John M. Mariadason - Publications

Affiliations: 
Ludwig Institute for Cancer Research, San Diego, CA, United States 

171 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Jenkins LJ, Luk IY, Chionh F, Tan T, Needham K, Ayton J, Reehorst CM, Vukelic N, Sieber OM, Mouradov D, Gibbs P, Williams DS, Tebbutt NC, Desai J, Hollande F, ... ... Mariadason JM, et al. BCL-X inhibitors enhance the apoptotic efficacy of BRAF inhibitors in BRAF colorectal cancer. Cell Death & Disease. 15: 183. PMID 38429301 DOI: 10.1038/s41419-024-06478-z  0.305
2023 Thilakasiri P, O'Keefe RN, To SQ, Chisanga D, Eissmann MF, Carli AL, Duscio B, Baloyan D, Dmello RS, Williams D, Mariadason J, Poh AR, Pal B, Kile BT, Vissers JH, et al. Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3. Life Science Alliance. 7. PMID 37957015 DOI: 10.26508/lsa.202302411  0.315
2023 Chüeh AC, Tse JWT, Dickinson M, Ioannidis P, Jenkins L, Togel L, Tan B, Luk I, Davalos-Salas M, Nightingale R, Thompson MR, Williams BRG, Lessene G, Lee EF, Fairlie WD, ... ... Mariadason JM, et al. Correction: ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors Across Tumor Types. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 29: 3826. PMID 37712140 DOI: 10.1158/1078-0432.CCR-23-2100  0.672
2023 Harris TJ, Liao Y, Shi W, Evangelista M, Pal B, Puthalakath H, Aston R, Mollard R, Mariadason JM, Lee EF, Fairlie WD. Induction of endoplasmic reticulum stress is associated with the anti-tumor activity of monepantel across cancer types. Cancer Medicine. PMID 37148543 DOI: 10.1002/cam4.6021  0.309
2023 Esmaeilniakooshkghazi A, Pham E, George SP, Ahrorov A, Villagomez FR, Byington M, Mukhopadhyay S, Patnaik S, Conrad JC, Naik M, Ravi S, Tebbutt N, Mooi J, Reehorst CM, Mariadason JM, et al. In colon cancer cells fascin1 regulates adherens junction remodeling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 37: e22786. PMID 36786724 DOI: 10.1096/fj.202201454R  0.383
2023 Tögel L, Nightingale R, Wu R, Chüeh AC, Al-Obaidi S, Luk I, Dávalos-Salas M, Chionh F, Murone C, Buchanan DD, Chatterton Z, Sieber OM, Arango D, Tebbutt NC, Williams D, ... ... Mariadason JM, et al. Author Correction: DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis. Scientific Reports. 13: 2422. PMID 36765160 DOI: 10.1038/s41598-023-29328-y  0.744
2022 Jenkins LJ, Luk IY, Fairlie WD, Lee EF, Palmieri M, Schoffer KL, Tan T, Ng I, Vukelic N, Tran S, Tse JW, Nightingale R, Alam Z, Chionh F, Iatropoulos G, ... ... Mariadason JM, et al. Genotype-tailored ERK/MAPK pathway and HDAC inhibition rewires the apoptotic rheostat to trigger colorectal cancer cell death. Molecular Cancer Therapeutics. PMID 36343387 DOI: 10.1158/1535-7163.MCT-22-0101  0.397
2022 Luk IY, Jenkins LJ, Schoffer KL, Ng I, Tse JWT, Mouradov D, Kaczmarczyk S, Nightingale R, Burrows AD, Anderson RL, Arango D, Dopeso H, Croft L, Richardson MF, Sieber OM, ... ... Mariadason JM, et al. Epithelial de-differentiation triggered by co-ordinate epigenetic inactivation of the EHF and CDX1 transcription factors drives colorectal cancer progression. Cell Death and Differentiation. PMID 35606410 DOI: 10.1038/s41418-022-01016-w  0.369
2022 Weickhardt AJ, Lau DK, Hodgson-Garms M, Lavis A, Jenkins LJ, Vukelic N, Ioannidis P, Luk IY, Mariadason JM. Dual targeting of FGFR3 and ERBB3 enhances the efficacy of FGFR inhibitors in FGFR3 fusion-driven bladder cancer. Bmc Cancer. 22: 478. PMID 35501832 DOI: 10.1186/s12885-022-09478-4  0.312
2022 Chionh F, Gebski V, Al-Obaidi SJ, Mooi JK, Bruhn MA, Lee CK, Chüeh AC, Williams DS, Weickhardt AJ, Wilson K, Scott AM, Simes J, Hardingham JE, Price TJ, Mariadason JM, et al. VEGF-A, VEGFR1 and VEGFR2 single nucleotide polymorphisms and outcomes from the AGITG MAX trial of capecitabine, bevacizumab and mitomycin C in metastatic colorectal cancer. Scientific Reports. 12: 1238. PMID 35075138 DOI: 10.1038/s41598-021-03952-y  0.644
2021 Arulananda S, O'Brien M, Evangelista M, Jenkins LJ, Poh AR, Walkiewicz M, Leong T, Mariadason JM, Cebon J, Balachander SB, Cidado JR, Lee EF, John T, Fairlie WD. A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma. Cell Death Discovery. 7: 122. PMID 34050131 DOI: 10.1038/s41420-021-00505-0  0.301
2021 Bazzocco S, Dopeso H, Martínez-Barriocanal Á, Anguita E, Nieto R, Li J, García-Vidal E, Maggio V, Rodrigues P, de Marcondes PG, Schwartz S, Aaltonen LA, Sánchez A, Mariadason JM, Arango D. Identification of ZBTB18 as a novel colorectal tumor suppressor gene through genome-wide promoter hypermethylation analysis. Clinical Epigenetics. 13: 88. PMID 33892786 DOI: 10.1186/s13148-021-01070-0  0.303
2021 Chüeh AC, Advani G, Foroutan M, Smith J, Ng N, Nandurkar H, Lio DS, Zhu HJ, Chong YP, Verkade H, Fujita DJ, Bjorge J, Basheer F, Lim JP, Luk I, ... ... Mariadason JM, et al. CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation. Oncogene. PMID 33767439 DOI: 10.1038/s41388-021-01755-z  0.76
2021 Mariadason JM, Lau DK, Luk IY, Jenkins LJ, Martin A, Williams DS, Schoffer KL, Chionh F, Buchert M, Sjoquist K, Boussioutas A, Hayes SA, Ernst M, Weickhardt AJ, Pavlakis N, et al. Rapid resistance of FGFR-driven gastric cancers to regorafenib and targeted FGFR inhibitors can be overcome by parallel inhibition of MEK. Molecular Cancer Therapeutics. PMID 33563752 DOI: 10.1158/1535-7163.MCT-20-0836  0.35
2020 Arulananda S, O'Brien M, Evangelista M, Harris TJ, Steinohrt NS, Jenkins LJ, Walkiewicz M, O'Donoghue RJJ, Poh AR, Thapa B, Williams DS, Leong T, Mariadason JM, Li X, Cebon J, et al. BCL-XL is an actionable target for treatment of malignant pleural mesothelioma. Cell Death Discovery. 6: 114. PMID 33298868 DOI: 10.1038/s41420-020-00348-1  0.307
2020 Owen KL, Gearing LJ, Zanker DJ, Brockwell NK, Khoo WH, Roden DL, Cmero M, Mangiola S, Hong MK, Spurling AJ, McDonald M, Chan CL, Pasam A, Lyons RJ, Duivenvoorden HM, ... ... Mariadason JM, et al. Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone. Embo Reports. e50162. PMID 32314873 DOI: 10.15252/Embr.202050162  0.411
2019 Dávalos-Salas M, Montgomery MK, Reehorst CM, Nightingale R, Ng I, Anderton H, Al-Obaidi S, Lesmana A, Scott CM, Ioannidis P, Kalra H, Keerthikumar S, Tögel L, Rigopoulos A, Gong SJ, ... ... Mariadason JM, et al. Deletion of intestinal Hdac3 remodels the lipidome of enterocytes and protects mice from diet-induced obesity. Nature Communications. 10: 5291. PMID 31757939 DOI: 10.1038/S41467-019-13180-8  0.352
2019 Lau DK, Mouradov D, Wasenang W, Luk IY, Scott CM, Williams DS, Yeung YH, Limpaiboon T, Iatropoulos GF, Jenkins LJ, Reehorst CM, Chionh F, Nikfarjam M, Croagh D, Dhillon AS, ... ... Mariadason JM, et al. Genomic Profiling of Biliary Tract Cancer Cell Lines Reveals Molecular Subtypes and Actionable Drug Targets. Iscience. 21: 624-637. PMID 31731200 DOI: 10.1016/J.Isci.2019.10.044  0.444
