| Year |
Citation |
Score |
| 2024 |
Pocivavsek A, Schwarcz R, Erhardt S. Neuroactive Kynurenines as Pharmacological Targets: New Experimental Tools and Exciting Therapeutic Opportunities. Pharmacological Reviews. 76: 978-1008. PMID 39304346 DOI: 10.1124/pharmrev.124.000239 |
0.703 |
|
| 2024 |
Sathyasaikumar KV, Blanco-Ayala T, Zheng Y, Schwieler L, Erhardt S, Tufvesson-Alm M, Poeggeler B, Schwarcz R. The Tryptophan Metabolite Indole-3-Propionic Acid Raises Kynurenic Acid Levels in the Rat Brain In Vivo. International Journal of Tryptophan Research : Ijtr. 17: 11786469241262876. PMID 38911967 DOI: 10.1177/11786469241262876 |
0.376 |
|
| 2022 |
Sathyasaikumar KV, Pérez de la Cruz V, Pineda B, Vázquez Cervantes GI, Ramírez Ortega D, Donley DW, Severson PL, West BL, Giorgini F, Fox JH, Schwarcz R. Cellular Localization of Kynurenine 3-Monooxygenase in the Brain: Challenging the Dogma. Antioxidants (Basel, Switzerland). 11. PMID 35204197 DOI: 10.3390/antiox11020315 |
0.349 |
|
| 2021 |
Blanco Ayala TB, Ramírez Ortega DR, Ovalle Rodríguez PO, Pineda B, Pérez de la Cruz GP, González Esquivel DG, Schwarcz R, Sathyasaikumar KV, Jiménez Anguiano AJ, Pérez de la Cruz VP. Subchronic -acetylcysteine Treatment Decreases Brain Kynurenic Acid Levels and Improves Cognitive Performance in Mice. Antioxidants (Basel, Switzerland). 10. PMID 33498402 DOI: 10.3390/antiox10020147 |
0.37 |
|
| 2020 |
Coyle JT, Schwarcz R. The Discovery and Characterization of Targeted Perikaryal-Specific Brain Lesions With Excitotoxins. Frontiers in Neuroscience. 14: 927. PMID 33013307 DOI: 10.3389/fnins.2020.00927 |
0.477 |
|
| 2020 |
Blanco-Ayala T, Sathyasaikumar KV, Uys JD, Pérez-de-la-Cruz V, Pidugu LS, Schwarcz R. N-Acetylcysteine Inhibits Kynurenine Aminotransferase II. Neuroscience. 444: 160-169. PMID 32768617 DOI: 10.1016/J.Neuroscience.2020.07.049 |
0.446 |
|
| 2020 |
Klausing AD, Fukuwatari T, Bucci DJ, Schwarcz R. Stress-induced impairment in fear discrimination is causally related to increased kynurenic acid formation in the prefrontal cortex. Psychopharmacology. PMID 32215686 DOI: 10.1007/s00213-020-05507-x |
0.394 |
|
| 2020 |
Phenis D, Vunck SA, Valentini V, Arias H, Schwarcz R, Bruno JP. Activation of alpha7 nicotinic and NMDA receptors is necessary for performance in a working memory task. Psychopharmacology. PMID 32162104 DOI: 10.1007/s00213-020-05495-y |
0.385 |
|
| 2020 |
Beggiato S, Ieraci A, Tomasini MC, Schwarcz R, Ferraro L. Prenatal THC exposure raises kynurenic acid levels in the prefrontal cortex of adult rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 100: 109883. PMID 32032697 DOI: 10.1016/j.pnpbp.2020.109883 |
0.398 |
|
| 2019 |
Notarangelo FM, Beggiato S, Schwarcz R. Assessment of Prenatal Kynurenine Metabolism Using Tissue Slices: Focus on the Neosynthesis of Kynurenic Acid in Mice. Developmental Neuroscience. 1-10. PMID 31117076 DOI: 10.1159/000499736 |
0.421 |
|
| 2018 |
Beggiato S, Notarangelo FM, Sathyasaikumar KV, Giorgini F, Schwarcz R. Maternal genotype determines kynurenic acid levels in the fetal brain: Implications for the pathophysiology of schizophrenia. Journal of Psychopharmacology (Oxford, England). 269881118805492. PMID 30354938 DOI: 10.1177/0269881118805492 |
0.421 |
|
| 2018 |
Pocivavsek A, Elmer GI, Schwarcz R. Inhibition of Kynurenine Aminotransferase II Attenuates Hippocampus-dependent Memory Deficit in Adult Rats Treated Prenatally with Kynurenine. Hippocampus. PMID 30311334 DOI: 10.1002/hipo.23040 |
0.746 |
|
| 2018 |
Clark SM, Notarangelo FM, Li X, Chen S, Schwarcz R, Tonelli LH. Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 30267854 DOI: 10.1016/j.pnpbp.2018.09.011 |
0.346 |
|
| 2018 |
Secci ME, Mascia P, Sagheddu C, Beggiato S, Melis M, Borelli AC, Tomasini MC, Panlilio LV, Schindler CW, Tanda G, Ferré S, Bradberry CW, Ferraro L, Pistis M, Goldberg SR, ... Schwarcz R, et al. Astrocytic Mechanisms Involving Kynurenic Acid Control Δ-Tetrahydrocannabinol-Induced Increases in Glutamate Release in Brain Reward-Processing Areas. Molecular Neurobiology. PMID 30151725 DOI: 10.1007/s12035-018-1319-y |
0.451 |
|
| 2018 |
Notarangelo FM, Pocivavsek A, Schwarcz R. Exercise Your Kynurenines to Fight Depression. Trends in Neurosciences. 41: 491-493. PMID 30053952 DOI: 10.1016/j.tins.2018.05.010 |
0.662 |
|
| 2018 |
Tufvesson-Alm M, Schwieler L, Schwarcz R, Goiny M, Erhardt S, Engberg G. Importance of kynurenine 3-monooxygenase for spontaneous firing and pharmacological responses of midbrain dopamine neurons: relevance for schizophrenia. Neuropharmacology. PMID 29879409 DOI: 10.1016/j.neuropharm.2018.06.003 |
0.364 |
|
| 2018 |
Chiappelli J, Rowland LM, Notarangelo FM, Wijtenburg SA, Thomas MAR, Pocivavsek A, Jones A, Wisner K, Kochunov P, Schwarcz R, Hong LE. Salivary kynurenic acid response to psychological stress: inverse relationship to cortical glutamate in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29728648 DOI: 10.1038/S41386-018-0072-2 |
0.675 |
|
| 2018 |
Chiappelli J, Notarangelo FM, Pocivavsek A, Thomas MAR, Rowland LM, Schwarcz R, Hong LE. Influence of plasma cytokines on kynurenine and kynurenic acid in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29520060 DOI: 10.1038/S41386-018-0038-4 |
0.692 |
|
| 2018 |
Schwarcz R. 178. Dysfunction of Kynurenic Acid in Major Psychiatric Diseases: Causes, Effects and Therapeutic Opportunities Biological Psychiatry. 83: S72. DOI: 10.1016/j.biopsych.2018.02.197 |
0.355 |
|
| 2017 |
Hahn B, Reneski CH, Pocivavsek A, Schwarcz R. Prenatal kynurenine treatment in rats causes schizophrenia-like broad monitoring deficits in adulthood. Psychopharmacology. PMID 29128872 DOI: 10.1007/S00213-017-4780-9 |
0.714 |
|
| 2017 |
Song C, Clark SM, Vaughn CN, Nicholson JD, Murphy KJ, Mou TM, Schwarcz R, Hoffman GE, Tonelli LH. Quantitative analysis of kynurenine aminotransferase II in the adult rat brain reveals high expression in proliferative zones and corpus callosum. Neuroscience. PMID 29126954 DOI: 10.1016/j.neuroscience.2017.11.001 |
0.458 |
|
| 2017 |
Goeden N, Notarangelo FM, Pocivavsek A, Beggiato S, Bonnin A, Schwarcz R. Prenatal Dynamics of Kynurenine Pathway Metabolism in Mice: Focus on Kynurenic Acid. Developmental Neuroscience. PMID 29080891 DOI: 10.1159/000481168 |
0.702 |
|
| 2017 |
Sathyasaikumar KV, Tararina M, Wu HQ, Neale SA, Weisz F, Salt TE, Schwarcz R. Xanthurenic Acid Formation from 3-Hydroxykynurenine in the Mammalian Brain: Neurochemical Characterization and Physiological Effects. Neuroscience. PMID 29031603 DOI: 10.1016/J.Neuroscience.2017.10.006 |
0.504 |
|
| 2017 |
Flores-Barrera E, Thomases DR, Cass DK, Bhandari A, Schwarcz R, Bruno JP, Tseng KY. Preferential Disruption of prefrontal GABAergic function by nanomolar concentrations of the α7nACh negative modulator kynurenic acid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28729445 DOI: 10.1523/Jneurosci.0932-17.2017 |
0.378 |
|
| 2017 |
Yaksh TL, Schwarcz R, Snodgrass HR. Characterization of the effects of L-4-chlorokynurenine on nociception in rodents. The Journal of Pain : Official Journal of the American Pain Society. PMID 28428091 DOI: 10.1016/j.jpain.2017.03.014 |
0.383 |
|
| 2017 |
Bortz DM, Wu HQ, Schwarcz R, Bruno JP. Oral administration of a specific kynurenic acid synthesis (KAT II) inhibitor attenuates evoked glutamate release in rat prefrontal cortex. Neuropharmacology. PMID 28419874 DOI: 10.1016/J.Neuropharm.2017.04.023 |
0.416 |
|
| 2017 |
Notarangelo FM, Schwarcz R. Restraint Stress during Pregnancy Rapidly Raises Kynurenic Acid Levels in Mouse Placenta and Fetal Brain. Developmental Neuroscience. PMID 28214871 DOI: 10.1159/000455228 |
0.388 |
|
| 2017 |
Secci ME, Auber A, Panlilio LV, Redhi GH, Thorndike EB, Schindler CW, Schwarcz R, Goldberg SR, Justinova Z. Attenuating Nicotine Reinforcement and Relapse by Enhancing Endogenous Brain Levels of Kynurenic Acid in Rats and Squirrel Monkeys. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28139681 DOI: 10.1038/npp.2017.21 |
0.352 |
|
| 2016 |
Erhardt S, Pocivavsek A, Repici M, Liu XC, Imbeault S, Maddison DC, Thomas MA, Smalley JL, Larsson MK, Muchowski PJ, Giorgini F, Schwarcz R. Adaptive and Behavioral Changes in Kynurenine 3-Monooxygenase Knockout Mice: Relevance to Psychotic Disorders. Biological Psychiatry. PMID 28187857 DOI: 10.1016/J.Biopsych.2016.12.011 |
0.712 |
|
| 2016 |
Pershing ML, Phenis D, Valentini V, Pocivavsek A, Lindquist DH, Schwarcz R, Bruno JP. Prenatal kynurenine exposure in rats: age-dependent changes in NMDA receptor expression and conditioned fear responding. Psychopharmacology. PMID 27527585 DOI: 10.1007/s00213-016-4404-9 |
0.725 |
|
| 2016 |
Schwarcz R, Stone TW. The kynurenine pathway and the brain: Challenges, controversies and promises. Neuropharmacology. PMID 27511838 DOI: 10.1016/j.neuropharm.2016.08.003 |
0.383 |
|
| 2016 |
Larkin PB, Sathyasaikumar KV, Notarangelo FM, Funakoshi H, Nakamura T, Schwarcz R, Muchowski PJ. Tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase 1 make separate, tissue-specific contributions to basal and inflammation-induced kynurenine pathway metabolism in mice. Biochimica Et Biophysica Acta. PMID 27392942 DOI: 10.1016/J.Bbagen.2016.07.002 |
0.396 |
|
| 2016 |
Schwarcz R. Kynurenines and Glutamate: Multiple Links and Therapeutic Implications. Advances in Pharmacology (San Diego, Calif.). 76: 13-37. PMID 27288072 DOI: 10.1016/bs.apha.2016.01.005 |
0.444 |
|
| 2016 |
Breda C, Sathyasaikumar KV, Sograte Idrissi S, Notarangelo FM, Estranero JG, Moore GG, Green EW, Kyriacou CP, Schwarcz R, Giorgini F. Tryptophan-2,3-dioxygenase (TDO) inhibition ameliorates neurodegeneration by modulation of kynurenine pathway metabolites. Proceedings of the National Academy of Sciences of the United States of America. PMID 27114543 DOI: 10.1136/Jnnp-2016-314597.273 |
