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David Brooks - Publications

Affiliations: 
2003-2008 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Izzati FN, Choksi H, Giuliana P, Abd-Rabbo D, Elsaesser H, Blundell A, Affe V, Kannen V, Jame-Chenarboo Z, Schmidt E, Kuypers M, Avila DB, Chiu ESY, Badmaev D, Cui H, ... ... Brooks DG, et al. A Unified Atlas of T cell Glycophysiology. Biorxiv : the Preprint Server For Biology. PMID 39229125 DOI: 10.1101/2024.08.24.609521  0.346
2024 Guo M, Liu MYR, Brooks DG. Regulation and impact of tumor-specific CD4 T cells in cancer and immunotherapy. Trends in Immunology. PMID 38508931 DOI: 10.1016/j.it.2024.02.005  0.395
2023 Guo M, Abd-Rabbo D, Bertol BC, Carew M, Lukhele S, Snell LM, Xu W, Boukhaled GM, Elsaesser H, Halaby MJ, Hirano N, McGaha TL, Brooks DG. Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control. Cell Reports. 42: 113047. PMID 37651234 DOI: 10.1016/j.celrep.2023.113047  0.387
2023 Guo M, Abd-Rabbo D, Bertol B, Carew M, Lukhele S, Snell LM, Xu W, Boukhaled GM, Elsaesser H, Halaby MJ, Hirano N, McGaha TL, Brooks DG. Molecular, metabolic and functional CD4 T cell paralysis impedes tumor control. Biorxiv : the Preprint Server For Biology. PMID 37131587 DOI: 10.1101/2023.04.15.536946  0.385
2022 Lukhele S, Rabbo DA, Guo M, Shen J, Elsaesser HJ, Quevedo R, Carew M, Gadalla R, Snell LM, Mahesh L, Ciudad MT, Snow BE, You-Ten A, Haight J, Wakeham A, ... ... Brooks DG, et al. The transcription factor IRF2 drives interferon-mediated CD8 T cell exhaustion to restrict anti-tumor immunity. Immunity. PMID 36370712 DOI: 10.1016/j.immuni.2022.10.020  0.356
2021 Snell LM, Xu W, Abd-Rabbo D, Boukhaled G, Guo M, Macleod BL, Elsaesser HJ, Hezaveh K, Alsahafi N, Lukhele S, Nejat S, Prabhakaran R, Epelman S, McGaha TL, Brooks DG. Dynamic CD4 T cell heterogeneity defines subset-specific suppression and PD-L1-blockade-driven functional restoration in chronic infection. Nature Immunology. PMID 34795443 DOI: 10.1038/s41590-021-01060-7  0.386
2021 Brooks DG, Tishon A, Oldstone MBA, McGavern DB. Prevention of CD8 T Cell Deletion during Chronic Viral Infection. Viruses. 13. PMID 34206262 DOI: 10.3390/v13071189  0.687
2021 Loo Yau H, Bell E, Ettayebi I, de Almeida FC, Boukhaled GM, Shen SY, Allard D, Morancho B, Marhon SA, Ishak CA, Gonzaga IM, da Silva Medina T, Singhania R, Chakravarthy A, Chen R, ... ... Brooks DG, et al. DNA hypomethylating agents increase activation and cytolytic activity of CD8 T cells. Molecular Cell. PMID 33609448 DOI: 10.1016/j.molcel.2021.01.038  0.374
2021 Xu W, Snell LM, Guo M, Boukhaled G, Macleod BL, Li M, Tullius MV, Guidos CJ, Tsao MS, Divangahi M, Horwitz MA, Liu J, Brooks DG. Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection. Immunity. PMID 33515487 DOI: 10.1016/j.immuni.2021.01.003  0.38
2020 Macleod BL, Elsaesser HJ, Snell LM, Dickson RJ, Guo M, Hezaveh K, Xu W, Kothari A, McGaha TL, Guidos CJ, Brooks DG. A network of immune and microbial modifications underlies viral persistence in the gastrointestinal tract. The Journal of Experimental Medicine. 217. PMID 32880629 DOI: 10.1084/Jem.20191473  0.464
2020 Elsaesser HJ, Mohtashami M, Osokine I, Snell LM, Cunningham CR, Boukhaled GM, McGavern DB, Zúñiga-Pflücker JC, Brooks DG. Chronic virus infection drives CD8 T cell-mediated thymic destruction and impaired negative selection. Proceedings of the National Academy of Sciences of the United States of America. PMID 32094187 DOI: 10.1073/Pnas.1913776117  0.692
2019 Lukhele S, Boukhaled GM, Brooks DG. Type I interferon signaling, regulation and gene stimulation in chronic virus infection. Seminars in Immunology. PMID 31155227 DOI: 10.1016/j.smim.2019.05.001  0.316