2019 Rao D, Mallick AB, Augustine T, Daroqui C, Jiffry J, Merla A, Chaudhary I, Seetharam R, Sood A, Gajavelli S, Aparo S, Rajdev L, Kaubisch A, Chuy J, Negassa A, ... Mariadason JM, et al. Excision repair cross-complementing group-1 (ERCC1) induction kinetics and polymorphism are markers of inferior outcome in patients with colorectal cancer treated with oxaliplatin. Oncotarget. 10: 5510-5522. PMID 31565185 DOI: 10.18632/Oncotarget.27140  0.351
2019 Williams DS, Mouradov D, Browne C, Palmieri M, Elliott MJ, Nightingale R, Fang CG, Li R, Mariadason JM, Faragher I, Jones IT, Churilov L, Tebbutt NC, Gibbs P, Sieber OM. Overexpression of TP53 protein is associated with the lack of adjuvant chemotherapy benefit in patients with stage III colorectal cancer. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. PMID 31471586 DOI: 10.1038/S41379-019-0353-2  0.37
2019 Lee EF, Harris TJ, Tran S, Evangelista M, Arulananda S, John T, Ramnac C, Hobbs C, Zhu H, Gunasingh G, Segal D, Behren A, Cebon J, Dobrovic A, Mariadason JM, et al. BCL-XL and MCL-1 are the key BCL-2 family proteins in melanoma cell survival. Cell Death & Disease. 10: 342. PMID 31019203 DOI: 10.1038/S41419-019-1568-3  0.418
2019 Bazzocco S, Dopeso JH, Martínez-Barriocanal Á, Anguita E, Nieto R, Sanchez A, Mariadason JM, Arango D. Abstract 840: Identification of novel colorectal tumor suppressor genes through genome-wide promoter hypermethylation analysis Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-840  0.357
2019 Jenkins LJ, Chionh F, Luk IY, Lee EF, Dhillon AS, Tebbutt N, Fairlie WD, Mariadason JM. Abstract 2492: BRAF inhibitors synergize with BH3 mimetics to induce apoptosis in BRAF mutant colorectal cancer cells Cancer Research. 79: 2492-2492. DOI: 10.1158/1538-7445.Am2019-2492  0.522
2018 Meka AK, Jenkins LJ, Dàvalos-Salas M, Pujara N, Wong KY, Kumeria T, Mariadason JM, Popat A. Enhanced Solubility, Permeability and Anticancer Activity of Vorinostat Using Tailored Mesoporous Silica Nanoparticles. Pharmaceutics. 10. PMID 30562958 DOI: 10.3390/Pharmaceutics10040283  0.405
2018 Mooi JK, Wirapati P, Asher R, Lee CK, Savas PS, Price TJ, Townsend A, Hardingham J, Buchanan D, Williams D, Tejpar S, Mariadason JM, Tebbutt NC. The prognostic impact of Consensus Molecular Subtypes (CMS) and its predictive effects for bevacizumab benefit in metastatic colorectal cancer: molecular analysis of the AGITG MAX clinical trial. Annals of Oncology : Official Journal of the European Society For Medical Oncology. PMID 30247524 DOI: 10.1093/Annonc/Mdy410  0.358
2018 Luk IY, Reehorst CM, Mariadason JM. ELF3, ELF5, EHF and SPDEF Transcription Factors in Tissue Homeostasis and Cancer. Molecules (Basel, Switzerland). 23. PMID 30200227 DOI: 10.3390/Molecules23092191  0.458
2018 Mooi JK, Luk IY, Mariadason JM. Cell Line Models of Molecular Subtypes of Colorectal Cancer. Methods in Molecular Biology (Clifton, N.J.). 1765: 3-26. PMID 29589298 DOI: 10.1007/978-1-4939-7765-9_1  0.416
2018 Lau DK, Tay RY, Yeung YH, Chionh F, Mooi J, Murone C, Skrinos E, Price TJ, Mariadason JM, Tebbutt NC. Phase II study of everolimus (RAD001) monotherapy as first-line treatment in advanced biliary tract cancer with biomarker exploration: the RADiChol Study. British Journal of Cancer. PMID 29527009 DOI: 10.1038/S41416-018-0021-1  0.374
2018 Eissmann MF, Dijkstra C, Wouters MA, Baloyan D, Mouradov D, Nguyen PM, Davalos-Salas M, Putoczki TL, Sieber OM, Mariadason JM, Ernst M, Masson F. Interleukin 33 signaling restrains sporadic colon cancer in an interferon-gamma-dependent manner. Cancer Immunology Research. PMID 29463593 DOI: 10.1158/2326-6066.Cir-17-0218  0.379
2018 Tögel L, Nightingale R, Wu R, Chüeh AC, Al-Obaidi S, Luk I, Dávalos-Salas M, Chionh F, Murone C, Buchanan DD, Chatterton Z, Sieber OM, Arango D, Tebbutt NC, Williams D, ... ... Mariadason JM, et al. DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis. Scientific Reports. 8: 1767. PMID 29379130 DOI: 10.1038/S41598-018-20176-9  0.778
2017 Dopeso H, Rodrigues P, Bilic J, Bazzocco S, Cartón-García F, Macaya I, de Marcondes PG, Anguita E, Masanas M, Jiménez-Flores LM, Martínez-Barriocanal Á, Nieto R, Segura MF, Schwartz S, Mariadason JM, et al. Mechanisms of inactivation of the tumour suppressor gene RHOA in colorectal cancer. British Journal of Cancer. PMID 29206819 DOI: 10.1038/Bjc.2017.420  0.447
2017 Chüeh AC, Liew MS, Russell PA, Walkiewicz M, Jayachandran A, Starmans MHW, Boutros PC, Wright G, Barnett SA, Mariadason JM, John T. Promoter hypomethylation of NY-ESO-1, association with clinicopathological features and PD-L1 expression in non-small cell lung cancer. Oncotarget. 8: 74036-74048. PMID 29088766 DOI: 10.18632/Oncotarget.18198  0.722
2017 Tse JWT, Jenkins LJ, Chionh F, Mariadason JM. Aberrant DNA Methylation in Colorectal Cancer: What Should We Target? Trends in Cancer. 3: 698-712. PMID 28958388 DOI: 10.1016/J.Trecan.2017.08.003  0.41
2017 Tutuka CSA, Andrews MC, Mariadason JM, Ioannidis P, Hudson C, Cebon J, Behren A. PLX8394, a new generation BRAF inhibitor, selectively inhibits BRAF in colonic adenocarcinoma cells and prevents paradoxical MAPK pathway activation. Molecular Cancer. 16: 112. PMID 28659148 DOI: 10.1186/S12943-017-0684-X  0.424
2017 Wang J, Mouradov D, Wang X, Jorissen RN, Chambers MC, Zimmerman LJ, Vasaikar S, Love CG, Li S, Lowes K, Leuchowius KJ, Jousset H, Weinstock J, Yau C, Mariadason J, et al. Colorectal cancer cell line proteomes are representative of primary tumors and predict drug sensitivity. Gastroenterology. PMID 28625833 DOI: 10.1053/J.Gastro.2017.06.008  0.47
2017 Chüeh AC, Tse JW, Dickinson M, Ioannidis P, Jenkins L, Tögel L, Tan B, Luk I, Dávalos-Salas M, Nightingale R, Thompson MR, Williams BR, Lessene G, Lee EF, Fairlie WD, ... ... Mariadason JM, et al. ATF3 repression of BCL-XL determines apoptotic sensitivity toHDAC inhibitors across tumour types. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28611196 DOI: 10.1158/1078-0432.Ccr-17-0466  0.771
2017 Yeung Y, Lau DK, Chionh F, Tran H, Tse JWT, Weickhardt AJ, Nikfarjam M, Scott AM, Tebbutt NC, Mariadason JM. K-Ras mutation and amplification status is predictive of resistance and high basal pAKT is predictive of sensitivity to everolimus in biliary tract cancer cell lines. Molecular Oncology. PMID 28544747 DOI: 10.1002/1878-0261.12078  0.418
2017 Mateo-Lozano S, Bazzocco S, Rodrigues P, Mazzolini R, Andretta E, Dopeso H, Fernández Y, Del Llano E, Bilic J, Suárez-López L, Macaya I, Cartón-García F, Nieto R, Jimenez-Flores LM, de Marcondes PG, ... ... Mariadason JM, et al. Loss of the EPH receptor B6 contributes to colorectal cancer metastasis. Scientific Reports. 7: 43702. PMID 28262839 DOI: 10.1038/Srep43702  0.479
2017 Gangoda L, Mathew N, Liem M, Keertikumar S, Ang C, Mariadason J, Mathivanan S. Abstract 5880: Acquired chemotherapeutic drug resistance in colorectal cancer is regulated by epithelial-to-mesenchymal transition and altered cellular pathways Cancer Research. 77: 5880-5880. DOI: 10.1158/1538-7445.Am2017-5880  0.395
