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Francesco Tombola - Publications

Affiliations: 
University of California, Berkeley, Berkeley, CA, United States 
Area:
Ion channels
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70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Zhao C, Webster PD, De Angeli A, Tombola F. Mechanically-primed voltage-gated proton channels from angiosperm plants. Nature Communications. 14: 7515. PMID 37980353 DOI: 10.1038/s41467-023-43280-5  0.516
2023 Noh S, Tombola F, Burke PJ. Nanowire Biosensors with Olfactory Proteins: Towards a genuine electronic nose with single molecule sensitivity and high selectivity. Nanotechnology. PMID 37524056 DOI: 10.1088/1361-6528/acebf3  0.326
2021 Zhao C, Hong L, Riahi S, Lim VT, Tobias DJ, Tombola F. A novel Hv1 inhibitor reveals a new mechanism of inhibition of a voltage-sensing domain. The Journal of General Physiology. 153. PMID 34228045 DOI: 10.1085/jgp.202012833  0.442
2021 Zhao C, Hong L, Galpin JD, Riahi S, Lim VT, Webster PD, Tobias DJ, Ahern CA, Tombola F. HIFs: New arginine mimic inhibitors of the Hv1 channel with improved VSD-ligand interactions. The Journal of General Physiology. 153. PMID 34228044 DOI: 10.1085/jgp.202012832  0.381
2021 Zhao C, Tombola F. Voltage-gated proton channels from fungi highlight role of peripheral regions in channel activation. Communications Biology. 4: 261. PMID 33637875 DOI: 10.1038/s42003-021-01792-0  0.531
2020 Lim VT, Freites JA, Tombola F, Tobias DJ. Thermodynamics and Mechanism of the Membrane Permeation of Hv1 Channel Blockers. The Journal of Membrane Biology. PMID 33196887 DOI: 10.1007/s00232-020-00149-8  0.405
2020 Lim VT, Geragotelis AD, Lim NM, Freites JA, Tombola F, Mobley DL, Tobias DJ. Insights on small molecule binding to the Hv1 proton channel from free energy calculations with molecular dynamics simulations. Scientific Reports. 10: 13587. PMID 32788614 DOI: 10.1038/s41598-020-70369-4  0.403
2020 Lim VT, Geragotelis AD, Lim NM, Freites JA, Tombola F, Mobley DL, Tobias DJ. Insights on small molecule binding to the Hv1 proton channel from free energy calculations with molecular dynamics simulations. Scientific Reports. 10: 13587. PMID 32788614 DOI: 10.1038/S41598-020-70369-4  0.5
2020 Geragotelis AD, Wood ML, Göddeke H, Hong L, Webster PD, Wong EK, Freites JA, Tombola F, Tobias DJ. Voltage-dependent structural models of the human Hv1 proton channel from long-timescale molecular dynamics simulations. Proceedings of the National Academy of Sciences of the United States of America. PMID 32461356 DOI: 10.1073/Pnas.1920943117  0.555
2020 Zhao C, Hong L, Riahi S, Galpin JD, Ahern CA, Tobias DJ, Tombola F. Rationally Designed Proton Channel Inhibitors Reveal a Druggable Pocket in a Voltage-sensing Domain Biophysical Journal. 118: 111a. DOI: 10.1016/J.Bpj.2019.11.754  0.544
2019 Ellefsen KL, Holt JR, Chang AC, Nourse JL, Arulmoli J, Mekhdjian AH, Abuwarda H, Tombola F, Flanagan LA, Dunn AR, Parker I, Pathak MM. Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca flickers. Communications Biology. 2: 298. PMID 31925072 DOI: 10.1038/s42003-019-0514-3  0.732
2019 Ellefsen KL, Holt JR, Chang AC, Nourse JL, Arulmoli J, Mekhdjian AH, Abuwarda H, Tombola F, Flanagan LA, Dunn AR, Parker I, Pathak MM. Myosin-II mediated traction forces evoke localized Piezo1-dependent Ca flickers. Communications Biology. 2: 298. PMID 31396578 DOI: 10.1038/s42003-019-0514-3  0.732