2018 Snell LM, MacLeod BL, Law JC, Osokine I, Elsaesser HJ, Hezaveh K, Dickson RJ, Gavin MA, Guidos CJ, McGaha TL, Brooks DG. CD8 T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity. Immunity. PMID 30314757 DOI: 10.1016/J.Immuni.2018.08.002  0.529
2017 Clemente-Casares X, Hosseinzadeh S, Barbu I, Dick SA, Macklin JA, Wang Y, Momen A, Kantores C, Aronoff L, Farno M, Lucas TM, Avery J, Zarrin-Khat D, Elsaesser HJ, Razani B, ... ... Brooks DG, et al. A CD103(+) Conventional Dendritic Cell Surveillance System Prevents Development of Overt Heart Failure during Subclinical Viral Myocarditis. Immunity. 47: 974-989.e8. PMID 29166591 DOI: 10.1016/J.Immuni.2017.10.011  0.325
2017 Chan J, Kim PY, Kranz E, Nagaoka Y, Lee Y, Wen J, Elsaesser HJ, Qin M, Brooks DG, Ringpis GE, Chen ISY, Kamata M. Purging Exhausted Virus-Specific CD8 T Cell Phenotypes by Somatic Cell Reprogramming. Aids Research and Human Retroviruses. 33: S59-S69. PMID 29140111 DOI: 10.1089/aid.2017.0161  0.485
2016 Zhen A, Rezek V, Youn C, Lam B, Chang N, Rick J, Carrillo M, Martin H, Kasparian S, Syed P, Rice N, Brooks DG, Kitchen SG. Targeting type I interferon-mediated activation restores immune function in chronic HIV infection. The Journal of Clinical Investigation. PMID 27941243 DOI: 10.1172/Jci89488  0.33
2016 Snell LM, Osokine I, Yamada DH, De la Fuente JR, Elsaesser HJ, Brooks DG. Overcoming CD4 Th1 Cell Fate Restrictions to Sustain Antiviral CD8 T Cells and Control Persistent Virus Infection. Cell Reports. 16: 3286-96. PMID 27653690 DOI: 10.1016/j.celrep.2016.08.065  0.46
2016 Cunningham CR, Champhekar A, Tullius MV, Dillon BJ, Zhen A, de la Fuente JR, Herskovitz J, Elsaesser H, Snell LM, Wilson EB, de la Torre JC, Kitchen SG, Horwitz MA, Bensinger SJ, Smale ST, ... Brooks DG, et al. Type I and Type II Interferon Coordinately Regulate Suppressive Dendritic Cell Fate and Function during Viral Persistence. Plos Pathogens. 12: e1005356. PMID 26808628 DOI: 10.1371/Journal.Ppat.1005356  0.429
2015 Walsh NC, Waters LR, Fowler JA, Lin M, Cunningham CR, Brooks DG, Rehg JE, Morse HC, Teitell MA. LKB1 inhibition of NF-κB in B cells prevents T follicular helper cell differentiation and germinal center formation. Embo Reports. 16: 753-68. PMID 25916856 DOI: 10.15252/Embr.201439505  0.317
2015 Snell LM, Brooks DG. New insights into type I interferon and the immunopathogenesis of persistent viral infections. Current Opinion in Immunology. 34: 91-8. PMID 25771184 DOI: 10.1016/j.coi.2015.03.002  0.423
2015 Yamada DH, Elsaesser H, Lux A, Timmerman JM, Morrison SL, de la Torre JC, Nimmerjahn F, Brooks DG. Suppression of Fcγ-receptor-mediated antibody effector function during persistent viral infection. Immunity. 42: 379-90. PMID 25680277 DOI: 10.1016/J.Immuni.2015.01.005  0.392
2014 Osokine I, Snell LM, Cunningham CR, Yamada DH, Wilson EB, Elsaesser HJ, de la Torre JC, Brooks D. Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection. Proceedings of the National Academy of Sciences of the United States of America. 111: 7409-14. PMID 24799699 DOI: 10.1073/Pnas.1401662111  0.589
2013 Wilson EB, Brooks DG. Decoding the complexity of type I interferon to treat persistent viral infections. Trends in Microbiology. 21: 634-40. PMID 24216022 DOI: 10.1016/j.tim.2013.10.003  0.306
2013 Ng CT, Snell LM, Brooks DG, Oldstone MB. Networking at the level of host immunity: immune cell interactions during persistent viral infections. Cell Host & Microbe. 13: 652-64. PMID 23768490 DOI: 10.1016/J.Chom.2013.05.014  0.538