2017 Reehorst CM, Luk IY, Nightingale R, Davalos-Salas M, Dhillon AS, Mariadason JM. Abstract 3529: Investigating the in vivo role of the EHF transcription factor in intestinal epithelial differentiation Cancer Research. 77: 3529-3529. DOI: 10.1158/1538-7445.Am2017-3529  0.32
2017 Jenkins LJ, Luk IY, Tse JW, Mooi J, Dhillon AS, Mariadason JM. Abstract 3089: Combining MEK and HDAC inhibitors as a therapeutic strategy to promote differentiation of colorectal cancer Cancer Research. 77: 3089-3089. DOI: 10.1158/1538-7445.Am2017-3089  0.529
2017 Mooi J, Wirapati P, Asher R, Lee C, Savas P, Price TJ, Tejpar S, Mariadason J, Tebbutt N. 479OConsensus molecular subtypes (cms) as predictors of benefit from bevacizumab in first line treatment of metastatic colorectal cancer: Retrospective analysis of the MAX clinical trial Annals of Oncology. 28. DOI: 10.1093/Annonc/Mdx393.006  0.376
2016 Tögel L, Nightingale R, Chueh AC, Jayachandran A, Tran H, Phesse T, Wu R, Sieber OM, Arango D, Dhillon AS, Dawson MA, Diez-Dacal B, Gahman TC, Filippakopoulos P, Shiau AK, ... Mariadason JM, et al. Dual targeting of bromodomain and extra-terminal domain proteins, and WNT or MAPK signaling, inhibits c-MYC expression and proliferation of colorectal cancer cells. Molecular Cancer Therapeutics. PMID 26983878 DOI: 10.1158/1535-7163.Mct-15-0724  0.757
2016 Chueh AC, Tse J, Ioannidis P, Tögel L, Tan BS, Davlos-Salas M, Nightingale R, Thompson MR, Williams B, Dickinson M, Dhillon AS, Mariadason JM. Abstract 4728: Histone deacetylase inhibitors induce apoptosis in multiple tumor types through induction of ATF3 Cancer Research. 76: 4728-4728. DOI: 10.1158/1538-7445.Am2016-4728  0.756
2016 Hodgson-Garms M, Mariadason J, Weickhardt A. Mechanisms of acquired resistance to the fibroblast growth factor receptor (FGFR) inhibitor BGJ398 in FGFR driven bladder cancer Annals of Oncology. 27. DOI: 10.1093/Annonc/Mdw392.43  0.38
2015 Patnaik S, George SP, Pham E, Swati R, Singh K, Mariadason JM, Khurana S. By moonlighting in the nucleus villin regulates epithelial plasticity. Molecular Biology of the Cell. PMID 26658611 DOI: 10.1091/Mbc.E15-06-0453  0.325
2015 Chisanga D, Keerthikumar S, Pathan M, Ariyaratne D, Kalra H, Boukouris S, Mathew NA, Saffar HA, Gangoda L, Ang CS, Sieber OM, Mariadason JM, Dasgupta R, Chilamkurti N, Mathivanan S. Colorectal cancer atlas: An integrative resource for genomic and proteomic annotations from colorectal cancer cell lines and tissues. Nucleic Acids Research. PMID 26496946 DOI: 10.1093/Nar/Gkv1097  0.427
2015 Shin J, Carr A, Corner GA, Tögel L, Dávalos-Salas M, Tran H, Chueh AC, Al-Obaidi S, Chionh F, Ahmed N, Buchanan DD, Young JP, Malo MS, Hodin RA, Arango D, ... ... Mariadason JM, et al. The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner. The Journal of Biological Chemistry. 290: 15392. PMID 26092983 DOI: 10.1074/Jbc.A114.557546  0.751
2015 Bazzocco S, Dopeso H, Carton-Garcia F, Macaya I, Andretta E, Chionh F, Rodrigues P, Garrido M, Alazzouzi H, Nieto R, Sanchez A, Schwartz S, Bilic J, Mariadason JM, Arango D. Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 3695-704. PMID 25944804 DOI: 10.1158/1078-0432.Ccr-14-2457  0.548
2015 Pereira L, Mariadason JM, Hannan RD, Dhillon AS. Implications of epithelial-mesenchymal plasticity for heterogeneity in colorectal cancer. Frontiers in Oncology. 5: 13. PMID 25699236 DOI: 10.3389/Fonc.2015.00013  0.411
2015 Augustine TA, Baig M, Sood A, Budagov T, Atzmon G, Mariadason JM, Aparo S, Maitra R, Goel S. Telomere length is a novel predictive biomarker of sensitivity to anti-EGFR therapy in metastatic colorectal cancer. British Journal of Cancer. 112: 313-8. PMID 25412235 DOI: 10.1038/Bjc.2014.561  0.377
2015 Gilan O, Diesch J, Amalia M, Jastrzebski K, Chueh AC, Verrills NM, Pearson RB, Mariadason JM, Tulchinsky E, Hannan RD, Dhillon AS. PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity. Oncogene. 34: 1333-9. PMID 24632621 DOI: 10.1038/Onc.2014.26  0.716
2015 Chueh AC, Tse JW, Tögel L, Mariadason JM. Mechanisms of Histone Deacetylase Inhibitor-Regulated Gene Expression in Cancer Cells. Antioxidants & Redox Signaling. 23: 66-84. PMID 24512308 DOI: 10.1089/Ars.2014.5863  0.729
2015 Maitra R, Nayak JB, Merla A, Sood A, Augustine TA, Baig M, Reynolds DM, Mariadason JM, Aparo S, Goel S. A single nucleotide polymorphism in the MGMT gene is a novel prognostic biomarker in patients with metastatic colorectal cancer. British Journal of Medicine and Medical Research. 5: 604-611. DOI: 10.9734/Bjmmr/2015/12841  0.391
2015 Rodrigues P, Macaya I, Bazzocco S, Andretta E, Mazzolini R, Dopeso H, Mateo-Lozano S, Bilic J, Cartón-García F, Nieto R, Suárez-López L, Afonso E, Landolfi S, Hernandez-Losa J, Kobayashi K, ... ... Mariadason JM, et al. Abstract 2058: RHOA inactivation enhances Wnt signaling and promotes colorectal cancer Cancer Research. 75: 2058-2058. DOI: 10.1158/1538-7445.Am2015-2058  0.463
2014 Rodrigues P, Macaya I, Bazzocco S, Mazzolini R, Andretta E, Dopeso H, Mateo-Lozano S, Bili? J, Cartón-García F, Nieto R, Suárez-López L, Afonso E, Landolfi S, Hernandez-Losa J, Kobayashi K, ... ... Mariadason JM, et al. RHOA inactivation enhances Wnt signalling and promotes colorectal cancer. Nature Communications. 5: 5458. PMID 25413277 DOI: 10.1038/Ncomms6458  0.476
2014 Donnard E, Asprino PF, Correa BR, Bettoni F, Koyama FC, Navarro FC, Perez RO, Mariadason J, Sieber OM, Strausberg RL, Simpson AJ, Jardim DL, Reis LF, Parmigiani RB, Galante PA, et al. Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy. Oncotarget. 5: 9199-213. PMID 25193853 DOI: 10.18632/Oncotarget.2374  0.436
2014 Shin J, Carr A, Corner GA, Tögel L, Dávaos-Salas M, Tran H, Chueh AC, Al-Obaidi S, Chionh F, Ahmed N, Buchanan DD, Young JP, Malo MS, Hodin RA, Arango D, ... ... Mariadason JM, et al. The intestinal epithelial cell differentiation marker intestinal alkaline phosphatase (ALPi) is selectively induced by histone deacetylase inhibitors (HDACi) in colon cancer cells in a Kruppel-like factor 5 (KLF5)-dependent manner. The Journal of Biological Chemistry. 289: 25306-16. PMID 25037223 DOI: 10.1074/Jbc.M114.557546  0.768
2014 Maitra R, Seetharam R, Tesfa L, Augustine TA, Klampfer L, Coffey MC, Mariadason JM, Goel S. Oncolytic reovirus preferentially induces apoptosis in KRAS mutant colorectal cancer cells, and synergizes with irinotecan. Oncotarget. 5: 2807-19. PMID 24798549 DOI: 10.18632/Oncotarget.1921  0.496
2014 Mouradov D, Sloggett C, Jorissen RN, Love CG, Li S, Burgess AW, Arango D, Strausberg RL, Buchanan D, Wormald S, O'Connor L, Wilding JL, Bicknell D, Tomlinson IP, Bodmer WF, ... Mariadason JM, et al. Colorectal cancer cell lines are representative models of the main molecular subtypes of primary cancer. Cancer Research. 74: 3238-47. PMID 24755471 DOI: 10.1158/0008-5472.Can-14-0013  0.494