0.373 |
|
| 2016 |
Clark SM, Pocivavsek A, Nicholson JD, Notarangelo FM, Langenberg P, McMahon RP, Kleinman JE, Hyde TM, Stiller J, Postolache TT, Schwarcz R, Tonelli LH. Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals. Journal of Psychiatry & Neuroscience : Jpn. 41: 150226. PMID 27070351 DOI: 10.1503/Jpn.150226 |
0.689 |
|
| 2016 |
Pocivavsek A, Notarangelo FM, Wu H, Bruno JP, Schwarcz R. Chapter 25 – Astrocytes as Pharmacological Targets in the Treatment of Schizophrenia: Focus on Kynurenic Acid Handbook of Behavioral Neuroscience. 23: 423-443. DOI: 10.1016/B978-0-12-800981-9.00025-0 |
0.74 |
|
| 2015 |
Notarangelo FM, Wang XD, Horning KJ, Schwarcz R. Role of D-amino acid oxidase in the production of kynurenine pathway metabolites from D-tryptophan in mice. Journal of Neurochemistry. PMID 26661897 DOI: 10.1111/jnc.13455 |
0.347 |
|
| 2015 |
Zanos P, Piantadosi SC, Wu HQ, Pribut HJ, Dell MJ, Can A, Snodgrass HR, Zarate CA, Schwarcz R, Gould TD. The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/GlycineB-Site Inhibition. The Journal of Pharmacology and Experimental Therapeutics. 355: 76-85. PMID 26265321 DOI: 10.1124/Jpet.115.225664 |
0.371 |
|
| 2015 |
Blanco Ayala T, Lugo Huitrón R, Carmona Aparicio L, Ramírez Ortega D, González Esquivel D, Pedraza Chaverrí J, Pérez de la Cruz G, Ríos C, Schwarcz R, Pérez de la Cruz V. Alternative kynurenic acid synthesis routes studied in the rat cerebellum. Frontiers in Cellular Neuroscience. 9: 178. PMID 26041992 DOI: 10.3389/fncel.2015.00178 |
0.405 |
|
| 2015 |
Drewes JL, Meulendyke KA, Liao Z, Witwer KW, Gama L, Ubaida-Mohien C, Li M, Notarangelo FM, Tarwater PM, Schwarcz R, Graham DR, Zink MC. Quinolinic acid/tryptophan ratios predict neurological disease in SIV-infected macaques and remain elevated in the brain under cART. Journal of Neurovirology. PMID 25776527 DOI: 10.1007/S13365-015-0334-2 |
0.415 |
|
| 2015 |
Pershing ML, Bortz DM, Pocivavsek A, Fredericks PJ, Jørgensen CV, Vunck SA, Leuner B, Schwarcz R, Bruno JP. Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia. Neuropharmacology. 90: 33-41. PMID 25446576 DOI: 10.1016/J.Neuropharm.2014.10.017 |
0.698 |
|
| 2014 |
Chiappelli J, Pocivavsek A, Nugent KL, Notarangelo FM, Kochunov P, Rowland LM, Schwarcz R, Hong LE. Stress-induced increase in kynurenic acid as a potential biomarker for patients with schizophrenia and distress intolerance. Jama Psychiatry. 71: 761-8. PMID 24806441 DOI: 10.1001/Jamapsychiatry.2014.243 |
0.66 |
|
| 2014 |
Beggiato S, Tanganelli S, Fuxe K, Antonelli T, Schwarcz R, Ferraro L. Endogenous kynurenic acid regulates extracellular GABA levels in the rat prefrontal cortex. Neuropharmacology. 82: 11-8. PMID 24607890 DOI: 10.1016/j.neuropharm.2014.02.019 |
0.447 |
|
| 2014 |
Pocivavsek A, Thomas MA, Elmer GI, Bruno JP, Schwarcz R. Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats. Psychopharmacology. 231: 2799-809. PMID 24590052 DOI: 10.1007/s00213-014-3452-2 |
0.693 |
|
| 2014 |
Wu HQ, Okuyama M, Kajii Y, Pocivavsek A, Bruno JP, Schwarcz R. Targeting kynurenine aminotransferase II in psychiatric diseases: promising effects of an orally active enzyme inhibitor. Schizophrenia Bulletin. 40: S152-8. PMID 24562494 DOI: 10.1093/schbul/sbt157 |
0.749 |
|
| 2014 |
Notarangelo FM, Wilson EH, Horning KJ, Thomas MA, Harris TH, Fang Q, Hunter CA, Schwarcz R. Evaluation of kynurenine pathway metabolism in Toxoplasma gondii-infected mice: implications for schizophrenia. Schizophrenia Research. 152: 261-7. PMID 24345671 DOI: 10.1016/J.Schres.2013.11.011 |
0.394 |
|
| 2013 |
Vallerini GP, Amori L, Beato C, Tararina M, Wang XD, Schwarcz R, Costantino G. 2-Aminonicotinic acid 1-oxides are chemically stable inhibitors of quinolinic acid synthesis in the mammalian brain: a step toward new antiexcitotoxic agents. Journal of Medicinal Chemistry. 56: 9482-95. PMID 24274468 DOI: 10.1021/jm401249c |
0.45 |
|
| 2013 |
Giorgini F, Huang SY, Sathyasaikumar KV, Notarangelo FM, Thomas MA, Tararina M, Wu HQ, Schwarcz R, Muchowski PJ. Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain. The Journal of Biological Chemistry. 288: 36554-66. PMID 24189070 DOI: 10.1074/Jbc.M113.503813 |
0.431 |
|
| 2013 |
Justinova Z, Mascia P, Wu HQ, Secci ME, Redhi GH, Panlilio LV, Scherma M, Barnes C, Parashos A, Zara T, Fratta W, Solinas M, Pistis M, Bergman J, Kangas BD, ... ... Schwarcz R, et al. Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid. Nature Neuroscience. 16: 1652-61. PMID 24121737 DOI: 10.1038/Nn.3540 |
0.424 |
|
| 2013 |
Beggiato S, Antonelli T, Tomasini MC, Tanganelli S, Fuxe K, Schwarcz R, Ferraro L. Kynurenic acid, by targeting α7 nicotinic acetylcholine receptors, modulates extracellular GABA levels in the rat striatum in vivo. The European Journal of Neuroscience. 37: 1470-7. PMID 23442092 DOI: 10.1111/ejn.12160 |
0.38 |
|
| 2013 |
Alexander KS, Pocivavsek A, Wu HQ, Pershing ML, Schwarcz R, Bruno JP. Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine. Neuroscience. 238: 19-28. PMID 23395862 DOI: 10.1016/j.neuroscience.2013.01.063 |
0.712 |
|
| 2013 |
Albuquerque EX, Schwarcz R. Kynurenic acid as an antagonist of α7 nicotinic acetylcholine receptors in the brain: facts and challenges. Biochemical Pharmacology. 85: 1027-32. PMID 23270993 DOI: 10.1016/j.bcp.2012.12.014 |
0.393 |
|
| 2012 |
Schwarcz R, Bruno JP, Muchowski PJ, Wu HQ. Kynurenines in the mammalian brain: when physiology meets pathology. Nature Reviews. Neuroscience. 13: 465-77. PMID 22678511 DOI: 10.1038/Nrn3257 |
0.432 |
|
| 2012 |
Green EW, Campesan S, Breda C, Sathyasaikumar KV, Muchowski PJ, Schwarcz R, Kyriacou CP, Giorgini F. Drosophila eye color mutants as therapeutic tools for Huntington disease. Fly. 6: 117-20. PMID 22634544 DOI: 10.4161/Fly.19999 |
0.408 |
|
| 2012 |
Pocivavsek A, Wu HQ, Elmer GI, Bruno JP, Schwarcz R. Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood. The European Journal of Neuroscience. 35: 1605-12. PMID 22515201 DOI: 10.1111/j.1460-9568.2012.08064.x |
0.736 |
|
| 2012 |
Wang XD, Notarangelo FM, Wang JZ, Schwarcz R. Kynurenic acid and 3-hydroxykynurenine production from D-kynurenine in mice. Brain Research. 1455: 1-9. PMID 22498176 DOI: 10.1016/j.brainres.2012.03.026 |
0.364 |
|
| 2012 |
Notarangelo FM, Wu HQ, Macherone A, Graham DR, Schwarcz R. Gas chromatography/tandem mass spectrometry detection of extracellular kynurenine and related metabolites in normal and lesioned rat brain. Analytical Biochemistry. 421: 573-81. PMID 22239963 DOI: 10.1016/j.ab.2011.12.032 |
0.413 |
|
| 2012 |
Pérez-de la Cruz V, Amori L, Sathyasaikumar KV, Wang XD, Notarangelo FM, Wu HQ, Schwarcz R. Enzymatic transamination of D-kynurenine generates kynurenic acid in rat and human brain. Journal of Neurochemistry. 120: 1026-35. PMID 22224417 DOI: 10.1111/j.1471-4159.2012.07653.x |
0.472 |
|
| 2012 |
Alexander KS, Wu HQ, Schwarcz R, Bruno JP. Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine. Psychopharmacology. 220: 627-37. PMID 22038535 DOI: 10.1007/s00213-011-2539-2 |
0.479 |
|
| 2012 |
Stachowski EK, Schwarcz R. Regulation of quinolinic acid neosynthesis in mouse, rat and human brain by iron and iron chelators in vitro. Journal of Neural Transmission (Vienna, Austria : 1996). 119: 123-31. PMID 21833493 DOI: 10.1007/s00702-011-0694-6 |
0.337 |
|
| 2011 |
Pocivavsek A, Wu HQ, Potter MC, Elmer GI, Pellicciari R, Schwarcz R. Fluctuations in endogenous kynurenic acid control hippocampal glutamate and memory. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2357-67. PMID 21796108 DOI: 10.1038/Npp.2011.127 |
0.725 |
|
| 2011 |
Wonodi I, Stine OC, Sathyasaikumar KV, Roberts RC, Mitchell BD, Hong LE, Kajii Y, Thaker GK, Schwarcz R. Downregulated kynurenine 3-monooxygenase gene expression and enzyme activity in schizophrenia and genetic association with schizophrenia endophenotypes. Archives of General Psychiatry. 68: 665-74. PMID 21727251 DOI: 10.1001/Archgenpsychiatry.2011.71 |
0.539 |
|
| 2011 |
Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, ... ... Schwarcz R, et al. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell. 145: 863-74. PMID 21640374 DOI: 10.1016/J.Cell.2011.05.020 |
0.415 |
|
| 2011 |
Campesan S, Green EW, Breda C, Sathyasaikumar KV, Muchowski PJ, Schwarcz R, Kyriacou CP, Giorgini F. The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease. Current Biology : Cb. 21: 961-6. PMID 21636279 DOI: 10.1016/J.Cub.2011.04.028 |
0.349 |
|
| 2011 |
Alkondon M, Pereira EF, Eisenberg HM, Kajii Y, Schwarcz R, Albuquerque EX. Age dependency of inhibition of alpha7 nicotinic receptors and tonically active N-methyl-D-aspartate receptors by endogenously produced kynurenic acid in the brain. The Journal of Pharmacology and Experimental Therapeutics. 337: 572-82. PMID 21270133 DOI: 10.1124/jpet.110.177386 |
0.454 |
|
| 2011 |
Sathyasaikumar KV, Stachowski EK, Wonodi I, Roberts RC, Rassoulpour A, McMahon RP, Schwarcz R. Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia. Schizophrenia Bulletin. 37: 1147-56. PMID 21036897 DOI: 10.1093/Schbul/Sbq112 |
0.625 |
|
| 2010 |
Thevandavakkam MA, Schwarcz R, Muchowski PJ, Giorgini F. Targeting kynurenine 3-monooxygenase (KMO): implications for therapy in Huntington's disease. Cns & Neurological Disorders Drug Targets. 9: 791-800. PMID 20942784 DOI: 10.2174/187152710793237430 |
0.386 |
|
| 2010 |
Rossi F, Valentina C, Garavaglia S, Sathyasaikumar KV, Schwarcz R, Kojima S, Okuwaki K, Ono S, Kajii Y, Rizzi M. Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement. Journal of Medicinal Chemistry. 53: 5684-9. PMID 20684605 DOI: 10.1021/jm100464k |
0.404 |
|
| 2010 |
