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Keith Syson Chan - Publications

Affiliations: 
2004-2009 Stem Cell & Regenerative Medicine Center Stanford University, Palo Alto, CA 
 2016- Baylor College of Medicine, Houston, TX 
 2019- Cedars-Sinai Medical Center, Los Angeles, CA, United States 
Area:
Pathology
Website:
https://alliedacademies.com/profile/Keith%20Syson%20Chan
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50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Rohena-Rivera K, You S, Kim M, Billet S, Ten Hoeve J, Gonzales G, Huang C, Heard A, Chan KS, Bhowmick NA. Targeting ketone body metabolism in mitigating gemcitabine resistance. Jci Insight. PMID 39509334 DOI: 10.1172/jci.insight.177840  0.394
2024 Broz MT, Ko EY, Ishaya K, Xiao J, De Simone M, Hoi XP, Piras R, Gala B, Tessaro FHG, Karlstaedt A, Orsulic S, Lund AW, Chan KS, Guarnerio J. Metabolic targeting of cancer associated fibroblasts overcomes T-cell exclusion and chemoresistance in soft-tissue sarcomas. Nature Communications. 15: 2498. PMID 38509063 DOI: 10.1038/s41467-024-46504-4  0.367
2023 Heiser CN, Simmons AJ, Revetta F, McKinley ET, Ramirez-Solano MA, Wang J, Kaur H, Shao J, Ayers GD, Wang Y, Glass SE, Tasneem N, Chen Z, Qin Y, Kim W, ... ... Chan KS, et al. Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors. Cell. 186: 5620-5637.e16. PMID 38065082 DOI: 10.1016/j.cell.2023.11.006  0.326
2023 Riveros C, Ranganathan S, Haque W, Huang E, Xu J, Kulkarni GS, Geng M, Anis M, Muhammad T, Chan KS, Farach A, Teh BS, Miles BJ, Klaassen Z, Sonpavde GP, et al. Comparative real-world survival outcomes of muscle-invasive bladder cancer treated with bladder-only vs. whole-pelvis concurrent chemoradiation. Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada. PMID 37931278 DOI: 10.5489/cuaj.8386  0.368
2022 Piras R, Ko EY, Barrett C, De Simone M, Lin X, Broz MT, Tessaro FHG, Castillo-Martin M, Cordon-Cardo C, Goodridge HS, Di Vizio D, Batish M, Lawrenson K, Chen YG, Chan KS, et al. circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment. Nature Communications. 13: 7243. PMID 36433954 DOI: 10.1038/s41467-022-34872-8  0.31
2022 You S, Kim M, Hoi XP, Lee YC, Wang L, Spetzler D, Abraham J, Magee D, Jain P, Galsky MD, Chan KS, Theodorescu D. Discoidin domain receptor-driven gene signatures as markers of patient response to anti-PD-L1 immune checkpoint therapy. Journal of the National Cancer Institute. PMID 35918812 DOI: 10.1093/jnci/djac140  0.539
2022 Lee YC, Lam HM, Rosser C, Theodorescu D, Parks WC, Chan KS. The dynamic roles of the bladder tumour microenvironment. Nature Reviews. Urology. PMID 35764795 DOI: 10.1038/s41585-022-00608-y  0.422
2022 You S, Kim M, Widen S, Yu A, Galvan GC, Choi-Kuaea Y, Eyzaguirre EJ, Dyrskjøt L, McConkey DJ, Choi W, Theodorescu D, Chan KS, Shan Y, Tyler DS, De Hoedt AM, et al. Characterizing molecular subtypes of high-risk non-muscle-invasive bladder cancer in African American patients. Urologic Oncology. PMID 35618577 DOI: 10.1016/j.urolonc.2022.04.013  0.313
2022 Nikolos F, Hayashi K, Hoi XP, Alonzo ME, Mo Q, Kasabyan A, Furuya H, Trepel J, Di Vizio D, Guarnerio J, Theodorescu D, Rosser C, Apolo A, Galsky M, Chan KS. Cell death-induced immunogenicity enhances chemoimmunotherapeutic response by converting immune-excluded into T-cell inflamed bladder tumors. Nature Communications. 13: 1487. PMID 35347124 DOI: 10.1038/s41467-022-29026-9  0.824
2022 Tyner JW, Haderk F, Kumaraswamy A, Baughn LB, Van Ness BG, Liu S, Marathe H, Alumkal JJ, Bivona TG, Chan KS, Druker BJ, Hutson AD, Nelson PS, Sawyers CL, Willey CD. Understanding Drug Sensitivity and Tackling Resistance in Cancer. Cancer Research. PMID 35195258 DOI: 10.1158/0008-5472.CAN-21-3695  0.325