2014 Diesch J, Sanij E, Gilan O, Love C, Tran H, Fleming NI, Ellul J, Amalia M, Haviv I, Pearson RB, Tulchinsky E, Mariadason JM, Sieber OM, Hannan RD, Dhillon AS. Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells. Plos One. 9: e88950. PMID 24658684 DOI: 10.1371/Journal.Pone.0088950  0.51
2014 Ung N, Putoczki TL, Stylli SS, Ng I, Mariadason JM, Chan TA, Zhu HJ, Luwor RB. Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity. Cancer Biology & Therapy. 15: 623-32. PMID 24556630 DOI: 10.4161/Cbt.28179  0.438
2014 Tan B, Anaka M, Deb S, Freyer C, Ebert LM, Chueh AC, Al-Obaidi S, Behren A, Jayachandran A, Cebon J, Chen W, Mariadason JM. FOXP3 over-expression inhibits melanoma tumorigenesis via effects on proliferation and apoptosis. Oncotarget. 5: 264-76. PMID 24406338 DOI: 10.18632/Oncotarget.1600  0.737
2014 Aisner DL, Nguyen TT, Paskulin DD, Le AT, Haney J, Schulte N, Chionh F, Hardingham J, Mariadason J, Tebbutt N, Doebele RC, Weickhardt AJ, Varella-Garcia M. ROS1 and ALK fusions in colorectal cancer, with evidence of intratumoral heterogeneity for molecular drivers. Molecular Cancer Research : McR. 12: 111-8. PMID 24296758 DOI: 10.1158/1541-7786.Mcr-13-0479-T  0.425
2014 Yeung YH, Chionh FJM, Price TJ, Scott AM, Tran H, Fang G, Skrinos E, Murone C, Mariadason JM, Tebbutt NC. Phase II study of everolimus monotherapy as first-line treatment in advanced biliary tract cancer: RADichol. Journal of Clinical Oncology. 32: 4101-4101. DOI: 10.1200/Jco.2014.32.15_Suppl.4101  0.378
2014 Chionh FJM, Gebski V, Chueh AC, Al-Obaidi SJ, Weickhardt AJ, Lee C, Williams DS, Murone C, Wilson K, Scott AM, Simes J, Price TJ, Mariadason JM, Tebbutt NC. Single nucleotide polymorphisms (SNPs) in vascular endothelial growth factor (VEGF) family genes as predictive or prognostic biomarkers in patients (pts) with metastatic colorectal cancer (mCRC): Analysis of the phase III MAX study. Journal of Clinical Oncology. 32: 3609-3609. DOI: 10.1200/Jco.2014.32.15_Suppl.3609  0.669
2014 Sieber O, Mouradov D, Sloggett C, Jorissen R, Love C, Li S, Burgess A, Arango D, Strausberg R, Buchanan D, Wormald S, O'Connor L, Wilding J, Bicknell D, Tomlinson I, ... ... Mariadason J, et al. Abstract 5172: Whole exome mutation landscape of 70 commonly used colorectal cancer cell lines Cancer Research. 74: 5172-5172. DOI: 10.1158/1538-7445.Am2014-5172  0.468
2014 Tse JW, Chueh AC, Luk IY, Chionh F, Yeung Y, Corner GA, Ng DC, Tran H, Dhillon AS, Mariadason JM. Abstract 5112: Histone deacetylase and proteasome inhibitors synergistically induce apoptosis in colon cancer, multiple myeloma and CTCL cells through induction of the immediate early genes ATF3 and JUN Cancer Research. 74: 5112-5112. DOI: 10.1158/1538-7445.Am2014-5112  0.77
2014 Augustine TA, Baig MA, Mariadason JM, Maitra R, Goel S. Abstract 2835: Telomere length: A novel biomarker for anti-EGFR therapy in colorectal cancer Cancer Research. 74: 2835-2835. DOI: 10.1158/1538-7445.Am2014-2835  0.447
2014 Luk IY, Tran H, Tse JW, Chueh AC, Chionh F, Clemons NJ, Mariadason JM. Abstract 2339: Transcriptional basis for loss of cellular differentiation in colon cancer Cancer Research. 74: 2339-2339. DOI: 10.1158/1538-7445.Am2014-2339  0.778
2013 Andrews MC, Behren A, Chionh F, Mariadason J, Vella LJ, Do H, Dobrovic A, Tebbutt N, Cebon J. BRAF inhibitor-driven tumor proliferation in a KRAS-mutated colon carcinoma is not overcome by MEK1/2 inhibition. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: e448-51. PMID 24190114 DOI: 10.1200/Jco.2013.50.4118  0.338
2013 Burvenich IJ, Lee FT, Cartwright GA, O'Keefe GJ, Makris D, Cao D, Gong S, Chueh AC, Mariadason JM, Brechbiel MW, Beckman RA, Fujiwara K, von Roemeling R, Scott AM. Molecular imaging of death receptor 5 occupancy and saturation kinetics in vivo by humanized monoclonal antibody CS-1008. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 5984-93. PMID 24045184 DOI: 10.1158/1078-0432.Ccr-12-3104  0.701
2013 Lee ST, Ji H, Greening DW, Speirs RW, Rigopoulos A, Pillay V, Murone C, Vitali A, Stühler K, Johns TG, Corner GA, Mariadason JM, Simpson RJ, Scott AM. Global protein profiling reveals anti-EGFR monoclonal antibody 806-modulated proteins in A431 tumor xenografts. Growth Factors (Chur, Switzerland). 31: 154-64. PMID 23957735 DOI: 10.3109/08977194.2013.824435  0.38
2013 Mao M, Tian F, Mariadason JM, Tsao CC, Lemos R, Dayyani F, Gopal YN, Jiang ZQ, Wistuba II, Tang XM, Bornman WG, Bollag G, Mills GB, Powis G, Desai J, et al. Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 657-67. PMID 23251002 DOI: 10.1158/1078-0432.Ccr-11-1446  0.431
2013 Fleming NI, Jorissen RN, Mouradov D, Christie M, Sakthianandeswaren A, Palmieri M, Day F, Li S, Tsui C, Lipton L, Desai J, Jones IT, McLaughlin S, Ward RL, Hawkins NJ, ... ... Mariadason JM, et al. SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer. Cancer Research. 73: 725-35. PMID 23139211 DOI: 10.1158/0008-5472.Can-12-2706  0.346
2013 Mazzolini R, Rodrigues P, Bazzocco S, Dopeso H, Ferreira AM, Mateo-Lozano S, Andretta E, Woerner SM, Alazzouzi H, Landolfi S, Hernandez-Losa J, Macaya I, Suzuki H, Ramón y Cajal S, Mooseker MS, ... Mariadason JM, et al. Brush border myosin Ia inactivation in gastric but not endometrial tumors. International Journal of Cancer. Journal International Du Cancer. 132: 1790-9. PMID 23002058 DOI: 10.1002/Ijc.27856  0.365
2013 Weickhardt AJ, Nguyen TT, Paskulin DD, Le AT, Aisner D, Schulte N, Chionh FJM, Mariadason J, Tebbutt NC, Doebele RC, Varella-Garcia M. ALK and ROS1 gene rearrangements detected in colorectal cancer (CRC) by fluorescence in situ hybridization (FISH). Journal of Clinical Oncology. 31: 3545-3545. DOI: 10.1200/Jco.2013.31.15_Suppl.3545  0.409
2013 Mariadason J, Carr A, Corner GA, Al-Obaidi S, Chueh A, Chionh F, Tögel L, Ahmed N, Arango D, Buchanan D, Young J, Augenlicht LH, Malo MS, Hodin R, Sieber OM, et al. Abstract 2991: Coordinate methylation of the alkaline phosphatase gene family in colon cancer. Implications for understanding the manifestation of the CpG island methylator phenotype (CIMP). . Molecular and Cellular Biology. 73: 2991-2991. DOI: 10.1158/1538-7445.Am2013-2991  0.765
2013 Patnaik S, George SP, Mariadason JM, Khurana S. 340 Regulation of EMT in Colorectal Cancer Gastroenterology. 144. DOI: 10.1016/S0016-5085(13)60264-4  0.45
2012 Smartt HJM, Greenhough A, Ordóñez-Morán P, Al-Kharusi M, Collard TJ, Mariadason JM, Huelsken J, Williams AC, Paraskeva C. β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin? British Journal of Cancer. 107: 1514-1517. PMID 23033009 DOI: 10.1038/Bjc.2012.430  0.411
2012 Haigentz M, Kim M, Sarta C, Lin J, Keresztes RS, Culliney B, Gaba AG, Smith RV, Shapiro GI, Chirieac LR, Mariadason JM, Belbin TJ, Greally JM, Wright JJ, Haddad RI. Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer. Oral Oncology. 48: 1281-8. PMID 22748449 DOI: 10.1016/J.Oraloncology.2012.05.024  0.373
