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Thomas Nicholls - Publications

Affiliations: 
2009-2013 MRC Mitochondrial Biology Unit University of Cambridge, Cambridge, England, United Kingdom 
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Erdinc D, Rodríguez-Luis A, Fassad MR, Mackenzie S, Watson CM, Valenzuela S, Xie X, Menger KE, Sergeant K, Craig K, Hopton S, Falkous G, Poulton J, Garcia-Moreno H, Giunti P, ... ... Nicholls TJ, et al. Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability. Embo Molecular Medicine. e16775. PMID 37013609 DOI: 10.15252/emmm.202216775  0.546
2023 Menger KE, Nicholls TJ. Isolating Mitochondria, Mitoplasts, and mtDNA from Cultured Mammalian Cells. Methods in Molecular Biology (Clifton, N.J.). 2615: 17-30. PMID 36807781 DOI: 10.1007/978-1-0716-2922-2_2  0.525
2022 Menger KE, Chapman J, Díaz-Maldonado H, Khazeem MM, Deen D, Erdinc D, Casement JW, Di Leo V, Pyle A, Rodríguez-Luis A, Cowell IG, Falkenberg M, Austin CA, Nicholls TJ. Two type I topoisomerases maintain DNA topology in human mitochondria. Nucleic Acids Research. PMID 36215039 DOI: 10.1093/nar/gkac857  0.567
2022 Tan BG, Mutti CD, Shi Y, Xie X, Zhu X, Silva-Pinheiro P, Menger KE, Díaz-Maldonado H, Wei W, Nicholls TJ, Chinnery PF, Minczuk M, Falkenberg M, Gustafsson CM. The human mitochondrial genome contains a second light strand promoter. Molecular Cell. PMID 36044900 DOI: 10.1016/j.molcel.2022.08.011  0.724
2022 Misic J, Milenkovic D, Al-Behadili A, Xie X, Jiang M, Jiang S, Filograna R, Koolmeister C, Siira SJ, Jenninger L, Filipovska A, Clausen AR, Caporali L, Valentino ML, La Morgia C, ... ... Nicholls TJ, et al. Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion. Nucleic Acids Research. PMID 35947649 DOI: 10.1093/nar/gkac661  0.402
2021 Menger KE, Rodríguez-Luis A, Chapman J, Nicholls TJ. Controlling the topology of mammalian mitochondrial DNA. Open Biology. 11: 210168. PMID 34547213 DOI: 10.1098/rsob.210168  0.636
2021 Jiang M, Xie X, Zhu X, Jiang S, Milenkovic D, Misic J, Shi Y, Tandukar N, Li X, Atanassov I, Jenninger L, Hoberg E, Albarran-Gutierrez S, Szilagyi Z, Macao B, ... ... Nicholls TJ, et al. The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication. Science Advances. 7. PMID 34215584 DOI: 10.1126/sciadv.abf8631  0.591
2020 Chapman J, Ng YS, Nicholls TJ. The Maintenance of Mitochondrial DNA Integrity and Dynamics by Mitochondrial Membranes. Life (Basel, Switzerland). 10. PMID 32858900 DOI: 10.3390/life10090164  0.657
2020 Strakova A, Nicholls TJ, Baez-Ortega A, Ní Leathlobhair M, Sampson AT, Hughes K, Bolton IAG, Gori K, Wang J, Airikkala-Otter I, Allen JL, Allum KM, Arnold CL, Bansse-Issa L, Bhutia TN, et al. Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer. Nature Communications. 11: 3059. PMID 32546718 DOI: 10.1038/S41467-020-16765-W  0.449
2019 Nicholls TJ, Spåhr H, Jiang S, Siira SJ, Koolmeister C, Sharma S, Kauppila JHK, Jiang M, Kaever V, Rackham O, Chabes A, Falkenberg M, Filipovska A, Larsson NG, Gustafsson CM. Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria. Molecular Cell. PMID 31588022 DOI: 10.1016/J.Molcel.2019.09.010  0.494
2019 Andreazza S, Samstag CL, Sanchez-Martinez A, Fernandez-Vizarra E, Gomez-Duran A, Lee JJ, Tufi R, Hipp MJ, Schmidt EK, Nicholls TJ, Gammage PA, Chinnery PF, Minczuk M, Pallanck LJ, Kennedy SR, et al. Mitochondrially-targeted APOBEC1 is a potent mtDNA mutator affecting mitochondrial function and organismal fitness in Drosophila. Nature Communications. 10: 3280. PMID 31337756 DOI: 10.1038/S41467-019-10857-Y  0.728
2019 Lehmann D, Tuppen HAL, Campbell GE, Alston CL, Lawless C, Rosa HS, Rocha MC, Reeve AK, Nicholls TJ, Deschauer M, Zierz S, Taylor RW, Turnbull DM, Vincent AE. Understanding mitochondrial DNA maintenance disorders at the single muscle fibre level. Nucleic Acids Research. PMID 31147703 DOI: 10.1093/Nar/Gkz472  0.512
2018 Nicholls TJ, Gustafsson CM. Separating and Segregating the Human Mitochondrial Genome. Trends in Biochemical Sciences. 43: 869-881. PMID 30224181 DOI: 10.1016/j.tibs.2018.08.007  0.593