2021 Pollan SG, Teng PC, Jan YJ, Livingstone J, Huang C, Kim M, Mariscal J, Rodriguez M, Chen JF, You S, DiVizio D, Boutros PC, Chan KS, Rasorenova O, Cress A, et al. Loss of CDCP1 triggers FAK activation in detached prostate cancer cells. American Journal of Clinical and Experimental Urology. 9: 350-366. PMID 34541033  0.342
2021 Gouin KH, Ing N, Plummer JT, Rosser CJ, Ben Cheikh B, Oh C, Chen SS, Chan KS, Furuya H, Tourtellotte WG, Knott SRV, Theodorescu D. An N-Cadherin 2 expressing epithelial cell subpopulation predicts response to surgery, chemotherapy and immunotherapy in bladder cancer. Nature Communications. 12: 4906. PMID 34385456 DOI: 10.1038/s41467-021-25103-7  0.469
2021 Hayashi K, Nikolos F, Chan KS. Inhibitory DAMPs in immunogenic cell death and its clinical implications. Cell Stress. 5: 52-54. PMID 33821233 DOI: 10.15698/cst2021.04.247  0.784
2020 Mo Q, Li R, Adeegbe DO, Peng G, Chan KS. Integrative multi-omics analysis of muscle-invasive bladder cancer identifies prognostic biomarkers for frontline chemotherapy and immunotherapy. Communications Biology. 3: 784. PMID 33335285 DOI: 10.1038/s42003-020-01491-2  0.306
2020 Furuya H, Hayashi K, Shimizu Y, Kim N, Tsukikawa Y, Chen R, Sun Y, Chan OTM, Pagano I, Peres R, Hokutan K, Igari F, Chan KS, Rosser CJ. Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model. Journal of Translational Medicine. 18: 57. PMID 32024545 DOI: 10.1186/S12967-020-02239-6  0.804
2019 Furuya H, Chan OTM, Hokutan K, Tsukikawa Y, Chee K, Kozai L, Chan KS, Dai Y, Wong RS, Rosser CJ. Prognostic Significance of Lymphocyte Infiltration and a Stromal Immunostaining of a Bladder Cancer Associated Diagnostic Panel in Urothelial Carcinoma. Diagnostics (Basel, Switzerland). 10. PMID 31905599 DOI: 10.3390/diagnostics10010014  0.43
2019 Kamoun A, Reyniès A, Allory Y, Sjödahl G, Gordon Robertson A, Seiler R, Hoadley KA, Groeneveld CS, Al-Ahmadie H, Choi W, Castro MAA, Fontugne J, Eriksson P, Mo Q, Kardos J, ... ... Chan KS, et al. A Consensus Molecular Classification of Muscle-invasive Bladder Cancer. European Urology. PMID 31563503 DOI: 10.1016/J.Eururo.2019.09.006  0.342
2019 Lee YC, Kurtova AV, Xiao J, Nikolos F, Hayashi K, Tramel Z, Jain A, Chen F, Chokshi M, Lee C, Bao G, Zhang X, Shen J, Mo Q, Jung SY, ... ... Chan KS, et al. Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung. Nature Communications. 10: 2131. PMID 31086186 DOI: 10.1038/S41467-019-09878-4  0.716
2019 Mo Q, Li R, Chan K. Abstract 1647: Integrative subtype analysis of muscle-invasive bladder cancer reveals subtypes that have different overall survival and respond differently to neoadjuvant chemotherapy Cancer Research. 79: 1647-1647. DOI: 10.1158/1538-7445.Am2019-1647  0.413
2018 Mo Q, Nikolos F, Chen F, Tramel Z, Lee YC, Hayashi K, Xiao J, Shen J, Chan KS. Prognostic Power of a Tumor Differentiation Gene Signature for Bladder Urothelial Carcinomas. Journal of the National Cancer Institute. PMID 29342309 DOI: 10.1093/Jnci/Djx243  0.734
2017 Mo Q, Shen R, Guo C, Vannucci M, Chan KS, Hilsenbeck SG. A fully Bayesian latent variable model for integrative clustering analysis of multi-type omics data. Biostatistics (Oxford, England). PMID 28541380 DOI: 10.1093/Biostatistics/Kxx017  0.333
2017 Rodriguez-Brenes I, Kurtova AV, Lin C, Lee YC, Xiao J, Mims MP, Chan KS, Wodarz D. Cellular hierarchy as a determinant of tumor sensitivity to chemotherapy. Cancer Research. PMID 28235762 DOI: 10.1158/0008-5472.Can-16-2434  0.824