2012 Dhomen NS, Mariadason J, Tebbutt N, Scott AM. Therapeutic targeting of the epidermal growth factor receptor in human cancer. Critical Reviews in Oncogenesis. 17: 31-50. PMID 22471663 DOI: 10.1615/Critrevoncog.V17.I1.40  0.379
2012 Weickhardt AJ, Price TJ, Chong G, Gebski V, Pavlakis N, Johns TG, Azad A, Skrinos E, Fluck K, Dobrovic A, Salemi R, Scott AM, Mariadason JM, Tebbutt NC. Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 1505-12. PMID 22412142 DOI: 10.1200/Jco.2011.38.6599  0.367
2012 Arango D, Al-Obaidi S, Williams DS, Dopeso H, Mazzolini R, Corner G, Byun DS, Carr AA, Murone C, Tögel L, Zeps N, Aaltonen LA, Iacopetta B, Mariadason JM. Villin expression is frequently lost in poorly differentiated colon cancer. The American Journal of Pathology. 180: 1509-21. PMID 22349300 DOI: 10.1016/J.Ajpath.2012.01.006  0.518
2012 Mazzolini R, Dopeso H, Mateo-Lozano S, Chang W, Rodrigues P, Bazzocco S, Alazzouzi H, Landolfi S, Hernández-Losa J, Andretta E, Alhopuro P, Espín E, Armengol M, Tabernero J, Ramón y Cajal S, ... ... Mariadason JM, et al. Brush border myosin Ia has tumor suppressor activity in the intestine. Proceedings of the National Academy of Sciences of the United States of America. 109: 1530-5. PMID 22307608 DOI: 10.1073/Pnas.1108411109  0.431
2012 Sood A, McClain D, Maitra R, Basu-Mallick A, Seetharam R, Kaubisch A, Rajdev L, Mariadason JM, Tanaka K, Goel S. PTEN gene expression and mutations in the PIK3CA gene as predictors of clinical benefit to anti-epidermal growth factor receptor antibody therapy in patients with KRAS wild-type metastatic colorectal cancer. Clinical Colorectal Cancer. 11: 143-50. PMID 22285706 DOI: 10.1016/J.Clcc.2011.12.001  0.392
2012 Smartt HJ, Greenhough A, Ordóñez-Morán P, Talero E, Cherry CA, Wallam CA, Parry L, Al Kharusi M, Roberts HR, Mariadason JM, Clarke AR, Huelsken J, Williams AC, Paraskeva C. β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. Gut. 61: 1306-14. PMID 22082586 DOI: 10.1136/Gutjnl-2011-300817  0.401
2012 Pakay JL, Diesch J, Gilan O, Yip YY, Sayan E, Kolch W, Mariadason JM, Hannan RD, Tulchinsky E, Dhillon AS. A 19S proteasomal subunit cooperates with an ERK MAPK-regulated degron to regulate accumulation of Fra-1 in tumour cells. Oncogene. 31: 1817-24. PMID 21874050 DOI: 10.1038/Onc.2011.375  0.371
2012 Merla A, Mallick AB, Augustine TA, Chaudhary I, Gajavelli S, Maitra R, Daroqui C, Aparo S, Seetharam R, Rajdev L, Kaubisch A, Madajewicz S, Negassa A, Mariadason J, Ghalib MH, et al. The kinetics of the excision repair cross-complementing group-1 (ERCC1) gene in patients with colorectal cancer. Journal of Clinical Oncology. 30. DOI: 10.1200/Jco.2012.30.15_Suppl.E14019  0.397
2012 Arango D, Al-Obaidi S, Williams DS, Dopeso J, Mazzolini R, Corner GA, Byun D, Murone C, Togel L, Zeps N, Aaltonen LA, Iacopetta B, Mariadason JM. Abstract 4316: Villin expression is frequently lost in colon cancers with microsatellite instability. Cancer Research. 72: 4316-4316. DOI: 10.1158/1538-7445.Am2012-4316  0.529
2012 Tögel L, Arango D, Chueh A, Sieber O, Mariadason JM. 654 Epigenetic Silencing of the Negative Feedback Regulator of Mitogen-activated Protein Kinase (MAPK) Signalling, DUSP5, in Colorectal Cancer European Journal of Cancer. 48. DOI: 10.1016/S0959-8049(12)71301-1  0.723
2012 Diesch J, Sanij E, Ellul J, Haviv I, Love C, Tulchinsky E, Mariadason JM, Sieber O, Hannan RD, Dhillon AS. 513 A Fra-1-regulated Gene Expression Network Required for Maintenance of Epithelial-mesenchymal Transition in Human Colon Cancer Cells European Journal of Cancer. 48. DOI: 10.1016/S0959-8049(12)71177-2  0.45
2011 Nayak JB, Maitra R, Basu-Mallick A, Sood A, Mariadason J, Reynolds DM, Goel S. High throughput sequencing technology (Sequenom) as a tool to detect SNPs in human metastatic colorectal cancer (mCRC) and cell lines. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: e14083. PMID 28022460 DOI: 10.1200/Jco.2011.29.15_Suppl.E14083  0.344
2011 Weickhardt AJ, Williams D, Lee C, Simes J, Murone C, Wilson K, Cummins M, Asadi K, Price TJ, Mariadason J, Tebbutt NC. Vascular endothelial growth factors (VEGF) and VEGF receptor expression as predictive biomarkers for benefit with bevacizumab in metastatic colorectal cancer (mCRC): Analysis of the phase III MAX study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 3531. PMID 28020309 DOI: 10.1200/Jco.2011.29.15_Suppl.3531  0.322
2011 Byun DS, Ahmed N, Nasser S, Shin J, Al-Obaidi S, Goel S, Corner GA, Wilson AJ, Flanagan DJ, Williams DS, Augenlicht LH, Vincan E, Mariadason JM. Intestinal epithelial-specific PTEN inactivation results in tumor formation. American Journal of Physiology. Gastrointestinal and Liver Physiology. 301: G856-64. PMID 21836055 DOI: 10.1152/Ajpgi.00178.2011  0.429
2011 Wang D, Peregrina K, Dhima E, Lin EY, Mariadason JM, Augenlicht LH. Paneth cell marker expression in intestinal villi and colon crypts characterizes dietary induced risk for mouse sporadic intestinal cancer Proceedings of the National Academy of Sciences of the United States of America. 108: 10272-10277. PMID 21652773 DOI: 10.1073/Pnas.1017668108  0.453
2011 Mariadason JM, Tebbutt NC. Biomarkers of 5-FU response in colon cancer. Cancer Biology & Therapy. 11: 771-2. PMID 21343696 DOI: 10.4161/Cbt.11.8.15109  0.446
2011 Chueh AC, Togel L, Mariadason JM. Abstract 2629: Sustained immediate-early gene induction is linked to histone deacetylase inhibitor-induced apoptosis in multiple tumour types Cancer Research. 71: 2629-2629. DOI: 10.1158/1538-7445.Am2011-2629  0.789
2010 Patel VN, Bebek G, Mariadason JM, Wang D, Augenlicht LH, Chance MR. Prediction and testing of biological networks underlying intestinal cancer. Plos One. 5. PMID 20824133 DOI: 10.1371/Journal.Pone.0012497  0.347
2010 Weickhardt AJ, Tebbutt NC, Mariadason JM. Strategies for overcoming inherent and acquired resistance to EGFR inhibitors by targeting downstream effectors in the RAS/PI3K pathway. Current Cancer Drug Targets. 10: 824-33. PMID 20718704 DOI: 10.2174/156800910793357961  0.326
2010 Seetharam RN, Sood A, Basu-Mallick A, Augenlicht LH, Mariadason JM, Goel S. Oxaliplatin resistance induced by ERCC1 up-regulation is abrogated by siRNA-mediated gene silencing in human colorectal cancer cells. Anticancer Research. 30: 2531-8. PMID 20682979  0.38
2010 Wang D, Pezo RC, Corner G, Sison C, Lesser ML, Shenoy SM, Mariadason JM, Singer RH, Augenlicht LH. Altered dynamics of intestinal cell maturation in Apc1638N/+ mice. Cancer Research. 70: 5348-57. PMID 20570902 DOI: 10.1158/0008-5472.Can-09-4593  0.38
2010 Janakiraman M, Vakiani E, Zeng Z, Pratilas CA, Taylor BS, Chitale D, Halilovic E, Wilson M, Huberman K, Ricarte Filho JC, Persaud Y, Levine DA, Fagin JA, Jhanwar SC, Mariadason JM, et al. Genomic and biological characterization of exon 4 KRAS mutations in human cancer. Cancer Research. 70: 5901-11. PMID 20570890 DOI: 10.1158/0008-5472.Can-10-0192  0.388
