Sophia Khom - Publications

Affiliations: 
University of Vienna, Wien, Wien, Austria 
Area:
Alcohol, Synaptic transmission, GABAA receptor

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Rodriguez L, Kirson D, Wolfe SA, Patel RR, Varodayan FP, Snyder AE, Gandhi PJ, Khom S, Vlkolinsky R, Bajo M, Roberto M. Alcohol Dependence Induces CRF Sensitivity in Female Central Amygdala GABA Synapses. International Journal of Molecular Sciences. 23. PMID 35887190 DOI: 10.3390/ijms23147842  0.776
2022 Varodayan FP, Patel RR, Matzeu A, Wolfe SA, Curley DE, Khom S, Gandhi PJ, Rodriguez L, Bajo M, D'Ambrosio S, Sun H, Kerr TM, Gonzales RA, Leggio L, Natividad LA, et al. The Amygdala Noradrenergic System Is Compromised With Alcohol Use Disorder. Biological Psychiatry. PMID 35430085 DOI: 10.1016/j.biopsych.2022.02.006  0.755
2021 Khom S, Nguyen JD, Vandewater SA, Grant Y, Roberto M, Taffe MA. Self-Administration of Entactogen Psychostimulants Dysregulates Gamma-Aminobutyric Acid (GABA) and Kappa Opioid Receptor Signaling in the Central Nucleus of the Amygdala of Female Wistar Rats. Frontiers in Behavioral Neuroscience. 15: 780500. PMID 34975428 DOI: 10.3389/fnbeh.2021.780500  0.533
2021 Kirson D, Khom S, Rodriguez L, Wolfe SA, Varodayan FP, Gandhi PJ, Patel RR, Vlkolinsky R, Bajo M, Roberto M. Sex Differences in Acute Alcohol Sensitivity of Naïve and Alcohol Dependent Central Amygdala GABA Synapses. Alcohol and Alcoholism (Oxford, Oxfordshire). PMID 33912894 DOI: 10.1093/alcalc/agab034  0.776
2020 Steinman MQ, Kirson D, Wolfe SA, Khom S, D'Ambrosio SR, Spierling Bagsic SR, Bajo M, Vlkolinský R, Hoang NK, Singhal A, Sureshchandra S, Oleata CS, Messaoudi I, Zorrilla EP, Roberto M. Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use disorders. Molecular Psychiatry. PMID 33087855 DOI: 10.1038/s41380-020-00920-2  0.765
2020 Demoret RM, Baker MA, Ohtawa M, Chen S, Lam CC, Khom S, Roberto M, Forli S, Houk KN, Shenvi RA. Synthetic, Mechanistic and Biological Interrogation of Ginkgo biloba Chemical Space en route to (-)-Bilobalide. Journal of the American Chemical Society. PMID 32991152 DOI: 10.1021/jacs.0c08231  0.405
2020 Khom S, Wolfe SA, Patel RR, Kirson D, Hedges DM, Varodayan FP, Bajo M, Roberto M. Alcohol Dependence and Withdrawal Impair Serotonergic Regulation of GABA Transmission in the Rat Central Nucleus of the Amygdala. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 40: 6842-6853. PMID 32769108 DOI: 10.1523/Jneurosci.0733-20.2020  0.797
2020 Warden AS, Wolfe SA, Khom S, Varodayan FP, Patel RR, Steinman MQ, Bajo M, Montgomery SE, Vlkolinsky R, Nadav T, Polis I, Roberts AJ, Mayfield RD, Harris RA, Roberto M. Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers. Biological Psychiatry. PMID 32680583 DOI: 10.1016/J.Biopsych.2020.05.011  0.779
2020 Khom S, Steinkellner T, Hnasko TS, Roberto M. Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala. Science Advances. 6: eaaz1050. PMID 32206720 DOI: 10.1126/Sciadv.Aaz1050  0.593
2020 Roberto M, Kirson D, Khom S. The Role of the Central Amygdala in Alcohol Dependence. Cold Spring Harbor Perspectives in Medicine. PMID 31988201 DOI: 10.1101/Cshperspect.A039339  0.671
2019 Roberts AJ, Khom S, Bajo M, Vlkolinsky R, Polis I, Cates-Gatto C, Roberto M, Gruol DL. Increased IL-6 expression in astrocytes is associated with emotionality, alterations in central amygdala GABAergic transmission, and excitability during alcohol withdrawal. Brain, Behavior, and Immunity. PMID 31437534 DOI: 10.1016/J.Bbi.2019.08.185  0.554
2019 Suárez J, Khom S, Alén F, Natividad LA, Varodayan FP, Patel RR, Kirson D, Arco R, Ballesta A, Bajo M, Rubio L, Martin-Fardon R, Rodríguez de Fonseca F, Roberto M. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala. Addiction Biology. e12813. PMID 31339221 DOI: 10.1111/Adb.12813  0.811