2019 Zhao C, Hong L, Galpin JD, Ahern CA, Tombola F. Two-Pronged Aromatic Arginine-Mimics as Hv1 Proton Channel Inhibitors Biophysical Journal. 116: 540a. DOI: 10.1016/J.Bpj.2018.11.2904  0.505
2019 Lim VT, Lim NM, Geragotelis AD, Freites JA, Tombola F, Mobley DL, Tobias DJ. Computational Insights on Small Molecule Binding to the Hv1 Proton Channel Biophysical Journal. 116: 432a. DOI: 10.1016/J.Bpj.2018.11.2326  0.452
2019 Ellefsen KL, Chang A, Nourse JL, Holt JR, Arulmoli J, Mekhdjian A, Aburwarda H, Tombola F, Flanagan LA, Dunn AR, Parker I, Pathak MM. Myosin-II Mediated Traction Forces Evoke Localized Piezo1 Ca2+ Flickers Biophysical Journal. 116: 377a. DOI: 10.1016/J.Bpj.2018.11.2049  0.674
2018 Zhao C, Hong L, Galpin JD, Ahern CA, Tombola F. Exploiting Π-Stacking Interactions to Improve Inhibition of the Hv1 Channel by Aromatic Guanidine Derivatives Biophysical Journal. 114: 374a. DOI: 10.1016/J.Bpj.2017.11.2073  0.459
2017 Wood ML, Freites JA, Tombola F, Tobias DJ. Atomistic Modeling of Ion Conduction Through the Voltage-Sensing Domain of the Shaker K(+) Ion Channel. The Journal of Physical Chemistry. B. PMID 28074656 DOI: 10.1021/Acs.Jpcb.6B12639  0.562
2016 Pathak MM, Tran T, Hong L, Joós B, Morris CE, Tombola F. The Hv1 proton channel responds to mechanical stimuli. The Journal of General Physiology. 148: 405-418. PMID 27799320 DOI: 10.1085/jgp.201611672  0.81
2016 Hong L, Tombola F. Allostery: A lipid two-step. Nature Chemical Biology. PMID 26878551 DOI: 10.1038/nchembio.2037  0.377
2016 Tombola F. Voltage-Sensing Domains as Ion Channels Biophysical Journal. 110: 510a. DOI: 10.1016/j.bpj.2015.11.2724  0.574
2016 Geragotelis A, Wood ML, Goeddeke H, Riahi S, Hollingsworth SA, Freites JA, Tombola F, Tobias DJ. Multi-Microsecond Molecular Dynamics Simulations of the HV1 Proton Channel Biophysical Journal. 110: 282a-283a. DOI: 10.1016/J.Bpj.2015.11.1529  0.538
2016 Hong L, Galpin JD, Ahern CA, Tombola F. Energetic Contributions of Aromatic Residues in HV1 Block by 2-Guanidinoimidazoles and in HV1 Voltage-Dependent Activation Biophysical Journal. 110: 281a. DOI: 10.1016/J.Bpj.2015.11.1522  0.558
2015 Phan L, Kautz R, Arulmoli J, Kim IH, Le DT, Shenk MA, Pathak MM, Flanagan LA, Tombola F, Gorodetsky AA. Reflectin as a Material for Neural Stem Cell Growth. Acs Applied Materials & Interfaces. PMID 26703760 DOI: 10.1021/Acsami.5B08717  0.692
2015 Hong L, Singh V, Wulff H, Tombola F. Interrogation of the intersubunit interface of the open Hv1 proton channel with a probe of allosteric coupling. Scientific Reports. 5: 14077. PMID 26365828 DOI: 10.1038/Srep14077  0.565
2015 Arulmoli J, Pathak MM, McDonnell LP, Nourse JL, Tombola F, Earthman JC, Flanagan LA. Static stretch affects neural stem cell differentiation in an extracellular matrix-dependent manner. Scientific Reports. 5: 8499. PMID 25686615 DOI: 10.1038/Srep08499  0.697
2015 Pathak MM, Nourse JL, Tran T, Hwe J, Arulmoli J, Le DTT, Bernardis E, Flanagan LA, Tombola F. Piezo1 Transduces Extracellular Matrix Mechanical Cues to Direct Human Neural Stem Cell Fate Biophysical Journal. 108: 506a. DOI: 10.1016/J.Bpj.2014.11.2767  0.764
2015 Hong L, Singh V, Wulff H, Tombola F. Allosteric Coupling between Open Subunits in the Hv1 Proton Channel Probed by Guanidino-Thiazoles Biophysical Journal. 108: 425a. DOI: 10.1016/J.Bpj.2014.11.2324  0.542
