David J. Craik - Publications

IMB University of Queensland, Saint Lucia, Queensland, Australia 

176 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Bleackley MR, Vasa S, Harvey PJ, Shafee TMA, Kerenga BK, Soares da Costa TP, Craik DJ, Lowe RGT, Anderson MA. Histidine-Rich Defensins from the and Are Antifungal and Metal Binding Proteins. Journal of Fungi (Basel, Switzerland). 6. PMID 32847065 DOI: 10.3390/jof6030145  0.36
2020 Peacock H, Henriques ST, Benfield AH, Elliott AG, Luo J, Luccarelli J, Nagano M, Craik DJ, Hamilton AD. Antimicrobial peptide mimetics based on a diphenylacetylene scaffold: synthesis, conformational analysis and activity. Chemmedchem. PMID 32754982 DOI: 10.1002/cmdc.202000474  0.32
2020 Peigneur S, Tsarev AV, Paramonov AS, Schroeder CI, Ikonomopoulou MP, Inagaki H, Craik DJ, Konno K, Shenkarev ZO, Tytgat J. The insecticidal wasp toxin Γ-Pompilidotoxin is a linear peptide modulating voltage-gated sodium channels. Toxicon : Official Journal of the International Society On Toxinology. 177: S40. PMID 32635028 DOI: 10.1016/j.toxicon.2019.12.069  0.36
2020 Huynh PN, Harvey PJ, Gajewiak J, Craik DJ, Michael McIntosh J. Critical residue properties for potency and selectivity of α-Conotoxin RgIA towards α9α10 nicotinic acetylcholine receptors. Biochemical Pharmacology. 114124. PMID 32593612 DOI: 10.1016/j.bcp.2020.114124  0.36
2020 Israel MR, Dash TS, Bothe SN, Robinson SD, Deuis JR, Craik DJ, Lampert A, Vetter I, Durek T. Characterization of Synthetic Tf2 as a Na1.3 Selective Pharmacological Probe. Biomedicines. 8. PMID 32545167 DOI: 10.3390/biomedicines8060155  0.6
2020 Dang TT, Chan LY, Huang YH, Nguyen LTT, Kaas Q, Huynh T, Craik DJ. Exploring the Sequence Diversity of Cyclotides from Vietnamese Species. Journal of Natural Products. PMID 32437150 DOI: 10.1021/acs.jnatprod.9b01218  0.68
2020 Du Q, Chan LY, Gilding EK, Henriques ST, Condon ND, Ravipati AS, Kaas Q, Huang YH, Craik DJ. Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus. The Journal of Biological Chemistry. PMID 32414842 DOI: 10.1074/jbc.RA120.012627  0.68
2020 Yin H, Huang YH, Deprey K, Condon ND, Kritzer JA, Craik DJ, Wang CK. Cellular Uptake and Cytosolic Delivery of a Cyclic Cystine Knot Scaffold. Acs Chemical Biology. PMID 32315152 DOI: 10.1021/acschembio.0c00297  0.36
2020 White A, de Veer S, Wu G, Harvey P, Yap K, King GJ, Swedberg JE, Wang CK, Law RHP, Durek T, Craik D. Application and Structural Analysis of Triazole-Bridged Disulfide Mimetics in Cyclic Peptides. Angewandte Chemie (International Ed. in English). PMID 32270580 DOI: 10.1002/anie.202003435  0.44
2020 Du J, Yap K, Chan LY, Rehm FBH, Looi FY, Poth AG, Gilding EK, Kaas Q, Durek T, Craik DJ. A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors. Nature Communications. 11: 1575. PMID 32221295 DOI: 10.1038/s41467-020-15418-2  0.68
2020 Smithies BJ, Huang YH, Jackson MA, Yap K, Gilding EK, Harris KS, Anderson MA, Craik DJ. Circular permutation of the native enzyme-mediated cyclization position in cyclotides. Acs Chemical Biology. PMID 32203656 DOI: 10.1021/acschembio.9b00996  0.36
2020 Agwa AJ, Tran P, Mueller A, Tran HNT, Deuis JR, Israel MR, McMahon KL, Craik DJ, Vetter I, Schroeder CI. Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. The Journal of Biological Chemistry. PMID 32139508 DOI: 10.1074/jbc.RA119.012281  0.6
2020 Yu R, Wang J, So LY, Harvey PJ, Shi J, Liang J, Dou Q, Li X, Yan X, Huang YH, Xu Q, Kaas Q, Chow HY, Wong KY, Craik DJ, et al. Enhanced Activity against Multi-drug Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway. Journal of Medicinal Chemistry. PMID 32003561 DOI: 10.1021/acs.jmedchem.9b01563  0.68
2020 Xu P, Kaas Q, Wu Y, Zhu X, Li X, Harvey PJ, Zhangsun D, Craik DJ, Luo S. Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA. Journal of Medicinal Chemistry. PMID 31986036 DOI: 10.1021/acs.jmedchem.9b01409  0.68
2019 Bleackley MR, Dawson CS, Payne JAE, Harvey PJ, Rosengren KJ, Quimbar P, Garcia-Ceron D, Lowe R, Bulone V, van der Weerden NL, Craik DJ, Anderson MA. The interaction with fungal cell wall polysaccharides determines the salt tolerance of antifungal plant defensins. Cell Surface (Amsterdam, Netherlands). 5: 100026. PMID 32743142 DOI: 10.1016/j.tcsw.2019.100026  0.4
2019 Huang YH, Du Q, Craik DJ. Cyclotides: disulfide-rich peptide toxins in plants. Toxicon : Official Journal of the International Society On Toxinology. PMID 31682883 DOI: 10.1016/j.toxicon.2019.10.244  0.36
2019 Jin AH, Muttenthaler M, Dutertre S, Himaya SWA, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. Conotoxins: Chemistry and Biology. Chemical Reviews. PMID 31633928 DOI: 10.1021/acs.chemrev.9b00207  0.68
2019 Sang J, Kulkarni K, Watson GM, Ma X, Craik DJ, Henriques ST, Poth AG, Benfield AH, Wilce JA. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules (Basel, Switzerland). 24. PMID 31627265 DOI: 10.3390/molecules24203739  0.32
2019 Rehm FBH, Harmand TJ, Yap K, Durek T, Craik DJ, Ploegh HL. Site-specific sequential protein labeling catalyzed by a single recombinant ligase. Journal of the American Chemical Society. PMID 31573802 DOI: 10.1021/jacs.9b09166  0.44
2019 Vernen F, Harvey PJ, Dias SA, Veiga AS, Huang YH, Craik DJ, Lawrence N, Troeira Henriques S. Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties. International Journal of Molecular Sciences. 20. PMID 31455019 DOI: 10.3390/ijms20174184  0.36
2019 Ma H, Qiu P, Harvey PJ, Li X, Zhang Z, Xu Q, Liang J, Kaas Q, Craik DJ, Yang J, Jiang T, Bi X, Yu R. In Silico Design of MDM2-Targeting Peptides from Naturally Occurring Constrained Peptide. Chemmedchem. PMID 31444979 DOI: 10.1002/cmdc.201900366  0.68
2019 Philippe GJ, Gaspar D, Sheng C, Huang YH, Benfield AH, Condon ND, Weidmann J, Lawrence N, Löwer A, Castanho MARB, Craik DJ, Troeira Henriques S. Cell membrane composition drives selectivity and toxicity of designed cyclic helix-loop-helix peptides with cell penetrating and tumor suppressor properties. Acs Chemical Biology. PMID 31390185 DOI: 10.1021/acschembio.9b00593  0.36