Konradsson-Geuken A, Wu HQ, Gash CR, Alexander KS, Campbell A, Sozeri Y, Pellicciari R, Schwarcz R, Bruno JP. Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry. Neuroscience. 169: 1848-59. PMID 20600676 DOI: 10.1016/J.Neuroscience.2010.05.052 |
0.42 |
|
| 2010 |
Potter MC, Elmer GI, Bergeron R, Albuquerque EX, Guidetti P, Wu HQ, Schwarcz R. Reduction of endogenous kynurenic acid formation enhances extracellular glutamate, hippocampal plasticity, and cognitive behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1734-42. PMID 20336058 DOI: 10.1038/npp.2010.39 |
0.463 |
|
| 2010 |
Sathyasaikumar KV, Stachowski EK, Amori L, Guidetti P, Muchowski PJ, Schwarcz R. Dysfunctional kynurenine pathway metabolism in the R6/2 mouse model of Huntington's disease. Journal of Neurochemistry. 113: 1416-25. PMID 20236387 DOI: 10.1111/J.1471-4159.2010.06675.X |
0.405 |
|
| 2010 |
Wonodi I, Schwarcz R. Cortical kynurenine pathway metabolism: a novel target for cognitive enhancement in Schizophrenia. Schizophrenia Bulletin. 36: 211-8. PMID 20147364 DOI: 10.1093/schbul/sbq002 |
0.434 |
|
| 2010 |
Wu HQ, Pereira EF, Bruno JP, Pellicciari R, Albuquerque EX, Schwarcz R. The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex. Journal of Molecular Neuroscience : Mn. 40: 204-10. PMID 19690987 DOI: 10.1007/S12031-009-9235-2 |
0.442 |
|
| 2010 |
Schwarcz R, Guidetti P, Sathyasaikumar KV, Muchowski PJ. Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease. Progress in Neurobiology. 90: 230-45. PMID 19394403 DOI: 10.1016/J.Pneurobio.2009.04.005 |
0.409 |
|
| 2010 |
Campesan S, Green EW, Sathyasaikumar KV, Breda C, Muchowski PJ, Schwarcz R, Kyriacou CP, Giorgini F. B06 Validation of KMO as a candidate therapeutic target for Huntington's disease in Drosophila melanogaster Journal of Neurology, Neurosurgery & Psychiatry. 81: A12.3-A13. DOI: 10.1136/Jnnp.2010.222596.6 |
0.356 |
|
| 2009 |
Köhler C, Schwarcz R, Fuxe K. Perforant path transections protect hippocampal granule cells from kainate lesion. Neuroscience Letters. 10: 241-6. PMID 19605287 DOI: 10.1016/0304-3940(78)90233-1 |
0.377 |
|
| 2009 |
Amori L, Guidetti P, Pellicciari R, Kajii Y, Schwarcz R. On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. Journal of Neurochemistry. 109: 316-25. PMID 19226371 DOI: 10.1111/J.1471-4159.2009.05893.X |
0.442 |
|
| 2009 |
Zmarowski A, Wu HQ, Brooks JM, Potter MC, Pellicciari R, Schwarcz R, Bruno JP. Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release. The European Journal of Neuroscience. 29: 529-38. PMID 19187269 DOI: 10.1111/J.1460-9568.2008.06594.X |
0.405 |
|
| 2009 |
Amori L, Wu HQ, Marinozzi M, Pellicciari R, Guidetti P, Schwarcz R. Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum. Neuroscience. 159: 196-203. PMID 19138730 DOI: 10.1016/J.Neuroscience.2008.11.055 |
0.44 |
|
| 2008 |
Rossi F, Schwarcz R, Rizzi M. Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis. Current Opinion in Structural Biology. 18: 748-55. PMID 18950711 DOI: 10.1016/j.sbi.2008.09.009 |
0.418 |
|
| 2008 |
Lehrmann E, Guidetti P, Löve A, Williamson J, Bertram EH, Schwarcz R. Glial activation precedes seizures and hippocampal neurodegeneration in measles virus-infected mice. Epilepsia. 49: 13-23. PMID 18226168 DOI: 10.1111/j.1528-1167.2008.01489.x |
0.338 |
|
| 2008 |
Giorgini F, Möller T, Kwan W, Zwilling D, Wacker JL, Hong S, Tsai LC, Cheah CS, Schwarcz R, Guidetti P, Muchowski PJ. Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment. The Journal of Biological Chemistry. 283: 7390-400. PMID 18079112 DOI: 10.1074/Jbc.M708192200 |
0.326 |
|
| 2008 |
Grégoire L, Rassoulpour A, Guidetti P, Samadi P, Bédard PJ, Izzo E, Schwarcz R, Di Paolo T. Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys. Behavioural Brain Research. 186: 161-7. PMID 17868931 DOI: 10.1016/j.bbr.2007.08.007 |
0.383 |
|
| 2007 |
Poeggeler B, Rassoulpour A, Wu HQ, Guidetti P, Roberts RC, Schwarcz R. Dopamine receptor activation reveals a novel, kynurenate-sensitive component of striatal N-methyl-D-aspartate neurotoxicity. Neuroscience. 148: 188-97. PMID 17629627 DOI: 10.1016/J.Neuroscience.2007.05.033 |
0.58 |
|
| 2007 |
Lopes C, Pereira EF, Wu HQ, Purushottamachar P, Njar V, Schwarcz R, Albuquerque EX. Competitive antagonism between the nicotinic allosteric potentiating ligand galantamine and kynurenic acid at alpha7* nicotinic receptors. The Journal of Pharmacology and Experimental Therapeutics. 322: 48-58. PMID 17446300 DOI: 10.1124/Jpet.107.123109 |
0.353 |
|
| 2007 |
Guidetti P, Amori L, Sapko MT, Okuno E, Schwarcz R. Mitochondrial aspartate aminotransferase: a third kynurenate-producing enzyme in the mammalian brain. Journal of Neurochemistry. 102: 103-11. PMID 17442055 DOI: 10.1111/J.1471-4159.2007.04556.X |
0.809 |
|
| 2007 |
Schwarcz R, Hunter CA. Toxoplasma gondii and schizophrenia: linkage through astrocyte-derived kynurenic acid? Schizophrenia Bulletin. 33: 652-3. PMID 17434932 DOI: 10.1093/Schbul/Sbm030 |
0.441 |
|
| 2007 |
Ceresoli-Borroni G, Guidetti P, Amori L, Pellicciari R, Schwarcz R. Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications. Journal of Neuroscience Research. 85: 845-54. PMID 17279543 DOI: 10.1002/Jnr.21183 |
0.473 |
|
| 2007 |
Alkondon M, Pereira EF, Potter MC, Kauffman FC, Schwarcz R, Albuquerque EX. Strain-specific nicotinic modulation of glutamatergic transmission in the CA1 field of the rat hippocampus: August Copenhagen Irish versus Sprague-Dawley. Journal of Neurophysiology. 97: 1163-70. PMID 17151218 DOI: 10.1152/Jn.01119.2006 |
0.373 |
|
| 2007 |
Guidetti P, Hoffman GE, Melendez-Ferro M, Albuquerque EX, Schwarcz R. Astrocytic localization of kynurenine aminotransferase II in the rat brain visualized by immunocytochemistry. Glia. 55: 78-92. PMID 17024659 DOI: 10.1002/Glia.20432 |
0.786 |
|
| 2007 |
Wu HQ, Rassoulpour A, Schwarcz R. Kynurenic acid leads, dopamine follows: a new case of volume transmission in the brain? Journal of Neural Transmission (Vienna, Austria : 1996). 114: 33-41. PMID 16932989 DOI: 10.1007/s00702-006-0562-y |
0.443 |
|
| 2006 |
Guidetti P, Bates GP, Graham RK, Hayden MR, Leavitt BR, MacDonald ME, Slow EJ, Wheeler VC, Woodman B, Schwarcz R. Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice. Neurobiology of Disease. 23: 190-7. PMID 16697652 DOI: 10.1016/J.Nbd.2006.02.011 |
0.392 |
|
| 2006 |
Ceresoli-Borroni G, Rassoulpour A, Wu HQ, Guidetti P, Schwarcz R. Chronic neuroleptic treatment reduces endogenous kynurenic acid levels in rat brain. Journal of Neural Transmission (Vienna, Austria : 1996). 113: 1355-65. PMID 16465454 DOI: 10.1007/s00702-005-0432-z |
0.487 |
|
| 2006 |
Bari F, Nagy K, Guidetti P, Schwarcz R, Busija DW, Domoki F. Kynurenic acid attenuates NMDA-induced pial arteriolar dilation in newborn pigs. Brain Research. 1069: 39-46. PMID 16388784 DOI: 10.1016/J.Brainres.2005.11.033 |
0.395 |
|
| 2006 |
Sapko MT, Guidetti P, Yu P, Tagle DA, Pellicciari R, Schwarcz R. Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease. Experimental Neurology. 197: 31-40. PMID 16099455 DOI: 10.1016/J.Expneurol.2005.07.004 |
0.816 |
|
| 2005 |
Zhang DX, Williamson JM, Wu HQ, Schwarcz R, Bertram EH. In situ-produced 7-chlorokynurenate has different effects on evoked responses in rats with limbic epilepsy in comparison to naive controls. Epilepsia. 46: 1708-15. PMID 16302850 DOI: 10.1111/j.1528-1167.2005.00281.x |
0.392 |
|
| 2005 |
Wu HQ, Rassoulpour A, Goodman JH, Scharfman HE, Bertram EH, Schwarcz R. Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats. Epilepsia. 46: 1010-6. PMID 16026552 DOI: 10.1111/j.1528-1167.2005.67404.x |
0.451 |
|
| 2005 |
Samadi P, Grégoire L, Rassoulpour A, Guidetti P, Izzo E, Schwarcz R, Bédard PJ. Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in Parkinsonian monkeys. Movement Disorders : Official Journal of the Movement Disorder Society. 20: 792-802. PMID 15954116 DOI: 10.1002/mds.20596 |
0.389 |
|
| 2005 |
Rassoulpour A, Wu HQ, Ferre S, Schwarcz R. Nanomolar concentrations of kynurenic acid reduce extracellular dopamine levels in the striatum. Journal of Neurochemistry. 93: 762-5. PMID 15836634 DOI: 10.1111/j.1471-4159.2005.03134.x |
0.443 |
|
| 2005 |
Rassoulpour A, Wu HQ, Albuquerque EX, Schwarcz R. Prolonged nicotine administration results in biphasic, brain-specific changes in kynurenate levels in the rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 697-704. PMID 15496939 DOI: 10.1038/sj.npp.1300583 |
0.402 |
|
| 2004 |
Guidetti P, Luthi-Carter RE, Augood SJ, Schwarcz R. Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease. Neurobiology of Disease. 17: 455-61. PMID 15571981 DOI: 10.1016/j.nbd.2004.07.006 |
0.428 |
|
| 2004 |
Yu P, Di Prospero NA, Sapko MT, Cai T, Chen A, Melendez-Ferro M, Du F, Whetsell WO, Guidetti P, Schwarcz R, Tagle DA. Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice. Molecular and Cellular Biology. 24: 6919-30. PMID 15282294 DOI: 10.1128/Mcb.24.16.6919-6930.2004 |
0.785 |
|
| 2004 |
Wu HQ, Fuxe K, Schwarcz R. Neuronal A1 receptors mediate increase in extracellular kynurenic acid after local intrastriatal adenosine infusion. Journal of Neurochemistry. 90: 621-8. PMID 15255939 DOI: 10.1111/j.1471-4159.2004.02531.x |
0.366 |
|
| 2004 |
Alkondon M, Pereira EF, Yu P, Arruda EZ, Almeida LE, Guidetti P, Fawcett WP, Sapko MT, Randall WR, Schwarcz R, Tagle DA, Albuquerque EX. Targeted deletion of the kynurenine aminotransferase ii gene reveals a critical role of endogenous kynurenic acid in the regulation of synaptic transmission via alpha7 nicotinic receptors in the hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4635-48. PMID 15140935 DOI: 10.1523/Jneurosci.5631-03.2004 |
0.797 |
|
| 2004 |
Schwarcz R. The kynurenine pathway of tryptophan degradation as a drug target. Current Opinion in Pharmacology. 4: 12-7. PMID 15018833 DOI: 10.1016/j.coph.2003.10.006 |
0.344 |
|
| 2004 |