2015 Gianti E, Delemotte L, Carnevale V, Tombola F, Tobias D, Klein ML. Unveiling Potential Binding Sites in the Hv1 Four Helix Bundle Biophysical Journal. 108: 424a-425a. DOI: 10.1016/J.Bpj.2014.11.2323  0.544
2014 Pathak MM, Nourse JL, Tran T, Hwe J, Arulmoli J, Le DT, Bernardis E, Flanagan LA, Tombola F. Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 16148-53. PMID 25349416 DOI: 10.1073/Pnas.1409802111  0.785
2014 Kim IH, Hevezi P, Varga C, Pathak MM, Hong L, Ta D, Tran CT, Zlotnik A, Soltesz I, Tombola F. Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1. Plos One. 9: e105926. PMID 25165868 DOI: 10.1371/Journal.Pone.0105926  0.795
2014 Hong L, Kim IH, Tombola F. Molecular determinants of Hv1 proton channel inhibition by guanidine derivatives. Proceedings of the National Academy of Sciences of the United States of America. 111: 9971-6. PMID 24912149 DOI: 10.1073/pnas.1324012111  0.575
2014 Nourse JL, Prieto JL, Dickson AR, Lu J, Pathak MM, Tombola F, Demetriou M, Lee AP, Flanagan LA. Membrane biophysics define neuron and astrocyte progenitors in the neural lineage. Stem Cells (Dayton, Ohio). 32: 706-16. PMID 24105912 DOI: 10.1002/Stem.1535  0.699
2014 Hong L, Kim I, Tombola F. Inhibition of Voltage-Gated Hv1 Channel by Guanidine Derivatives Biophysical Journal. 106: 745a. DOI: 10.1016/j.bpj.2013.11.4101  0.611
2014 Pathak MM, Nourse JL, Tran T, Arulmoli J, Flanagan LA, Tombola F. Extracellular Matrix Elasticity Determines Stem Cell Fate through Stretch-Activated Ion Channels Biophysical Journal. 106: 572a. DOI: 10.1016/J.Bpj.2013.11.3170  0.767
2014 Wood ML, Freites JA, Tombola F, White SH, Tobias DJ. Atomistic Modeling of Ion Conduction through Voltage-Sensing Domains Biophysical Journal. 106: 538a. DOI: 10.1016/J.Bpj.2013.11.3000  0.519
2013 Hong L, Pathak MM, Kim IH, Ta D, Tombola F. Voltage-sensing domain of voltage-gated proton channel Hv1 shares mechanism of block with pore domains. Neuron. 77: 274-87. PMID 23352164 DOI: 10.1016/j.neuron.2012.11.013  0.808
2013 Wood ML, Starek G, Freites JA, White SH, William Kuo I, Tombola F, Tobias DJ. Molecular Dynamics Simulation Studies of Ion Permeation Pathways and Energetics in the Hv1 Proton Channel Biophysical Journal. 104: 276a. DOI: 10.1016/J.Bpj.2012.11.1547  0.529
2013 Hong L, Kim I, Tombola F. Molecular Determinants of Hv1 Inhibition by Guanidine Derivatives Biophysical Journal. 104: 207a. DOI: 10.1016/j.bpj.2012.11.1171  0.557
2012 Wood ML, Schow EV, Freites JA, White SH, Tombola F, Tobias DJ. Water wires in atomistic models of the Hv1 proton channel. Biochimica Et Biophysica Acta. 1818: 286-93. PMID 21843503 DOI: 10.1016/J.Bbamem.2011.07.045  0.473
2012 Wood ML, Schow EV, Freites JA, White SH, Tombola F, Tobias DJ. Voltage-Gating in the Hv1 Proton Channel: Clues from Atomistic Molecular Dynamics Simulations Biophysical Journal. 102: 686a. DOI: 10.1016/J.Bpj.2011.11.3727  0.608
2012 Hong L, Kim I, Pathak MM, Ta D, Tombola F. Hv1 Inhibitors Reveal Gating Properties Typical of Pore Domains in a Voltage-Sensing Domain Biophysical Journal. 102: 685a-686a. DOI: 10.1016/j.bpj.2011.11.3726  0.82
2011 Schow EV, Freites JA, White SH, Tombola F, Tobias DJ. Proton Conduction via Water Wire in the Hv1 Proton Channel Biophysical Journal. 100: 131a. DOI: 10.1016/J.Bpj.2010.12.919  0.544
2010 Tombola F, Ulbrich MH, Kohout SC, Isacoff EY. The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity. Nature Structural & Molecular Biology. 17: 44-50. PMID 20023640 DOI: 10.1038/Nsmb.1738  0.822