2019 Harris KS, Guarino RF, Dissanayake RS, Quimbar P, McCorkelle OC, Poon S, Kaas Q, Durek T, Gilding EK, Jackson MA, Craik DJ, van der Weerden NL, Anders RF, Anderson MA. A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein. Scientific Reports. 9: 10820. PMID 31346249 DOI: 10.1038/s41598-019-47273-7  0.68
2019 El Hamdaoui Y, Wu X, Clark RJ, Giribaldi J, Anangi R, Craik DJ, King GF, Dutertre S, Kaas Q, Herzig V, Nicke A. Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR. Frontiers in Pharmacology. 10: 577. PMID 31214027 DOI: 10.3389/fphar.2019.00577  0.68
2019 Agwa AJ, Craik DJ, Schroeder CI. Cyclizing Disulfide-Rich Peptides Using Sortase A. Methods in Molecular Biology (Clifton, N.J.). 2012: 29-41. PMID 31161502 DOI: 10.1007/978-1-4939-9546-2_3  0.36
2019 Jackson MA, Yap K, Poth AG, Gilding EK, Swedberg JE, Poon S, Qu H, Durek T, Harris K, Anderson MA, Craik DJ. Rapid and Scalable Plant-Based Production of a Potent Plasmin Inhibitor Peptide. Frontiers in Plant Science. 10: 602. PMID 31156672 DOI: 10.3389/fpls.2019.00602  0.44
2019 Chambers C, Cutler P, Huang YH, Goodchild JA, Blythe J, Wang CK, Bigot A, Kaas Q, Craik DJ, Sabbadin D, Earley FG. Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor. Febs Letters. PMID 31102259 DOI: 10.1002/1873-3468.13435  0.68
2019 Israel MR, Tanaka BS, Castro J, Thongyoo P, Robinson SD, Zhao P, Deuis JR, Craik DJ, Durek T, Brierley SM, Waxman SG, Dib-Hajj SD, Vetter I. Na 1.6 regulates excitability of mechanosensitive sensory neurons. The Journal of Physiology. PMID 31087362 DOI: 10.1113/JP278148  0.6
2019 Poth AG, Huang YH, Le TT, Kan MW, Craik DJ. Pharmacokinetic characterization of kalata B1 and related therapeutics built on the cyclotide scaffold. International Journal of Pharmaceutics. PMID 31063836 DOI: 10.1016/j.ijpharm.2019.05.001  0.36
2019 Yu R, Tae HS, Xu Q, Craik DJ, Adams DJ, Jiang T, Kaas Q. Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor. British Journal of Pharmacology. PMID 31062355 DOI: 10.1111/bph.14698  0.68
2019 Kerenga BK, McKenna JA, Harvey PJ, Quimbar P, Garcia-Ceron D, Lay FT, Phan TK, Veneer PK, Vasa S, Parisi K, Shafee TMA, van der Weerden NL, Hulett MD, Craik DJ, Anderson MA, et al. Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32. Frontiers in Microbiology. 10: 795. PMID 31031739 DOI: 10.3389/fmicb.2019.00795  0.36
2019 Rehm FBH, Jackson MA, De Geyter E, Yap K, Gilding EK, Durek T, Craik DJ. Papain-like cysteine proteases prepare plant cyclic peptide precursors for cyclization. Proceedings of the National Academy of Sciences of the United States of America. PMID 30944220 DOI: 10.1073/pnas.1901807116  0.44
2019 Schmidt M, Huang YH, Texeira de Oliveira EF, Toplak A, Wijma HJ, Janssen DB, van Maarseveen JH, Craik DJ, Nuijens T. Efficient Enzymatic Cyclization of Disulfide-rich Peptides using Peptiligases. Chembiochem : a European Journal of Chemical Biology. PMID 30735312 DOI: 10.1002/cbic.201900033  0.36
2018 Dash TS, Shafee T, Harvey PJ, Zhang C, Peigneur S, Deuis JR, Vetter I, Tytgat J, Anderson MA, Craik DJ, Durek T, Undheim EAB. A Centipede Toxin Family Defines an Ancient Class of CSαβ Defensins. Structure (London, England : 1993). PMID 30554841 DOI: 10.1016/j.str.2018.10.022  0.6
2018 Swedberg JE, Wu G, Mahatmanto T, Durek T, Caradoc-Davies T, Whisstock JC, Law R, Craik DJ. Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma. Journal of Medicinal Chemistry. PMID 30520638 DOI: 10.1021/acs.jmedchem.8b01139  0.44
2018 Peigneur S, Cheneval O, Maiti M, Leipold E, Heinemann SH, Lescrinier E, Herdewijn P, De Lima ME, Craik DJ, Schroeder CI, Tytgat J. Where cone snails and spiders meet: design of small cyclic sodium-channel inhibitors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801909R. PMID 30509130 DOI: 10.1096/fj.201801909R  0.36
2018 Lawrence N, Wu B, Ligutti J, Cheneval O, Agwa AJ, Benfield AH, Biswas K, Craik DJ, Miranda LP, Troeira Henriques S, Schroeder CI. Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1. Acs Chemical Biology. PMID 30507158 DOI: 10.1021/acschembio.8b00989  0.36
2018 Niyomploy P, Chan LY, Harvey PJ, Poth AG, Colgrave ML, Craik DJ. Discovery and Characterization of Cyclotides from Rinorea Species. Journal of Natural Products. PMID 30387611 DOI: 10.1021/acs.jnatprod.8b00572  0.36
2018 Harvey PJ, Kurniawan ND, Finol-Urdaneta RK, McArthur JR, Van Lysebetten D, Dash TS, Hill JM, Adams DJ, Durek T, Craik DJ. NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced Na Channel Potency. Molecules (Basel, Switzerland). 23. PMID 30360356 DOI: 10.3390/molecules23102715  0.6
2018 Ramalho SD, Wang CK, King GJ, Byriel KA, Huang YH, Bolzani VS, Craik DJ. Synthesis, Racemic X-ray Crystallographic, and Permeability Studies of Bioactive Orbitides from Jatropha Species. Journal of Natural Products. PMID 30345754 DOI: 10.1021/acs.jnatprod.8b00447  0.36
2018 Yu J, Zhu X, Harvey PJ, Kaas Q, Zhangsun D, Craik DJ, Luo S. A Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist. Journal of Medicinal Chemistry. PMID 30252466 DOI: 10.1021/acs.jmedchem.8b00967  0.68
2018 Hone AJ, Talley TT, Bobango J, Huidobro Melo C, Hararah F, Gajewiak JB, Christensen SB, Harvey PJ, Craik DJ, McIntosh JM. Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. PMID 30249616 DOI: 10.1074/jbc.RA118.005649  0.52
2018 Kwon S, Duarte JN, Li Z, Ling JJ, Cheneval O, Durek T, Schroeder CI, Craik DJ, Ploegh HL. Targeted delivery of cyclotides via conjugation to a nanobody. Acs Chemical Biology. PMID 30248263 DOI: 10.1021/acschembio.8b00653  0.44
2018 Agwa A, Blomster L, Craik DJ, King GF, Schroeder CI. Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase A to form double-knottins to probe voltage-gated sodium channel NaV1.7. Bioconjugate Chemistry. PMID 30148615 DOI: 10.1021/acs.bioconjchem.8b00505  0.36