Kiss C, Shepard PD, Bari F, Schwarcz R. Cortical spreading depression augments kynurenate levels and reduces malonate toxicity in the rat cortex. Brain Research. 1002: 129-35. PMID 14988042 DOI: 10.1016/J.Brainres.2004.01.004 |
0.406 |
|
| 2003 |
Guidetti P, Schwarcz R. 3-Hydroxykynurenine and quinolinate: pathogenic synergism in early grade Huntington's disease? Advances in Experimental Medicine and Biology. 527: 137-45. PMID 15206726 DOI: 10.1007/978-1-4615-0135-0_16 |
0.415 |
|
| 2003 |
Guidetti P, Schwarcz R. Determination of alpha-aminoadipic acid in brain, peripheral tissues, and body fluids using GC/MS with negative chemical ionization. Brain Research. Molecular Brain Research. 118: 132-9. PMID 14559362 DOI: 10.1016/j.molbrainres.2003.08.004 |
0.448 |
|
| 2003 |
Shepard PD, Joy B, Clerkin L, Schwarcz R. Micromolar brain levels of kynurenic acid are associated with a disruption of auditory sensory gating in the rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1454-62. PMID 12700696 DOI: 10.1038/Sj.Npp.1300188 |
0.429 |
|
| 2003 |
Kiss C, Ceresoli-Borroni G, Guidetti P, Zielke CL, Zielke HR, Schwarcz R. Kynurenate production by cultured human astrocytes. Journal of Neural Transmission (Vienna, Austria : 1996). 110: 1-14. PMID 12541009 DOI: 10.1007/s00702-002-0770-z |
0.413 |
|
| 2002 |
Wu HQ, Lee SC, Scharfman HE, Schwarcz R. L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat. Experimental Neurology. 177: 222-32. PMID 12429224 DOI: 10.1006/exnr.2002.7971 |
0.413 |
|
| 2002 |
Schwarcz R, Pellicciari R. Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities. The Journal of Pharmacology and Experimental Therapeutics. 303: 1-10. PMID 12235226 DOI: 10.1124/Jpet.102.034439 |
0.509 |
|
| 2002 |
Schwarcz R, Witter MP. Memory impairment in temporal lobe epilepsy: the role of entorhinal lesions. Epilepsy Research. 50: 161-77. PMID 12151126 DOI: 10.1016/S0920-1211(02)00077-3 |
0.33 |
|
| 2002 |
Wu HQ, Rassoulpour A, Schwarcz R. Effect of systemic L-DOPA administration on extracellular kynurenate levels in the rat striatum. Journal of Neural Transmission (Vienna, Austria : 1996). 109: 239-49. PMID 11956948 DOI: 10.1007/s007020200020 |
0.403 |
|
| 2001 |
Lehrmann E, Molinari A, Speciale C, Schwarcz R. Immunohistochemical visualization of newly formed quinolinate in the normal and excitotoxically lesioned rat striatum. Experimental Brain Research. 141: 389-97. PMID 11715084 DOI: 10.1007/s002210100887 |
0.377 |
|
| 2001 |
Denslow MJ, Eid T, Du F, Schwarcz R, Lothman EW, Steward O. Disruption of inhibition in area CA1 of the hippocampus in a rat model of temporal lobe epilepsy. Journal of Neurophysiology. 86: 2231-45. PMID 11698514 DOI: 10.1152/Jn.2001.86.5.2231 |
0.305 |
|
| 2001 |
Schwarcz R, Rassoulpour A, Wu HQ, Medoff D, Tamminga CA, Roberts RC. Increased cortical kynurenate content in schizophrenia. Biological Psychiatry. 50: 521-30. PMID 11600105 DOI: 10.1016/S0006-3223(01)01078-2 |
0.622 |
|
| 2001 |
Eid T, Du F, Schwarcz R. Ibotenate injections into the pre- and parasubiculum provide partial protection against kainate-induced epileptic damage in layer III of rat entorhinal cortex. Epilepsia. 42: 817-24. PMID 11488878 DOI: 10.1046/j.1528-1157.2001.042007817.x |
0.311 |
|
| 2001 |
Ceresoli-Borroni G, Schwarcz R. Neonatal asphyxia in rats: acute effects on cerebral kynurenine metabolism. Pediatric Research. 50: 231-5. PMID 11477208 DOI: 10.1203/00006450-200108000-00011 |
0.485 |
|
| 2001 |
Guidetti P, Charles V, Chen EY, Reddy PH, Kordower JH, Whetsell WO, Schwarcz R, Tagle DA. Early degenerative changes in transgenic mice expressing mutant huntingtin involve dendritic abnormalities but no impairment of mitochondrial energy production. Experimental Neurology. 169: 340-50. PMID 11358447 DOI: 10.1006/Exnr.2000.7626 |
0.319 |
|
| 2001 |
Lee SC, Schwarcz R. Excitotoxic injury stimulates pro-drug-induced 7-chlorokynurenate formation in the rat striatum in vivo. Neuroscience Letters. 304: 185-8. PMID 11343833 DOI: 10.1016/S0304-3940(01)01791-8 |
0.403 |
|
| 2001 |
Hilmas C, Pereira EFR, Alkondon M, Rassoulpour A, Schwarcz R, Albuquerque EX. The Brain Metabolite Kynurenic Acid Inhibits α7 Nicotinic Receptor Activity and Increases Non-α7 Nicotinic Receptor Expression: Physiopathological Implications The Journal of Neuroscience. 21: 7463-7473. DOI: 10.1523/Jneurosci.21-19-07463.2001 |
0.396 |
|
| 2000 |
Battaglia G, Rassoulpour A, Wu HQ, Hodgkins PS, Kiss C, Nicoletti F, Schwarcz R. Some metabotropic glutamate receptor ligands reduce kynurenate synthesis in rats by intracellular inhibition of kynurenine aminotransferase II. Journal of Neurochemistry. 75: 2051-60. PMID 11032894 DOI: 10.1046/j.1471-4159.2000.0752051.x |
0.382 |
|
| 2000 |
Ceresoli-Borroni G, Schwarcz R. Perinatal kynurenine pathway metabolism in the normal and asphyctic rat brain. Amino Acids. 19: 311-23. PMID 11026502 DOI: 10.1007/s007260070062 |
0.462 |
|
| 2000 |
Scharfman HE, Goodman JH, Schwarcz R. Electrophysiological effects of exogenous and endogenous kynurenic acid in the rat brain: studies in vivo and in vitro. Amino Acids. 19: 283-97. PMID 11026500 DOI: 10.1007/s007260070060 |
0.482 |
|
| 2000 |
Schwarcz R, Eid T, Du F. Neurons in layer III of the entorhinal cortex. A role in epileptogenesis and epilepsy? Annals of the New York Academy of Sciences. 911: 328-42. PMID 10911883 DOI: 10.1111/J.1749-6632.2000.Tb06735.X |
0.316 |
|
| 2000 |
Wu HQ, Guidetti P, Goodman JH, Varasi M, Ceresoli-Borroni G, Speciale C, Scharfman HE, Schwarcz R. Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo. Neuroscience. 97: 243-51. PMID 10799756 DOI: 10.1016/S0306-4522(00)00030-0 |
0.409 |
|
| 2000 |
Guidetti P, Wu HQ, Schwarcz R. In situ produced 7-chlorokynurenate provides protection against quinolinate- and malonate-induced neurotoxicity in the rat striatum. Experimental Neurology. 163: 123-30. PMID 10785450 DOI: 10.1006/exnr.1999.7284 |
0.413 |
|
| 2000 |
Guidetti P, Reddy PH, Tagle DA, Schwarcz R. Early kynurenergic impairment in Huntington's disease and in a transgenic animal model. Neuroscience Letters. 283: 233-5. PMID 10754231 DOI: 10.1016/S0304-3940(00)00956-3 |
0.374 |
|
| 2000 |
Wu HQ, Lee SC, Schwarcz R. Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus. European Journal of Pharmacology. 390: 267-74. PMID 10708733 DOI: 10.1016/S0014-2999(00)00024-8 |
0.396 |
|
| 2000 |
Coyle JT, Schwarcz R. Mind glue: implications of glial cell biology for psychiatry. Archives of General Psychiatry. 57: 90-3. PMID 10632240 DOI: 10.1001/Archpsyc.57.1.90 |
0.364 |
|
| 1999 |
Schwarcz R, Ceresoli-Borroni G, Wu HQ, Rassoulpour A, Poeggeler B, Hodgkins PS, Guidetti P. Modulation and function of kynurenic acid in the immature rat brain. Advances in Experimental Medicine and Biology. 467: 113-23. PMID 10721048 DOI: 10.1007/978-1-4615-4709-9_17 |
0.443 |
|
| 1999 |
Fornstedt-Wallin B, Lundström J, Fredriksson G, Schwarcz R, Luthman J. 3-Hydroxyanthranilic acid accumulation following administration of the 3-hydroxyanthranilic acid 3,4-dioxygenase inhibitor NCR-631. European Journal of Pharmacology. 386: 15-24. PMID 10611459 DOI: 10.1016/S0014-2999(99)00683-4 |
0.437 |
|
| 1999 |
Guidetti P, Schwarcz R. 3-Hydroxykynurenine potentiates quinolinate but not NMDA toxicity in the rat striatum. The European Journal of Neuroscience. 11: 3857-63. PMID 10583474 DOI: 10.1046/j.1460-9568.1999.00806.x |
0.365 |
|
| 1999 |
Scharfman HE, Hodgkins PS, Lee SC, Schwarcz R. Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices. Neuroscience Letters. 274: 111-4. PMID 10553950 DOI: 10.1016/S0304-3940(99)00690-4 |
0.43 |
|
| 1999 |
Ceresoli-Borroni G, Guidetti P, Schwarcz R. Acute and chronic changes in kynurenate formation following an intrastriatal quinolinate injection in rats. Journal of Neural Transmission (Vienna, Austria : 1996). 106: 229-42. PMID 10392532 DOI: 10.1007/s007020050153 |
0.412 |
|
| 1999 |
Eid T, Schwarcz R, Ottersen OP. Ultrastructure and immunocytochemical distribution of GABA in layer III of the rat medial entorhinal cortex following aminooxyacetic acid-induced seizures. Experimental Brain Research. 125: 463-75. PMID 10323293 DOI: 10.1007/s002210050704 |
0.335 |
|
| 1999 |
Hodgkins PS, Wu HQ, Zielke HR, Schwarcz R. 2-Oxoacids regulate kynurenic acid production in the rat brain: studies in vitro and in vivo. Journal of Neurochemistry. 72: 643-51. PMID 9930736 DOI: 10.1046/j.1471-4159.1999.0720643.x |
0.462 |
|
| 1999 |
Poeggeler B, Pappolla MA, Hardeland R, Rassoulpour A, Hodgkins PS, Guidetti P, Schwarcz R. Indole-3-propionate: a potent hydroxyl radical scavenger in rat brain. Brain Research. 815: 382-8. PMID 9878843 DOI: 10.1016/S0006-8993(98)01027-0 |
0.31 |
|
| 1999 |
Linderberg M, Hellberg S, Björk S, Gotthammar B, Högberg T, Persson K, Schwarcz R, Luthman J, Johansson R. Synthesis and QSAR of substituted 3-hydroxyanthranilic acid derivatives as inhibitors of 3-hydroxyanthranilic acid dioxygenase (3-HAO) European Journal of Medicinal Chemistry. 34: 729-744. DOI: 10.1016/S0223-5234(99)00220-2 |
0.381 |
|
| 1998 |
Schwarcz R, Poeggeler B, Rassoulpour A, Ceresoli-Borroni G, Hodgkins PS. Regulation of kynurenic acid levels in the developing rat brain. Amino Acids. 14: 243-9. PMID 9871469 DOI: 10.1007/BF01345270 |
0.488 |
|
| 1998 |
Scharfman HE, Goodman JH, Du F, Schwarcz R. Chronic changes in synaptic responses of entorhinal and hippocampal neurons after amino-oxyacetic acid (AOAA)-induced entorhinal cortical neuron loss. Journal of Neurophysiology. 80: 3031-46. PMID 9862904 DOI: 10.1152/Jn.1998.80.6.3031 |
0.346 |
|
| 1998 |
Wu HQ, Schwarcz R. Focal microinjection of gamma-acetylenic GABA into the rat entorhinal cortex: behavioral and electroencephalographic abnormalities and preferential neuron loss in layer III. Experimental Neurology. 153: 203-13. PMID 9784280 DOI: 10.1006/exnr.1998.6908 |
