Eric P. Zorrilla - Publications

Affiliations: 
Scripps Research Institute 
 University of California, San Diego, La Jolla, CA 

119 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Spierling S, de Guglielmo G, Kirson D, Kreisler A, Roberto M, George O, Zorrilla EP. Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31593982 DOI: 10.1038/s41386-019-0538-x  0.92
2019 Zorrilla EP, Koob GF. Corrigendum: Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency. Frontiers in Behavioral Neuroscience. 13: 188. PMID 31501652 DOI: 10.3389/fnbeh.2019.00188  1
2019 Zorrilla EP, Koob GF. Impulsivity Derived From the Dark Side: Neurocircuits That Contribute to Negative Urgency. Frontiers in Behavioral Neuroscience. 13: 136. PMID 31293401 DOI: 10.3389/fnbeh.2019.00136  1
2018 Serrano A, Pavon FJ, Buczynski MW, Schlosburg J, Natividad LA, Polis IY, Stouffer DG, Zorrilla EP, Roberto M, Cravatt BF, Martin-Fardon R, Rodriguez de Fonseca F, Parsons LH. Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29748627 DOI: 10.1038/s41386-018-0055-3  0.84
2018 Spierling SR, Kreisler AD, Williams CA, Fang SY, Pucci SN, Kines KT, Zorrilla EP. Intermittent, extended access to preferred food leads to escalated food reinforcement and cyclic whole-body metabolism in rats: Sex differences and individual vulnerability. Physiology & Behavior. PMID 29654812 DOI: 10.1016/j.physbeh.2018.04.001  0.4
2018 Logrip ML, Walker JR, Ayanwuyi LO, Sabino V, Ciccocioppo R, Koob GF, Zorrilla EP. Evaluation of Alcohol Preference and Drinking in msP Rats Bearing aPromoter Polymorphism. Frontiers in Psychiatry. 9: 28. PMID 29497387 DOI: 10.3389/fpsyt.2018.00028  1
2018 Rupprecht LE, Kreisler AD, Spierling SR, de Guglielmo G, Kallupi M, George O, Donny EC, Zorrilla EP, Sved AF. Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats. Psychopharmacology. PMID 29354872 DOI: 10.1007/s00213-018-4830-y  0.92
2017 Roberto M, Spierling SR, Kirson D, Zorrilla EP. Corticotropin-Releasing Factor (CRF) and Addictive Behaviors. International Review of Neurobiology. 136: 5-51. PMID 29056155 DOI: 10.1016/bs.irn.2017.06.004  0.48
2017 Kimbrough A, de Guglielmo G, Kononoff J, Kallupi M, Zorrilla EP, George O. CRF1 receptor-dependent increases in irritability-like behavior during abstinence from chronic intermittent ethanol vapor exposure. Alcoholism, Clinical and Experimental Research. PMID 28833238 DOI: 10.1111/acer.13484  0.92
2017 Somkuwar SS, Vendruscolo LF, Fannon MJ, Schmeichel BE, Nguyen TB, Guevara J, Sidhu H, Contet C, Zorrilla EP, Mandyam CD. Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors. Psychoneuroendocrinology. 84: 17-31. PMID 28647675 DOI: 10.1016/j.psyneuen.2017.06.006  0.84
2017 Spierling SR, Mattock M, Zorrilla EP. Modeling hypohedonia following repeated social defeat: Individual vulnerability and dopaminergic involvement. Physiology & Behavior. PMID 28433467 DOI: 10.1016/j.physbeh.2017.04.016  0.4
2017 Spierling SR, Zorrilla EP. Don't stress about CRF: assessing the translational failures of CRF1antagonists. Psychopharmacology. PMID 28265716 DOI: 10.1007/s00213-017-4556-2  0.4
2015 Wang J, Shanmugam A, Markand S, Zorrilla E, Ganapathy V, Smith SB. Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger. Free Radical Biology & Medicine. 86: 25-36. PMID 25920363 DOI: 10.1016/j.freeradbiomed.2015.04.009  1
2014 Shanmugam A, Wang J, Markand S, Perry RL, Tawfik A, Zorrilla E, Ganapathy V, Smith SB. Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells. Journal of Neurochemistry. PMID 25439327 DOI: 10.1111/jnc.13002  1