2010 Dopeso H, Mateo-Lozano S, Elez E, Landolfi S, Ramos Pascual FJ, Hernández-Losa J, Mazzolini R, Rodrigues P, Bazzocco S, Carreras MJ, Espín E, Armengol M, Wilson AJ, Mariadason JM, Ramon Y Cajal S, et al. Aprataxin tumor levels predict response of colorectal cancer patients to irinotecan-based treatment. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 2375-82. PMID 20371676 DOI: 10.1158/1078-0432.Ccr-09-3275  0.369
2010 Wilson AJ, Chueh AC, Tögel L, Corner GA, Ahmed N, Goel S, Byun DS, Nasser S, Houston MA, Jhawer M, Smartt HJ, Murray LB, Nicholas C, Heerdt BG, Arango D, ... ... Mariadason JM, et al. Apoptotic sensitivity of colon cancer cells to histone deacetylase inhibitors is mediated by an Sp1/Sp3-activated transcriptional program involving immediate-early gene induction. Cancer Research. 70: 609-20. PMID 20068171 DOI: 10.1158/0008-5472.Can-09-2327  0.769
2010 Guilmeau S, Flandez M, Mariadason JM, Augenlicht LH. Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling. Oncogene. 29: 992-1002. PMID 19935714 DOI: 10.1038/Onc.2009.393  0.335
2010 Ganepola GA, Mazziotta RM, Weeresinghe D, Corner GA, Parish CJ, Chang DH, Tebbutt NC, Murone C, Ahmed N, Augenlicht LH, Mariadason JM. Gene expression profiling of primary and metastatic colon cancers identifies a reduced proliferative rate in metastatic tumors. Clinical & Experimental Metastasis. 27: 1-9. PMID 19882219 DOI: 10.1007/S10585-009-9295-2  0.417
2010 Gollamudi R, Ghalib MH, Desai KK, Chaudhary I, Wong B, Einstein M, Coffey M, Gill GM, Mettinger K, Mariadason JM, Mani S, Goel S. Intravenous administration of Reolysin, a live replication competent RNA virus is safe in patients with advanced solid tumors. Investigational New Drugs. 28: 641-9. PMID 19572105 DOI: 10.1007/S10637-009-9279-8  0.305
2010 Mallick AB, Seetharam R, Sood A, Mariadason J, Goel S. Evaluation of inducible expression of ERCC1 as a biomarker of drug response in human colorectal cancer cell lines. Journal of Clinical Oncology. 28. DOI: 10.1200/Jco.2010.28.15_Suppl.E14048  0.431
2010 Sood A, McClain D, Seetharam R, Al-rahamneh M, Kaubisch A, Rajdev L, Tanaka K, Mariadason J, Goel S. Beyond KRAS: The quest for novel genetic markers predictive for response to anti-epidermal growth factor receptor (EGFR) therapy in patients with metastatic colorectal cancer (mCRC). Journal of Clinical Oncology. 28: 3567-3567. DOI: 10.1200/Jco.2010.28.15_Suppl.3567  0.369
2010 Weickhardt AJ, Price TJ, Pavlakis N, Skrinos E, Dobrovic A, Salemi R, Scott AM, Mariadason J, Chong G, Tebbutt NC. DUX study: A phase II study of evaluating dual targeting of the EGFR using the combination of cetuximab and erlotinib in patients with chemotherapy refractory metastatic colorectal cancer. Journal of Clinical Oncology. 28: 3533-3533. DOI: 10.1200/Jco.2010.28.15_Suppl.3533  0.332
2010 Dopeso H, Mateo-Lozano S, Davalos V, Mazzolini R, Rodrigues P, Lagares-Tena L, Ceron J, Romero J, Vilardell F, Landolfi S, Hernández-Losa J, Wilson AJ, Cajal SRy, Capella G, Aaltonen LA, ... Mariadason JM, et al. Abstract 5756: The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis Cancer Research. 70: 5756-5756. DOI: 10.1158/1538-7445.Am10-5756  0.501
2010 Shin J, Azarbayejani A, Lai V, Ahmed N, Hodin R, Malo M, Arango D, Weber T, Mariadason JM. Abstract 4921: Selective promoter methylation of the cell differentiation marker, intestinal alkaline phosphatase (iALP), in microsatellite unstable colon cancer Cancer Research. 70: 4921-4921. DOI: 10.1158/1538-7445.Am10-4921  0.559
2010 Wang D, Peregrina K, Dhima E, Mariadason J, Augenlicht LH. Abstract 4157: Genetic and dietary complementation in risk for mouse intestinal tumorigenesis Cancer Research. 70: 4157-4157. DOI: 10.1158/1538-7445.Am10-4157  0.403
2010 Seetharam RN, Coffey MC, Klampfer L, Mariadason J, Goel S. Abstract 1773: The addition of Reolysin, an oncolytic reovirus, to irinotecan shows synergistic anticancer activity in colorectal cancer cell lines Cancer Research. 70: 1773-1773. DOI: 10.1158/1538-7445.Am10-1773  0.487
2010 Yuan Z, Shin J, Wilson A, Goel S, Ling YH, Ahmed N, Dopeso H, Jhawer M, Nasser S, Montagna C, Fordyce K, Augenlicht LH, Aaltonen LA, Arango D, Weber TK, ... Mariadason JM, et al. An A13 repeat within the 3′-untranslated region of Epidermal Growth Factor Receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression (Cancer Research (2009) 69, (7811-7818)) Cancer Research. 70. DOI: 10.1158/0008-5472.Can-09-4496  0.389
2009 Yuan Z, Shin J, Wilson A, Goel S, Ling YH, Ahmed N, Dopeso H, Jhawer M, Nasser S, Montagna C, Fordyce K, Augenlicht LH, Aaltonen LA, Arango D, Weber TK, ... Mariadason JM, et al. An A13 repeat within the 3'-untranslated region of epidermal growth factor receptor (EGFR) is frequently mutated in microsatellite instability colon cancers and is associated with increased EGFR expression. Cancer Research. 69: 7811-8. PMID 19789347 DOI: 10.1158/0008-5472.Can-09-0986  0.441
2009 Dopeso H, Mateo-Lozano S, Mazzolini R, Rodrigues P, Lagares-Tena L, Ceron J, Romero J, Esteves M, Landolfi S, Hernández-Losa J, Castaño J, Wilson AJ, Ramon y Cajal S, Mariadason JM, Schwartz S, et al. The receptor tyrosine kinase EPHB4 has tumor suppressor activities in intestinal tumorigenesis. Cancer Research. 69: 7430-8. PMID 19738063 DOI: 10.1158/0008-5472.Can-09-0706  0.491
2009 Azarbayejani A, Shin J, Ady J, Ahmed N, Weber T, Mariadason J. QS306. Resistance of Microsatellite (MSI) Human Colorectal Cancers (CRC) to Histone Deacetylase Inhibitor (HDACI) Mediated Differentiation is Regulated at the Epigenetic Level Journal of Surgical Research. 151: 296. DOI: 10.1016/J.Jss.2008.11.612  0.442
2008 Mariadason JM. Making sense of HDAC2 mutations in colon cancer. Gastroenterology. 135: 1457-9. PMID 18851967 DOI: 10.1053/J.Gastro.2008.09.039  0.38
2008 Chang J, Chance MR, Nicholas C, Ahmed N, Guilmeau S, Flandez M, Wang D, Byun DS, Nasser S, Albanese JM, Corner GA, Heerdt BG, Wilson AJ, Augenlicht LH, Mariadason JM. Proteomic changes during intestinal cell maturation in vivo. Journal of Proteomics. 71: 530-46. PMID 18824147 DOI: 10.1016/J.Jprot.2008.08.003  0.405
2008 Mariadason JM. Dissecting HDAC3-mediated tumor progression. Cancer Biology & Therapy. 7: 1581-3. PMID 18787408 DOI: 10.4161/Cbt.7.10.6863  0.412
2008 Sohal D, Yeatts A, Ye K, Pellagatti A, Zhou L, Pahanish P, Mo Y, Bhagat T, Mariadason J, Boultwood J, Melnick A, Greally J, Verma A. Meta-analysis of microarray studies reveals a novel hematopoietic progenitor cell signature and demonstrates feasibility of inter-platform data integration. Plos One. 3: e2965. PMID 18698424 DOI: 10.1371/Journal.Pone.0002965  0.361
2008 Wilson AJ, Byun DS, Nasser S, Murray LB, Ayyanar K, Arango D, Figueroa M, Melnick A, Kao GD, Augenlicht LH, Mariadason JM. HDAC4 promotes growth of colon cancer cells via repression of p21. Molecular Biology of the Cell. 19: 4062-75. PMID 18632985 DOI: 10.1091/Mbc.E08-02-0139  0.444