2018 Lawrence N, Dennis ASM, Lehane AM, Ehmann A, Harvey PJ, Benfield AH, Cheneval O, Henriques ST, Craik DJ, McMorran BJ. Defense Peptides Engineered from Human Platelet Factor 4 Kill Plasmodium by Selective Membrane Disruption. Cell Chemical Biology. PMID 30033131 DOI: 10.1016/j.chembiol.2018.06.009  0.36
2018 Wu X, Tae HS, Huang YH, Adams DJ, Craik DJ, Kaas Q. Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB. Biochemical Pharmacology. PMID 30009767 DOI: 10.1016/j.bcp.2018.07.007  0.68
2018 de Veer SJ, Li CY, Swedberg JE, Schroeder CI, Craik DJ. Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1. European Journal of Medicinal Chemistry. 155: 695-704. PMID 29936356 DOI: 10.1016/j.ejmech.2018.06.029  0.36
2018 Sadeghi M, Carstens BB, Callaghan BP, Daniel JT, Tae HS, O'Donnell T, Castro J, Brierley SM, Adams DJ, Craik DJ, Clark RJ. Structure-activity studies reveal the molecular basis for GABAB-receptor mediated inhibition of high voltage-activated calcium channels by α-conotoxin Vc1.1. Acs Chemical Biology. PMID 29746088 DOI: 10.1021/acschembio.8b00190  0.6
2018 Wang CK, Abdul Ghani H, Bundock A, Weidmann J, Harvey PJ, Edwards IA, Schroeder CI, Swedberg JE, Craik DJ. Calcium-mediated allostery of the EGF fold. Acs Chemical Biology. PMID 29715432 DOI: 10.1021/acschembio.8b00291  0.36
2018 Agwa AJ, Peigneur S, Chow CY, Lawrence N, Craik DJ, Tytgat J, King GF, Henriques ST, Schroeder CI. Gating modifier toxins isolated from spider venom: modulation of voltage-gated sodium channels and the role of lipid membranes. The Journal of Biological Chemistry. PMID 29703751 DOI: 10.1074/jbc.RA118.002553  0.52
2018 Turner AH, Craik DJ, Kaas Q, Schroeder CI. Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods. Marine Drugs. 16. PMID 29621159 DOI: 10.3390/md16040118  0.68
2018 Durek T, Cromm PM, White AM, Schroeder CI, Kaas Q, Weidmann J, Ahmad Fuaad A, Cheneval O, Harvey PJ, Daly NL, Zhou Y, Dellsén A, Österlund T, Larsson N, Knerr L, ... ... Craik DJ, et al. Development of novel melanocortin receptor agonists based on the cyclic peptide framework of sunflower trypsin inhibitor-1. Journal of Medicinal Chemistry. PMID 29605997 DOI: 10.1021/acs.jmedchem.8b00170  0.68
2018 Wang CK, Swedberg JE, Harvey PJ, Kaas Q, Craik DJ. Conformational Flexibility Is a Determinant of Permeability for Cyclosporin. The Journal of Physical Chemistry. B. PMID 29400464 DOI: 10.1021/acs.jpcb.7b12419  0.68
2018 Israel MR, Thongyoo P, Deuis JR, Craik DJ, Vetter I, Durek T. The E15R point mutation in scorpion toxin Cn2 uncouples its depressant and excitatory activities on human NaV1.6. Journal of Medicinal Chemistry. PMID 29378414 DOI: 10.1021/acs.jmedchem.7b01609  0.6
2017 Poon S, Harris KS, Jackson MA, McCorkelle OC, Gilding EK, Durek T, van der Weerden NL, Craik DJ, Anderson MA. Co-expression of a cyclizing asparaginyl endopeptidase enables efficient production of cyclic peptides in planta. Journal of Experimental Botany. PMID 29309615 DOI: 10.1093/jxb/erx422  0.44
2017 Pérez-Peinado C, Almeida Dias S, Domingues MM, Benfield AH, Freire JM, Radis-Baptista G, Gaspar D, Castanho MARB, Craik DJ, Henriques ST, Veiga AS, Andreu D. Mechanism of bacterial membrane permeabilization of crotalicidin (Ctn) and its fragment Ctn[15-34], antimicrobial peptides from rattlesnake venom. The Journal of Biological Chemistry. PMID 29255091 DOI: 10.1074/jbc.RA117.000125  0.32
2017 Castro J, Grundy L, Deiteren A, Harrington AM, O'Donnell T, Maddern J, Moore J, Garcia-Caraballo S, Rychkov GY, Yu R, Kaas Q, Craik DJ, Adams DJ, Brierley SM. Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain. British Journal of Pharmacology. PMID 29194563 DOI: 10.1111/bph.14115  0.68
2017 Durek T, Shelukhina IV, Tae HS, Thongyoo P, Spirova EN, Kudryavtsev DS, Kasheverov IE, Faure G, Corringer PJ, Craik DJ, Adams DJ, Tsetlin VI. Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors. Scientific Reports. 7: 16606. PMID 29192197 DOI: 10.1038/s41598-017-16809-0  0.6
2017 Wu X, Huang YH, Kaas Q, Harvey PJ, Wang CK, Tae HS, Adams DJ, Craik DJ. Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer. The Journal of Biological Chemistry. PMID 28851841 DOI: 10.1074/jbc.M117.808386  0.68
2017 Agwa AJ, Lawrence N, Deplazes E, Cheneval O, Chen RM, Craik DJ, Schroeder CI, Henriques ST. Corrigendum to "Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7" [Biochim. Biophys. Acta 1859(5) (2017) 835-844]. Biochimica Et Biophysica Acta. PMID 28842331 DOI: 10.1016/j.bbamem.2017.08.008  0.52
2017 Agwa AJ, Huang YH, Craik DJ, Henriques ST, Schroeder CI. Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins. Toxins. 9. PMID 28805686 DOI: 10.3390/toxins9080248  0.52
2017 Troeira Henriques S, Lawrence N, Chaousis S, Ravipati AS, Cheneval O, Benfield AH, Elliott AG, Kavanagh AM, Cooper MA, Chan LY, Huang YH, Craik DJ. Redesigned spider peptide with improved antimicrobial and anticancer properties. Acs Chemical Biology. PMID 28741926 DOI: 10.1021/acschembio.7b00459  0.36
2017 Craik DJ, Henriques ST. Editorial Overview. Current Opinion in Chemical Biology. 38: iv-vi. PMID 28619206 DOI: 10.1016/j.cbpa.2017.05.012  0.32
2017 Cranfield CG, Henriques ST, Martinac B, Duckworth PA, Craik DJ, Cornell B. Kalata B1 and Kalata B2 Have a Surfactant-Like Activity in Phosphatidylethanolomine Containing Lipid Membranes. Langmuir : the Acs Journal of Surfaces and Colloids. PMID 28605904 DOI: 10.1021/acs.langmuir.7b01642  0.32
2017 Wu Y, Zhangsun D, Zhu X, Kaas Q, Zhangsun M, Harvey PJ, Craik DJ, McIntosh JM, Luo S. α-Conotoxin [S9A]TxID Potently discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors. Journal of Medicinal Chemistry. PMID 28603989 DOI: 10.1021/acs.jmedchem.7b00546  0.68
2017 Ravipati AS, Poth AG, Troeira Henriques S, Bhandari M, Huang YH, Nino J, Colgrave ML, Craik DJ. Understanding the Diversity and Distribution of Cyclotides from Plants of Varied Genetic Origin. Journal of Natural Products. PMID 28471681 DOI: 10.1021/acs.jnatprod.7b00061  0.36