2014 Logrip ML, Zorrilla EP. Differential changes in amygdala and frontal cortex Pde10a expression during acute and protracted withdrawal. Frontiers in Integrative Neuroscience. 8: 30. PMID 24782725 DOI: 10.3389/fnint.2014.00030  1
2014 Logrip ML, Vendruscolo LF, Schlosburg JE, Koob GF, Zorrilla EP. Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1722-31. PMID 24549104 DOI: 10.1038/npp.2014.20  1
2014 Ha Y, Shanmugam AK, Markand S, Zorrilla E, Ganapathy V, Smith SB. Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. Cell and Tissue Research. 356: 15-27. PMID 24469320 DOI: 10.1007/s00441-013-1774-8  1
2014 Zorrilla EP, Logrip ML, Koob GF. Corticotropin releasing factor: a key role in the neurobiology of addiction. Frontiers in Neuroendocrinology. 35: 234-44. PMID 24456850 DOI: 10.1016/j.yfrne.2014.01.001  1
2014 Zorrilla EP, Conti B. Interleukin-18 null mutation increases weight and food intake and reduces energy expenditure and lipid substrate utilization in high-fat diet fed mice. Brain, Behavior, and Immunity. 37: 45-53. PMID 24316258 DOI: 10.1016/j.bbi.2013.12.001  1
2013 Zorrilla EP, Roberts AJ, Rivier JE, Koob GF. Anxiolytic-like effects of antisauvagine-30 in mice are not mediated by CRF2 receptors. Plos One. 8: e63942. PMID 24015170 DOI: 10.1371/journal.pone.0063942  1
2013 Blasio A, Iemolo A, Sabino V, Petrosino S, Steardo L, Rice KC, Orlando P, Iannotti FA, Di Marzo V, Zorrilla EP, Cottone P. Rimonabant precipitates anxiety in rats withdrawn from palatable food: role of the central amygdala. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2498-507. PMID 23793355 DOI: 10.1038/npp.2013.153  1
2013 Cottone P, Sabino V, Nagy TR, Coscina DV, Levin BE, Zorrilla EP. Centrally administered urocortin 2 decreases gorging on high-fat diet in both diet-induced obesity-prone and -resistant rats. International Journal of Obesity (2005). 37: 1515-23. PMID 23478425 DOI: 10.1038/ijo.2013.22  1
2013 Zorrilla EP, Heilig M, de Wit H, Shaham Y. Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. Drug and Alcohol Dependence. 128: 175-86. PMID 23294766 DOI: 10.1016/j.drugalcdep.2012.12.017  1
2013 Zorrilla EP, Koob GF. Amygdalostriatal projections in the neurocircuitry for motivation: a neuroanatomical thread through the career of Ann Kelley. Neuroscience and Biobehavioral Reviews. 37: 1932-45. PMID 23220696 DOI: 10.1016/j.neubiorev.2012.11.019  1
2012 Ha Y, Saul A, Tawfik A, Zorrilla EP, Ganapathy V, Smith SB. Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1. Molecular Vision. 18: 2860-70. PMID 23233788  1
2012 Parylak SL, Cottone P, Sabino V, Rice KC, Zorrilla EP. Effects of CB1 and CRF1 receptor antagonists on binge-like eating in rats with limited access to a sweet fat diet: lack of withdrawal-like responses. Physiology & Behavior. 107: 231-42. PMID 22776620 DOI: 10.1016/j.physbeh.2012.06.017  1
2012 Logrip ML, Zorrilla EP. Stress history increases alcohol intake in relapse: relation to phosphodiesterase 10A. Addiction Biology. 17: 920-33. PMID 22741603 DOI: 10.1111/j.1369-1600.2012.00460.x  1
2012 Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield TW, Logrip ML, Rivier C, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF. Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7563-71. PMID 22649234 DOI: 10.1523/JNEUROSCI.0069-12.2012  1
2012 Koob GF, Zorrilla EP. Update on corticotropin-releasing factor pharmacotherapy for psychiatric disorders: a revisionist view. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 308-9. PMID 22157874 DOI: 10.1038/npp.2011.213  1
2012 Zakhari JS, Zorrilla EP, Zhou B, Mayorov AV, Janda KD. Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice. Molecular Pharmaceutics. 9: 281-9. PMID 22149064 DOI: 10.1021/mp200376c  1