2008 Mercier I, Vuolo M, Jasmin JF, Medina CM, Williams M, Mariadason JM, Qian H, Xue X, Pestell RG, Lisanti MP, Kitsis RN. ARC (apoptosis repressor with caspase recruitment domain) is a novel marker of human colon cancer Cell Cycle. 7: 1640-1647. PMID 18469522 DOI: 10.4161/Cc.7.11.5979  0.478
2008 Li T, Yang W, Li M, Byun DS, Tong C, Nasser S, Zhuang M, Arango D, Mariadason JM, Augenlicht LH. Expression of selenium-binding protein 1 characterizes intestinal cell maturation and predicts survival for patients with colorectal cancer. Molecular Nutrition & Food Research. 52: 1289-99. PMID 18435490 DOI: 10.1002/Mnfr.200700331  0.505
2008 Jhawer M, Goel S, Wilson AJ, Montagna C, Ling YH, Byun DS, Nasser S, Arango D, Shin J, Klampfer L, Augenlicht LH, Perez-Soler R, Soler RP, Mariadason JM. PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Research. 68: 1953-61. PMID 18339877 DOI: 10.1158/0008-5472.Can-07-5659  0.458
2008 Mariadason JM. HDACs and HDAC inhibitors in colon cancer. Epigenetics. 3: 28-37. PMID 18326939 DOI: 10.4161/Epi.3.1.5736  0.523
2008 Jhawer M, Goel S, Wilson AJ, Montagna C, Ling YH, Byun DS, Nasser S, Arango D, Shin J, Klampfer L, Augenlicht LH, Perez-Soler R, Mariadason JM. Erratum: PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. (Cancer Res (2008) 68 (1953-61)) Cancer Research. 68. DOI: 10.1158/0008-5472.Can-68-16-Cor1  0.467
2008 Shin J, Yuan Z, Sreeramoju P, Fordyce K, Lai V, White N, Mariadason J, Weber TK. QS295. Epidermal Growth Factor Receptor (EGFR) Over Expression in Microsatellite Unstable (MSI) Colorectal Cancer (CRC) Is Characterized by a Deletion Mutation in the 3’ UTR Poly (A) 13 Tract and Is not Associated With Intron 1 CA Repeat Length Variation Journal of Surgical Research. 144: 384. DOI: 10.1016/J.Jss.2007.12.546  0.373
2008 Shin J, Azarbayejani A, Yuan Z, Jhawer M, Nasser S, Fordyce K, Arrango D, Mariadason JM, Weber TK. A novel deletion A mutation within the 3' untranslated region of the EGFR gene contributes to EGFR overexpression in microsatellite unstable (MSI) colon cancer (CRC) that results from increased mRNA stability Journal of the American College of Surgeons. 207. DOI: 10.1016/J.Jamcollsurg.2008.06.261  0.377
2008 Azarbayejani A, Shin J, Lai V, Ahmed N, Weber TK, Mariadason JM. De-differentiation of microsatellite unstable (MSI) colorectal cancer (CRC) is resistant to differentiation induction by the HDAC inhibitor butyrate as measured by intestinal alkaline phosphatase (ALPI) induction Journal of the American College of Surgeons. 207. DOI: 10.1016/J.Jamcollsurg.2008.06.010  0.434
2007 Gassler N, Roth W, Funke B, Schneider A, Herzog F, Tischendorf JJ, Grund K, Penzel R, Bravo IG, Mariadason J, Ehemann V, Sykora J, Haas TL, Walczak H, Ganten T, et al. Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing. Gastroenterology. 133: 587-98. PMID 17681178 DOI: 10.1053/J.Gastro.2007.06.005  0.416
2007 Smartt HJ, Guilmeau S, Nasser SV, Nicholas C, Bancroft L, Simpson SA, Yeh N, Yang W, Mariadason JM, Koff A, Augenlicht LH. p27kip1 Regulates cdk2 activity in the proliferating zone of the mouse intestinal epithelium: potential role in neoplasia. Gastroenterology. 133: 232-43. PMID 17631145 DOI: 10.1053/J.Gastro.2007.04.043  0.376
2007 Tong C, Yin Z, Song Z, Dockendorff A, Huang C, Mariadason J, Flavell RA, Davis RJ, Augenlicht LH, Yang W. c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. The American Journal of Pathology. 171: 297-303. PMID 17591974 DOI: 10.2353/Ajpath.2007.061036  0.475
2007 Khabele D, Son DS, Parl AK, Goldberg GL, Augenlicht LH, Mariadason JM, Rice VM. Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy. Cancer Biology & Therapy. 6: 795-801. PMID 17387270 DOI: 10.4161/Cbt.6.5.4007  0.472
2007 Haigentz M, Kim M, Sarta C, Keresztes RS, Smith RV, Belbin TJ, Mariadason JM, Greally JM, Shapiro GI, Haddad RI. Clinical and translational studies of depsipeptide (romidepsin), a histone deacetylase (HDAC) inhibitor, in patients with squamous cell carcinoma of the head and neck (SCCHN): New York Cancer Consortium Trial P6335 Journal of Clinical Oncology. 25: 6065-6065. DOI: 10.1200/Jco.2007.25.18_Suppl.6065  0.369
2007 Sohal D, Yeatts A, Ye K, Pellagatti A, Zhou L, Pahanish P, Mariadason J, Melnick A, Greally J, Boultwood J, Verma A. Data Mining of Hematopoietic Stem Cell Microarray Studies Reveals a Novel Stem Cell Gene Expression Signature and Demonstrates Feasibility of Integrating Data from Different Labs and Different Microarray Platforms. Blood. 110: 4073-4073. DOI: 10.1182/Blood.V110.11.4073.4073  0.357
2007 Shin J, Yuan Z, Mariadason J, Fordyce K, Sreeramoju P, Kent T, Kim J, Wang V, Weber TK. P59: Microsatellite unstable (MSI) colorectal cancer (CRC) is characterized by significantly increased epidermal growth factor receptor (EGFR) expression Journal of Surgical Research. 137: 261. DOI: 10.1016/J.Jss.2006.12.288  0.397
2006 Augenlicht LH, Yang W, Mariadason J, Velcich A, Klampfer L, Lipkin M, Yang K. Interaction of Genetic and Dietary Factors in Mouse Intestinal Tumorigenesis Journal of Nutrition. 136. PMID 16988154 DOI: 10.1093/Jn/136.10.2695S  0.4
2006 Davalos V, Dopeso H, Castaño J, Wilson AJ, Vilardell F, Romero-Gimenez J, Espín E, Armengol M, Capella G, Mariadason JM, Aaltonen LA, Schwartz S, Arango D. EPHB4 and survival of colorectal cancer patients. Cancer Research. 66: 8943-8. PMID 16982731 DOI: 10.1158/0008-5472.Can-05-4640  0.497
2006 Paroder V, Spencer SR, Paroder M, Arango D, Schwartz S, Mariadason JM, Augenlicht LH, Eskandari S, Carrasco N. Na(+)/monocarboxylate transport (SMCT) protein expression correlates with survival in colon cancer: molecular characterization of SMCT. Proceedings of the National Academy of Sciences of the United States of America. 103: 7270-5. PMID 16670197 DOI: 10.1073/Pnas.0602365103  0.404
2006 Wilson AJ, Byun DS, Popova N, Murray LB, L'Italien K, Sowa Y, Arango D, Velcich A, Augenlicht LH, Mariadason JM. Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer. The Journal of Biological Chemistry. 281: 13548-58. PMID 16533812 DOI: 10.1074/Jbc.M510023200  0.526
2006 Prokhortchouk A, Sansom O, Selfridge J, Caballero IM, Salozhin S, Aithozhina D, Cerchietti L, Meng FG, Augenlicht LH, Mariadason JM, Hendrich B, Melnick A, Prokhortchouk E, Clarke A, Bird A. Kaiso-deficient mice show resistance to intestinal cancer. Molecular and Cellular Biology. 26: 199-208. PMID 16354691 DOI: 10.1128/Mcb.26.1.199-208.2006  0.426
2006 Sohal D, Yeatts A, Opalinska J, Zhou L, Pahanish P, Ye K, Figueroa M, Mariadason J, Melnick A, Greally J, Verma A. Meta-Transcriptome of Bone Marrow Stem Cells Demonstrates Platform and Lab Dependant Variability in Gene Expression and Reveals a Novel Set of Enriched Genes. Blood. 108: 4189-4189. DOI: 10.1182/Blood.V108.11.4189.4189  0.358
