Paul D. Shepard, Ph.D. - Publications

Affiliations: 
Psychiatry University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Dopamine, Ion channels, habenula

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Wang L, Lu H, Brown PL, Rea W, Vaupel B, Yang Y, Stein E, Shepard PD. Manganese-Enhanced MRI Reflects Both Activity-Independent and Activity-Dependent Uptake within the Rat Habenulomesencephalic Pathway. Plos One. 10: e0127773. PMID 26009889 DOI: 10.1371/journal.pone.0127773  1
2015 Du X, Choa FS, Summerfelt A, Tagamets MA, Rowland LM, Kochunov P, Shepard P, Hong LE. Neural summation in human motor cortex by subthreshold transcranial magnetic stimulations. Experimental Brain Research. 233: 671-7. PMID 25399245 DOI: 10.1007/s00221-014-4146-z  1
2014 Yu N, Tucker KR, Levitan ES, Shepard PD, Canavier CC. Implications of cellular models of dopamine neurons for schizophrenia. Progress in Molecular Biology and Translational Science. 123: 53-82. PMID 24560140 DOI: 10.1016/B978-0-12-397897-4.00011-5  1
2014 Shepard PD. Basic science, RDoC, and schizophrenia bulletin Schizophrenia Bulletin. 40: 717-718. DOI: 10.1093/schbul/sbu077  1
2013 Brown PL, Shepard PD. Lesions of the fasciculus retroflexus alter footshock-induced cFos expression in the mesopontine rostromedial tegmental area of rats. Plos One. 8: e60678. PMID 23593280 DOI: 10.1371/journal.pone.0060678  1
2013 Shepard PD, Smith JL, Carpenter WT. Changes ahead for the bulletin in 2013 Schizophrenia Bulletin. 39: 1-2. DOI: 10.1093/schbul/sbs140  1
2012 Ji H, Tucker KR, Putzier I, Huertas MA, Horn JP, Canavier CC, Levitan ES, Shepard PD. Functional characterization of ether-à-go-go-related gene potassium channels in midbrain dopamine neurons - implications for a role in depolarization block. The European Journal of Neuroscience. 36: 2906-16. PMID 22780096 DOI: 10.1111/j.1460-9568.2012.08190.x  1
2012 Brown PL, Shepard PD, Elmer GI, Stockman S, McFarland R, Mayo CL, Cadet JL, Krasnova IN, Greenwald M, Schoonover C, Vogel MW. Altered spatial learning, cortical plasticity and hippocampal anatomy in a neurodevelopmental model of schizophrenia-related endophenotypes. The European Journal of Neuroscience. 36: 2773-81. PMID 22762562 DOI: 10.1111/j.1460-9568.2012.08204.x  1
2012 Herrik KF, Redrobe JP, Holst D, Hougaard C, Sandager-Nielsen K, Nielsen AN, Ji H, Holst NM, Rasmussen HB, Nielsen EØ, Strøbæk D, Shepard PD, Christophersen P. CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Frontiers in Pharmacology. 3: 11. PMID 22347859 DOI: 10.3389/fphar.2012.00011  1
2010 Herrik KF, Christophersen P, Shepard PD. Pharmacological modulation of the gating properties of small conductance Ca2+-activated K+ channels alters the firing pattern of dopamine neurons in vivo. Journal of Neurophysiology. 104: 1726-35. PMID 20660424 DOI: 10.1152/jn.01126.2009  1
2010 Carpenter WT, Thaker GK, Shepard PD. Manuscript rejection for the schizophrenia bulletin: Some reasons Schizophrenia Bulletin. 36: 649-650. DOI: 10.1093/schbul/sbq056  1
2009 Canavier CC, Shepard PD. Chaotic versus stochastic dynamics: a critical look at the evidence for nonlinear sequence dependent structure in dopamine neurons. Journal of Neural Transmission. Supplementum. 121-8. PMID 20411772 DOI: 10.1007/978-3-211-92660-4-9  1