2017 Ojeda PG, Henriques ST, Pan Y, Nicolazzo JA, Craik DJ, Wang CK. Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake. Biopolymers. PMID 28459137 DOI: 10.1002/bip.23025  0.32
2017 Zhangsun D, Zhu X, Kaas Q, Wu Y, Craik DJ, McIntosh JM, Luo S. αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype. Neuropharmacology. PMID 28416445 DOI: 10.1016/j.neuropharm.2017.04.015  0.68
2017 Grage SL, Sani MA, Cheneval O, Henriques ST, Schalck C, Heinzmann R, Mylne JS, Mykhailiuk PK, Afonin S, Komarov IV, Separovic F, Craik DJ, Ulrich AS. Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR. Biophysical Journal. 112: 630-642. PMID 28256223 DOI: 10.1016/j.bpj.2016.12.040  0.32
2017 Kubota T, Durek T, Dang B, Finol-Urdaneta RK, Craik DJ, Kent SB, French RJ, Bezanilla F, Correa AM. Mapping of voltage sensor positions in resting and inactivated mammalian sodium channels by LRET. Proceedings of the National Academy of Sciences of the United States of America. PMID 28202723 DOI: 10.1073/pnas.1700453114  0.44
2017 Agwa AJ, Lawrence N, Deplazes E, Cheneval O, Chen R, Craik DJ, Schroeder CI, Henriques ST. Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7. Biochimica Et Biophysica Acta. PMID 28115115 DOI: 10.1016/j.bbamem.2017.01.020  0.52
2016 Chan LY, Craik DJ, Daly NL. Dual-targeting anti-angiogenic cyclic peptides as potential drug leads for cancer therapy. Scientific Reports. 6: 35347. PMID 27734947 DOI: 10.1038/srep35347  0.6
2016 Elliott AG, Franke B, Armstrong DA, Craik DJ, Mylne JS, Rosengren KJ. Natural structural diversity within a conserved cyclic peptide scaffold. Amino Acids. PMID 27695949 DOI: 10.1007/s00726-016-2333-x  0.4
2016 Bhardwaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SV, Kaas Q, Eletsky A, Huang PS, Johnsen WA, Greisen PJ, Rocklin GJ, Song Y, ... ... Craik DJ, et al. Accurate de novo design of hyperstable constrained peptides. Nature. PMID 27626386 DOI: 10.1038/nature19791  0.68
2016 Daly NL, Gunasekera S, Clark RJ, Lin F, Wade JD, Anderson MA, Craik DJ. The N-terminal pro-domain of the kalata B1 cyclotide precursor is intrinsically unstructured. Biopolymers. PMID 27564841 DOI: 10.1002/bip.22977  0.6
2016 Bleackley MR, Payne JA, Hayes BM, Durek T, Craik DJ, Shafee TM, Poon IK, Hulett MD, van der Weerden NL, Anderson MA. Nicotiana alata defensin chimeras reveal differences in the mechanism of fungal and tumour cell killing and an enhanced antifungal variant. Antimicrobial Agents and Chemotherapy. PMID 27503651 DOI: 10.1128/AAC.01479-16  0.44
2016 Verbandt S, Henriques ST, Spincemaille P, Harvey PJ, Chandhok G, Sauer V, Coninck B, Cassiman D, Craik DJ, Cammue BP, Cremer K, Thevissen K. Identification of survival-promoting OSIP108 peptide variants and their internalization in human cells. Mechanisms of Ageing and Development. PMID 27491841 DOI: 10.1016/j.mad.2016.07.013  0.36
2016 Abdul Ghani H, Henriques ST, Huang YH, Swedberg JE, Schroeder CI, Craik DJ. Structural and functional characterisation of chimeric cyclotides from the Möbius and trypsin inhibitor subfamilies. Biopolymers. PMID 27487329 DOI: 10.1002/bip.22927  0.52
2016 Swedberg JE, Mahatmanto T, Abdul Ghani H, de Veer SJ, Schroeder CI, Harris JM, Craik DJ. Substrate-Guided Design of Potent and Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold. Journal of Medicinal Chemistry. PMID 27434175 DOI: 10.1021/acs.jmedchem.6b00557  0.68
2016 Sable R, Durek T, Taneja V, Craik DJ, Pallerla S, Gauthier T, Jois S. Constrained Cyclic Peptides as Immunomodulatory Inhibitors of the CD2:CD58 Protein-Protein interaction. Acs Chemical Biology. PMID 27337048 DOI: 10.1021/acschembio.6b00486  0.44
2016 Henriques ST, Deplazes E, Lawrence N, Cheneval O, Chaousis S, Inserra M, Thongyoo P, King GF, Mark AE, Vetter I, Craik DJ, Schroeder CI. Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes is a Prerequisite for its Inhibition of Human Voltage-gated Sodium Channel NaV1.7. The Journal of Biological Chemistry. PMID 27311819 DOI: 10.1074/jbc.M116.729095  0.68
2016 Philippe G, Huang YH, Cheneval O, Lawrence N, Zhang Z, Fairlie DP, Craik DJ, de Araujo AD, Henriques ST. Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions. Biopolymers. PMID 27287767 DOI: 10.1002/bip.22893  0.6
2016 Swedberg JE, Schroeder CI, Mitchell J, Fairlie DP, Edmonds DJ, Griffith DA, Ruggeri RB, Derksen DR, Loria PM, Price DA, Liras S, Craik DJ. Truncated glucagon-like peptide-1 and exendin-4 α-conotoxin pl14a peptide chimeras maintain potency, α-helicity and reveal interactions vital for cAMP signaling in vitro. The Journal of Biological Chemistry. PMID 27226591 DOI: 10.1074/jbc.M116.724542  0.36
2016 Kwon S, Bosmans F, Kaas Q, Cheneval O, Conibear AC, Rosengren KJ, Wang CK, Schroeder CI, Craik DJ. Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide. Biotechnology and Bioengineering. PMID 27093300 DOI: 10.1002/bit.25993  0.68
2016 Wang CK, King GJ, Conibear AC, Ramos MC, Chaousis S, Henriques ST, Craik DJ. Mirror images of antimicrobial peptides provides reflections on their functions and amyloidogenic properties. Journal of the American Chemical Society. PMID 27064294 DOI: 10.1021/jacs.6b02575  0.68
2016 Carstens BB, Swedberg J, Berecki G, Adams DJ, Craik DJ, Clark RJ. Effects of linker sequence modifications on the structure, stability and biological activity of a cyclic α-conotoxin. Biopolymers. PMID 27038328 DOI: 10.1002/bip.22848  0.6
2016 Deuis JR, Dekan Z, Inserra MC, Lee TH, Aguilar MI, Craik DJ, Lewis RJ, Alewood PF, Mobli M, Schroeder CI, Henriques ST, Vetter I. Development of a μO-conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Target NaV1.8. The Journal of Biological Chemistry. PMID 27026701 DOI: 10.1074/jbc.M116.721662  0.68
2016 Carstens BB, Berecki G, Daniel JT, Lee HS, Jackson KA, Tae HS, Sadeghi M, Castro J, O'Donnell T, Deiteren A, Brierley SM, Craik DJ, Adams DJ, Clark RJ. Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High Voltage-Activated Calcium Channels via GABAB Receptor Activation Reveal a Minimal Functional Motif. Angewandte Chemie (International Ed. in English). PMID 26948522 DOI: 10.1002/anie.201600297  0.4