2012 Logrip ML, Zorrilla EP, Koob GF. Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder. Neuropharmacology. 62: 552-64. PMID 21782834 DOI: 10.1016/j.neuropharm.2011.07.007  1
2012 Zorrilla EP, Wee S, Zhao Y, Specio S, Boutrel B, Koob GF, Weiss F. Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats. Addiction Biology. 17: 300-8. PMID 21762287 DOI: 10.1111/j.1369-1600.2011.00329.x  1
2011 Ha Y, Saul A, Tawfik A, Williams C, Bollinger K, Smith R, Tachikawa M, Zorrilla E, Ganapathy V, Smith SB. Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1). Investigative Ophthalmology & Visual Science. 52: 7749-60. PMID 21862648 DOI: 10.1167/iovs.11-8169  1
2011 Fekete EM, Zhao Y, Szücs A, Sabino V, Cottone P, Rivier J, Vale WW, Koob GF, Zorrilla EP. Systemic urocortin 2, but not urocortin 1 or stressin 1-A, suppresses feeding via CRF2 receptors without malaise and stress. British Journal of Pharmacology. 164: 1959-75. PMID 21627635 DOI: 10.1111/j.1476-5381.2011.01512.x  1
2011 Parylak SL, Koob GF, Zorrilla EP. The dark side of food addiction. Physiology & Behavior. 104: 149-56. PMID 21557958 DOI: 10.1016/j.physbeh.2011.04.063  1
2011 Logrip ML, Koob GF, Zorrilla EP. Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention. Cns Drugs. 25: 271-87. PMID 21425881 DOI: 10.2165/11587790-000000000-00000  1
2011 Sabino V, Cottone P, Blasio A, Iyer MR, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1207-18. PMID 21346735 DOI: 10.1038/npp.2011.5  1
2011 Walker BM, Zorrilla EP, Koob GF. Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats. Addiction Biology. 16: 116-9. PMID 20579007 DOI: 10.1111/j.1369-1600.2010.00226.x  1
2010 Power ML, Williams LE, Gibson SV, Schulkin J, Helfers J, Zorrilla EP. Pattern of maternal circulating CRH in laboratory-housed squirrel and owl monkeys. American Journal of Primatology. 72: 1004-12. PMID 20872786 DOI: 10.1002/ajp.20850  1
2010 Repunte-Canonigo V, van der Stap LD, Chen J, Sabino V, Wagner U, Zorrilla EP, Schumann G, Roberts AJ, Sanna PP. Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake. Brain Research. 1339: 1-10. PMID 20388501 DOI: 10.1016/j.brainres.2010.03.063  1
2010 Zorrilla EP, Koob GF. Progress in corticotropin-releasing factor-1 antagonist development. Drug Discovery Today. 15: 371-83. PMID 20206287 DOI: 10.1016/j.drudis.2010.02.011  1
2010 Roberto M, Cruz MT, Gilpin NW, Sabino V, Schweitzer P, Bajo M, Cottone P, Madamba SG, Stouffer DG, Zorrilla EP, Koob GF, Siggins GR, Parsons LH. Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence. Biological Psychiatry. 67: 831-9. PMID 20060104 DOI: 10.1016/j.biopsych.2009.11.007  1
2010 Koob GF, Zorrilla EP. Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor. Current Opinion in Investigational Drugs (London, England : 2000). 11: 63-71. PMID 20047160  1
2010 Martin-Fardon R, Zorrilla EP, Ciccocioppo R, Weiss F. Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin. Brain Research. 1314: 145-61. PMID 20026088 DOI: 10.1016/j.brainres.2009.12.027  1
2010 Zorrilla EP, Zhao Y, Koob GF. Anti-CRF Encyclopedia of Stress. 206-214. DOI: 10.1016/B978-012373947-6.00412-8  1
2010 Fekete EM, Zorrilla EP. Urocortins Encyclopedia of Stress. 804-811. DOI: 10.1016/B978-012373947-6.00386-X  1
2010 Zorrilla EP, Koob GF. Peptides Encyclopedia of Stress. 91-96. DOI: 10.1016/B978-012373947-6.00293-2  1
2009 Cottone P, Sabino V, Roberto M, Bajo M, Pockros L, Frihauf JB, Fekete EM, Steardo L, Rice KC, Grigoriadis DE, Conti B, Koob GF, Zorrilla EP. CRF system recruitment mediates dark side of compulsive eating. Proceedings of the National Academy of Sciences of the United States of America. 106: 20016-20. PMID 19901333 DOI: 10.1073/pnas.0908789106  1