2009 Ji H, Hougaard C, Herrik KF, Strøbaek D, Christophersen P, Shepard PD. Tuning the excitability of midbrain dopamine neurons by modulating the Ca2+ sensitivity of SK channels. The European Journal of Neuroscience. 29: 1883-95. PMID 19473240 DOI: 10.1111/j.1460-9568.2009.06735.x  1
2008 Hikosaka O, Sesack SR, Lecourtier L, Shepard PD. Habenula: crossroad between the basal ganglia and the limbic system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11825-9. PMID 19005047 DOI: 10.1523/JNEUROSCI.3463-08.2008  1
2008 Shepard PD, Trudeau MC. Emerging roles for ether-á-go-go-related gene potassium channels in the brain. The Journal of Physiology. 586: 4785-6. PMID 18854431 DOI: 10.1113/jphysiol.2008.162669  1
2008 Shepard PD. Schizophrenia Bulletin and the revised NIH public access policy. Schizophrenia Bulletin. 34: 799-800. PMID 18644852 DOI: 10.1093/schbul/sbn086  1
2008 Hong LE, Buchanan RW, Thaker GK, Shepard PD, Summerfelt A. Beta (~16 Hz) frequency neural oscillations mediate auditory sensory gating in humans. Psychophysiology. 45: 197-204. PMID 17995907 DOI: 10.1111/j.1469-8986.2007.00624.x  1
2007 Shepard PD, Canavier CC, Levitan ES. Ether-a-go-go-related gene potassium channels: what's all the buzz about? Schizophrenia Bulletin. 33: 1263-9. PMID 17905786 DOI: 10.1093/schbul/sbm106  1
2007 Canavier CC, Oprisan SA, Callaway JC, Ji H, Shepard PD. Computational model predicts a role for ERG current in repolarizing plateau potentials in dopamine neurons: implications for modulation of neuronal activity. Journal of Neurophysiology. 98: 3006-22. PMID 17699694 DOI: 10.1152/jn.00422.2007  1
2007 Thaker G, Shepard P, Carpenter W. Editorial: The Wayne Fenton award and first awardee Schizophrenia Bulletin. 33: 1055. PMID 17636182 DOI: 10.1093/schbul/sbm086  1
2007 Ji H, Shepard PD. Lateral habenula stimulation inhibits rat midbrain dopamine neurons through a GABA(A) receptor-mediated mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6923-30. PMID 17596440 DOI: 10.1523/JNEUROSCI.0958-07.2007  1
2006 Shepard PD, Holcomb HH, Gold JM. Schizophrenia in translation: the presence of absence: habenular regulation of dopamine neurons and the encoding of negative outcomes. Schizophrenia Bulletin. 32: 417-21. PMID 16717257 DOI: 10.1093/schbul/sbj083  1
2006 Shepard PD. Editorial--modeling negative symptoms: what's missing? Schizophrenia Bulletin. 32: 403-4. PMID 16707774 DOI: 10.1093/schbul/sbj084  1
2006 Ji H, Shepard PD. SK Ca2+-activated K+ channel ligands alter the firing pattern of dopamine-containing neurons in vivo. Neuroscience. 140: 623-33. PMID 16564639 DOI: 10.1016/j.neuroscience.2006.02.020  1
2005 Koenig JI, Elmer GI, Shepard PD, Lee PR, Mayo C, Joy B, Hercher E, Brady DL. Prenatal exposure to a repeated variable stress paradigm elicits behavioral and neuroendocrinological changes in the adult offspring: potential relevance to schizophrenia. Behavioural Brain Research. 156: 251-61. PMID 15582111 DOI: 10.1016/j.bbr.2004.05.030  1
2004 Canavier CC, Perla SR, Shepard PD. Scaling of prediction error does not confirm chaotic dynamics underlying irregular firing using interspike intervals from midbrain dopamine neurons. Neuroscience. 129: 491-502. PMID 15501606 DOI: 10.1016/j.neuroscience.2004.08.003  1
2004 Sarpal D, Koenig JI, Adelman JP, Brady D, Prendeville LC, Shepard PD. Regional distribution of SK3 mRNA-containing neurons in the adult and adolescent rat ventral midbrain and their relationship to dopamine-containing cells. Synapse (New York, N.Y.). 53: 104-13. PMID 15170822 DOI: 10.1002/syn.20042  1