2005 Alazzouzi H, Davalos V, Kokko A, Domingo E, Woerner SM, Wilson AJ, Konrad L, Laiho P, Espín E, Armengol M, Imai K, Yamamoto H, Mariadason JM, Gebert JF, Aaltonen LA, et al. Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors. Cancer Research. 65: 10170-3. PMID 16288001 DOI: 10.1158/0008-5472.Can-05-2580  0.466
2005 Yang K, Yang W, Mariadason J, Velcich A, Lipkin M, Augenlicht L. Dietary components modify gene expression: implications for carcinogenesis. Journal of Nutrition. 135: 2710-2714. PMID 16251635 DOI: 10.1093/Jn/135.11.2710  0.378
2005 Mariadason JM, Nicholas C, L'Italien KE, Zhuang M, Smartt HJ, Heerdt BG, Yang W, Corner GA, Wilson AJ, Klampfer L, Arango D, Augenlicht LH. Gene expression profiling of intestinal epithelial cell maturation along the crypt-villus axis. Gastroenterology. 128: 1081-8. PMID 15825089 DOI: 10.1053/J.Gastro.2005.01.054  0.434
2005 Velcich A, Corner G, Paul D, Zhuang M, Mariadason JM, Laboisse C, Augenlicht L. Quantitative rather than qualitative differences in gene expression predominate in intestinal cell maturation along distinct cell lineages. Experimental Cell Research. 304: 28-39. PMID 15707571 DOI: 10.1016/J.Yexcr.2004.10.014  0.422
2004 Arango D, Wilson AJ, Shi Q, Corner GA, Arañes MJ, Nicholas C, Lesser M, Mariadason JM, Augenlicht LH. Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells. British Journal of Cancer. 91: 1931-46. PMID 15545975 DOI: 10.1038/Sj.Bjc.6602215  0.482
2004 Mariadason JM, Arango D, Augenlicht LH. Customizing chemotherapy for colon cancer: the potential of gene expression profiling. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 7: 209-18. PMID 15296862 DOI: 10.1016/J.Drup.2004.05.001  0.501
2003 Mariadason JM, Arango D, Shi Q, Wilson AJ, Corner GA, Nicholas C, Aranes MJ, Lesser M, Schwartz EL, Augenlicht LH. Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin. Cancer Research. 63: 8791-812. PMID 14695196  0.309
2003 Arango D, Mariadason JM, Wilson AJ, Yang W, Corner GA, Nicholas C, Aranes MJ, Augenlicht LH. c-Myc overexpression sensitises colon cancer cells to camptothecin-induced apoptosis. British Journal of Cancer. 89: 1757-65. PMID 14583781 DOI: 10.1038/Sj.Bjc.6601338  0.407
2003 Wilson AJ, Arango D, Mariadason JM, Heerdt BG, Augenlicht LH. TR3/Nur77 in colon cancer cell apoptosis. Cancer Research. 63: 5401-7. PMID 14500374  0.383
2003 Klampfer L, Huang J, Corner G, Mariadason J, Arango D, Sasazuki T, Shirasawa S, Augenlicht L. Oncogenic Ki-ras inhibits the expression of interferon-responsive genes through inhibition of STAT1 and STAT2 expression. The Journal of Biological Chemistry. 278: 46278-87. PMID 12972432 DOI: 10.1074/Jbc.M304721200  0.442
2003 Augenlicht L, Shi L, Mariadason J, Laboisse C, Velcich A. Repression of MUC2 gene expression by butyrate, a physiological regulator of intestinal cell maturation Oncogene. 22: 4983-4992. PMID 12902981 DOI: 10.1038/Sj.Onc.1206521  0.473
2003 Augenlicht LH, Velcich A, Klampfer L, Huang J, Corner G, Aranes M, Laboisse C, Rigas B, Lipkin M, Yang K, Shi Q, Lesser M, Heerdt B, Arango D, Yang W, ... ... Mariadason JM, et al. Application of gene expression profiling to colon cell maturation, transformation and chemoprevention. The Journal of Nutrition. 133: 2410S-2416S. PMID 12840217 DOI: 10.1093/Jn/133.7.2410S  0.447
2003 Mariadason JM, Augenlicht LH, Arango D. Microarray analysis in the clinical management of cancer. Hematology/Oncology Clinics of North America. 17: 377-87. PMID 12737394 DOI: 10.1016/S0889-8588(03)00006-6  0.402
2002 Augenlicht LH, Mariadason JM, Wilson A, Arango D, Yang W, Heerdt BG, Velcich A. Short chain fatty acids and colon cancer. The Journal of Nutrition. 132: 3804S-3808S. PMID 12468628 DOI: 10.1093/Jn/132.12.3804S  0.485
2002 Mariadason JM, Arango D, Corner GA, Arañes MJ, Hotchkiss KA, Yang W, Augenlicht LH. A gene expression profile that defines colon cell maturation in vitro. Cancer Research. 62: 4791-804. PMID 12183439  0.341
2001 Mariadason JM, Velcich A, Wilson AJ, Augenlicht LH, Gibson PR. Resistance to butyrate-induced cell differentiation and apoptosis during spontaneous Caco-2 cell differentiation. Gastroenterology. 120: 889-99. PMID 11231943 DOI: 10.1053/Gast.2001.22472  0.442
2000 Mariadason JM, Rickard KL, Barkla DH, Augenlicht LH, Gibson PR. Divergent phenotypic patterns and commitment to apoptosis of Caco-2 cells during spontaneous and butyrate-induced differentiation. Journal of Cellular Physiology. 183: 347-54. PMID 10797309 DOI: 10.1002/(Sici)1097-4652(200006)183:3<347::Aid-Jcp7>3.0.Co;2-W  0.421
2000 Rickard KL, Gibson PR, Wilson NJ, Mariadason JM, Phillips WA. Short-chain fatty acids reduce expression of specific protein kinase C isoforms in human colonic epithelial cells. Journal of Cellular Physiology. 182: 222-31. PMID 10623886 DOI: 10.1002/(Sici)1097-4652(200002)182:2<222::Aid-Jcp11>3.0.Co;2-B  0.438
1999 Augenlicht L, Velcich A, Mariadason J, Bordonaro M, Heerdt B. Colonic Cell Proliferation, Differentiation, and Apoptosis Advances in Experimental Medicine and Biology. 470: 15-22. PMID 10709670 DOI: 10.1007/978-1-4615-4149-3_2  0.383
1999 Augenlicht LH, Bordonaro M, Heerdt BG, Mariadason J, Velcich A. Cellular mechanisms of risk and transformation. Annals of the New York Academy of Sciences. 889: 20-31. PMID 10668479 DOI: 10.1111/J.1749-6632.1999.Tb08720.X  0.408
1999 Gibson PR, Nov R, Fielding M, McIntyre A, Finch CF, Rosella O, Mariadason JM, Barkla DH, Young GP. Relationship of hydrolase activities to epithelial cell turnover in distal colonic mucosa of normal rats. Journal of Gastroenterology and Hepatology. 14: 866-72. PMID 10535467 DOI: 10.1046/J.1440-1746.1999.01973.X  0.304
1999 Gibson PR, Rosella O, Wilson AJ, Mariadason JM, Rickard K, Byron K, Barkla DH. Colonic epithelial cell activation and the paradoxical effects of butyrate. Carcinogenesis. 20: 539-44. PMID 10223179 DOI: 10.1093/Carcin/20.4.539  0.405
1999 Mariadason JM, Catto-Smith A, Gibson PR. Modulation of distal colonic epithelial barrier function by dietary fibre in normal rats. Gut. 44: 394-399. PMID 10026327 DOI: 10.1136/Gut.44.3.394  0.306
1998 Mariadason J, Rickard K, Gibson P. Resistance to butyrate-induced apoptosis and differentiation during spontaneous Caco-2 cell differentiation Gastroenterology. 114. DOI: 10.1016/S0016-5085(98)82610-3  0.347
1997 Mariadason JM, Barkla DH, Gibson P. Effect of short-chain fatty acids on paracellular permeability in Caco-2 intestinal epithelium model American Journal of Physiology-Gastrointestinal and Liver Physiology. 272: 705-712. PMID 9142899 DOI: 10.1152/Ajpgi.1997.272.4.G705  0.343
1996 Gibson PR, Anderson RP, Mariadason JM, Wilson AJ. Protective role of the epithelium of the small intestine and colon. Inflammatory Bowel Diseases. 2: 279-302. DOI: 10.1097/00054725-199612000-00011  0.324
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