2016 Brooks M, Mo Q, Krasnow R, Ho PL, Lee YC, Xiao J, Kurtova A, Lerner S, Godoy G, Jian W, Castro P, Chen F, Rowley D, Ittmann M, Chan KS. Positive association of collagen type I with non-muscle invasive bladder cancer progression. Oncotarget. PMID 27655672 DOI: 10.18632/Oncotarget.12089  0.795
2016 Lerner SP, McConkey DJ, Hoadley KA, Chan KS, Kim WY, Radvanyi F, Höglund M, Real FX. Bladder Cancer Molecular Taxonomy: Summary from a Consensus Meeting. Bladder Cancer. 2: 37-47. PMID 27376123 DOI: 10.3233/BLC-150037  0.358
2015 Chan KS. Molecular Pathways: Targeting Cancer Stem Cells Awakened by Chemotherapy to Abrogate Tumor Repopulation. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26671994 DOI: 10.1158/1078-0432.Ccr-15-0183  0.563
2015 Kurtova AV, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, Lerner SP, Chen F, Roh TT, Lay E, Ho PL, Chan KS. Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance. Nature. 517: 209-13. PMID 25470039 DOI: 10.1038/Nature14034  0.779
2015 Kurtova AV, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, Lerner SP, Chen F, Roh T, Lay E, Ho PL, Chan KS. Abstract 5470: Blocking wound-induced tumor repopulation between chemotherapy cycles as a novel approach to abrogate chemoresistance Cancer Research. 75: 5470-5470. DOI: 10.1158/1538-7445.Am2015-5470  0.82
2014 Kim W, Barron DA, San Martin R, Chan KS, Tran LL, Yang F, Ressler SJ, Rowley DR. RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation. Proceedings of the National Academy of Sciences of the United States of America. 111: 16389-94. PMID 25313057 DOI: 10.1073/Pnas.1407097111  0.437
2014 Kurtova AV, Xiao J, Lay EJ, Mo Q, Lerner SP, Rowley DR, Chan KS. Abstract 4801: Stromal-mediated collagen I signal in promoting bladder cancer progression Cancer Research. 74: 4801-4801. DOI: 10.1158/1538-7445.Am2014-4801  0.587
2014 Ho PL, Kurtova A, Xiao J, Krasnow R, Lay E, Pazhanisamy S, Lerner SP, Chan KS. Abstract 1928: Reporter construct for functional and real-time evaluation of cytokeratin 14+ bladder cancer stem cells Cancer Research. 74: 1928-1928. DOI: 10.1158/1538-7445.Am2014-1928  0.791
2013 Levitt JM, Chan KS, Lerner SP, Sonpavde G. The preclinical anti-angiogenic and pro-apoptotic activity of lenalidomide in urothelial carcinoma (UC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 31: 294. PMID 28136773 DOI: 10.1200/Jco.2013.31.6_Suppl.294  0.328
2012 Ho PL, Kurtova A, Chan KS. Normal and neoplastic urothelial stem cells: Getting to the root of the problem Nature Reviews Urology. 9: 583-594. PMID 22890301 DOI: 10.1038/Nrurol.2012.142  0.804
2012 Ho PL, Lay EJ, Jian W, Parra D, Chan KS. Stat3 activation in urothelial stem cells leads to direct progression to invasive bladder cancer Cancer Research. 72: 3135-3142. PMID 22532166 DOI: 10.1158/0008-5472.Can-11-3195  0.826
2012 Volkmer JP, Sahoo D, Chin RK, Ho PL, Tang C, Kurtova AV, Willingham SB, Pazhanisamy SK, Contreras-Trujillo H, Storm TA, Lotan Y, Beck AH, Chung BI, Alizadeh AA, Godoy G, ... ... Chan KS, et al. Three differentiation states risk-stratify bladder cancer into distinct subtypes. Proceedings of the National Academy of Sciences of the United States of America. 109: 2078-83. PMID 22308455 DOI: 10.1073/Pnas.1120605109  0.786
2012 Levitt JM, Chan KS, Jian W, Lerner SP, Sonpavde G. The preclinical activity of lenalidomide in urothelial carcinoma (UC). Journal of Clinical Oncology. 30: e15002-e15002. DOI: 10.1200/Jco.2012.30.15_Suppl.E15002  0.473