2009 Fonareva I, Spangler E, Cannella N, Sabino V, Cottone P, Ciccocioppo R, Zorrilla EP, Ryabinin AE. Increased perioculomotor urocortin 1 immunoreactivity in genetically selected alcohol preferring rats. Alcoholism, Clinical and Experimental Research. 33: 1956-65. PMID 19673740 DOI: 10.1111/j.1530-0277.2009.01033.x  1
2009 Sabino V, Cottone P, Zhao Y, Steardo L, Koob GF, Zorrilla EP. Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist. Psychopharmacology. 205: 327-35. PMID 19440699 DOI: 10.1007/s00213-009-1548-x  1
2009 Szabadfi K, Atlasz T, Reglodi D, Kiss P, Dányádi B, Fekete EM, Zorrilla EP, Tamás A, Szabó K, Gábriel R. Urocortin 2 protects against retinal degeneration following bilateral common carotid artery occlusion in the rat. Neuroscience Letters. 455: 42-5. PMID 19429103 DOI: 10.1016/j.neulet.2009.03.013  1
2009 Francesconi W, Berton F, Repunte-Canonigo V, Hagihara K, Thurbon D, Lekic D, Specio SE, Greenwell TN, Chen SA, Rice KC, Richardson HN, O'Dell LE, Zorrilla EP, Morales M, Koob GF, et al. Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5389-401. PMID 19403807 DOI: 10.1523/JNEUROSCI.5129-08.2009  1
2009 Fekete EM, Zhao Y, Li C, Sabino V, Vale WW, Zorrilla EP. Social defeat stress activates medial amygdala cells that express type 2 corticotropin-releasing factor receptor mRNA. Neuroscience. 162: 5-13. PMID 19358876 DOI: 10.1016/j.neuroscience.2009.03.078  1
2009 Greenwell TN, Funk CK, Cottone P, Richardson HN, Chen SA, Rice KC, Zorrilla EP, Koob GF. Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats. Addiction Biology. 14: 130-43. PMID 19291009 DOI: 10.1111/j.1369-1600.2008.00142.x  1
2009 Nie Z, Zorrilla EP, Madamba SG, Rice KC, Roberto M, Siggins GR. Presynaptic CRF1 receptors mediate the ethanol enhancement of GABAergic transmission in the mouse central amygdala. Thescientificworldjournal. 9: 68-85. PMID 19151899 DOI: 10.1100/tsw.2009.1  1
2009 Sabino V, Cottone P, Parylak SL, Steardo L, Zorrilla EP. Sigma-1 receptor knockout mice display a depressive-like phenotype. Behavioural Brain Research. 198: 472-6. PMID 19100292 DOI: 10.1016/j.bbr.2008.11.036  1
2009 Sabino V, Cottone P, Zhao Y, Iyer MR, Steardo L, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1482-93. PMID 18946467 DOI: 10.1038/npp.2008.192  1
2009 Cottone P, Sabino V, Steardo L, Zorrilla EP. Consummatory, anxiety-related and metabolic adaptations in female rats with alternating access to preferred food. Psychoneuroendocrinology. 34: 38-49. PMID 18842344 DOI: 10.1016/j.psyneuen.2008.08.010  1
2009 Greenwell TN, Walker BM, Cottone P, Zorrilla EP, Koob GF. The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration. Pharmacology, Biochemistry, and Behavior. 91: 295-302. PMID 18703080 DOI: 10.1016/j.pbb.2008.07.012  1
2008 Mayorov AV, Amara N, Chang JY, Moss JA, Hixon MS, Ruiz DI, Meijler MM, Zorrilla EP, Janda KD. Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 17487-92. PMID 18981425 DOI: 10.1073/pnas.0711808105  1
2008 Osborn O, Gram H, Zorrilla EP, Conti B, Bartfai T. Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance. Swiss Medical Weekly. 138: 665-73. PMID 18855149  1
2008 Cottone P, Sabino V, Steardo L, Zorrilla EP. Intermittent access to preferred food reduces the reinforcing efficacy of chow in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 295: R1066-76. PMID 18667718 DOI: 10.1152/ajpregu.90309.2008  1
2008 Lu X, Ross B, Sanchez-Alavez M, Zorrilla EP, Bartfai T. Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests. Neuropeptides. 42: 387-97. PMID 18554714 DOI: 10.1016/j.npep.2008.04.009  1