0.352 |
|
| 1998 |
Hodgkins PS, Schwarcz R. Metabolic control of kynurenic acid formation in the rat brain. Developmental Neuroscience. 20: 408-16. PMID 9778579 DOI: 10.1159/000017338 |
0.478 |
|
| 1998 |
Hodgkins PS, Schwarcz R. Interference with cellular energy metabolism reduces kynurenic acid formation in rat brain slices: reversal by lactate and pyruvate. The European Journal of Neuroscience. 10: 1986-94. PMID 9753086 DOI: 10.1046/J.1460-9568.1998.00208.X |
0.436 |
|
| 1998 |
Rassoulpour A, Wu HQ, Poeggeler B, Schwarcz R. Systemic d-amphetamine administration causes a reduction of kynurenic acid levels in rat brain. Brain Research. 802: 111-8. PMID 9748528 DOI: 10.1016/S0006-8993(98)00577-0 |
0.453 |
|
| 1998 |
Poeggeler B, Rassoulpour A, Guidetti P, Wu HQ, Schwarcz R. Dopaminergic control of kynurenate levels and N-methyl-D-aspartate toxicity in the developing rat striatum. Developmental Neuroscience. 20: 146-53. PMID 9691189 DOI: 10.1159/000017309 |
0.394 |
|
| 1998 |
Du F, Eid T, Schwarcz R. Neuronal damage after the injection of aminooxyacetic acid into the rat entorhinal cortex: a silver impregnation study. Neuroscience. 82: 1165-78. PMID 9466438 DOI: 10.1016/S0306-4522(97)00354-0 |
0.362 |
|
| 1997 |
Guidetti P, Okuno E, Schwarcz R. Characterization of rat brain kynurenine aminotransferases I and II. Journal of Neuroscience Research. 50: 457-65. PMID 9364331 DOI: 10.1002/(SICI)1097-4547(19971101)50:3<457::AID-JNR12>3.0.CO;2-3 |
0.445 |
|
| 1997 |
Ogren SO, Ferré S, Schwarcz R, Fuxe K. Prolonged treatment with haloperidol and clozapine in the rat: differential effects on spontaneous and theophylline-induced motor activity. Neuroscience Letters. 232: 21-4. PMID 9292882 DOI: 10.1016/S0304-3940(97)00564-8 |
0.312 |
|
| 1997 |
Gramsbergen JB, Hodgkins PS, Rassoulpour A, Turski WA, Guidetti P, Schwarcz R. Brain-specific modulation of kynurenic acid synthesis in the rat. Journal of Neurochemistry. 69: 290-8. PMID 9202322 DOI: 10.1046/J.1471-4159.1997.69010290.X |
0.475 |
|
| 1997 |
Ceresoli G, Guidetti P, Schwarcz R. Metabolism of [5-(3)H]kynurenine in the developing rat brain in vivo: effect of intrastriatal ibotenate injections. Brain Research. Developmental Brain Research. 100: 73-81. PMID 9174248 DOI: 10.1016/S0165-3806(97)00029-1 |
0.443 |
|
| 1997 |
Wu HQ, Salituro FG, Schwarcz R. Enzyme-catalyzed production of the neuroprotective NMDA receptor antagonist 7-chlorokynurenic acid in the rat brain in vivo. European Journal of Pharmacology. 319: 13-20. PMID 9030892 DOI: 10.1016/S0014-2999(96)00829-1 |
0.431 |
|
| 1997 |
Schwarcz R, Wu H, Rassoulpour A, Tamminga CA, Medoff DR, Roberts RC. Post-mortem determination of kynurenine and kynurenic acid levels in the brains of schizophrenic patients Schizophrenia Research. 24: 36. DOI: 10.1016/S0920-9964(97)82100-7 |
0.603 |
|
| 1996 |
Hokari M, Wu HQ, Schwarcz R, Smith QR. Facilitated brain uptake of 4-chlorokynurenine and conversion to 7-chlorokynurenic acid. Neuroreport. 8: 15-8. PMID 9051744 DOI: 10.1097/00001756-199612200-00004 |
0.448 |
|
| 1996 |
Speciale C, Wu HQ, Cini M, Marconi M, Varasi M, Schwarcz R. (R,S)-3,4-dichlorobenzoylalanine (FCE 28833A) causes a large and persistent increase in brain kynurenic acid levels in rats. European Journal of Pharmacology. 315: 263-7. PMID 8982663 DOI: 10.1016/S0014-2999(96)00613-9 |
0.441 |
|
| 1996 |
Giordani A, Corti L, Cini M, Marconi M, Pillan A, Ferrario R, Schwarcz R, Guidetti P, Speciale C, Varasi M. Benzoylalanine analogues as inhibitors of rat brain kynureninase and kynurenine 3-hydroxylase. Advances in Experimental Medicine and Biology. 398: 499-505. PMID 8906311 DOI: 10.1007/978-1-4613-0381-7_77 |
0.452 |
|
| 1996 |
Mosca M, Cozzi L, Breton J, Avanzi N, Toma S, Okuno E, Schwarcz R, Speciale C, Magagnin S, Mostardini M, Benatti L. Cloning of rat and human kynurenine aminotransferase. Advances in Experimental Medicine and Biology. 398: 449-54. PMID 8906304 DOI: 10.1007/978-1-4613-0381-7_70 |
0.334 |
|
| 1996 |
Curatolo L, Caccia C, Speciale C, Raimondi L, Cini M, Marconi M, Molinari A, Schwarcz R. Modulation of extracellular kynurenic acid content by excitatory amino acids in primary cultures of rat astrocytes. Advances in Experimental Medicine and Biology. 398: 273-6. PMID 8906277 DOI: 10.1007/978-1-4613-0381-7_43 |
0.448 |
|
| 1996 |
Speciale C, Cini M, Wu HQ, Salvati P, Schwarcz R, Molinari A, Calabresi M, Varasi M. Kynurenic acid-enhancing and anti-ischemic effects of the potent kynurenine 3-hydroxylase inhibitor FCE 28833 in rodents. Advances in Experimental Medicine and Biology. 398: 221-7. PMID 8906269 DOI: 10.1007/978-1-4613-0381-7_35 |
0.336 |
|
| 1996 |
Schwarcz R, Ceresoli G, Guidetti P. Kynurenine metabolism in the rat brain in vivo. Effect of acute excitotoxic insults. Advances in Experimental Medicine and Biology. 398: 211-9. PMID 8906268 DOI: 10.1007/978-1-4613-0381-7_34 |
0.473 |
|
| 1996 |
Wu HQ, Schwarcz R. Seizure activity causes elevation of endogenous extracellular kynurenic acid in the rat brain. Brain Research Bulletin. 39: 155-62. PMID 8866691 DOI: 10.1016/0361-9230(95)02087-X |
0.46 |
|
| 1996 |
Ceresoli G, Fuller MS, Schwarcz R. Excitotoxic lesions of the rat striatum: different responses of kynurenine pathway enzymes during ontogeny. Brain Research. Developmental Brain Research. 92: 61-9. PMID 8861723 DOI: 10.1016/0165-3806(95)00200-6 |
0.437 |
|
| 1996 |
Eid T, Jorritsma-Byham B, Schwarcz R, Witter MP. Afferents to the seizure-sensitive neurons in layer III of the medial entorhinal area: a tracing study in the rat. Experimental Brain Research. 109: 209-18. PMID 8738371 DOI: 10.1007/Bf00231782 |
0.305 |
|
| 1996 |
Giulian D, Yu J, Li X, Tom D, Li J, Wendt E, Lin SN, Schwarcz R, Noonan C. Study of receptor-mediated neurotoxins released by HIV-1-infected mononuclear phagocytes found in human brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 3139-53. PMID 8627353 DOI: 10.1523/Jneurosci.16-10-03139.1996 |
0.344 |
|
| 1996 |
Varasi M, Della Torre A, Heidempergher F, Pevarello P, Speciale C, Guidetti P, Wells DR, Schwarcz R. Derivatives of kynurenine as inhibitors of rat brain kynurenine aminotransferase European Journal of Medicinal Chemistry. 31: 11-21. DOI: 10.1016/S0223-5234(96)80002-X |
0.381 |
|
| 1996 |
Schwarcz R. Novel neuroprotective strategies based on the enhancement of brain kynurenic acid levels European Neuropsychopharmacology. 6: S4-10-S4-11. DOI: 10.1016/0924-977X(96)83159-2 |
0.33 |
|
| 1995 |
Wu HQ, Monno A, Schwarcz R, Vezzani A. Electrical kindling is associated with a lasting increase in the extracellular levels of kynurenic acid in the rat hippocampus. Neuroscience Letters. 198: 91-4. PMID 8592649 DOI: 10.1016/0304-3940(95)11971-X |
0.409 |
|
| 1995 |
Eid T, Du F, Schwarcz R. Differential neuronal vulnerability to amino-oxyacetate and quinolinate in the rat parahippocampal region. Neuroscience. 68: 645-56. PMID 8577365 DOI: 10.1016/0306-4522(95)00183-J |
0.399 |
|
| 1995 |
Wu HQ, Ungerstedt U, Schwarcz R. L-alpha-aminoadipic acid as a regulator of kynurenic acid production in the hippocampus: a microdialysis study in freely moving rats. European Journal of Pharmacology. 281: 55-61. PMID 8566117 DOI: 10.1016/0014-2999(95)00224-9 |
0.407 |
|
| 1995 |
Roberts RC, McCarthy KE, Du F, Ottersen OP, Okuno E, Schwarcz R. 3-Hydroxyanthranilic acid oxygenase-containing astrocytic processes surround glutamate-containing axon terminals in the rat striatum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 1150-61. PMID 7869091 DOI: 10.1523/Jneurosci.15-02-01150.1995 |
0.573 |
|
| 1995 |
Jauch D, Urba?ska EM, Guidetti P, Bird ED, Vonsattel JP, Whetsell WO, Schwarcz R. Dysfunction of brain kynurenic acid metabolism in Huntington's disease: focus on kynurenine aminotransferases. Journal of the Neurological Sciences. 130: 39-47. PMID 7650530 DOI: 10.1016/0022-510X(94)00280-2 |
0.454 |
|
| 1995 |
Guidetti P, Eastman CL, Schwarcz R. Metabolism of [5-3H]kynurenine in the rat brain in vivo: evidence for the existence of a functional kynurenine pathway. Journal of Neurochemistry. 65: 2621-32. PMID 7595559 DOI: 10.1046/J.1471-4159.1995.65062621.X |
0.385 |
|
| 1995 |
Du F, Eid T, Lothman EW, Köhler C, Schwarcz R. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 6301-13. PMID 7472396 DOI: 10.1523/Jneurosci.15-10-06301.1995 |
0.352 |
|
| 1994 |
Salituro FG, Tomlinson RC, Baron BM, Palfreyman MG, McDonald IA, Schmidt W, Wu HQ, Guidetti P, Schwarcz R. Enzyme-activated antagonists of the strychnine-insensitive glycine/NMDA receptor. Journal of Medicinal Chemistry. 37: 334-6. PMID 8308859 DOI: 10.1021/Jm00029A003 |
0.321 |
|
| 1994 |
Baran H, Okuno E, Kido R, Schwarcz R. Purification and characterization of kynurenine aminotransferase I from human brain. Journal of Neurochemistry. 62: 730-8. PMID 8294935 DOI: 10.1046/J.1471-4159.1994.62020730.X |
0.397 |
|
| 1994 |
Walsh JL, Wu HQ, Ungerstedt U, Schwarcz R. 4-Chloro-3-hydroxyanthranilate inhibits quinolinate production in the rat hippocampus in vivo. Brain Research Bulletin. 33: 513-6. PMID 8186995 DOI: 10.1016/0361-9230(94)90076-0 |
0.449 |
|
| 1994 |
Guidetti P, Walsh JL, Schwarcz R. A fluorimetric assay for the determination of anthranilic acid in biological materials. Analytical Biochemistry. 220: 181-4. PMID 7978243 DOI: 10.1006/abio.1994.1316 |
0.459 |
|
| 1994 |
Roberts RC, McCarthy KE, Du F, Okuno E, Schwarcz R. Immunocytochemical localization of the quinolinic acid synthesizing enzyme, 3-hydroxyanthranilic acid oxygenase, in the rat substantia nigra. Brain Research. 650: 229-38. PMID 7953687 DOI: 10.1016/0006-8993(94)91786-8 |
0.61 |
|
| 1994 |