2004 Kiss C, Shepard PD, Bari F, Schwarcz R. Cortical spreading depression augments kynurenate levels and reduces malonate toxicity in the rat cortex. Brain Research. 1002: 129-35. PMID 14988042 DOI: 10.1016/j.brainres.2004.01.004  1
2004 Joy B, McMahon RP, Shepard PD. Effects of acute and chronic clozapine on D-amphetamine-induced disruption of auditory gating in the rat. Psychopharmacology. 174: 274-82. PMID 14726994 DOI: 10.1007/s00213-003-1731-4  1
2003 Shepard PD, Joy B, Clerkin L, Schwarcz R. Micromolar brain levels of kynurenic acid are associated with a disruption of auditory sensory gating in the rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1454-62. PMID 12700696 DOI: 10.1038/sj.npp.1300188  1
2001 Lovejoy LP, Shepard PD, Canavier CC. Apamin-induced irregular firing in vitro and irregular single-spike firing observed in vivo in dopamine neurons is chaotic. Neuroscience. 104: 829-40. PMID 11440813 DOI: 10.1016/S0306-4522(01)00121-X  1
2000 Carpenter WT, Breier A, Buchanan RW, Kirkpatrick B, Shepard P, Weiner E. Mazindol treatment of negative symptoms. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 23: 365-74. PMID 10989263 DOI: 10.1016/S0893-133X(00)00115-9  1
1999 Kitai ST, Shepard PD, Callaway JC, Scroggs R. Afferent modulation of dopamine neuron firing patterns. Current Opinion in Neurobiology. 9: 690-7. PMID 10607649 DOI: 10.1016/S0959-4388(99)00040-9  1
1999 Shepard PD, Connelly ST. Pertussis toxin lesions of the rat substantia nigra block the inhibitory effects of the gamma-hydroxybutyrate agent, S(-)HA-966 without affecting the basal firing properties of dopamine neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 21: 650-61. PMID 10516961 DOI: 10.1016/S0893-133X(99)00063-9  1
1999 Ping HX, Shepard PD. Blockade of SK-type Ca2+-activated K+ channels uncovers a Ca2+-dependent slow afterdepolarization in nigral dopamine neurons. Journal of Neurophysiology. 81: 977-84. PMID 10085326  1
1999 Shepard PD, Stump D. Nifedipine blocks apamin-induced bursting activity in nigral dopamine-containing neurons. Brain Research. 817: 104-9. PMID 9889338 DOI: 10.1016/S0006-8993(98)01231-1  1
1997 Connelly ST, Shepard PD. Competitive NMDA receptor antagonists differentially affect dopamine cell firing pattern. Synapse (New York, N.Y.). 25: 234-42. PMID 9068121 DOI: 10.1002/(SICI)1098-2396(199703)25:3<234::AID-SYN2>3.0.CO;2-C  1
1997 Grobaski KC, Ping H, daSilva HM, Bowery NG, Connelly ST, Shepard PD. Responses of rat substantia nigra dopamine-containing neurones to (-)-HA-966 in vitro. British Journal of Pharmacology. 120: 575-80. PMID 9051293 DOI: 10.1038/sj.bjp.0700938  1
1996 Ping HX, Shepard PD. Apamin-sensitive Ca(2+)-activated K+ channels regulate pacemaker activity in nigral dopamine neurons. Neuroreport. 7: 809-14. PMID 8733751  1
1995 Shepard PD, Connelly ST, Lehmann H, Grobaski KC. Effects of the enantiomers of (+/-)-HA-966 on dopamine neurons: an electrophysiological study of a chiral molecule. European Journal of Pharmacology. 285: 79-88. PMID 8846814 DOI: 10.1016/0014-2999(95)00390-7  1
1994 Shepard PD, Tamminga CA. Images in neuroscience. Human Brain receptors, VI. Ionotropic receptors. The American Journal of Psychiatry. 151: 956. PMID 8010380  1