2016 Wang CK, Stalmans S, De Spiegeleer B, Craik DJ. Biodistribution of the cyclotide MCoTI-II, a cyclic disulfide-rich peptide drug scaffold. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 26929247 DOI: 10.1002/psc.2862  0.68
2016 Castro J, Harrington AM, Garcia-Caraballo S, Maddern J, Grundy L, Zhang J, Page G, Miller PE, Craik DJ, Adams DJ, Brierley SM. α-Conotoxin Vc1.1 inhibits human dorsal root ganglion neuroexcitability and mouse colonic nociception via GABAB receptors. Gut. PMID 26887818 DOI: 10.1136/gutjnl-2015-310971  0.68
2016 Deplazes E, Henriques ST, Smith JJ, King GF, Craik DJ, Mark AE, Schroeder CI. Membrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gating. Biochimica Et Biophysica Acta. PMID 26850736 DOI: 10.1016/j.bbamem.2016.02.002  0.52
2016 Wang CK, Northfield SE, Huang YH, Ramos MC, Craik DJ. Inhibition of tau aggregation using a naturally-occurring cyclic peptide scaffold. European Journal of Medicinal Chemistry. 109: 342-349. PMID 26807864 DOI: 10.1016/j.ejmech.2016.01.006  0.36
2015 Dsouza C, Henriques ST, Wang CK, Cheneval O, Chan LY, Bokil NJ, Sweet MJ, Craik DJ. Using the MCoTI-II cyclotide scaffold to design a stable cyclic peptide antagonist of SET, a protein overexpressed in human cancer. Biochemistry. PMID 26685975 DOI: 10.1021/acs.biochem.5b00529  0.68
2015 Harris KS, Durek T, Kaas Q, Poth AG, Gilding EK, Conlan BF, Saska I, Daly NL, van der Weerden NL, Craik DJ, Anderson MA. Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase. Nature Communications. 6: 10199. PMID 26680698 DOI: 10.1038/ncomms10199  0.68
2015 Gilding EK, Jackson MA, Poth AG, Henriques ST, Prentis PJ, Mahatmanto T, Craik DJ. Gene coevolution and regulation lock cyclic plant defence peptides to their targets. The New Phytologist. PMID 26668107 DOI: 10.1111/nph.13789  0.68
2015 Wang CK, Swedberg JE, Northfield SE, Craik DJ. On the Effect of Cyclization on Peptide Backbone Dynamics. The Journal of Physical Chemistry. B. PMID 26633076 DOI: 10.1021/acs.jpcb.5b11085  0.68
2015 Vriens K, Cools TL, Harvey PJ, Craik DJ, Braem A, Vleugels J, Coninck B, Cammue BP, Thevissen K. The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms. Peptides. PMID 26592804 DOI: 10.1016/j.peptides.2015.11.001  0.36
2015 Burman R, Yeshak MY, Larsson S, Craik DJ, Rosengren KJ, Göransson U. Distribution of circular proteins in plants: large-scale mapping of cyclotides in the Violaceae. Frontiers in Plant Science. 6: 855. PMID 26579135 DOI: 10.3389/fpls.2015.00855  0.68
2015 Conibear AC, Chaousis S, Durek T, Rosengren KJ, Craik DJ, Schroeder CI. Approaches to the stabilisation of bioactive epitopes by grafting and peptide cyclisation. Biopolymers. PMID 26566734 DOI: 10.1002/bip.22767  0.44
2015 Chan LY, Craik DJ, Daly NL. Cyclic thrombospondin-1 mimetics: grafting of a thrombospondin sequence into circular disulfide-rich frameworks to inhibit endothelial cell migration. Bioscience Reports. PMID 26464514 DOI: 10.1042/BSR20150210  0.68
2015 de Veer SJ, Wang CK, Harris JM, Craik DJ, Swedberg JE. Improving the Selectivity of Engineered Protease Inhibitors: Optimizing the P2 Prime Residue Using a Versatile Cyclic Peptide Library. Journal of Medicinal Chemistry. 58: 8257-68. PMID 26393374 DOI: 10.1021/acs.jmedchem.5b01148  0.68
2015 Swedberg JE, Schroeder CI, Mitchell JM, Durek T, Fairlie DP, Edmonds DJ, Griffith DA, Ruggeri RB, Derksen DR, Loria PM, Liras S, Price DA, Craik DJ. Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists. European Journal of Medicinal Chemistry. 103: 175-184. PMID 26352676 DOI: 10.1016/j.ejmech.2015.08.046  0.44
2015 Ravipati AS, Henriques ST, Poth AG, Kaas Q, Wang CK, Colgrave ML, Craik DJ. Lysine-rich cyclotides: a new subclass of circular knotted proteins from Violaceae. Acs Chemical Biology. PMID 26322745 DOI: 10.1021/acschembio.5b00454  0.68
2015 Yu R, Seymour VA, Berecki G, Jia X, Akcan M, Adams DJ, Kaas Q, Craik DJ. Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1. Scientific Reports. 5: 13264. PMID 26290113 DOI: 10.1038/srep13264  0.68
2015 Babbitt PC, Bagos PG, Bairoch A, Bateman A, Chatonnet A, Chen MJ, Craik DJ, Finn RD, Gloriam D, Haft DH, Henrissat B, Holliday GL, Isberg V, Kaas Q, Landsman D, et al. Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat. Database : the Journal of Biological Databases and Curation. 2015: bav063. PMID 26284514 DOI: 10.1093/database/bav063  0.68
2015 Henriques ST, Huang YH, Chaousis S, Sani MA, Poth AG, Separovic F, Craik DJ. The Prototypic Cyclotide Kalata B1 Has a Unique Mechanism of Entering Cells. Chemistry & Biology. 22: 1087-97. PMID 26278183 DOI: 10.1016/j.chembiol.2015.07.012  0.68
2015 Huang YH, Henriques ST, Wang CK, Thorstholm L, Daly NL, Kaas Q, Craik DJ. Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Scientific Reports. 5: 12974. PMID 26264857 DOI: 10.1038/srep12974  0.68
2015 Vriens K, Cools TL, Harvey PJ, Craik DJ, Spincemaille P, Cassiman D, Braem A, Vleugels J, Nibbering PH, Drijfhout JW, De Coninck B, Cammue BP, Thevissen K. Synergistic Activity of the Plant Defensin HsAFP1 and Caspofungin against Candida albicans Biofilms and Planktonic Cultures. Plos One. 10: e0132701. PMID 26248029 DOI: 10.1371/journal.pone.0132701  0.68
2015 Himeno K, Rosengren KJ, Inoue T, Perez RH, Colgrave ML, Lee HS, Chan LY, Henriques ST, Fujita K, Ishibashi N, Zendo T, Wilaipun P, Nakayama J, Leelawatcharamas V, Jikuya H, ... Craik DJ, et al. Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faecium. Biochemistry. 54: 4863-76. PMID 26174911 DOI: 10.1021/acs.biochem.5b00196  0.68
2015 Akcan M, Clark RJ, Daly NL, Conibear AC, de Faoite A, Heghinian MD, Sahil T, Adams DJ, Marí F, Craik DJ. Transforming conotoxins into cyclotides: Backbone cyclization of P-superfamily conotoxins. Biopolymers. PMID 26172377 DOI: 10.1002/bip.22699  0.68