2008 Richardson HN, Zhao Y, Fekete EM, Funk CK, Wirsching P, Janda KD, Zorrilla EP, Koob GF. MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist. Pharmacology, Biochemistry, and Behavior. 88: 497-510. PMID 18031798 DOI: 10.1016/j.pbb.2007.10.008  1
2008 Specio SE, Wee S, O'Dell LE, Boutrel B, Zorrilla EP, Koob GF. CRF(1) receptor antagonists attenuate escalated cocaine self-administration in rats. Psychopharmacology. 196: 473-82. PMID 17965976 DOI: 10.1007/s00213-007-0983-9  1
2008 Cottone P, Sabino V, Steardo L, Zorrilla EP. Opioid-dependent anticipatory negative contrast and binge-like eating in rats with limited access to highly preferred food. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 524-35. PMID 17443124 DOI: 10.1038/sj.npp.1301430  1
2007 Tabarin A, Diz-Chaves Y, Consoli D, Monsaingeon M, Bale TL, Culler MD, Datta R, Drago F, Vale WW, Koob GF, Zorrilla EP, Contarino A. Role of the corticotropin-releasing factor receptor type 2 in the control of food intake in mice: a meal pattern analysis. The European Journal of Neuroscience. 26: 2303-14. PMID 17953621 DOI: 10.1111/j.1460-9568.2007.05856.x  1
2007 George O, Ghozland S, Azar MR, Cottone P, Zorrilla EP, Parsons LH, O'Dell LE, Richardson HN, Koob GF. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proceedings of the National Academy of Sciences of the United States of America. 104: 17198-203. PMID 17921249 DOI: 10.1073/pnas.0707585104  1
2007 Zhao Y, Valdez GR, Fekete EM, Rivier JE, Vale WW, Rice KC, Weiss F, Zorrilla EP. Subtype-selective corticotropin-releasing factor receptor agonists exert contrasting, but not opposite, effects on anxiety-related behavior in rats. The Journal of Pharmacology and Experimental Therapeutics. 323: 846-54. PMID 17855476 DOI: 10.1124/jpet.107.123208  1
2007 Zhao Y, Weiss F, Zorrilla EP. Remission and resurgence of anxiety-like behavior across protracted withdrawal stages in ethanol-dependent rats. Alcoholism, Clinical and Experimental Research. 31: 1505-15. PMID 17760785 DOI: 10.1111/j.1530-0277.2007.00456.x  1
2007 Cottone P, Sabino V, Nagy TR, Coscina DV, Zorrilla EP. Feeding microstructure in diet-induced obesity susceptible versus resistant rats: central effects of urocortin 2. The Journal of Physiology. 583: 487-504. PMID 17627984 DOI: 10.1113/jphysiol.2007.138867  1
2007 Zorrilla EP, Sanchez-Alavez M, Sugama S, Brennan M, Fernandez R, Bartfai T, Conti B. Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Proceedings of the National Academy of Sciences of the United States of America. 104: 11097-102. PMID 17578927 DOI: 10.1073/pnas.0611523104  1
2007 Chu K, Koob GF, Cole M, Zorrilla EP, Roberts AJ. Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1 receptor antagonist antalarmin and by CRF1 receptor knockout. Pharmacology, Biochemistry, and Behavior. 86: 813-21. PMID 17482248 DOI: 10.1016/j.pbb.2007.03.009  1
2007 Sabino V, Cottone P, Steardo L, Schmidhammer H, Zorrilla EP. 14-Methoxymetopon, a highly potent mu opioid agonist, biphasically affects ethanol intake in Sardinian alcohol-preferring rats. Psychopharmacology. 192: 537-46. PMID 17345066 DOI: 10.1007/s00213-007-0746-7  1
2007 Zorrilla EP, Brennan M, Sabino V, Lu X, Bartfai T. Galanin type 1 receptor knockout mice show altered responses to high-fat diet and glucose challenge. Physiology & Behavior. 91: 479-85. PMID 17223141 DOI: 10.1016/j.physbeh.2006.11.011  1
2007 Fekete EM, Zorrilla EP. Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs. Frontiers in Neuroendocrinology. 28: 1-27. PMID 17083971 DOI: 10.1016/j.yfrne.2006.09.002  1