2019 Tunstall BJ, Kirson D, Zallar LJ, McConnell SA, Vendruscolo JCM, Ho CP, Oleata CS, Khom S, Manning M, Lee MR, Leggio L, Koob GF, Roberto M, Vendruscolo LF. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala. Plos Biology. 17: e2006421. PMID 30990816 DOI: 10.1371/Journal.Pbio.2006421  0.677
2019 Patel RR, Khom S, Steinman MQ, Varodayan FP, Kiosses WB, Hedges DM, Vlkolinsky R, Nadav T, Polis I, Bajo M, Roberts AJ, Roberto M. IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala. Brain, Behavior, and Immunity. 75: 208-219. PMID 30791967 DOI: 10.1016/J.Bbi.2018.10.009  0.739
2018 Stadler M, Monticelli S, Seidel T, Luger D, Salzer I, Boehm S, Holzer W, Schwarzer C, Urban E, Khom S, Langer T, Pace V, Hering S. Design, synthesis and pharmacological evaluation of novel β2/3 subunit-selective γ-Aminobutyric Acid Type A (GABAA) receptor modulators. Journal of Medicinal Chemistry. PMID 30289721 DOI: 10.1021/acs.jmedchem.8b00859  0.555
2018 Varodayan FP, Khom S, Patel RR, Steinman MQ, Hedges DM, Oleata CS, Homanics GE, Roberto M, Bajo M. Role of TLR4 in the Modulation of Central Amygdala GABA Transmission by CRF Following Restraint Stress. Alcohol and Alcoholism (Oxford, Oxfordshire). PMID 29309503 DOI: 10.1093/Alcalc/Agx114  0.74
2017 Varodayan FP, Correia D, Kirson D, Khom S, Oleata CS, Luu G, Schweitzer P, Roberto M. CRF modulates glutamate transmission in the central amygdala of naïve and ethanol-dependent rats. Neuropharmacology. PMID 28807676 DOI: 10.1016/J.Neuropharm.2017.08.009  0.601
2017 Nguyen JD, Kirson D, Grant Y, Varodayan FP, Khom S, Patel R, Hedges DM, Roberto M, Taffe MA. Kappa Opioid Receptor Signaling Contributes to Re‐escalation of Oxycodone Self‐administration Under Extended Access Conditions The Faseb Journal. 31. DOI: 10.1096/Fasebj.31.1_Supplement.985.1  0.418
2017 Khom S, Rice K, Roberto M. Alcohol dependence alters substance P/neurokinin 1 receptor signaling in the central nucleus of the amygdala Alcohol. 60: 228. DOI: 10.1016/J.Alcohol.2017.02.288  0.639
2017 Bajo M, Steinman MQ, Varodayan FP, Khom S, Patel RR, Hedges DM, Herman MA, Montgomery SE, Nadav T, Steiner N, Mandyam CD, Roberts AJ, Roberto M. Chronic ethanol-induced immune responses in the mouse central amygdala: Focus on glia and IL-1 system Alcohol. 60: 225. DOI: 10.1016/J.Alcohol.2017.02.278  0.752
2016 Khom S, Hintersteiner J, Luger D, Haider M, Pototschnig G, Mihovilovic MD, Schwarzer C, Hering S. Analysis of β-Subunit-dependent GABAA Receptor Modulation and Behavioral Effects of Valerenic Acid Derivatives. The Journal of Pharmacology and Experimental Therapeutics. 357: 580-90. PMID 27190170 DOI: 10.1124/jpet.116.232983  0.505
2015 Luger D, Poli G, Wieder M, Stadler M, Ke S, Ernst M, Hohaus A, Linder T, Seidel T, Langer T, Khom S, Hering S. Identification of the putative binding pocket of valerenic acid on GABAA receptors using docking studies and site-directed mutagenesis. British Journal of Pharmacology. PMID 26375408 DOI: 10.1111/bph.13329  0.51
2015 Wimmer L, Schönbauer D, Pakfeifer P, Schöffmann A, Khom S, Hering S, Mihovilovic MD. Developing piperine towards TRPV1 and GABAA receptor ligands--synthesis of piperine analogs via Heck-coupling of conjugated dienes. Organic & Biomolecular Chemistry. 13: 990-4. PMID 25438036 DOI: 10.1039/c4ob02242d  0.513
2014 Strommer B, Khom S, Kastenberger I, Cicek SS, Stuppner H, Schwarzer C, Hering S. A cycloartane glycoside derived from Actaea racemosa L. modulates GABAA receptors and induces pronounced sedation in mice. The Journal of Pharmacology and Experimental Therapeutics. 351: 234-42. PMID 25161170 DOI: 10.1124/jpet.114.218024  0.564
2014 Schöffmann A, Wimmer L, Goldmann D, Khom S, Hintersteiner J, Baburin I, Schwarz T, Hintersteininger M, Pakfeifer P, Oufir M, Hamburger M, Erker T, Ecker GF, Mihovilovic MD, Hering S. Efficient modulation of γ-aminobutyric acid type A receptors by piperine derivatives. Journal of Medicinal Chemistry. 57: 5602-19. PMID 24905252 DOI: 10.1021/Jm5002277  0.496