2015 Luo S, Zhangsun D, Harvey PJ, Kaas Q, Wu Y, Zhu X, Hu Y, Li X, Tsetlin VI, Christensen S, Romero HK, McIntyre M, Dowell C, Baxter JC, Elmslie KS, ... Craik DJ, et al. Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist. Proceedings of the National Academy of Sciences of the United States of America. 112: E4026-35. PMID 26170295 DOI: 10.1073/pnas.1503617112  0.68
2015 Kaas Q, Craik DJ. Bioinformatics-Aided Venomics. Toxins. 7: 2159-87. PMID 26110505 DOI: 10.3390/toxins7062159  0.68
2015 Durek T, Craik DJ. Therapeutic conotoxins: a US patent literature survey. Expert Opinion On Therapeutic Patents. 1-15. PMID 26065897 DOI: 10.1517/13543776.2015.1054095  0.68
2015 De Veer SJ, Swedberg JE, Akcan M, Rosengren KJ, Brattsand M, Craik DJ, Harris JM. Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition. The Biochemical Journal. PMID 25981970 DOI: 10.1042/BJ20150412  0.68
2015 Wang CK, Northfield SE, Swedberg JE, Colless B, Chaousis S, Price DA, Liras S, Craik DJ. Exploring experimental and computational markers of cyclic peptides: Charting islands of permeability. European Journal of Medicinal Chemistry. 97: 202-13. PMID 25974856 DOI: 10.1016/j.ejmech.2015.04.049  0.68
2015 Bernath-Levin K, Nelson C, Elliott AG, Jayasena AS, Millar AH, Craik DJ, Mylne JS. Peptide macrocyclization by a bifunctional endoprotease. Chemistry & Biology. 22: 571-82. PMID 25960260 DOI: 10.1016/j.chembiol.2015.04.010  0.68
2015 Holliday GL, Bairoch A, Bagos PG, Chatonnet A, Craik DJ, Finn RD, Henrissat B, Landsman D, Manning G, Nagano N, O'Donovan C, Pruitt KD, Rawlings ND, Saier M, Sowdhamini R, et al. Key challenges for the creation and maintenance of specialist protein resources. Proteins. 83: 1005-13. PMID 25820941 DOI: 10.1002/prot.24803  0.68
2015 Zhang J, Li J, Huang Z, Yang B, Zhang X, Li D, Craik DJ, Baker AJ, Shu W, Liao B. Transcriptomic screening for cyclotides and other cysteine-rich proteins in the metallophyte Viola baoshanensis. Journal of Plant Physiology. 178: 17-26. PMID 25756919 DOI: 10.1016/j.jplph.2015.01.017  0.68
2015 Zhangsun D, Zhu X, Wu Y, Hu Y, Kaas Q, Craik DJ, McIntosh JM, Luo S. Key residues in the nicotinic acetylcholine receptor β2 subunit contribute to α-conotoxin LvIA binding. The Journal of Biological Chemistry. 290: 9855-62. PMID 25713061 DOI: 10.1074/jbc.M114.632646  0.68
2015 Huang YH, Chaousis S, Cheneval O, Craik DJ, Henriques ST. Optimization of the cyclotide framework to improve cell penetration properties. Frontiers in Pharmacology. 6: 17. PMID 25709580 DOI: 10.3389/fphar.2015.00017  0.68
2015 Haugaard-Kedström LM, Hossain MA, Daly NL, Bathgate RA, Rinderknecht E, Wade JD, Craik DJ, Rosengren KJ. Solution structure, aggregation behavior, and flexibility of human relaxin-2. Acs Chemical Biology. 10: 891-900. PMID 25547165 DOI: 10.1021/cb500918v  0.68
2015 Zhang J, Hua Z, Huang Z, Chen Q, Long Q, Craik DJ, Baker AJ, Shu W, Liao B. Two Blast-independent tools, CyPerl and CyExcel, for harvesting hundreds of novel cyclotides and analogues from plant genomes and protein databases. Planta. 241: 929-40. PMID 25528148 DOI: 10.1007/s00425-014-2229-5  0.68
2015 Fensterseifer IC, Silva ON, Malik U, Ravipati AS, Novaes NR, Miranda PR, Rodrigues EA, Moreno SE, Craik DJ, Franco OL. Effects of cyclotides against cutaneous infections caused by Staphylococcus aureus. Peptides. 63: 38-42. PMID 25451333 DOI: 10.1016/j.peptides.2014.10.019  0.68
2015 Mahatmanto T, Mylne JS, Poth AG, Swedberg JE, Kaas Q, Schaefer H, Craik DJ. The evolution of Momordica cyclic peptides. Molecular Biology and Evolution. 32: 392-405. PMID 25376175 DOI: 10.1093/molbev/msu307  0.68
2014 Wang CK, Northfield SE, Colless B, Chaousis S, Hamernig I, Lohman RJ, Nielsen DS, Schroeder CI, Liras S, Price DA, Fairlie DP, Craik DJ. Rational design and synthesis of an orally bioavailable peptide guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America. 111: 17504-9. PMID 25416591 DOI: 10.1073/pnas.1417611111  0.68
2014 Ojeda PG, Chan LY, Poth AG, Wang CK, Craik DJ. The role of disulfide bonds in structure and activity of chlorotoxin. Future Medicinal Chemistry. 6: 1617-28. PMID 25406003 DOI: 10.4155/fmc.14.93  0.68
2014 Conibear AC, Wang CK, Bi T, Rosengren KJ, Camarero JA, Craik DJ. Insights into the molecular flexibility of θ-defensins by NMR relaxation analysis. The Journal of Physical Chemistry. B. 118: 14257-66. PMID 25375365 DOI: 10.1021/jp507754c  0.68
2014 Hill TA, Lohman RJ, Hoang HN, Nielsen DS, Scully CC, Kok WM, Liu L, Lucke AJ, Stoermer MJ, Schroeder CI, Chaousis S, Colless B, Bernhardt PV, Edmonds DJ, Griffith DA, ... ... Craik DJ, et al. Cyclic Penta- and Hexaleucine Peptides without N-Methylation Are Orally Absorbed. Acs Medicinal Chemistry Letters. 5: 1148-51. PMID 25313329 DOI: 10.1021/ml5002823  0.68
2014 Spincemaille P, Alborzinia H, Dekervel J, Windmolders P, van Pelt J, Cassiman D, Cheneval O, Craik DJ, Schur J, Ott I, Wölfl S, Cammue BP, Thevissen K. The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells. Molecules (Basel, Switzerland). 19: 15088-102. PMID 25244288 DOI: 10.3390/molecules190915088  0.68
2014 Nielsen DS, Hoang HN, Lohman RJ, Hill TA, Lucke AJ, Craik DJ, Edmonds DJ, Griffith DA, Rotter CJ, Ruggeri RB, Price DA, Liras S, Fairlie DP. Improving on nature: making a cyclic heptapeptide orally bioavailable. Angewandte Chemie (International Ed. in English). 53: 12059-63. PMID 25219505 DOI: 10.1002/anie.201405364  0.68
2014 Wang CK, Northfield SE, Swedberg JE, Harvey PJ, Mathiowetz AM, Price DA, Liras S, Craik DJ. Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR. The Journal of Physical Chemistry. B. 118: 11129-36. PMID 25184622 DOI: 10.1021/jp506678f  0.68
2014 Vink S, Daly NL, Steen N, Craik DJ, Alewood PF. Holocyclotoxin-1, a cystine knot toxin from Ixodes holocyclus. Toxicon : Official Journal of the International Society On Toxinology. 90: 308-17. PMID 25172536 DOI: 10.1016/j.toxicon.2014.08.068  0.68