2007 Cottone P, Sabino V, Steardo L, Zorrilla EP. FG 7142 specifically reduces meal size and the rate and regularity of sustained feeding in female rats: evidence that benzodiazepine inverse agonists reduce food palatability. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1069-81. PMID 17077811 DOI: 10.1038/sj.npp.1301229  1
2007 O'Dell LE, Chen SA, Smith RT, Specio SE, Balster RL, Paterson NE, Markou A, Zorrilla EP, Koob GF. Extended access to nicotine self-administration leads to dependence: Circadian measures, withdrawal measures, and extinction behavior in rats. The Journal of Pharmacology and Experimental Therapeutics. 320: 180-93. PMID 17050784 DOI: 10.1124/jpet.106.105270  1
2007 Fekete EM, Inoue K, Zhao Y, Rivier JE, Vale WW, Szücs A, Koob GF, Zorrilla EP. Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1052-68. PMID 17019404 DOI: 10.1038/sj.npp.1301214  1
2007 Funk CK, Zorrilla EP, Lee MJ, Rice KC, Koob GF. Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats. Biological Psychiatry. 61: 78-86. PMID 16876134 DOI: 10.1016/j.biopsych.2006.03.063  1
2006 Conti B, Sanchez-Alavez M, Winsky-Sommerer R, Morale MC, Lucero J, Brownell S, Fabre V, Huitron-Resendiz S, Henriksen S, Zorrilla EP, de Lecea L, Bartfai T. Transgenic mice with a reduced core body temperature have an increased life span. Science (New York, N.Y.). 314: 825-8. PMID 17082459 DOI: 10.1126/science.1132191  1
2006 Sabino V, Cottone P, Koob GF, Steardo L, Lee MJ, Rice KC, Zorrilla EP. Dissociation between opioid and CRF1 antagonist sensitive drinking in Sardinian alcohol-preferring rats. Psychopharmacology. 189: 175-86. PMID 17047935 DOI: 10.1007/s00213-006-0546-5  1
2006 Zorrilla EP, Iwasaki S, Moss JA, Chang J, Otsuji J, Inoue K, Meijler MM, Janda KD. Vaccination against weight gain. Proceedings of the National Academy of Sciences of the United States of America. 103: 13226-31. PMID 16891413 DOI: 10.1073/pnas.0605376103  1
2006 Chen A, Zorrilla E, Smith S, Rousso D, Levy C, Vaughan J, Donaldson C, Roberts A, Lee KF, Vale W. Urocortin 2-deficient mice exhibit gender-specific alterations in circadian hypothalamus-pituitary-adrenal axis and depressive-like behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5500-10. PMID 16707802 DOI: 10.1523/JNEUROSCI.3955-05.2006  1
2006 Richardson HN, Zorrilla EP, Mandyam CD, Rivier CL. Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood. Endocrinology. 147: 2506-17. PMID 16455779 DOI: 10.1210/en.2005-1054  1
2006 Chen SA, O'Dell LE, Hoefer ME, Greenwell TN, Zorrilla EP, Koob GF. Unlimited access to heroin self-administration: independent motivational markers of opiate dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2692-707. PMID 16452993 DOI: 10.1038/sj.npp.1301008  1
2005 Tabarin A, Diz-Chaves Y, Chaves YD, Carmona Mdel C, Catargi B, Zorrilla EP, Roberts AJ, Coscina DV, Rousset S, Redonnet A, Parker GC, Inoue K, Ricquier D, Pénicaud L, Kieffer BL, et al. Resistance to diet-induced obesity in mu-opioid receptor-deficient mice: evidence for a "thrifty gene". Diabetes. 54: 3510-6. PMID 16306369 DOI: 10.2337/diabetes.54.12.3510  1
2005 Zorrilla EP, Inoue K, Fekete EM, Tabarin A, Valdez GR, Koob GF. Measuring meals: structure of prandial food and water intake of rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288: R1450-67. PMID 15637168 DOI: 10.1152/ajpregu.00175.2004  1
2005 Zorrilla EP, Inoue K, Valdez GR, Tabarin A, Koob GF. Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat. Psychopharmacology. 177: 324-35. PMID 15609069 DOI: 10.1007/s00213-004-1952-1  1
2005 Stinus L, Cador M, Zorrilla EP, Koob GF. Buprenorphine and a CRF1 antagonist block the acquisition of opiate withdrawal-induced conditioned place aversion in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 90-8. PMID 15138444 DOI: 10.1038/sj.npp.1300487  1