2013 Wilson EB, Yamada DH, Elsaesser H, Herskovitz J, Deng J, Cheng G, Aronow BJ, Karp CL, Brooks DG. Blockade of chronic type I interferon signaling to control persistent LCMV infection. Science (New York, N.Y.). 340: 202-7. PMID 23580528 DOI: 10.1126/Science.1235208  0.354
2013 Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, Marbois BN, Komisopoulou E, Wilson EB, Osborne TF, Graeber TG, Reue K, Brooks DG, Bensinger SJ. Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nature Immunology. 14: 489-99. PMID 23563690 DOI: 10.1038/Ni.2570  0.373
2013 Wilson EB, Brooks DG. Inflammation makes T cells sensitive. Immunity. 38: 5-7. PMID 23352218 DOI: 10.1016/j.immuni.2013.01.001  0.368
2012 Wilson EB, Kidani Y, Elsaesser H, Barnard J, Raff L, Karp CL, Bensinger S, Brooks DG. Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection. Cell Host & Microbe. 11: 481-91. PMID 22607801 DOI: 10.1016/J.Chom.2012.03.009  0.514
2011 Tomassian T, Humphries LA, Liu SD, Silva O, Brooks DG, Miceli MC. Caveolin-1 orchestrates TCR synaptic polarity, signal specificity, and function in CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 2993-3002. PMID 21849673 DOI: 10.4049/Jimmunol.1101447  0.381
2011 Fahey LM, Wilson EB, Elsaesser H, Fistonich CD, McGavern DB, Brooks DG. Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. The Journal of Experimental Medicine. 208: 987-99. PMID 21536743 DOI: 10.1084/Jem.20101773  0.688
2011 Wilson EB, Brooks DG. The role of IL-10 in regulating immunity to persistent viral infections. Current Topics in Microbiology and Immunology. 350: 39-65. PMID 20703965 DOI: 10.1007/82_2010_96  0.355
2010 Wilson EB, Brooks DG. Translating insights from persistent LCMV infection into anti-HIV immunity. Immunologic Research. 48: 3-13. PMID 20725865 DOI: 10.1007/s12026-010-8162-1  0.3
2010 Alter G, Kavanagh D, Rihn S, Luteijn R, Brooks D, Oldstone M, Van Lunzen J, Altfeld M. IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection Journal of Clinical Investigation. 120: 1905-1913. PMID 20440075 DOI: 10.1172/Jci40913  0.532
2010 Fahey LM, Brooks DG. Opposing positive and negative regulation of T cell activity during viral persistence. Current Opinion in Immunology. 22: 348-54. PMID 20381328 DOI: 10.1016/j.coi.2010.03.004  0.492
2010 Brooks DG, Walsh KB, Elsaesser H, Oldstone MB. IL-10 directly suppresses CD4 but not CD8 T cell effector and memory responses following acute viral infection. Proceedings of the National Academy of Sciences of the United States of America. 107: 3018-23. PMID 20133700 DOI: 10.1073/pnas.0914500107  0.612
2009 Garidou L, Heydari S, Truong P, Brooks DG, McGavern DB. Therapeutic memory T cells require costimulation for effective clearance of a persistent viral infection. Journal of Virology. 83: 8905-15. PMID 19553326 DOI: 10.1128/Jvi.00027-09  0.737
2009 Elsaesser H, Sauer K, Brooks DG. IL-21 is required to control chronic viral infection. Science (New York, N.Y.). 324: 1569-72. PMID 19423777 DOI: 10.1126/Science.1174182  0.477
2008 Brooks DG, Ha SJ, Elsaesser H, Sharpe AH, Freeman GJ, Oldstone MB. IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection. Proceedings of the National Academy of Sciences of the United States of America. 105: 20428-33. PMID 19075244 DOI: 10.1073/Pnas.0811139106  0.594
2008 Brooks DG, Lee AM, Elsaesser H, McGavern DB, Oldstone MB. IL-10 blockade facilitates DNA vaccine-induced T cell responses and enhances clearance of persistent virus infection. The Journal of Experimental Medicine. 205: 533-41. PMID 18332180 DOI: 10.1084/Jem.20071948  0.691