2014 Hintersteiner J, Haider M, Luger D, Schwarzer C, Reznicek G, Jäger W, Khom S, Mihovilovic MD, Hering S. Esters of valerenic acid as potential prodrugs. European Journal of Pharmacology. 735: 123-31. PMID 24680924 DOI: 10.1016/j.ejphar.2014.03.019  0.576
2013 Khom S, Strommer B, Schöffmann A, Hintersteiner J, Baburin I, Erker T, Schwarz T, Schwarzer C, Zaugg J, Hamburger M, Hering S. GABAA receptor modulation by piperine and a non-TRPV1 activating derivative. Biochemical Pharmacology. 85: 1827-36. PMID 23623790 DOI: 10.1016/J.Bcp.2013.04.017  0.582
2012 Singhuber J, Baburin I, Khom S, Zehl M, Urban E, Hering S, Kopp B. GABA(A) receptor modulators from the Chinese herbal drug Junci Medulla--the pith of Juncus effusus. Planta Medica. 78: 455-8. PMID 22271080 DOI: 10.1055/s-0031-1298174  0.576
2011 Zaugg J, Khom S, Eigenmann D, Baburin I, Hamburger M, Hering S. Identification and characterization of GABA(A) receptor modulatory diterpenes from Biota orientalis that decrease locomotor activity in mice. Journal of Natural Products. 74: 1764-72. PMID 21793559 DOI: 10.1021/np200317p  0.543
2010 Cicek SS, Khom S, Taferner B, Hering S, Stuppner H. Bioactivity-guided isolation of GABA(A) receptor modulating constituents from the rhizomes of Actaea racemosa. Journal of Natural Products. 73: 2024-8. PMID 21082802 DOI: 10.1021/np100479w  0.568
2010 Khom S, Strommer B, Ramharter J, Schwarz T, Schwarzer C, Erker T, Ecker GF, Mulzer J, Hering S. Valerenic acid derivatives as novel subunit-selective GABAA receptor ligands - in vitro and in vivo characterization. British Journal of Pharmacology. 161: 65-78. PMID 20718740 DOI: 10.1111/J.1476-5381.2010.00865.X  0.576
2009 Baburin I, Khom S, Timin E, Hohaus A, Sieghart W, Hering S. Benzodiazepines modulate GABAA receptors by reducing a gamma-subunit-mediated inhibition of GABA sensitivity Bmc Pharmacology. 9: A23. DOI: 10.1186/1471-2210-9-S2-A23  0.564
2008 Baburin I, Khom S, Timin E, Hohaus A, Sieghart W, Hering S. Estimating the efficiency of benzodiazepines on GABA(A) receptors comprising gamma1 or gamma2 subunits. British Journal of Pharmacology. 155: 424-33. PMID 18604239 DOI: 10.1038/bjp.2008.271  0.565
2008 Kim HJ, Baburin I, Khom S, Hering S, Hamburger M. HPLC-based activity profiling approach for the discovery of GABAA receptor ligands using an automated two microelectrode voltage clamp assay on Xenopus oocytes. Planta Medica. 74: 521-6. PMID 18543148 DOI: 10.1055/s-2008-1074491  0.549
2008 Trauner G, Khom S, Baburin I, Benedek B, Hering S, Kopp B. Modulation of GABAA receptors by valerian extracts is related to the content of valerenic acid. Planta Medica. 74: 19-24. PMID 18095218 DOI: 10.1055/s-2007-993761  0.535
2007 Khom S, Baburin I, Timin E, Hohaus A, Trauner G, Kopp B, Hering S. Valerenic acid potentiates and inhibits GABA(A) receptors: molecular mechanism and subunit specificity. Neuropharmacology. 53: 178-87. PMID 17585957 DOI: 10.1016/j.neuropharm.2007.04.018  0.549
2007 Kim H, Khom S, Baburin I, Hering S, Hamburger M. HPLC-based activity profiling of plant and fungal extracts for GABAA receptor ligands using a functional assay with Xenopus oocytes Planta Medica. 73. DOI: 10.1055/s-2007-986720  0.489
2006 Khom S, Baburin I, Timin EN, Hohaus A, Sieghart W, Hering S. Pharmacological properties of GABAA receptors containing gamma1 subunits. Molecular Pharmacology. 69: 640-9. PMID 16272224 DOI: 10.1124/mol.105.017236  0.543
2006 Brattström A, Baburin I, Khom S, Hering S, Koetter U. Valerian extract modulates the GABAA-action on its receptors Planta Medica. 72. DOI: 10.1055/S-2006-950024  0.527
2006 Trauner G, Khom S, Benedek B, Hering S, Kopp B. Identification of GABAA-modulators obtained from Valeriana officinalis L Planta Medica. 72. DOI: 10.1055/S-2006-949848  0.459
0 Khom S. . PMID 32206720  0.367
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