Mosca M, Cozzi L, Breton J, Speciale C, Okuno E, Schwarcz R, Benatti L. Molecular cloning of rat kynurenine aminotransferase: identity with glutamine transaminase K. Febs Letters. 353: 21-4. PMID 7926014 DOI: 10.1016/0014-5793(94)01003-X |
0.326 |
|
| 1994 |
Eastman CL, Urba?ska E, Löve A, Kristensson K, Schwarcz R. Increased brain quinolinic acid production in mice infected with a hamster neurotropic measles virus. Experimental Neurology. 125: 119-24. PMID 7905834 DOI: 10.1006/exnr.1994.1015 |
0.452 |
|
| 1994 |
Eastman CL, Urba?ska EM, Chapman AG, Schwarcz R. Differential expression of the astrocytic enzymes 3-hydroxyanthranilic acid oxygenase, kynurenine aminotransferase and glutamine synthetase in seizure-prone and non-epileptic mice. Epilepsy Research. 18: 185-94. PMID 7805640 DOI: 10.1016/0920-1211(94)90039-6 |
0.345 |
|
| 1994 |
Wu HQ, Schwarcz R, Shepard PD. Excitatory amino acid-induced excitation of dopamine-containing neurons in the rat substantia nigra: modulation by kynurenic acid. Synapse (New York, N.Y.). 16: 219-30. PMID 7515199 DOI: 10.1002/Syn.890160307 |
0.409 |
|
| 1993 |
Speciale C, Schwarcz R. On the production and disposition of quinolinic acid in rat brain and liver slices. Journal of Neurochemistry. 60: 212-8. PMID 8417142 DOI: 10.1111/J.1471-4159.1993.Tb05840.X |
0.434 |
|
| 1993 |
Baran H, Schwarcz R. Regional differences in the ontogenetic pattern of kynurenine aminotransferase in the rat brain. Brain Research. Developmental Brain Research. 74: 283-6. PMID 8403387 DOI: 10.1016/0165-3806(93)90014-2 |
0.494 |
|
| 1993 |
Andersson T, Schwarcz R, Löve A, Kristensson K. Measles virus-induced hippocampal neurodegeneration in the mouse: a novel, subacute model for testing neuroprotective agents. Neuroscience Letters. 154: 109-12. PMID 8361621 DOI: 10.1016/0304-3940(93)90183-L |
0.318 |
|
| 1993 |
Schmidt W, Guidetti P, Okuno E, Schwarcz R. Characterization of human brain kynurenine aminotransferases using [3H]kynurenine as a substrate. Neuroscience. 55: 177-84. PMID 8350986 DOI: 10.1016/0306-4522(93)90464-Q |
0.421 |
|
| 1993 |
McMaster OG, Baran H, Wu HQ, Du F, French ED, Schwarcz R. gamma-Acetylenic GABA produces axon-sparing neurodegeneration after focal injection into the rat hippocampus. Experimental Neurology. 124: 184-91. PMID 8287921 DOI: 10.1006/Exnr.1993.1188 |
0.384 |
|
| 1993 |
Du F, Williamson J, Bertram E, Lothman E, Okuno E, Schwarcz R. Kynurenine pathway enzymes in a rat model of chronic epilepsy: immunohistochemical study of activated glial cells. Neuroscience. 55: 975-89. PMID 8232907 DOI: 10.1016/0306-4522(93)90312-4 |
0.448 |
|
| 1992 |
Wu HQ, Baran H, Ungerstedt U, Schwarcz R. Kynurenic Acid in the Quinolinate-lesioned Rat Hippocampus: Studies In Vitro and In Vivo. The European Journal of Neuroscience. 4: 1264-1270. PMID 12106390 DOI: 10.1111/j.1460-9568.1992.tb00152.x |
0.455 |
|
| 1992 |
Wu HQ, Ungerstedt U, Schwarcz R. Regulation of kynurenic acid synthesis studied by microdialysis in the dorsal hippocampus of unanesthetized rats. European Journal of Pharmacology. 213: 375-80. PMID 1535598 DOI: 10.1016/0014-2999(92)90626-F |
0.442 |
|
| 1992 |
Du F, Schmidt W, Okuno E, Kido R, Köhler C, Schwarcz R. Localization of kynurenine aminotransferase immunoreactivity in the rat hippocampus. The Journal of Comparative Neurology. 321: 477-87. PMID 1506481 DOI: 10.1002/cne.903210313 |
0.388 |
|
| 1992 |
Roberts RC, Du F, McCarthy KE, Okuno E, Schwarcz R. Immunocytochemical localization of kynurenine aminotransferase in the rat striatum: a light and electron microscopic study. The Journal of Comparative Neurology. 326: 82-90. PMID 1479071 DOI: 10.1002/Cne.903260107 |
0.557 |
|
| 1992 |
Gramsbergen JB, Schmidt W, Turski WA, Schwarcz R. Age-related changes in kynurenic acid production in rat brain. Brain Research. 588: 1-5. PMID 1393560 DOI: 10.1016/0006-8993(92)91337-E |
0.474 |
|
| 1992 |
Schwarcz R. Minority ligands of excitatory amino acid receptors: focus on brain kynurenines. Clinical Neuropharmacology. 15: 693A-694A. PMID 1323416 DOI: 10.1097/00002826-199201001-00358 |
0.424 |
|
| 1992 |
Schwarcz R, Du F, Schmidt W, Turski WA, Gramsbergen JB, Okuno E, Roberts RC. Kynurenic acid: a potential pathogen in brain disorders. Annals of the New York Academy of Sciences. 648: 140-53. PMID 1322078 DOI: 10.1111/J.1749-6632.1992.Tb24532.X |
0.578 |
|
| 1992 |
Du F, Schwarcz R. Aminooxyacetic acid causes selective neuronal loss in layer III of the rat medial entorhinal cortex. Neuroscience Letters. 147: 185-8. PMID 1283457 DOI: 10.1016/0304-3940(92)90591-T |
0.351 |
|
| 1991 |
Andersson T, Schultzberg M, Schwarcz R, Löve A, Wickman C, Kristensson K. NMDA-Receptor Antagonist Prevents Measles Virus-induced Neurodegeneration. The European Journal of Neuroscience. 3: 66-71. PMID 12106270 DOI: 10.1111/J.1460-9568.1991.Tb00812.X |
0.385 |
|
| 1991 |
Okuno E, Schmidt W, Parks DA, Nakamura M, Schwarcz R. Measurement of rat brain kynurenine aminotransferase at physiological kynurenine concentrations. Journal of Neurochemistry. 57: 533-40. PMID 2072101 DOI: 10.1111/J.1471-4159.1991.Tb03783.X |
0.462 |
|
| 1991 |
Wu HQ, Turski WA, Ungerstedt U, Schwarcz R. Systemic kainic acid administration in rats: effects on kynurenic acid production in vitro and in vivo. Experimental Neurology. 113: 47-52. PMID 2044678 DOI: 10.1016/0014-4886(91)90145-3 |
0.465 |
|
| 1991 |
Okuno E, Nakamura M, Schwarcz R. Two kynurenine aminotransferases in human brain. Brain Research. 542: 307-12. PMID 2029638 DOI: 10.1016/0006-8993(91)91583-M |
0.426 |
|
| 1991 |
Vezzani A, Gramsbergen JB, Speciale C, Schwarcz R. Production of quinolinic acid and kynurenic acid by human glioma. Advances in Experimental Medicine and Biology. 294: 691-5. PMID 1837700 DOI: 10.1007/978-1-4684-5952-4_95 |
0.453 |
|
| 1991 |
Speciale C, Schwarcz R. On the disposition of de novo synthesized quinolinic acid in rat brain tissue. Advances in Experimental Medicine and Biology. 294: 583-6. PMID 1837692 DOI: 10.1007/978-1-4684-5952-4_71 |
0.401 |
|
| 1991 |
Walsh JL, Todd WP, Carpenter BK, Schwarcz R. 4-Halo-3-hydroxyanthranilates are potent inhibitors of 3-hydroxyanthranilate oxygenase in the rat brain in vitro and in vivo. Advances in Experimental Medicine and Biology. 294: 579-82. PMID 1837691 DOI: 10.1007/978-1-4684-5952-4_70 |
0.412 |
|
| 1991 |
McMaster OG, Du F, French ED, Schwarcz R. Focal injection of aminooxyacetic acid produces seizures and lesions in rat hippocampus: evidence for mediation by NMDA receptors. Experimental Neurology. 113: 378-85. PMID 1833221 DOI: 10.1016/0014-4886(91)90029-C |
0.389 |
|
| 1991 |
Du F, Okuno E, Whetsell WO, Köhler C, Schwarcz R. Immunohistochemical localization of quinolinic acid phosphoribosyltransferase in the human neostriatum. Neuroscience. 42: 397-406. PMID 1832752 DOI: 10.1016/0306-4522(91)90384-Z |
0.396 |
|
| 1991 |
Walsh JL, Todd WP, Carpenter BK, Schwarcz R. 4-halo-3-hydroxyanthranilic acids: potent competitive inhibitors of 3-hydroxy-anthranilic acid oxygenase in vitro. Biochemical Pharmacology. 42: 985-90. PMID 1831362 DOI: 10.1016/0006-2952(91)90279-E |
0.39 |
|
| 1991 |
Fukui S, Schwarcz R, Rapoport SI, Takada Y, Smith QR. Blood-brain barrier transport of kynurenines: implications for brain synthesis and metabolism. Journal of Neurochemistry. 56: 2007-17. PMID 1827495 DOI: 10.1111/J.1471-4159.1991.Tb03460.X |
0.41 |
|
| 1991 |
Kish SJ, Du F, Parks DA, Robitaille Y, Ball MJ, Schut L, Hornykiewicz O, Schwarcz R. Quinolinic acid catabolism is increased in cerebellum of patients with dominantly inherited olivopontocerebellar atrophy. Annals of Neurology. 29: 100-4. PMID 1825460 DOI: 10.1002/Ana.410290119 |
0.6 |
|
| 1991 |
Baran H, Schwarcz R. Evidence for the preferential production of 3-hydroxyanthranilic acid from anthranilic acid in the rat brain. Advances in Experimental Medicine and Biology. 294: 485-8. PMID 1772081 DOI: 10.1007/978-1-4684-5952-4_50 |
0.438 |
|
| 1991 |
Poston MR, Bailey MS, Schwarcz R, Shipley MT. Differential complementary localization of metabolic enzymes for quinolinic acid in olfactory bulb astrocytes. The Journal of Comparative Neurology. 311: 367-74. PMID 1720144 DOI: 10.1002/cne.903110307 |
0.332 |
|
| 1991 |
Schwarcz R, Du F. Quinolinic acid and kynurenic acid in the mammalian brain. Advances in Experimental Medicine and Biology. 294: 185-99. PMID 1685291 DOI: 10.1007/978-1-4684-5952-4_17 |
0.434 |
|
| 1991 |
Gramsbergen JB, Turski WA, Schwarcz R. Brain-specific control of kynurenic acid production by depolarizing agents. Advances in Experimental Medicine and Biology. 294: 587-90. PMID 1663319 DOI: 10.1007/978-1-4684-5952-4_72 |
0.358 |
|
| 1991 |
Eid T, Flood PR, Köhler C, Schwarcz R. Localization of quinolinic acid metabolizing enzymes as revealed by immunoelectron microscopy Micron and Microscopica Acta. 22: 35-36. DOI: 10.1016/0739-6260(91)90078-E |
0.337 |
|
| 1990 |
Baran H, Schwarcz R. Presence of 3-hydroxyanthranilic acid in rat tissues and evidence for its production from anthranilic acid in the brain. Journal of Neurochemistry. 55: 738-44. PMID 2384749 DOI: 10.1111/J.1471-4159.1990.Tb04553.X |
0.426 |
|
| 1990 |
Du F, Okuno E, Whetsell WO, Köhler C, Schwarcz R. Distribution of quinolinic acid phosphoribosyltransferase in the human hippocampal formation and parahippocampal gyrus. The Journal of Comparative Neurology. 295: 71-82. PMID 2341637 DOI: 10.1002/Cne.902950107 |
0.375 |
|
| 1990 |
Speciale C, Schwarcz R. Uptake of kynurenine into rat brain slices. Journal of Neurochemistry. 54: 156-63. PMID 2293608 DOI: 10.1111/J.1471-4159.1990.Tb13296.X |
0.407 |
|
| 1990 |
Speciale C, Wu HQ, Gramsbergen JB, Turski WA, Ungerstedt U, Schwarcz R. Determination of extracellular kynurenic acid in the striatum of unanesthetized rats: effect of aminooxyacetic acid. Neuroscience Letters. 116: 198-203. PMID 2259449 DOI: 10.1016/0304-3940(90)90410-B |