2007 Hryniewicz A, Price DA, Moniuszko M, Boasso A, Edghill-Spano Y, West SM, Venzon D, Vaccari M, Tsai WP, Tryniszewska E, Nacsa J, Villinger F, Ansari AA, Trindade CJ, Morre M, ... Brooks D, et al. Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques. Journal of Immunology (Baltimore, Md. : 1950). 178: 3492-504. PMID 17339444 DOI: 10.4049/Jimmunol.178.6.3492  0.513
2007 Homann D, Lewicki H, Brooks D, Eberlein J, Mallet-Designé V, Teyton L, Oldstone MB. Mapping and restriction of a dominant viral CD4+ T cell core epitope by both MHC class I and MHC class II. Virology. 363: 113-23. PMID 17320138 DOI: 10.1016/J.Virol.2006.12.025  0.618
2006 Brooks DG, Trifilo MJ, Edelmann KH, Teyton L, McGavern DB, Oldstone MB. Interleukin-10 determines viral clearance or persistence in vivo. Nature Medicine. 12: 1301-9. PMID 17041596 DOI: 10.1038/Nm1492  0.721
2006 Brooks DG, McGavern DB, Oldstone MB. Reprogramming of antiviral T cells prevents inactivation and restores T cell activity during persistent viral infection. The Journal of Clinical Investigation. 116: 1675-85. PMID 16710479 DOI: 10.1172/Jci26856  0.723
2006 Arlen PA, Brooks DG, Gao LY, Vatakis D, Brown HJ, Zack JA. Rapid expression of human immunodeficiency virus following activation of latently infected cells. Journal of Virology. 80: 1599-603. PMID 16415036 DOI: 10.1128/Jvi.80.3.1599-1603.2006  0.353
2005 Brooks DG, Teyton L, Oldstone MB, McGavern DB. Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection. Journal of Virology. 79: 10514-27. PMID 16051844 DOI: 10.1128/Jvi.79.16.10514-10527.2005  0.732
2004 Kitchen SG, Jones NR, LaForge S, Whitmire JK, Vu BA, Galic Z, Brooks DG, Brown SJ, Kitchen CM, Zack JA. CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection. Proceedings of the National Academy of Sciences of the United States of America. 101: 8727-32. PMID 15173593 DOI: 10.1073/Pnas.0401500101  0.369
2004 Ali A, Lubong R, Ng H, Brooks DG, Zack JA, Yang OO. Impacts of epitope expression kinetics and class I downregulation on the antiviral activity of human immunodeficiency virus type 1-specific cytotoxic T lymphocytes. Journal of Virology. 78: 561-7. PMID 14694087 DOI: 10.1128/Jvi.78.2.561-567.2004  0.32
2003 Brooks DG, Arlen PA, Gao L, Kitchen CM, Zack JA. Identification of T cell-signaling pathways that stimulate latent HIV in primary cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 12955-60. PMID 14569007 DOI: 10.1073/Pnas.2233345100  0.3
2003 Brooks DG, Hamer DH, Arlen PA, Gao L, Bristol G, Kitchen CM, Berger EA, Zack JA. Molecular characterization, reactivation, and depletion of latent HIV. Immunity. 19: 413-23. PMID 14499116 DOI: 10.1016/S1074-7613(03)00236-X  0.377
2002 Scripture-Adams DD, Brooks DG, Korin YD, Zack JA. Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype. Journal of Virology. 76: 13077-82. PMID 12438635 DOI: 10.1128/Jvi.76.24.13077-13082.2002  0.35
2002 Korin YD, Brooks DG, Brown S, Korotzer A, Zack JA. Effects of prostratin on T-cell activation and human immunodeficiency virus latency. Journal of Virology. 76: 8118-23. PMID 12134017 DOI: 10.1128/Jvi.76.16.8118-8123.2002  0.376
2002 Brooks DG, Zack JA. Effect of latent human immunodeficiency virus infection on cell surface phenotype. Journal of Virology. 76: 1673-81. PMID 11799162 DOI: 10.1128/Jvi.76.4.1673-1681.2002  0.387
2001 Brooks DG, Kitchen SG, Kitchen CM, Scripture-Adams DD, Zack JA. Generation of HIV latency during thymopoiesis. Nature Medicine. 7: 459-64. PMID 11283673 DOI: 10.1038/86531  0.352
1999 Koka PS, Jamieson BD, Brooks DG, Zack JA. Human immunodeficiency virus type 1-induced hematopoietic inhibition is independent of productive infection of progenitor cells in vivo. Journal of Virology. 73: 9089-97. PMID 10516015 DOI: 10.1128/Jvi.73.11.9089-9097.1999  0.306
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