2010 Tombola F. The Hv1 Voltage-Gated Proton Channel: Are Two Pores Better than One? Biophysical Journal. 98: 198a. DOI: 10.1016/j.bpj.2009.12.1057  0.636
2009 Tombola F, Ulbrich MH, Isacoff EY. Architecture and gating of Hv1 proton channels. The Journal of Physiology. 587: 5325-9. PMID 19915215 DOI: 10.1113/jphysiol.2009.180265  0.833
2008 Tombola F, Ulbrich MH, Isacoff EY. The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron. 58: 546-56. PMID 18498736 DOI: 10.1016/j.neuron.2008.03.026  0.828
2007 Pathak MM, Yarov-Yarovoy V, Agarwal G, Roux B, Barth P, Kohout S, Tombola F, Isacoff EY. Closing in on the resting state of the Shaker K(+) channel. Neuron. 56: 124-40. PMID 17920020 DOI: 10.1016/J.Neuron.2007.09.023  0.803
2007 Tombola F, Pathak MM, Gorostiza P, Isacoff EY. The twisted ion-permeation pathway of a resting voltage-sensing domain. Nature. 445: 546-9. PMID 17187057 DOI: 10.1038/nature05396  0.828
2006 Tombola F, Pathak MM, Isacoff EY. How does voltage open an ion channel? Annual Review of Cell and Developmental Biology. 22: 23-52. PMID 16704338 DOI: 10.1146/annurev.cellbio.21.020404.145837  0.839
2005 Gorostiza P, Tombola F, Verdaguer A, Smith SB, Bustamante C, Isacoff EY. Molecular handles for the mechanical manipulation of single-membrane proteins in living cells. Ieee Transactions On Nanobioscience. 4: 269-76. PMID 16433292 DOI: 10.1109/Tnb.2005.859552  0.667
2005 Tombola F, Pathak MM, Isacoff EY. How far will you go to sense voltage? Neuron. 48: 719-25. PMID 16337910 DOI: 10.1016/j.neuron.2005.11.024  0.822
2005 Campello S, De Marchi U, Szabò I, Tombola F, Martinou JC, Zoratti M. The properties of the mitochondrial megachannel in mitoplasts from human colon carcinoma cells are not influenced by Bax. Febs Letters. 579: 3695-700. PMID 15963994 DOI: 10.1016/j.febslet.2005.05.055  0.314
2005 Tombola F, Pathak MM, Isacoff EY. Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron. 45: 379-88. PMID 15694325 DOI: 10.1016/j.neuron.2004.12.047  0.815
2005 Pathak M, Kurtz L, Tombola F, Isacoff E. The cooperative voltage sensor motion that gates a potassium channel. The Journal of General Physiology. 125: 57-69. PMID 15623895 DOI: 10.1085/jgp.200409197  0.821
2003 Tombola F, Campello S, De Luca L, Ruggiero P, Del Giudice G, Papini E, Zoratti M. Plant polyphenols inhibit VacA, a toxin secreted by the gastric pathogen Helicobacter pylori. Febs Letters. 543: 184-9. PMID 12753930 DOI: 10.1016/S0014-5793(03)00443-5  0.337
2002 Campello S, Tombola F, Cabrini G, Zoratti M. The vacuolating toxin of Helicobacter pylori mimicks the CFTR-mediated chloride conductance. Febs Letters. 532: 237-40. PMID 12459497 DOI: 10.1016/S0014-5793(02)03656-6  0.441
2002 Moschioni M, Tombola F, de Bernard M, Coelho A, Zitzer A, Zoratti M, Montecucco C. The Vibrio cholerae haemolysin anion channel is required for cell vacuolation and death. Cellular Microbiology. 4: 397-409. PMID 12102686 DOI: 10.1046/J.1462-5822.2002.00199.X  0.513
2002 Szabo I, Tombola F, Martinucci S, Zoratti M. DNA interacts with Bacillus subtilis mechano-sensitive channels in native membrane patches. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 12: 127-34. PMID 12077558 DOI: 10.1159/000063789  0.484