2018 Matic S, Jiang M, Nicholls TJ, Uhler JP, Dirksen-Schwanenland C, Polosa PL, Simard ML, Li X, Atanassov I, Rackham O, Filipovska A, Stewart JB, Falkenberg M, Larsson NG, Milenkovic D. Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria. Nature Communications. 9: 1202. PMID 29572490 DOI: 10.1038/S41467-018-03552-X  0.587
2017 Nicholls TJ, Nadalutti CA, Motori E, Sommerville EW, Gorman GS, Basu S, Hoberg E, Turnbull DM, Chinnery PF, Larsson NG, Larsson E, Falkenberg M, Taylor RW, Griffith JD, Gustafsson CM. Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA. Molecular Cell. PMID 29290614 DOI: 10.1016/J.Molcel.2017.11.033  0.599
2016 Uhler JP, Thörn C, Nicholls TJ, Matic S, Milenkovic D, Gustafsson CM, Falkenberg M. MGME1 processes flaps into ligatable nicks in concert with DNA polymerase γ during mtDNA replication. Nucleic Acids Research. PMID 27220468 DOI: 10.1093/Nar/Gkw468  0.362
2015 Van Haute L, Pearce SF, Powell CA, D'Souza AR, Nicholls TJ, Minczuk M. Mitochondrial transcript maturation and its disorders. Journal of Inherited Metabolic Disease. PMID 26016801 DOI: 10.1007/S10545-015-9859-Z  0.791
2015 Powell CA, Nicholls TJ, Minczuk M. Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease. Frontiers in Genetics. 6: 79. PMID 25806043 DOI: 10.3389/Fgene.2015.00079  0.796
2014 Kopajtich R, Nicholls TJ, Rorbach J, Metodiev MD, Freisinger P, Mandel H, Vanlander A, Ghezzi D, Carrozzo R, Taylor RW, Marquard K, Murayama K, Wieland T, Schwarzmayr T, Mayr JA, et al. Mutations in GTPBP3 cause a mitochondrial translation defect associated with hypertrophic cardiomyopathy, lactic acidosis, and encephalopathy. American Journal of Human Genetics. 95: 708-20. PMID 25434004 DOI: 10.1016/J.Ajhg.2014.10.017  0.781
2014 Rorbach J, Boesch P, Gammage PA, Nicholls TJ, Pearce SF, Patel D, Hauser A, Perocchi F, Minczuk M. MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome. Molecular Biology of the Cell. 25: 2542-55. PMID 25009282 DOI: 10.1091/Mbc.E14-01-0014  0.763
2014 Nicholls TJ, Zsurka G, Peeva V, Schöler S, Szczesny RJ, Cysewski D, Reyes A, Kornblum C, Sciacco M, Moggio M, Dziembowski A, Kunz WS, Minczuk M. Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease. Human Molecular Genetics. 23: 6147-62. PMID 24986917 DOI: 10.1093/Hmg/Ddu336  0.765
2014 Nicholls TJ, Minczuk M. In D-loop: 40 years of mitochondrial 7S DNA. Experimental Gerontology. 56: 175-81. PMID 24709344 DOI: 10.1016/J.Exger.2014.03.027  0.696
2013 Haack TB, Kopajtich R, Freisinger P, Wieland T, Rorbach J, Nicholls TJ, Baruffini E, Walther A, Danhauser K, Zimmermann FA, Husain RA, Schum J, Mundy H, Ferrero I, Strom TM, et al. ELAC2 mutations cause a mitochondrial RNA processing defect associated with hypertrophic cardiomyopathy. American Journal of Human Genetics. 93: 211-23. PMID 23849775 DOI: 10.1016/J.Ajhg.2013.06.006  0.793
2013 Nicholls TJ, Rorbach J, Minczuk M. Mitochondria: mitochondrial RNA metabolism and human disease. The International Journal of Biochemistry & Cell Biology. 45: 845-9. PMID 23333854 DOI: 10.1016/J.Biocel.2013.01.005  0.762
2013 Kornblum C, Nicholls TJ, Haack TB, Schöler S, Peeva V, Danhauser K, Hallmann K, Zsurka G, Rorbach J, Iuso A, Wieland T, Sciacco M, Ronchi D, Comi GP, Moggio M, et al. Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease Nature Genetics. 45: 214-219. PMID 23313956 DOI: 10.1038/Ng.2501  0.782
2013 Kornblum C, Nicholls T, Haack TB, Schoeler S, Peeva V, Danhauser K, Hallmann K, Zsurka G, Rorbach J, Iuso A, Wieland T, Sciacco M, Ronchi D, Comi GP, Moggio M, et al. O.24 Loss of function of MGME1, a novel player in mitochondrial DNA replication, causes a distinct autosomal recessive mitochondrial disorder Neuromuscular Disorders. 23: 852-852. DOI: 10.1016/J.Nmd.2013.06.734  0.778
2011 Rorbach J, Nicholls TJ, Minczuk M. PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria. Nucleic Acids Research. 39: 7750-63. PMID 21666256 DOI: 10.1093/Nar/Gkr470  0.733
2010 Rorbach J, Nicholls T, Minczuk M. Polyadenylation of mt mRNA: Identification of novel deadenylase of human mitochondria Biochimica Et Biophysica Acta. 1797: 105. DOI: 10.1016/J.Bbabio.2010.04.317  0.665
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