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Issam Ben-Sahra, PhD - Publications

Affiliations: 
Department of Biochemistry and Molecular Genetics Northwestern University Feinberg School of Medicine, Chicago, IL, United States 
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Torrino S, Oldham WM, Tejedor AR, Burgos IS, Rachedi N, Fraissard K, Chauvet C, Sbai C, O'Hara BP, Abélanet S, Brau F, Clavel S, Collepardo-Guevara R, Espinosa JR, Ben-Sahra I, et al. Mechano-dependent sorbitol accumulation supports biomolecular condensate. Biorxiv : the Preprint Server For Biology. PMID 37546967 DOI: 10.1101/2023.07.24.550444  0.336
2023 Zhao Z, Cao K, Watanabe J, Philips CN, Zeidner JM, Ishi Y, Wang Q, Gold SR, Junkins K, Bartom ET, Yue F, Chandel NS, Hashizume R, Ben-Sahra I, Shilatifard A. Therapeutic targeting of metabolic vulnerabilities in cancers with MLL3/4-COMPASS epigenetic regulator mutations. The Journal of Clinical Investigation. PMID 37252797 DOI: 10.1172/JCI169993  0.325
2023 Ali ES, Ben-Sahra I. Regulation of nucleotide metabolism in cancers and immune disorders. Trends in Cell Biology. PMID 36967301 DOI: 10.1016/j.tcb.2023.03.003  0.433
2022 Jin Q, Gutierrez Diaz B, Pieters T, Zhou Y, Narang S, Fijalkwoski I, Borin C, Van Laere J, Payton M, Cho BK, Han C, Sun L, Serafin V, Yacu G, Von Loocke W, ... ... Ben-Sahra I, et al. Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Science Advances. 8: eabq8437. PMID 36490346 DOI: 10.1126/sciadv.abq8437  0.312
2022 Ali ES, Lipońska A, O'Hara BP, Amici DR, Torno MD, Gao P, Asara JM, Yap MF, Mendillo ML, Ben-Sahra I. The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis. Molecular Cell. PMID 35772404 DOI: 10.1016/j.molcel.2022.06.008  0.439
2022 Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, ... ... Ben-Sahra I, et al. Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nature Communications. 13: 2698. PMID 35577785 DOI: 10.1038/s41467-022-30362-z  0.639
2022 De Jesus A, Keyhani-Nejad F, Pusec CM, Goodman L, Geier JA, Stoolman JS, Stanczyk PJ, Nguyen T, Xu K, Suresh KV, Chen Y, Rodriguez AE, Shapiro JS, Chang HC, Chen C, ... ... Ben-Sahra I, et al. Hexokinase 1 cellular localization regulates the metabolic fate of glucose. Molecular Cell. PMID 35305311 DOI: 10.1016/j.molcel.2022.02.028  0.314
2021 Byles V, Cormerais Y, Kalafut K, Barrera V, Hughes Hallett JE, Sui SH, Asara JM, Adams CM, Hoxhaj G, Ben-Sahra I, Manning BD. Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. Molecular Metabolism. 101309. PMID 34303878 DOI: 10.1016/j.molmet.2021.101309  0.63
2021 Zerhouni M, Martin AR, Furstoss N, Gutierrez VS, Jaune E, Tekaya N, Beranger GE, Abbe P, Regazzetti C, Amdouni H, Driowya M, Dubreuil P, Luciano F, Jacquel A, Tulic MK, ... ... Ben-Sahra I, et al. Dual covalent inhibition of PKM and IMPDH targets metabolism in cutaneous metastatic melanoma. Cancer Research. PMID 34099492 DOI: 10.1158/0008-5472.CAN-20-2114  0.311
2021 Villa E, Sahu U, O'Hara BP, Ali ES, Helmin KA, Asara JM, Gao P, Singer BD, Ben-Sahra I. mTORC1 stimulates cell growth through SAM synthesis and mA mRNA-dependent control of protein synthesis. Molecular Cell. PMID 33756106 DOI: 10.1016/j.molcel.2021.03.009  0.364
2020 Ali ES, Sahu U, Villa E, O'Hara BP, Gao P, Beaudet C, Wood AW, Asara JM, Ben-Sahra I. ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis. Molecular Cell. PMID 32485148 DOI: 10.1016/J.Molcel.2020.05.001  0.54