0.41 |
|
| 1990 |
Vezzani A, Gramsbergen JB, Versari P, Stasi MA, Procaccio F, Schwarcz R. Kynurenic acid synthesis by human glioma. Journal of the Neurological Sciences. 99: 51-7. PMID 2250171 DOI: 10.1016/0022-510X(90)90198-V |
0.431 |
|
| 1990 |
Westerberg E, Magnusson K, Wieloch T, Ungerstedt U, Speciale C, Schwarcz R. Extracellular levels of quinolinic acid are moderately increased in rat neostriatum following severe insulin-induced hypoglycaemia. Acta Physiologica Scandinavica. 138: 417-22. PMID 2139298 DOI: 10.1111/J.1748-1716.1990.Tb08865.X |
0.324 |
|
| 1990 |
Okuno E, Du F, Ishikawa T, Tsujimoto M, Nakamura M, Schwarcz R, Kido R. Purification and characterization of kynurenine-pyruvate aminotransferase from rat kidney and brain. Brain Research. 534: 37-44. PMID 1963565 DOI: 10.1016/0006-8993(90)90109-O |
0.453 |
|
| 1989 |
Todd WP, Carpenter BK, Schwarcz R. Preparation of 4-halo-3-hydroxyanthranilates and demonstration of their inhibition of 3-hydroxyanthranilate oxygenase activity in rat and human brain tissue. Preparative Biochemistry. 19: 155-65. PMID 2798363 DOI: 10.1080/10826068908544905 |
0.309 |
|
| 1989 |
Speciale C, Hares K, Schwarcz R, Brookes N. High-affinity uptake of L-kynurenine by a Na+-independent transporter of neutral amino acids in astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 9: 2066-72. PMID 2723766 DOI: 10.1523/Jneurosci.09-06-02066.1989 |
0.371 |
|
| 1989 |
Turski WA, Gramsbergen JB, Traitler H, Schwarcz R. Rat brain slices produce and liberate kynurenic acid upon exposure to L-kynurenine. Journal of Neurochemistry. 52: 1629-36. PMID 2709016 DOI: 10.1111/J.1471-4159.1989.Tb09218.X |
0.392 |
|
| 1989 |
Speciale C, Ungerstedt U, Schwarcz R. Production of extracellular quinolinic acid in the striatum studied by microdialysis in unanesthetized rats. Neuroscience Letters. 104: 345-50. PMID 2530475 DOI: 10.1016/0304-3940(89)90601-0 |
0.391 |
|
| 1989 |
Schwarcz R, Okuno E, White RJ. Basal ganglia lesions in the rat: effects on quinolinic acid metabolism. Brain Research. 490: 103-9. PMID 2527078 DOI: 10.1016/0006-8993(89)90435-6 |
0.419 |
|
| 1989 |
Whetsell WO, Schwarcz R. Prolonged exposure to submicromolar concentrations of quinolinic acid causes excitotoxic damage in organotypic cultures of rat corticostriatal system. Neuroscience Letters. 97: 271-5. PMID 2524015 DOI: 10.1016/0304-3940(89)90609-5 |
0.324 |
|
| 1988 |
Turski WA, Schwarcz R. On the disposition of intrahippocampally injected kynurenic acid in the rat. Experimental Brain Research. 71: 563-7. PMID 3416969 DOI: 10.1007/Bf00248748 |
0.459 |
|
| 1988 |
Turski WA, Nakamura M, Todd WP, Carpenter BK, Whetsell WO, Schwarcz R. Identification and quantification of kynurenic acid in human brain tissue. Brain Research. 454: 164-9. PMID 3409000 DOI: 10.1016/0006-8993(88)90815-3 |
0.362 |
|
| 1988 |
Köhler C, Eriksson LG, Flood PR, Hardie JA, Okuno E, Schwarcz R. Quinolinic acid metabolism in the rat brain. Immunohistochemical identification of 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase in the hippocampal region. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 975-87. PMID 3346732 DOI: 10.1523/Jneurosci.08-03-00975.1988 |
0.364 |
|
| 1988 |
Köhler C, Peterson A, Eriksson LG, Okuno E, Schwarcz R. Immunohistochemical identification of quinolinic acid phosphoribosyltransferase in glial cultures from rat brain. Neuroscience Letters. 84: 115-9. PMID 3277086 DOI: 10.1016/0304-3940(88)90393-X |
0.405 |
|
| 1988 |
Okuno E, White RJ, Schwarcz R. Quinolinic acid phosphoribosyltransferase: purification and partial characterization from human liver and brain. Journal of Biochemistry. 103: 1054-9. PMID 3139649 DOI: 10.1093/Oxfordjournals.Jbchem.A122379 |
0.384 |
|
| 1988 |
Schwarcz R, Tamminga CA, Kurlan R, Shoulson I. Cerebrospinal fluid levels of quinolinic acid in Huntington's disease and schizophrenia. Annals of Neurology. 24: 580-2. PMID 2977086 DOI: 10.1002/Ana.410240417 |
0.348 |
|
| 1988 |
Köhler C, Eriksson LG, Okuno E, Schwarcz R. Localization of quinolinic acid metabolizing enzymes in the rat brain. Immunohistochemical studies using antibodies to 3-hydroxyanthranilic acid oxygenase and quinolinic acid phosphoribosyltransferase. Neuroscience. 27: 49-76. PMID 2974127 DOI: 10.1016/0306-4522(88)90219-9 |
0.411 |
|
| 1988 |
Speciale C, Ungerstedt U, Schwarcz R. Effect of kynurenine loading on quinolinic acid production in the rat: studies in vitro and in vivo. Life Sciences. 43: 777-86. PMID 2970571 DOI: 10.1016/0024-3205(88)90178-6 |
0.391 |
|
| 1988 |
Schwarcz R, Okuno E, White RJ, Bird ED, Whetsell WO. 3-Hydroxyanthranilate oxygenase activity is increased in the brains of Huntington disease victims. Proceedings of the National Academy of Sciences of the United States of America. 85: 4079-81. PMID 2967497 DOI: 10.1073/Pnas.85.11.4079 |
0.425 |
|
| 1988 |
Speciale C, Schwarcz R. Effect of systemic kainate administration on cerebral quinolinic acid metabolism in the rat. Experimental Neurology. 99: 213-8. PMID 2961590 DOI: 10.1016/0014-4886(88)90140-9 |
0.455 |
|
| 1988 |
Speciale C, Turski W, Gramsbergen J, Schwarcz R. Uptake and metabolism of L-kynurenine in the rat brain: Studies in vitro and in vivo Pharmacological Research Communications. 20: 368. DOI: 10.1016/S0031-6989(88)80498-3 |
0.381 |
|
| 1987 |
Köhler C, Okuno E, Flood PR, Schwarcz R. Quinolinic acid phosphoribosyltransferase: preferential glial localization in the rat brain visualized by immunocytochemistry. Proceedings of the National Academy of Sciences of the United States of America. 84: 3491-5. PMID 3472219 DOI: 10.1073/Pnas.84.10.3491 |
0.481 |
|
| 1987 |
Okuno E, Köhler C, Schwarcz R. Rat 3-hydroxyanthranilic acid oxygenase: purification from the liver and immunocytochemical localization in the brain. Journal of Neurochemistry. 49: 771-80. PMID 3112306 DOI: 10.1111/J.1471-4159.1987.Tb00960.X |
0.439 |
|
| 1987 |
Speciale C, Okuno E, Schwarcz R. Increased quinolinic acid metabolism following neuronal degeneration in the rat hippocampus. Brain Research. 436: 18-24. PMID 2961415 DOI: 10.1016/0006-8993(87)91551-4 |
0.474 |
|
| 1987 |
Vezzani A, Sangalli L, Wu HQ, Schwarcz R. ATP as a marker of excitotoxin-induced nerve cell death in vivo. Journal of Neural Transmission. 70: 349-56. PMID 2960779 DOI: 10.1007/Bf01253609 |
0.398 |
|
| 1987 |
Schwarcz R, Speciale C, French ED. Hippocampal kynurenines as etiological factors in seizure disorders. Polish Journal of Pharmacology and Pharmacy. 39: 485-94. PMID 2906431 |
0.305 |
|
| 1986 |
Schwarcz R, Speciale C, Okuno E, French ED, Köhler C. Quinolinic acid: a pathogen in seizure disorders? Advances in Experimental Medicine and Biology. 203: 697-707. PMID 3024466 DOI: 10.1007/978-1-4684-7971-3_53 |
0.437 |
|
| 1986 |
Foster AC, Okuno E, Brougher DS, Schwarcz R. A radioenzymatic assay for quinolinic acid. Analytical Biochemistry. 158: 98-103. PMID 2948416 DOI: 10.1016/0003-2697(86)90595-6 |
0.384 |
|
| 1986 |
Mazzari S, Aldinio C, Beccaro M, Toffano G, Schwarcz R. Intracerebral quinolinic acid injection in the rat: effects on dopaminergic neurons. Brain Research. 380: 309-16. PMID 2944562 DOI: 10.1016/0006-8993(86)90227-1 |
0.403 |
|
| 1986 |
Foster AC, White RJ, Schwarcz R. Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro. Journal of Neurochemistry. 47: 23-30. PMID 2940338 DOI: 10.1111/J.1471-4159.1986.Tb02826.X |
0.484 |
|
| 1986 |
Björklund H, Olson L, Dahl D, Schwarcz R. Short- and long-term consequences of intracranial injections of the excitotoxin, quinolinic acid, as evidenced by GFA immunohistochemistry of astrocytes. Brain Research. 371: 267-77. PMID 2938667 DOI: 10.1016/0006-8993(86)90362-8 |
0.422 |
|
| 1986 |
Goldstein M, Kuga S, Kusano N, Meller E, Dancis J, Schwarcz R. Dopamine agonist induced self-mutilative biting behavior in monkeys with unilateral ventromedial tegmental lesions of the brainstem: possible pharmacological model for Lesch-Nyhan syndrome. Brain Research. 367: 114-20. PMID 2938664 DOI: 10.1016/0006-8993(86)91584-2 |
0.322 |
|
| 1985 |
Okuno E, Schwarcz R. Purification of quinolinic acid phosphoribosyltransferase from rat liver and brain. Biochimica Et Biophysica Acta. 841: 112-9. PMID 3926003 DOI: 10.1016/0304-4165(85)90280-6 |
0.427 |
|
| 1985 |
Vezzani A, Ungerstedt U, French ED, Schwarcz R. In vivo brain dialysis of amino acids and simultaneous EEG measurements following intrahippocampal quinolinic acid injection: evidence for a dissociation between neurochemical changes and seizures. Journal of Neurochemistry. 45: 335-44. PMID 3159848 DOI: 10.1111/J.1471-4159.1985.Tb03993.X |
0.462 |
|
| 1985 |
Foster AC, Whetsell WO, Bird ED, Schwarcz R. Quinolinic acid phosphoribosyltransferase in human and rat brain: activity in Huntington's disease and in quinolinate-lesioned rat striatum. Brain Research. 336: 207-14. PMID 3159462 DOI: 10.1016/0006-8993(85)90647-X |
0.438 |
|
| 1985 |
Nemeroff CB, Mason GA, Bissette G, Parks DA, Schwarcz R. Effects of intrahypothalamic injection of quinolinic acid on anterior pituitary hormone secretion in the unanesthetized rat. Neuroendocrinology. 41: 332-6. PMID 2931614 DOI: 10.1159/000124197 |
0.413 |
|
| 1985 |
Vezzani A, Schwarcz R. A noradrenergic component of quinolinic acid-induced seizures. Experimental Neurology. 90: 254-8. PMID 2931301 DOI: 10.1016/0014-4886(85)90057-3 |
0.407 |
|
| 1985 |
Schwarcz R, Meldrum B. Excitatory aminoacid antagonists provide a therapeutic approach to neurological disorders. Lancet (London, England). 2: 140-3. PMID 2862329 DOI: 10.1016/S0140-6736(85)90238-7 |
0.306 |
|
| 1985 |
Foster AC, Schwarcz R. Characterization of quinolinic acid phosphoribosyltransferase in human blood and observations in Huntington's disease. Journal of Neurochemistry. 45: 199-205. PMID 2582090 DOI: 10.1111/J.1471-4159.1985.Tb05493.X |