2001 Morbiato L, Tombola F, Campello S, Del Giudice G, Rappuoli R, Zoratti M, Papini E. Vacuolation induced by VacA toxin of Helicobacter pylori requires the intracellular accumulation of membrane permeant bases, Cl(-) and water. Febs Letters. 508: 479-83. PMID 11728476 DOI: 10.1016/S0014-5793(01)03133-7  0.381
2001 Tombola F, Pagliaccia C, Campello S, Telford JL, Montecucco C, Papini E, Zoratti M. How the loop and middle regions influence the properties of Helicobacter pylori VacA channels. Biophysical Journal. 81: 3204-15. PMID 11720986 DOI: 10.1016/S0006-3495(01)75956-5  0.476
2001 Tombola F, Morbiato L, Del Giudice G, Rappuoli R, Zoratti M, Papini E. The Helicobacter pylori VacA toxin is a urea permease that promotes urea diffusion across epithelia. The Journal of Clinical Investigation. 108: 929-37. PMID 11560962 DOI: 10.1172/JCI13045  0.35
2000 Báthori G, Parolini I, Szabó I, Tombola F, Messina A, Oliva M, Sargiacomo M, De Pinto V, Zoratti M. Extramitochondrial porin: facts and hypotheses. Journal of Bioenergetics and Biomembranes. 32: 79-89. PMID 11768765 DOI: 10.1023/A:1005516513313  0.413
2000 Tombola F, Del Giudice G, Papini E, Zoratti M. Blockers of VacA provide insights into the structure of the pore. Biophysical Journal. 79: 863-73. PMID 10920018 DOI: 10.1016/S0006-3495(00)76342-9  0.549
1999 Tombola F, Oregna F, Brutsche S, Szabò I, Del Giudice G, Rappuoli R, Montecucco C, Papini E, Zoratti M. Inhibition of the vacuolating and anion channel activities of the VacA toxin of Helicobacter pylori. Febs Letters. 460: 221-5. PMID 10544239 DOI: 10.1016/S0014-5793(99)01348-4  0.526
1999 Szabò I, Brutsche S, Tombola F, Moschioni M, Satin B, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M. Formation of anion-selective channels in the cell plasma membrane by the toxin VacA of Helicobacter pylori is required for its biological activity. The Embo Journal. 18: 5517-27. PMID 10523296 DOI: 10.1093/Emboj/18.20.5517  0.488
1999 Bàthori G, Parolini I, Tombola F, Szabò I, Messina A, Oliva M, De Pinto V, Lisanti M, Sargiacomo M, Zoratti M. Porin is present in the plasma membrane where it is concentrated in caveolae and caveolae-related domains. The Journal of Biological Chemistry. 274: 29607-12. PMID 10514428 DOI: 10.1074/Jbc.274.42.29607  0.363
1999 Tombola F, Carlesso C, Szabò I, de Bernard M, Reyrat JM, Telford JL, Rappuoli R, Montecucco C, Papini E, Zoratti M. Helicobacter pylori vacuolating toxin forms anion-selective channels in planar lipid bilayers: possible implications for the mechanism of cellular vacuolation. Biophysical Journal. 76: 1401-9. PMID 10049322 DOI: 10.1016/S0006-3495(99)77301-7  0.56
1998 Szabò I, Bàthori G, Tombola F, Coppola A, Schmehl I, Brini M, Ghazi A, De Pinto V, Zoratti M. Double-stranded DNA can be translocated across a planar membrane containing purified mitochondrial porin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 12: 495-502. PMID 9535222 DOI: 10.1096/Fasebj.12.6.495  0.404
1998 Báthori G, Szabó I, Schmehl I, Tombola F, Messina A, De Pinto V, Zoratti M. Novel aspects of the electrophysiology of mitochondrial porin. Biochemical and Biophysical Research Communications. 243: 258-63. PMID 9473514 DOI: 10.1006/bbrc.1997.7926  0.476
1997 Szabò I, Bàthori G, Tombola F, Brini M, Coppola A, Zoratti M. DNA translocation across planar bilayers containing Bacillus subtilis ion channels. The Journal of Biological Chemistry. 272: 25275-82. PMID 9312144 DOI: 10.1074/jbc.272.40.25275  0.471
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