2019 Villa E, Ali ES, Sahu U, Ben-Sahra I. Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides. Cancers. 11. PMID 31108873 DOI: 10.3390/Cancers11050688  0.508
2019 Kaminski L, Torrino S, Dufies M, Djabari Z, Haider R, Roustan FR, Jaune E, Laurent K, Nottet N, Michiels JF, Gesson M, Rocchi S, Mazure NM, Durand M, Tanti JF, ... ... Ben-Sahra I, et al. PGC-1α inhibits polyamine synthesis to suppress prostate cancer aggressiveness. Cancer Research. PMID 31064849 DOI: 10.1158/0008-5472.Can-18-2043  0.374
2019 Hoxhaj G, Ben-Sahra I, Lockwood SE, Timson RC, Byles V, Henning GT, Gao P, Selfors LM, Asara JM, Manning BD. Direct stimulation of NADP synthesis through Akt-mediated phosphorylation of NAD kinase. Science (New York, N.Y.). 363: 1088-1092. PMID 30846598 DOI: 10.1126/Science.Aau3903  0.63
2019 Yuan M, Kremer DM, Huang H, Breitkopf SB, Ben-Sahra I, Manning BD, Lyssiotis CA, Asara JM. Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC-MS/MS. Nature Protocols. PMID 30683937 DOI: 10.1038/S41596-018-0102-X  0.576
2019 Shireman J, Ali E, Saathoff M, Park C, Ben-Sahra I, Ahmed AU. Abstract 81: ARL13B interacts with IMPDH2 to modulate purine synthesis and temozolomide resistance in glioblastoma Cancer Research. 79: 81-81. DOI: 10.1158/1538-7445.Am2019-81  0.352
2019 Saathoff M, Shireman J, Ali E, Park C, Ben-Sahra I, Ahmed A. Dres-09. Regulatory Effects Of The Ciliary Gtpase Arl13B On Purine Metabolism In Gbm Neuro-Oncology. 21. DOI: 10.1093/Neuonc/Noz175.297  0.42
2019 Ahmed AU, Shireman J, Atashi F, Saathoff M, Ali E, Lee G, Park C, Savchuk S, Rayyan J, James C, Ben-Sahra I. OS6.1 Targeting Purine Metabolism to Overcome Therapeutic Resistance in Glioblastoma Neuro-Oncology. 21: iii12-iii12. DOI: 10.1093/Neuonc/Noz126.039  0.463
2018 Zhang S, Weinberg S, DeBerge M, Gainullina A, Schipma M, Kinchen JM, Ben-Sahra I, Gius DR, Charvet LY, Chandel NS, Schumacker PT, Thorp EB. Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair. Cell Metabolism. PMID 30595481 DOI: 10.1016/J.Cmet.2018.12.004  0.348
2018 Ben-Sahra I, Puissant A. HER2 Signaling Hijacks the Creatine Shuttle to Fuel Breast Cancer Cell Growth. Cell Metabolism. 28: 805-807. PMID 30517893 DOI: 10.1016/J.Cmet.2018.11.009  0.461
2018 Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Treviño-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, Reynolds J, Mejia P, Tao M, Sharma G, Wang R, et al. Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and HS Production. Cell. 173: 117-129.e14. PMID 29570992 DOI: 10.1016/J.Cell.2018.03.001  0.58
2017 Hoxhaj G, Hughes-Hallett J, Timson RC, Ilagan E, Yuan M, Asara JM, Ben-Sahra I, Manning BD. The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels. Cell Reports. 21: 1331-1346. PMID 29091770 DOI: 10.1016/J.Celrep.2017.10.029  0.643
2017 Loubiere C, Clavel S, Gilleron J, Harisseh R, Fauconnier J, Ben-Sahra I, Kaminski L, Laurent K, Herkenne S, Lacas-Gervais S, Ambrosetti D, Alcor D, Rocchi S, Cormont M, Michiels JF, et al. The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells. Scientific Reports. 7: 5040. PMID 28698627 DOI: 10.1038/S41598-017-05052-2  0.302
2017 Ben-Sahra I, Manning BD. mTORC1 signaling and the metabolic control of cell growth. Current Opinion in Cell Biology. 45: 72-82. PMID 28411448 DOI: 10.1016/J.Ceb.2017.02.012  0.694
2017 Fenouille N, Bassil CF, Ben-Sahra I, Benajiba L, Alexe G, Ramos A, Pikman Y, Conway AS, Burgess MR, Li Q, Luciano F, Auberger P, Galinsky I, DeAngelo DJ, Stone RM, et al. The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia. Nature Medicine. PMID 28191887 DOI: 10.1038/Nm.4283  0.451