0.359 |
|
| 1985 |
Foster AC, Zinkand WC, Schwarcz R. Quinolinic acid phosphoribosyltransferase in rat brain. Journal of Neurochemistry. 44: 446-54. PMID 2578178 DOI: 10.1111/J.1471-4159.1985.Tb05435.X |
0.472 |
|
| 1985 |
Aldinio C, Mazzari S, Toffano G, Köhler C, Schwarcz R. Effects of intracerebral injections of quinolinic acid on serotonergic neurons in the rat brain. Brain Research. 341: 57-65. PMID 2412634 DOI: 10.1016/0006-8993(85)91472-6 |
0.453 |
|
| 1984 |
Schwarcz R, Brush GS, Foster AC, French ED. Seizure activity and lesions after intrahippocampal quinolinic acid injection. Experimental Neurology. 84: 1-17. PMID 6705878 DOI: 10.1016/0014-4886(84)90001-3 |
0.319 |
|
| 1984 |
Steiner HX, McBean GJ, Köhler C, Roberts PJ, Schwarcz R. Ibotenate-induced neuronal degeneration in immature rat brain. Brain Research. 307: 117-24. PMID 6466990 DOI: 10.1016/0006-8993(84)90467-0 |
0.457 |
|
| 1984 |
Foster AC, Vezzani A, French ED, Schwarcz R. Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid. Neuroscience Letters. 48: 273-8. PMID 6237279 DOI: 10.1016/0304-3940(84)90050-8 |
0.474 |
|
| 1984 |
Schwarcz R, Foster AC, French ED, Whetsell WO, Köhler C. Excitotoxic models for neurodegenerative disorders. Life Sciences. 35: 19-32. PMID 6234446 DOI: 10.1016/0024-3205(84)90148-6 |
0.465 |
|
| 1984 |
Foster AC, Miller LP, Oldendorf WH, Schwarcz R. Studies on the disposition of quinolinic acid after intracerebral or systemic administration in the rat. Experimental Neurology. 84: 428-40. PMID 6232146 DOI: 10.1016/0014-4886(84)90239-5 |
0.462 |
|
| 1984 |
Aldinio C, Mazzari S, Toffano G, Schwarcz R. EFFECTS OF INTRACEREBRAL OUINOLINIC ACID INJECTIONS ON SEROTONERGIC NEURONS Clinical Neuropharmacology. 7: S249. DOI: 10.1097/00002826-198406001-00225 |
0.341 |
|
| 1983 |
Schwarcz R, Whetsell WO, Mangano RM. Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain. Science (New York, N.Y.). 219: 316-8. PMID 6849138 DOI: 10.1126/Science.6849138 |
0.427 |
|
| 1983 |
Wolfensberger M, Amsler U, Cuénod M, Foster AC, Whetsell WO, Schwarcz R. Identification of quinolinic acid in rat and human brain tissue. Neuroscience Letters. 41: 247-52. PMID 6664615 DOI: 10.1016/0304-3940(83)90458-5 |
0.419 |
|
| 1983 |
Köhler C, Schwarcz R. Comparison of ibotenate and kainate neurotoxicity in rat brain: a histological study. Neuroscience. 8: 819-35. PMID 6346135 DOI: 10.1016/0306-4522(83)90013-1 |
0.406 |
|
| 1983 |
Aldinio C, French ED, Schwarcz R. The effects of intrahippocampal ibotenic acid and their blockade by (-) 2-amino-7-phosphonoheptanoic acid: morphological and electroencephalographical analysis. Experimental Brain Research. 51: 36-44. PMID 6309547 DOI: 10.1007/BF00236800 |
0.341 |
|
| 1983 |
Foster AC, Collins JF, Schwarcz R. On the excitotoxic properties of quinolinic acid, 2,3-piperidine dicarboxylic acids and structurally related compounds. Neuropharmacology. 22: 1331-42. PMID 6229703 DOI: 10.1016/0028-3908(83)90221-6 |
0.427 |
|
| 1983 |
Schwarcz R, Köhler C. Differential vulnerability of central neurons of the rat to quinolinic acid. Neuroscience Letters. 38: 85-90. PMID 6225037 DOI: 10.1016/0304-3940(83)90115-5 |
0.451 |
|
| 1983 |
Mangano RM, Schwarcz R. Chronic infusion of endogenous excitatory amino acids into rat striatum and hippocampus. Brain Research Bulletin. 10: 47-51. PMID 6130829 DOI: 10.1016/0361-9230(83)90073-4 |
0.437 |
|
| 1982 |
French ED, Aldinio C, Schwarcz R. Intrahippocampal kainic acid, seizures and local neuronal degeneration: relationships assessed in unanesthetized rats. Neuroscience. 7: 2525-36. PMID 7177385 DOI: 10.1016/0306-4522(82)90212-3 |
0.353 |
|
| 1982 |
Schwarcz R, Collins JF, Parks DA. alpha-Amino-omega-phosphono carboxylates block ibotenate but not kainate neurotoxicity in rat hippocampus. Neuroscience Letters. 33: 85-90. PMID 6130496 DOI: 10.1016/0304-3940(82)90134-3 |
0.401 |
|
| 1982 |
Schwarcz R, Whetsell WO. Post-mortem high affinity glutamate uptake in human brain. Neuroscience. 7: 1771-8. PMID 6126842 DOI: 10.1016/0306-4522(82)90034-3 |
0.41 |
|
| 1982 |
Mangano RM, Schwarcz R. Huntington's disease. Glutamate and aspartate metabolism in blood platelets. Journal of the Neurological Sciences. 53: 489-500. PMID 6121842 DOI: 10.1016/0022-510X(82)90245-3 |
0.379 |
|
| 1981 |
Köhler C, Schwarcz R. Monosodium glutamate: increased neurotoxicity after removal of neuronal re-uptake sites. Brain Research. 211: 485-91. PMID 7237140 DOI: 10.1016/0006-8993(81)90978-1 |
0.374 |
|
| 1981 |
Schwarcz R. Effects of tissue storage and freezing on brain glutamate uptake. Life Sciences. 28: 1147-54. PMID 7231044 DOI: 10.1016/0024-3205(81)90692-5 |
0.368 |
|
| 1981 |
Mangano RM, Schwarcz R. The human platelet as a model for the glutamatergic neuron: platelet uptake of L-glutamate. Journal of Neurochemistry. 36: 1067-76. PMID 7205257 DOI: 10.1111/J.1471-4159.1981.Tb01701.X |
0.324 |
|
| 1981 |
Mangano RM, Schwarcz R. Platelet glutamate and aspartate uptake in Huntington's disease. Journal of Neurochemistry. 37: 1072-4. PMID 6119355 DOI: 10.1111/J.1471-4159.1981.Tb04502.X |
0.367 |
|
| 1980 |
Andersson K, Schwarcz R, Fuxe K. Compensatory bilateral changes in dopamine turnover after striatal kainate lesion. Nature. 283: 94-6. PMID 7188627 DOI: 10.1038/283094A0 |
0.332 |
|
| 1980 |
Schwarcz R, Köhler C. Evidence against an exclusive role of glutamate in kainic acid neurotoxicity. Neuroscience Letters. 19: 243-9. PMID 7052530 DOI: 10.1016/0304-3940(80)90268-2 |
0.397 |
|
| 1980 |
Schwarcz R, Fuxe K, Hökfelt T, Terenius L, Goldstein M. Effects of chronic striatal kainate lesions on some dopaminergic parameters and enkephalin immunoreactive neurons in the basal ganglia. Journal of Neurochemistry. 34: 772-8. PMID 6102111 DOI: 10.1111/J.1471-4159.1980.Tb09646.X |
0.323 |
|
| 1980 |
Köhler C, Schwarcz R, Fuxe K. Intrahippocampal injections of ibotenic acid provide histological evidence for a neurotoxic mechanism different from kainic acid. Neuroscience Letters. 15: 223-8. PMID 231240 DOI: 10.1016/0304-3940(79)96117-2 |
0.334 |
|
| 1980 |
Schwarcz R, Hökfelt T, Fuxe K, Jonsson G, Goldstein M, Terenius L. Ibotenic acid-induced neuronal degeneration: a morphological and neurochemical study. Experimental Brain Research. 37: 199-216. PMID 40808 DOI: 10.1007/BF00237708 |
0.423 |
|
| 1979 |
Köhler C, Schwarcz R, Fuxe K. Hippocampal lesions indicate differences between the excitotoxic properties of acidic amono acids. Brain Research. 175: 366-71. PMID 487164 DOI: 10.1016/0006-8993(79)91018-7 |
0.357 |
|
| 1979 |
Schwarcz R, Fuxe K. 3H-kainic acid binding: relevance for evaluating the neurotoxicity of kainic acid. Life Sciences. 24: 1471-80. PMID 470546 DOI: 10.1016/0024-3205(79)90030-4 |
0.363 |
|
| 1979 |
Coyle JT, Schwarcz R, Bennett JP, Campochiaro P. Clinical, neuropathologic and pharmacologic aspects of Huntington's disease: correlates with a new animal model. Progress in Neuro-Psychopharmacology. 1: 13-30. PMID 214805 DOI: 10.1016/0364-7722(77)90025-X |
0.381 |
|
| 1979 |
Sieghart W, Forn J, Schwarcz R, Coyle JT, Greengard P. Neuronal localization of specific brain phosphoproteins. Brain Research. 156: 345-50. PMID 213165 DOI: 10.1016/0006-8993(78)90516-4 |
0.348 |
|
| 1979 |
Tjörnhammar ML, Schwarcz R, Bartfai T, Fuxe K. Guanylate cyclase activity increases after kainic acid lesion of rat striatum. Brain Research. 171: 567-72. PMID 38884 DOI: 10.1016/0006-8993(79)91064-3 |
0.37 |
|
| 1979 |
Schwarcz R, Fuxe K, Agnati LF, Hökfelt T, Coyle JT. Rotational behaviour in rats with unilateral striatal kainic acid lesions: a behavioural model for studies on intact dopamine receptors. Brain Research. 170: 485-95. PMID 37986 DOI: 10.1016/0006-8993(79)90966-1 |
0.366 |
|
| 1978 |
Campochiaro P, Schwarcz R, Coyle JT. GABA receptor binding in rat striatum: localization and effects of denervation. Brain Research. 136: 501-11. PMID 922498 DOI: 10.1016/0006-8993(77)90074-9 |
0.322 |
|
| 1978 |
Schwarcz R, Zaczek R, Coyle JT. Microinjection of kainic acid into the rat hippocampus. European Journal of Pharmacology. 50: 209-20. PMID 689077 DOI: 10.1016/0014-2999(78)90353-9 |
0.423 |
|
| 1978 |
Hruska RE, Schwarcz R, Coyle JT, Yamamura HI. Alterations of muscarinic cholinergic receptors in the rat striatum after kainic acid injections. Brain Research. 152: 620-5. PMID 687979 DOI: 10.1016/0006-8993(78)91120-4 |
0.41 |
|
| 1978 |
Schwarcz R, Scholz D, Coyle JT. Structure-activity relations for the neurotoxicity of kainic acid derivatives and glutamate analogues. Neuropharmacology. 17: 145-51. PMID 634450 DOI: 10.1016/0028-3908(78)90127-2 |
0.359 |
|
| 1978 |
Schwarcz R, Creese I, Coyle JT, Snyder SH. Dopamine receptors localised on cerebral cortical afferents to rat corpus striatum. Nature. 271: 766-8. PMID 625348 DOI: 10.1038/271766a0 |
0.32 |
|
| 1977 |
Schwarcz R, Bennett JP, Coyle JT. Loss of striatal serotonin synaptic receptor binding induced by kainic acid lesions: correlations with Huntington's Disease. Journal of Neurochemistry. 28: 867-9. PMID 142820 DOI: 10.1111/J.1471-4159.1977.Tb10641.X |
0.341 |
|
| 1977 |
Schwarcz R, Coyle JT. Striatal lesions with kainic acid: neurochemical characteristics. Brain Research. 127: 235-49. PMID 16686 DOI: 10.1016/0006-8993(77)90538-8 |
0.419 |
|
| 1977 |
Schwarcz R, Coyle JT. Neurochemical sequelae of kainate injections in corpus striatum and substantia nigra of the rat. Life Sciences. 20: 431-6. PMID 14287 DOI: 10.1016/0024-3205(77)90384-8 |
0.4 |
|
| 1976 |
Coyle JT, Schwarcz R. Lesion of striatal neurones with kainic acid provides a model for Huntington's chorea. Nature. 263: 244-6. PMID 8731 DOI: 10.1038/263244a0 |
0.4 |
|
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