich E, White CL, Crary JF, Richardson TE. The relationship between hippocampal amyloid beta burden and spatial distribution of neurofibrillary degeneration. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36738450 DOI: 10.1002/alz.12966  0.579
2022 Cherry JD, Baucom ZH, Eppich KG, Kirsch D, Dixon ER, Tripodis Y, Bieniek KF, Farrell K, Whitney K, Uretsky M, Crary JF, Dickson D, McKee AC. Neuroimmune proteins can differentiate between tauopathies. Journal of Neuroinflammation. 19: 278. PMID 36403052 DOI: 10.1186/s12974-022-02640-6  0.576
2022 Marx GA, Koenigsberg DG, McKenzie AT, Kauffman J, Hanson RW, Whitney K, Signaevsky M, Prastawa M, Iida MA, White CL, Walker JM, Richardson TE, Koll J, Fernandez G, Zeineh J, ... ... Farrell K, et al. Artificial intelligence-derived neurofibrillary tangle burden is associated with antemortem cognitive impairment. Acta Neuropathologica Communications. 10: 157. PMID 36316708 DOI: 10.1186/s40478-022-01457-x  0.796
2022 McKenzie AT, Marx GA, Koenigsberg D, Sawyer M, Iida MA, Walker JM, Richardson TE, Campanella G, Attems J, McKee AC, Stein TD, Fuchs TJ, White CL, Farrell K, Crary JF. Interpretable deep learning of myelin histopathology in age-related cognitive impairment. Acta Neuropathologica Communications. 10: 131. PMID 36127723 DOI: 10.1186/s40478-022-01425-5  0.777
2022 Farrell K, Iida MA, Cherry JD, Casella A, Stein TD, Bieniek KF, Walker JM, Richardson TE, White CL, Alvarez VE, Huber BR, Dickson DW, Insausti R, Dams-O'Connor K, McKee AC, et al. Differential Vulnerability of Hippocampal Subfields in Primary Age-Related Tauopathy and Chronic Traumatic Encephalopathy. Journal of Neuropathology and Experimental Neurology. PMID 36004533 DOI: 10.1093/jnen/nlac066  0.578
2022 Atherton K, Han X, Chung J, Cherry JD, Baucom Z, Saltiel N, Nair E, Abdolmohammadi B, Uretsky M, Khan MM, Shea C, Durape S, Martin BM, Palmisano JN, Farrell K, et al. Association of APOE Genotypes and Chronic Traumatic Encephalopathy. Jama Neurology. PMID 35759276 DOI: 10.1001/jamaneurol.2022.1634  0.488
2022 Walker JM, Richardson TE, Farrell K, White Iii CL, Crary JF. The Frequency of Cerebral Amyloid Angiopathy in Primary Age-Related Tauopathy. Journal of Neuropathology and Experimental Neurology. PMID 34981120 DOI: 10.1093/jnen/nlab131  0.549
2021 Navarro E, Udine E, de Paiva Lopes K, Parks M, Riboldi G, Schilder BM, Humphrey J, Snijders GJL, Vialle RA, Zhuang M, Sikder T, Argyrou C, Allan A, Chao MJ, Farrell K, et al. Dysregulation of mitochondrial and proteolysosomal genes in Parkinson's disease myeloid cells. Nature Aging. 1: 850-863. PMID 35005630 DOI: 10.1038/s43587-021-00110-x  0.502
2021 Bowles KR, Pugh DA, Oja LM, Jadow BM, Farrell K, Whitney K, Sharma A, Cherry JD, Raj T, Pereira AC, Crary JF, Goate AM. Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD. Acta Neuropathologica. PMID 34874463 DOI: 10.1007/s00401-021-02392-2  0.59
2021 Walker JM, White CL, Farrell K, Crary JF, Richardson TE. Neocortical Neurofibrillary Degeneration in Primary Age-Related Tauopathy. Journal of Neuropathology and Experimental Neurology. PMID 34865093 DOI: 10.1093/jnen/nlab113  0.558
2021 Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, et al. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathologica. PMID 34719765 DOI: 10.1007/s00401-021-02379-z  0.629
2021 Kim SH, Farrell K, Cosentino S, Vonsattel JG, Faust PL, Cortes EP, Bennet DA, Louis ED, Crary JF. Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies. Journal of Neuropathology and Experimental Neurology. PMID 34363663 DOI: 10.1093/jnen/nlab073  0.571
2021 Iida MA, Farrell K, Walker JM, Richardson TE, Marx GA, Bryce CH, Purohit D, Ayalon G, Beach TG, Bigio EH, Cortes EP, Gearing M, Haroutunian V, McMillan CT, Lee EB, et al. Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study. Acta Neuropathologica Communications. 9: 134. PMID 34353357 DOI: 10.1186/s40478-021-01233-3  0.798
2021 Walker JM, Fudym Y, Farrell K, Iida MA, Bieniek KF, Seshadri S, White CL, Crary JF, Richardson TE. Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease. Journal of Neuropathology and Experimental Neurology. 80: 436-445. PMID 33860327 DOI: 10.1093/jnen/nlab032  0.575
2020 Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, et al. Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. Journal of Neuropathology and Experimental Neurology. PMID 33367843 DOI: 10.1093/jnen/nlaa153  0.608
2020 Kothapalli C, Mahajan G, Farrell K. Substrate stiffness induced mechanotransduction regulates temporal evolution of human fetal neural progenitor cell phenotype, differentiation, and biomechanics. Biomaterials Science. 8: 5452-5464. PMID 32996962 DOI: 10.1039/D0Bm01349H  0.634