2014 Wang CK, King GJ, Northfield SE, Ojeda PG, Craik DJ. Racemic and quasi-racemic X-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angewandte Chemie (International Ed. in English). 53: 11236-41. PMID 25168664 DOI: 10.1002/anie.201406563  0.68
2014 Troeira Henriques S, Huang YH, Chaousis S, Wang CK, Craik DJ. Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. Chembiochem : a European Journal of Chemical Biology. 15: 1956-65. PMID 25099014 DOI: 10.1002/cbic.201402144  0.68
2014 Conibear AC, Craik DJ. The chemistry and biology of theta defensins. Angewandte Chemie (International Ed. in English). 53: 10612-23. PMID 25079086 DOI: 10.1002/anie.201402167  0.68
2014 D'Souza C, Henriques ST, Wang CK, Craik DJ. Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1. European Journal of Medicinal Chemistry. 88: 10-8. PMID 24985034 DOI: 10.1016/j.ejmech.2014.06.047  0.68
2014 Cheneval O, Schroeder CI, Durek T, Walsh P, Huang YH, Liras S, Price DA, Craik DJ. Fmoc-based synthesis of disulfide-rich cyclic peptides. The Journal of Organic Chemistry. 79: 5538-44. PMID 24918986 DOI: 10.1021/jo500699m  0.68
2014 Delattin N, De Brucker K, Craik DJ, Cheneval O, De Coninck B, Cammue BP, Thevissen K. Structure-activity relationship study of the plant-derived decapeptide OSIP108 inhibiting Candida albicans biofilm formation. Antimicrobial Agents and Chemotherapy. 58: 4974-7. PMID 24913176 DOI: 10.1128/AAC.03336-14  0.68
2014 Akondi KB, Muttenthaler M, Dutertre S, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. Discovery, synthesis, and structure-activity relationships of conotoxins. Chemical Reviews. 114: 5815-47. PMID 24720541 DOI: 10.1021/cr400401e  0.68
2014 Elliott AG, Delay C, Liu H, Phua Z, Rosengren KJ, Benfield AH, Panero JL, Colgrave ML, Jayasena AS, Dunse KM, Anderson MA, Schilling EE, Ortiz-Barrientos D, Craik DJ, Mylne JS. Evolutionary origins of a bioactive peptide buried within Preproalbumin. The Plant Cell. 26: 981-95. PMID 24681618 DOI: 10.1105/tpc.114.123620  0.68
2014 Northfield SE, Wang CK, Schroeder CI, Durek T, Kan MW, Swedberg JE, Craik DJ. Disulfide-rich macrocyclic peptides as templates in drug design. European Journal of Medicinal Chemistry. 77: 248-57. PMID 24650712 DOI: 10.1016/j.ejmech.2014.03.011  0.68
2014 Mahatmanto T, Poth AG, Mylne JS, Craik DJ. A comparative study of extraction methods reveals preferred solvents for cystine knot peptide isolation from Momordica cochinchinensis seeds. Fitoterapia. 95: 22-33. PMID 24613804 DOI: 10.1016/j.fitote.2014.02.016  0.68
2014 Delattin N, De Brucker K, Craik DJ, Cheneval O, Fröhlich M, Veber M, Girandon L, Davis TR, Weeks AE, Kumamoto CA, Cos P, Coenye T, De Coninck B, Cammue BP, Thevissen K. Plant-derived decapeptide OSIP108 interferes with Candida albicans biofilm formation without affecting cell viability. Antimicrobial Agents and Chemotherapy. 58: 2647-56. PMID 24566179 DOI: 10.1128/AAC.01274-13  0.68
2014 Lay FT, Poon S, McKenna JA, Connelly AA, Barbeta BL, McGinness BS, Fox JL, Daly NL, Craik DJ, Heath RL, Anderson MA. The C-terminal propeptide of a plant defensin confers cytoprotective and subcellular targeting functions. Bmc Plant Biology. 14: 41. PMID 24495600 DOI: 10.1186/1471-2229-14-41  0.68
2014 Schroeder CI, Swedberg JE, Withka JM, Rosengren KJ, Akcan M, Clayton DJ, Daly NL, Cheneval O, Borzilleri KA, Griffor M, Stock I, Colless B, Walsh P, Sunderland P, Reyes A, ... ... Craik DJ, et al. Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chemistry & Biology. 21: 284-94. PMID 24440079 DOI: 10.1016/j.chembiol.2013.11.014  0.68
2014 Jia X, Schulte L, Loukas A, Pickering D, Pearson M, Mobli M, Jones A, Rosengren KJ, Daly NL, Gobert GN, Jones MK, Craik DJ, Mulvenna J. Solution structure, membrane interactions, and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni. The Journal of Biological Chemistry. 289: 7151-63. PMID 24429291 DOI: 10.1074/jbc.M113.531558  0.68
2014 Jia X, Kwon S, Wang CI, Huang YH, Chan LY, Tan CC, Rosengren KJ, Mulvenna JP, Schroeder CI, Craik DJ. Semienzymatic cyclization of disulfide-rich peptides using Sortase A. The Journal of Biological Chemistry. 289: 6627-38. PMID 24425873 DOI: 10.1074/jbc.M113.539262  0.68
2014 Luo S, Zhangsun D, Schroeder CI, Zhu X, Hu Y, Wu Y, Weltzin MM, Eberhard S, Kaas Q, Craik DJ, McIntosh JM, Whiteaker P. A novel α4/7-conotoxin LvIA from Conus lividus that selectively blocks α3β2 vs. α6/α3β2β3 nicotinic acetylcholine receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 1842-53. PMID 24398291 DOI: 10.1096/fj.13-244103  0.68
2014 Conibear AC, Bochen A, Rosengren KJ, Stupar P, Wang C, Kessler H, Craik DJ. The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: A proof-of-concept study using the integrin-binding RGD motif. Chembiochem : a European Journal of Chemical Biology. 15: 451-9. PMID 24382674 DOI: 10.1002/cbic.201300568  0.68
2014 Schroeder CI, Rash LD, Vila-Farrés X, Rosengren KJ, Mobli M, King GF, Alewood PF, Craik DJ, Durek T. Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie (International Ed. in English). 53: 1017-20. PMID 24323786 DOI: 10.1002/anie.201308898  0.68
2013 Henriques ST, Thorstholm L, Huang YH, Getz JA, Daugherty PS, Craik DJ. A novel quantitative kinase assay using bacterial surface display and flow cytometry. Plos One. 8: e80474. PMID 24260399 DOI: 10.1371/journal.pone.0080474  0.68
2013 Grishin AA, Cuny H, Hung A, Clark RJ, Brust A, Akondi K, Alewood PF, Craik DJ, Adams DJ. Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 288: 34428-42. PMID 24100032 DOI: 10.1074/jbc.M113.512582  0.68
2013 Inserra MC, Kompella SN, Vetter I, Brust A, Daly NL, Cuny H, Craik DJ, Alewood PF, Adams DJ, Lewis RJ. Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochemical Pharmacology. 86: 791-9. PMID 23924607 DOI: 10.1016/j.bcp.2013.07.016  0.68
2013 Yu R, Kompella SN, Adams DJ, Craik DJ, Kaas Q. Determination of the α-conotoxin Vc1.1 binding site on the α9α10 nicotinic acetylcholine receptor. Journal of Medicinal Chemistry. 56: 3557-67. PMID 23566299 DOI: 10.1021/jm400041h  0.68