2012 Volkmer JP, Sahoo D, Chin RK, Ho PL, Tang C, Kurtova AV, Willingham SB, Pazhanisamy SK, Contreras-Trujillo H, Storm TA, Lotan Y, Beck AH, Chung BI, Alizadeh AA, Godoy G, ... ... Chan KS, et al. Three differentiation states risk-stratify bladder cancer into distinct subtypes (Proceedings of the National Academy of Sciences of the United States of America (2012) 109, 6 (2078-2083) DOI: 10.1073/pnas.1120605109) Proceedings of the National Academy of Sciences of the United States of America. 109: 3600. DOI: 10.1073/Pnas.1201493109  0.775
2010 Chan KS, Volkmer JP, Weissman I. Cancer stem cells in bladder cancer: A revisited and evolving concept Current Opinion in Urology. 20: 393-397. PMID 20657288 DOI: 10.1097/Mou.0B013E32833Cc9Df  0.615
2010 Chan KS, Volkmer J, Chao M, Shortliffe L, Weissman I. 965 CHARACTERIZATION AND PRECLINICAL TARGETING OF HUMAN BLADDER CANCER STEM CELLS Journal of Urology. 183. DOI: 10.1016/J.Juro.2010.02.1912  0.583
2009 Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J, Chang HY, van de Rijn M, Shortliffe L, Weissman IL. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 14016-21. PMID 19666525 DOI: 10.1073/Pnas.0906549106  0.621
2009 Xie X, Chan KS, Cao F, Huang M, Li Z, Lee A, Weissman IL, Wu JC. Imaging of STAT3 signaling pathway during mouse embryonic stem cell differentiation Stem Cells and Development. 18: 205-214. PMID 18576943 DOI: 10.1089/Scd.2008.0152  0.5
2008 Chan KS, Sano S, Kataoka K, Abel E, Carbajal S, Beltran L, Clifford J, Peavey M, Shen J, Digiovanni J. Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis. Oncogene. 27: 1087-94. PMID 17700521 DOI: 10.1038/Sj.Onc.1210726  0.585
2008 Sano S, Chan KS, DiGiovanni J. Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases. Journal of Dermatological Science. 50: 1-14. PMID 17601706 DOI: 10.1016/J.Jdermsci.2007.05.016  0.527
2008 Chan KS, Espinosa I, Kim J, Ailles L, Zahilay G, Gill H, Presti J, Rijn Mvd, Beachy P, Shortliffe L, Weissman I. Abstract 4998: Molecular profiling reveals heterogeneity of active self-renewal pathways in bladder cancer stem cells Cancer Research. 68: 4998-4998. DOI: 10.1158/1538-7445.Am2008-4998  0.621
2007 Kim DJ, Chan KS, Sano S, Digiovanni J. Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Molecular Carcinogenesis. 46: 725-31. PMID 17610223 DOI: 10.1002/Mc.20342  0.606
2007 Chan KS, Ailles L, Gill H, Presti JC, Shortliffe L, Weissman I. 767: Identification and Characterization of Cancer Stem Cells in Bladder Cancer Journal of Urology. 177: 257-257. DOI: 10.1016/S0022-5347(18)31007-3  0.614
2005 Sano S, Chan KS, Kira M, Kataoka K, Takagi S, Tarutani M, Itami S, Kiguchi K, Yokoi M, Sugasawa K, Mori T, Hanaoka F, Takeda J, DiGiovanni J. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer Research. 65: 5720-9. PMID 15994947 DOI: 10.1158/0008-5472.Can-04-4359  0.549
2005 Sano S, Chan KS, Carbajal S, Clifford J, Peavey M, Kiguchi K, Itami S, Nickoloff BJ, DiGiovanni J. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nature Medicine. 11: 43-9. PMID 15592573 DOI: 10.1038/Nm1162  0.489
2004 Chan KS, Sano S, Kiguchi K, Anders J, Komazawa N, Takeda J, DiGiovanni J. Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. The Journal of Clinical Investigation. 114: 720-8. PMID 15343391 DOI: 10.1172/Jci21032  0.629
2004 Chan KS, Carbajal S, Kiguchi K, Clifford J, Sano S, DiGiovanni J. Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis. Cancer Research. 64: 2382-9. PMID 15059889 DOI: 10.1158/0008-5472.Can-03-3197  0.553
2000 Kiguchi K, Bol D, Carbajal S, Beltrán L, Moats S, Chan K, Jorcano J, DiGiovanni J. Constitutive expression of erbB2 in epidermis of transgenic mice results in epidermal hyperproliferation and spontaneous skin tumor development Oncogene. 19: 4243-4254. PMID 10980598 DOI: 10.1038/Sj.Onc.1203778  0.532
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