1994 Shepard PD, Lehmann H, Connelly ST. Effects of NPC16377, a potent and selective sigma receptor ligand, on the activity of mesencephalic dopamine-containing neurons in the rat. European Journal of Pharmacology. 265: 141-9. PMID 7875229 DOI: 10.1016/0014-2999(94)90424-3  1
1994 Wu HQ, Schwarcz R, Shepard PD. Excitatory amino acid-induced excitation of dopamine-containing neurons in the rat substantia nigra: modulation by kynurenic acid. Synapse (New York, N.Y.). 16: 219-30. PMID 7515199 DOI: 10.1002/syn.890160307  1
1994 Shepard PD, Tamminga CA. Human brain receptors, VI: Ionotropic receptors American Journal of Psychiatry. 151: 956.  1
1992 Shepard PD, Lehmann H. (+-)-1-hydroxy-3-aminopyrrolidone-2 (HA-966) inhibits the activity of substantia nigra dopamine neurons through a non-N-methyl-D-aspartate receptor-mediated mechanism. The Journal of Pharmacology and Experimental Therapeutics. 261: 387-94. PMID 1578355  1
1992 McMillen BA, Williams HL, Lehmann H, Shepard PD. On central muscle relaxants, strychnine-insensitive glycine receptors and two old drugs: zoxazolamine and HA-966. Journal of Neural Transmission. General Section. 89: 11-25. PMID 1329854 DOI: 10.1007/BF01245348  1
1991 Shepard PD, Bunney BS. Repetitive firing properties of putative dopamine-containing neurons in vitro: regulation by an apamin-sensitive Ca(2+)-activated K+ conductance. Experimental Brain Research. 86: 141-50. PMID 1756785 DOI: 10.1007/BF00231048  1
1988 Shepard PD, German DC. Electrophysiological and pharmacological evidence for the existence of distinct subpopulations of nigrostriatal dopaminergic neuron in the rat. Neuroscience. 27: 537-46. PMID 3217003 DOI: 10.1016/0306-4522(88)90287-4  1
1988 Shepard PD, Bunney BS. Effects of apamin on the discharge properties of putative dopamine-containing neurons in vitro. Brain Research. 463: 380-4. PMID 3196925 DOI: 10.1016/0006-8993(88)90414-3  1
1988 Bean AJ, Shepard PD, Bunney BS, Nestler EJ, Roth RH. The effects of pertussis toxin on autoreceptor-mediated inhibition of dopamine synthesis in the rat striatum. Molecular Pharmacology. 34: 715-8. PMID 2974120  1
1988 Shepard PD, Mihailoff GA, German DC. Anatomical and electrophysiological characterization of presumed dopamine-containing neurons within the supramammillary region of the rat. Brain Research Bulletin. 20: 307-14. PMID 2896530 DOI: 10.1016/0361-9230(88)90060-3  1
1984 Shepard PD, German DC. A subpopulation of mesocortical dopamine neurons possesses autoreceptors. European Journal of Pharmacology. 98: 455-6. PMID 6723785 DOI: 10.1016/0014-2999(84)90300-5  1
1984 Matthews RT, McMillen BA, Speciale SG, Jarrah H, Shore PA, Sanghera MK, Shepard PD, German DC. Effects of zoxazolamine and related centrally acting muscle relaxants on nigrostriatal dopaminergic neurons. Brain Research Bulletin. 12: 479-86. PMID 6467036 DOI: 10.1016/0361-9230(84)90163-1  1
1983 McMillen BA, Matthews RT, Sanghera MK, Shepard PD, German DC. Dopamine receptor antagonism by the novel antianxiety drug, buspirone. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 3: 733-8. PMID 6131948  1
1982 Barker DJ, Shepard PD, McDermott KL. Fatigue in cat facial mechanoreceptors. Neuroscience Letters. 30: 117-22. PMID 6287362 DOI: 10.1016/0304-3940(82)90282-8  1
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