2005 Zorrilla EP, Koob GF. Chapter 2.4 The roles of urocortins 1, 2, and 3 in the brain Techniques in the Behavioral and Neural Sciences. 15: 179-203. DOI: 10.1016/S0921-0709(05)80013-6  1
2005 Valdez GR, Zorrilla EP, Koob GF. Homeostasis within the corticotropin-releasing factor system via CRF 2 receptor activation: A novel approach for the treatment of anxiety Drug Development Research. 65: 205-215. DOI: 10.1002/ddr.20024  1
2004 Zorrilla EP, Koob GF. The therapeutic potential of CRF1 antagonists for anxiety. Expert Opinion On Investigational Drugs. 13: 799-828. PMID 15212620 DOI: 10.1517/13543784.13.7.799  1
2004 Inoue K, Zorrilla EP, Tabarin A, Valdez GR, Iwasaki S, Kiriike N, Koob GF. Reduction of anxiety after restricted feeding in the rat: implication for eating disorders. Biological Psychiatry. 55: 1075-81. PMID 15158426 DOI: 10.1016/j.biopsych.2004.01.026  1
2004 Zorrilla EP, Reinhardt LE, Valdez GR, Inoue K, Rivier JE, Vale WW, Koob GF. Human urocortin 2, a corticotropin-releasing factor (CRF)2 agonist, and ovine CRF, a CRF1 agonist, differentially alter feeding and motor activity. The Journal of Pharmacology and Experimental Therapeutics. 310: 1027-34. PMID 15115804 DOI: 10.1124/jpet.104.068676  1
2003 Zorrilla EP, Taché Y, Koob GF. Nibbling at CRF receptor control of feeding and gastrocolonic motility. Trends in Pharmacological Sciences. 24: 421-7. PMID 12915052 DOI: 10.1016/S0165-6147(03)00177-9  1
2003 Valdez GR, Zorrilla EP, Rivier J, Vale WW, Koob GF. Locomotor suppressive and anxiolytic-like effects of urocortin 3, a highly selective type 2 corticotropin-releasing factor agonist. Brain Research. 980: 206-12. PMID 12867260 DOI: 10.1016/S0006-8993(03)02971-8  1
2003 Valdez GR, Zorrilla EP, Roberts AJ, Koob GF. Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence. Alcohol (Fayetteville, N.Y.). 29: 55-60. PMID 12782246 DOI: 10.1016/S0741-8329(03)00020-X  1
2003 Inoue K, Valdez GR, Reyes TM, Reinhardt LE, Tabarin A, Rivier J, Vale WW, Sawchenko PE, Koob GF, Zorrilla EP. Human urocortin II, a selective agonist for the type 2 corticotropin-releasing factor receptor, decreases feeding and drinking in the rat. The Journal of Pharmacology and Experimental Therapeutics. 305: 385-93. PMID 12649393 DOI: 10.1124/jpet.102.047712  1
2002 Valdez GR, Roberts AJ, Chan K, Davis H, Brennan M, Zorrilla EP, Koob GF. Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor. Alcoholism, Clinical and Experimental Research. 26: 1494-501. PMID 12394282 DOI: 10.1097/01.ALC.0000033120.51856.F0  1
2002 Zorrilla EP, Schulteis G, Ormsby A, Klaassen A, Ling N, McCarthy JR, Koob GF, De Souza EB. Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors. Brain Research. 952: 200-10. PMID 12376180 DOI: 10.1016/S0006-8993(02)03345-0  1
2002 Zorrilla EP, Valdez GR, Nozulak J, Koob GF, Markou A. Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. Brain Research. 952: 188-99. PMID 12376179 DOI: 10.1016/S0006-8993(02)03189-X  1
2002 Valdez GR, Inoue K, Koob GF, Rivier J, Vale W, Zorrilla EP. Human urocortin II: mild locomotor suppressive and delayed anxiolytic-like effects of a novel corticotropin-releasing factor related peptide. Brain Research. 943: 142-50. PMID 12088848 DOI: 10.1016/S0006-8993(02)02707-5  1
2002 Spina MG, Merlo-Pich E, Akwa Y, Balducci C, Basso AM, Zorrilla EP, Britton KT, Rivier J, Vale WW, Koob GF. Time-dependent induction of anxiogenic-like effects after central infusion of urocortin or corticotropin-releasing factor in the rat. Psychopharmacology. 160: 113-21. PMID 11875628 DOI: 10.1007/s00213-001-0940-y  1