2016 Ben-Sahra I, Hoxhaj G, Ricoult SJ, Asara JM, Manning BD. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle. Science (New York, N.Y.). 351: 728-33. PMID 26912861 DOI: 10.1126/Science.Aad0489  0.697
2016 Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, et al. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. Elife. 5. PMID 26894960 DOI: 10.7554/Elife.11612  0.669
2016 Puissant A, Fenouille N, Bassil CF, Ben-Sahra I, Benajiba L, Alexe G, Ramos A, Pikman Y, Burgess MR, Li Q, Luciano F, Auberger P, Galinsky I, DeAngelo DJ, Stone RM, et al. Targeting the Creatine Kinase Pathway in EVI1-Positive Acute Myeloid Leukemia Blood. 128: 523-523. DOI: 10.1182/Blood.V128.22.523.523  0.437
2015 Ricoult SJ, Yecies JL, Ben-Sahra I, Manning BD. Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Oncogene. PMID 26028026 DOI: 10.1038/Onc.2015.179  0.668
2015 Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, et al. Author response: Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation Elife. DOI: 10.7554/Elife.11612.024  0.652
2015 Puissant A, Fenouille N, Bassil CF, Ben-Sahra I, Alexe G, Benajiba L, Ramos A, Pikman Y, Burgess MR, Galinsky I, DeAngelo DJ, Stone RM, Shannon K, Hemann MT, Stegmaier K. Identification of CKMT1B As a New Target in EVI1-Positive AML Blood. 126: 3674-3674. DOI: 10.1182/Blood.V126.23.3674.3674  0.526
2014 Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM. ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Genes & Development. 28: 1917-28. PMID 25184678 DOI: 10.1101/Gad.245910.114  0.601
2014 Lall R, Ganapathy S, Yang M, Xiao S, Xu T, Su H, Shadfan M, Asara JM, Ha CS, Ben-Sahra I, Manning BD, Little JB, Yuan ZM. Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response. Cell Death and Differentiation. 21: 836-44. PMID 24583639 DOI: 10.1038/Cdd.2014.24  0.586
2014 Rosilio C, Ben-Sahra I, Bost F, Peyron JF. Metformin: a metabolic disruptor and anti-diabetic drug to target human leukemia. Cancer Letters. 346: 188-96. PMID 24462823 DOI: 10.1016/J.Canlet.2014.01.006  0.37
2014 Ben-Sahra I, Ricoult S, Howell J, Asara J, Manning B. mTORC1 stimulates nucleotide synthesis through both transcriptional and post-translational mechanisms. Cancer and Metabolism. 2: 6. DOI: 10.1186/2049-3002-2-S1-P6  0.664
2013 Byles V, Covarrubias AJ, Ben-Sahra I, Lamming DW, Sabatini DM, Manning BD, Horng T. The TSC-mTOR pathway regulates macrophage polarization. Nature Communications. 4: 2834. PMID 24280772 DOI: 10.1038/Ncomms3834  0.638
2013 Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD. A growing role for mTOR in promoting anabolic metabolism. Biochemical Society Transactions. 41: 906-12. PMID 23863154 DOI: 10.1042/Bst20130041  0.688
2013 Ben-Sahra I, Howell JJ, Asara JM, Manning BD. Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1. Science (New York, N.Y.). 339: 1323-8. PMID 23429703 DOI: 10.1126/Science.1228792  0.689
2013 Ben-Sahra I, Dirat B, Laurent K, Puissant A, Auberger P, Budanov A, Tanti JF, Bost F. Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death Cell Death and Differentiation. 20: 611-619. PMID 23238567 DOI: 10.1038/cdd.2012.157  0.306
2009 Regazzetti C, Peraldi P, Grémeaux T, Najem-Lendom R, Ben-Sahra I, Cormont M, Bost F, Le Marchand-Brustel Y, Tanti JF, Giorgetti-Peraldi S. Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes. 58: 95-103. PMID 18984735 DOI: 10.2337/Db08-0457  0.309
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