2020 Cherry JD, Kim SH, Stein TD, Pothast MJ, Nicks R, Meng G, Huber BR, Mez J, Alosco ML, Tripodis Y, Farrell K, Alvarez VE, McKee AC, Crary JF. Evolution of neuronal and glial tau isoforms in chronic traumatic encephalopathy. Brain Pathology (Zurich, Switzerland). PMID 32500646 DOI: 10.1111/Bpa.12867  0.595
2019 Hefti MM, Kim S, Bell AJ, Betters RK, Fiock KL, Iida MA, Smalley ME, Farrell K, Fowkes ME, Crary JF. Tau Phosphorylation and Aggregation in the Developing Human Brain. Journal of Neuropathology and Experimental Neurology. PMID 31504677 DOI: 10.1093/Jnen/Nlz073  0.637
2019 Farrell K, Simmers P, Mahajan G, Boytard L, Camardo A, Joshi J, Ramamurthi A, Pinet F, Kothapalli CR. Alterations in phenotype and gene expression of adult human aneurysmal smooth muscle cells by exogenous nitric oxide. Experimental Cell Research. 111589. PMID 31473210 DOI: 10.1016/J.Yexcr.2019.111589  0.724
2019 Signaevsky M, Prastawa M, Farrell K, Tabish N, Baldwin E, Han N, Iida MA, Koll J, Bryce C, Purohit D, Haroutunian V, McKee AC, Stein TD, White CL, Walker J, et al. Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 30770886 DOI: 10.1038/S41374-019-0202-4  0.6
2019 Han N, Farrell KW, Renton AE, Casella A, Bowles K, Iida MA, Cortes EP, Goate AM, Crary JF. P1-144: GENOME-WIDE ASSOCIATION STUDY IN AN AUTOPSY COHORT OF PROGRESSIVE SUPRANUCLEAR PALSY Alzheimer's & Dementia. 15: P292-P292. DOI: 10.1016/J.Jalz.2019.06.699  0.564
2019 Walker JM, Richardson T, Farrell KW, Fudym Y, Woltjer R, Seshadri S, Bigio EH, White C, Crary JF. O2-08-06: CA2 NEUROFIBRILLARY DEGENERATION AND ASYMMETRY IN PRIMARY AGE-RELATED TAUOPATHY Alzheimer's & Dementia. 15: P557-P558. DOI: 10.1016/J.Jalz.2019.06.4498  0.565
2019 Iida MA, Farrell KW, White C, Walker JM, Han N, Casella A, Richardson T, Crary JF. P4-065: Clinicopathological Correlations In Primary Age-Related Tauopathy Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.3725  0.597
2018 Farrell K, Cosentino S, Iida MA, Chapman S, Bennett DA, Faust PL, Louis ED, Crary JF. Quantitative Assessment of Pathological Tau Burden in Essential Tremor: A Postmortem Study. Journal of Neuropathology and Experimental Neurology. PMID 30476290 DOI: 10.1093/Jnen/Nly104  0.625
2018 Hefti MM, Farrell K, Kim S, Bowles KR, Fowkes ME, Raj T, Crary JF. High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development. Plos One. 13: e0195771. PMID 29634760 DOI: 10.1371/Journal.Pone.0195771  0.618
2018 Farrell KW, Iida M, White C, Walker J, Richardson T, Graham R, Bhangale T, Crary J. P4-247: A Pilot Genetic Study Reveals Candidate Risk Alleles For Primary Age-Related Tauopathy (Part) Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.07.068  0.582
2017 Farrell K, Mahajan G, Srinivasan P, Lee MY, Kothapalli CR. Pediatric glioblastoma cells inhibit neurogenesis and promote astrogenesis, phenotypic transformation and migration of human neural progenitor cells within cocultures. Experimental Cell Research. PMID 29129566 DOI: 10.1016/J.Yexcr.2017.11.013  0.629
2016 Farrell K, Joshi J, Kothapalli CR. Injectable uncrosslinked biomimetic hydrogels as candidate scaffolds for neural stem cell delivery. Journal of Biomedical Materials Research. Part A. PMID 27798959 DOI: 10.1002/Jbm.A.35956  0.638
2016 Farrell K, Borazjani A, Damaser M, Kothapalli CR. Differential regulation of NSC phenotype and genotype by chronically activated microglia within cocultures. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 27722366 DOI: 10.1039/C6Ib00126B  0.632
2016 Farrell K, Joshi P, Roth A, Kothapalli C, Lee MY. High-throughput screening of toxic chemicals on neural stem cells Issues in Toxicology. 2016: 31-63. DOI: 10.1039/9781782626787-00031  0.614
2015 Tasneem S, Farrell K, Lee MY, Kothapalli CR. Sensitivity of Neural Stem Cell Survival, Differentiation and Neurite Outgrowth within 3D Hydrogels to Environmental Heavy Metals. Toxicology Letters. PMID 26621541 DOI: 10.1016/J.Toxlet.2015.11.021  0.62
2015 Gishto A, Farrell K, Kothapalli CR. Tuning composition and architecture of biomimetic scaffolds for enhanced matrix synthesis by murine cardiomyocytes. Journal of Biomedical Materials Research. Part A. 103: 693-708. PMID 24798055 DOI: 10.1002/Jbm.A.35217  0.609
2006 Signaevski M, Farrell KW, Tabish N, Baldwin E, Prastawa M, Koll J, Fernandez G, Zeineh J, Purohit D, Hanson R, Crary J. P4-338: MACHINE LEARNING-BASED HISTOPATHOLOGICAL APPROACH TO TAU PATHOLOGY Alzheimer's & Dementia. 14: P1596-P1596. DOI: 10.1016/J.Jalz.2018.07.161  0.569
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