2012 Franco A, Kompella SN, Akondi KB, Melaun C, Daly NL, Luetje CW, Alewood PF, Craik DJ, Adams DJ, Marí F. RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs. Biochemical Pharmacology. 83: 419-26. PMID 22108175 DOI: 10.1016/j.bcp.2011.11.006  0.68
2011 Halai R, Callaghan B, Daly NL, Clark RJ, Adams DJ, Craik DJ. Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA B receptor Journal of Medicinal Chemistry. 54: 6984-6992. PMID 21888386 DOI: 10.1021/jm201060r  0.68
2011 de Araujo AD, Callaghan B, Nevin ST, Daly NL, Craik DJ, Moretta M, Hopping G, Christie MJ, Adams DJ, Alewood PF. Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angewandte Chemie (International Ed. in English). 50: 6527-9. PMID 21630402 DOI: 10.1002/anie.201101642  0.68
2011 Daly NL, Callaghan B, Clark RJ, Nevin ST, Adams DJ, Craik DJ. Structure and activity of α-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABAB receptor-coupled N-type calcium channels Journal of Biological Chemistry. 286: 10233-10237. PMID 21252227 DOI: 10.1074/jbc.M110.196170  0.68
2011 Lovelace ES, Gunasekera S, Alvarmo C, Clark RJ, Nevin ST, Grishin AA, Adams DJ, Craik DJ, Daly NL. Stabilization of α-conotoxin AuIB: Influences of disulfide connectivity and backbone cyclization Antioxidants and Redox Signaling. 14: 87-95. PMID 20486767 DOI: 10.1089/ars.2009.3068  0.68
2010 Clark RJ, Jensen J, Nevin ST, Callaghan BP, Adams DJ, Craik DJ. The engineering of an orally active conotoxin for the treatment of neuropathic pain Angewandte Chemie - International Edition. 49: 6545-6548. PMID 20533477 DOI: 10.1002/anie.201000620  0.68
2010 Muttenthaler M, Nevin ST, Grishin AA, Ngo ST, Choy PT, Daly NL, Hu SH, Armishaw CJ, Wang CI, Lewis RJ, Martin JL, Noakes PG, Craik DJ, Adams DJ, Alewood PF. Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists. Journal of the American Chemical Society. 132: 3514-22. PMID 20163143 DOI: 10.1021/ja910602h  0.68
2009 Halai R, Clark RJ, Nevin ST, Jensen JE, Adams DJ, Craik DJ. Scanning mutagenesis of α-conotoxin Vc1.1 reveals residues crucial for activity at the α9α10 nicotinic acetylcholine receptor Journal of Biological Chemistry. 284: 20275-20284. PMID 19447885 DOI: 10.1074/jbc.M109.015339  0.68
2009 Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL. Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. The Journal of Biological Chemistry. 284: 4944-51. PMID 19098004 DOI: 10.1074/jbc.M804950200  0.68
2008 Callaghan B, Haythornthwaite A, Berecki G, Clark RJ, Craik DJ, Adams DJ. Analgesic α-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation Journal of Neuroscience. 28: 10943-10951. PMID 18945902 DOI: 10.1523/JNEUROSCI.3594-08.2008  0.68
2008 Jin AH, Daly NL, Nevin ST, Wang CI, Dutertre S, Lewis RJ, Adams DJ, Craik DJ, Alewood PF. Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function. Journal of Medicinal Chemistry. 51: 5575-84. PMID 18754612 DOI: 10.1021/jm800278k  0.68
2008 Clark RJ, Daly NL, Halai R, Nevin ST, Adams DJ, Craik DJ. The three-dimensional structure of the analgesic α-conotoxin, RgIA Febs Letters. 582: 597-602. PMID 18242183 DOI: 10.1016/j.febslet.2008.01.027  0.68
2007 Craik DJ, Adams DJ. Chemical modification of conotoxins to improve stability and activity Acs Chemical Biology. 2: 457-468. PMID 17649970 DOI: 10.1021/cb700091j  0.68
2007 Jin AH, Brandstaetter H, Nevin ST, Tan CC, Clark RJ, Adams DJ, Alewood PF, Craik DJ, Daly NL. Structure of alpha-conotoxin BuIA: influences of disulfide connectivity on structural dynamics. Bmc Structural Biology. 7: 28. PMID 17445276 DOI: 10.1186/1472-6807-7-28  0.68
2006 Clark RJ, Fischer H, Nevin ST, Adams DJ, Craik DJ. The synthesis, structural characterization, and receptor specificity of the α-conotoxin Vc1.1 Journal of Biological Chemistry. 281: 23254-23263. PMID 16754662 DOI: 10.1074/jbc.M604550200  0.68
2006 Armishaw CJ, Daly NL, Nevin ST, Adams DJ, Craik DJ, Alewood PF. α-Selenoconotoxins, a new class of potent α7 neuronal nicotinic receptor antagonists Journal of Biological Chemistry. 281: 14136-14143. PMID 16500898 DOI: 10.1074/jbc.M512419200  0.68
2005 Clark RJ, Fischer H, Dempster L, Daly NL, Rosengren KJ, Nevin ST, Meunier FA, Adams DJ, Craik DJ. Engineering stable peptide toxins by means of backbone cyclization: Stabilization of the α-conotoxin MII Proceedings of the National Academy of Sciences of the United States of America. 102: 13767-13772. PMID 16162671 DOI: 10.1073/pnas.0504613102  0.68
2004 Daly NL, Ekberg JA, Thomas L, Adams DJ, Lewis RJ, Craik DJ. Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. The Journal of Biological Chemistry. 279: 25774-82. PMID 15044438 DOI: 10.1074/jbc.M313002200  0.68
2003 Blanchfield JT, Dutton JL, Hogg RC, Gallagher OP, Craik DJ, Jones A, Adams DJ, Lewis RJ, Alewood PF, Toth I. Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII. Journal of Medicinal Chemistry. 46: 1266-72. PMID 12646037 DOI: 10.1021/jm020426j  0.68
2003 Nicke A, Loughnan ML, Millard EL, Alewood PF, Adams DJ, Daly NL, Craik DJ, Lewis RJ. Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. The Journal of Biological Chemistry. 278: 3137-44. PMID 12419800 DOI: 10.1074/jbc.M210280200  0.68
2002 Dutton JL, Bansal PS, Hogg RC, Adams DJ, Alewood PF, Craik DJ. A new level of conotoxin diversity, a non-native disulfide bond connectivity in alpha-conotoxin AuIB reduces structural definition but increases biological activity. The Journal of Biological Chemistry. 277: 48849-57. PMID 12376538 DOI: 10.1074/jbc.M208842200  0.68
2002 Nielsen KJ, Watson M, Adams DJ, Hammarström AK, Gage PW, Hill JM, Craik DJ, Thomas L, Adams D, Alewood PF, Lewis RJ. Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels. The Journal of Biological Chemistry. 277: 27247-55. PMID 12006587 DOI: 10.1074/jbc.M201611200  0.68
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