2001 Zorrilla EP, Valdez GR, Weiss F. Changes in levels of regional CRF-like-immunoreactivity and plasma corticosterone during protracted drug withdrawal in dependent rats. Psychopharmacology. 158: 374-81. PMID 11797058 DOI: 10.1007/s002130100773  1
2001 Zorrilla EP, Luborsky L, McKay JR, Rosenthal R, Houldin A, Tax A, McCorkle R, Seligman DA, Schmidt K. The relationship of depression and stressors to immunological assays: a meta-analytic review. Brain, Behavior, and Immunity. 15: 199-226. PMID 11566046 DOI: 10.1006/brbi.2000.0597  1
2001 Weiss F, Ciccocioppo R, Parsons LH, Katner S, Liu X, Zorrilla EP, Valdez GR, Ben-Shahar O, Angeletti S, Richter RR. Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors. Annals of the New York Academy of Sciences. 937: 1-26. PMID 11458532  1
2001 Zorrilla EP, Schulteis G, Ling N, Koob GF, De Souza EB. Performance-enhancing effects of CRF-BP ligand inhibitors. Neuroreport. 12: 1231-4. PMID 11338197  1
2000 Richter RM, Zorrilla EP, Basso AM, Koob GF, Weiss F. Altered amygdalar CRF release and increased anxiety-like behavior in Sardinian alcohol-preferring rats: a microdialysis and behavioral study. Alcoholism, Clinical and Experimental Research. 24: 1765-72. PMID 11141034  1
2000 Spina MG, Basso AM, Zorrilla EP, Heyser CJ, Rivier J, Vale W, Merlo-Pich E, Koob GF. Behavioral effects of central administration of the novel CRF antagonist astressin in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 22: 230-9. PMID 10693150 DOI: 10.1016/S0893-133X(99)00108-6  1
1998 Zorrilla EP, Cannon TD, Kessler J, Gur RE. Leukocyte differentials predict short-term clinical outcome following antipsychotic treatment in schizophrenia. Biological Psychiatry. 43: 887-96. PMID 9627743 DOI: 10.1016/S0006-3223(97)00358-2  1
1997 Halasz I, Rittenhouse PA, Zorrilla EP, Redei E. Sexually dimorphic effects of maternal adrenalectomy on hypothalamic corticotrophin-releasing factor, glucocorticoid receptor and anterior pituitary POMC mRNA levels in rat neonates. Brain Research. Developmental Brain Research. 100: 198-204. PMID 9205810 DOI: 10.1016/S0165-3806(97)00033-3  1
1997 Kalichman SC, Zorrilla EP, McKay JR, Luborsky L, Schmidt K. Progression of viral illness [13] American Journal of Psychiatry. 154: 718. PMID 9137146  1
1997 Zorrilla EP. Multiparous species present problems (and possibilities) to developmentalists. Developmental Psychobiology. 30: 141-50. PMID 9068968 DOI: 10.1002/(SICI)1098-2302(199703)30:2<141::AID-DEV5>3.0.CO;2-Q  1
1997 McKay JR, Luborsky L, Barber JP, Kabasakalian-McKay R, Zorrilla EP, Cacciola JS. Affilitative trust-mistrust and immunity in depressed patients receiving supportive-expressive psychotherapy Psychotherapy Research. 7: 249-260.  1
1996 Zorrilla EP, Cannon TD, Gur RE, Kessler J. Leukocytes and organ-nonspecific autoantibodies in schizophrenics and their siblings: markers of vulnerability or disease? Biological Psychiatry. 40: 825-33. PMID 8896768 DOI: 10.1016/0006-3223(95)00598-6  1
1996 Zorrilla EP, McKay JR, Luborsky L, Schmidt K. Relation of stressors and depressive symptoms to clinical progression of viral illness. The American Journal of Psychiatry. 153: 626-35. PMID 8615407  1
1995 Zorrilla EP, DeRubeis RJ, Redei E. High self-esteem, hardiness and affective stability are associated with higher basal pituitary-adrenal hormone levels. Psychoneuroendocrinology. 20: 591-601. PMID 8584600 DOI: 10.1016/0306-4530(95)00005-9  1
1994 Zorrilla EP, Redei E, DeRubeis RJ. Reduced cytokine levels and T-cell function in healthy males: relation to individual differences in subclinical anxiety. Brain, Behavior, and Immunity. 8: 293-312. PMID 7696716 DOI: 10.1006/brbi.1994.1028  1
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