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Roman Alexander Melnyk - Publications

Affiliations: 
2004 Hospital for Sick Children, Toronto, ON 
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26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lim S, Khoo R, Peh KM, Teo J, Chang SC, Ng S, Beilhartz GL, Melnyk RA, Johannes CW, Brown CJ, Lane DP, Henry B, Partridge AW. bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA). Proceedings of the National Academy of Sciences of the United States of America. PMID 32123106 DOI: 10.1073/Pnas.1920251117  0.628
2018 Orrell KE, Tellgren-Roth Å, Di Bernardo M, Zhang Z, Cuviello F, Lundqvist J, von Heijne G, Nilsson I, Melnyk RA. Direct detection of membrane-inserting fragments defines the translocation pores of a family of pathogenic toxins. Journal of Molecular Biology. PMID 29990469 DOI: 10.1016/j.jmb.2018.07.001  0.364
2017 Orrell KE, Zhang Z, Sugiman-Marangos SN, Melnyk RA. Clostridium difficile toxins A and B: Receptors, pores, and translocation into cells. Critical Reviews in Biochemistry and Molecular Biology. 1-13. PMID 28545305 DOI: 10.1080/10409238.2017.1325831  0.308
2016 Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB. Crystal structure of Clostridium difficile toxin A. Nature Microbiology. 1: 15002. PMID 27571750 DOI: 10.1038/Nmicrobiol.2015.2  0.302
2016 Chumbler NM, Rutherford SA, Zhang Z, Farrow MA, Lisher JP, Farquhar E, Giedroc DP, Spiller BW, Melnyk RA, Lacy DB. Crystal structure of Clostridium difficile toxin A. Nature Microbiology. 1. PMID 27512603 DOI: 10.1038/nmicrobiol.2015.2  0.302
2014 Zhang Z, Park M, Tam J, Auger A, Beilhartz GL, Lacy DB, Melnyk RA. Translocation domain mutations affecting cellular toxicity identify the Clostridium difficile toxin B pore. Proceedings of the National Academy of Sciences of the United States of America. 111: 3721-6. PMID 24567384 DOI: 10.1073/Pnas.1400680111  0.361
2012 Lam V, Henault M, Khougaz K, Fortin LJ, Ouellet M, Melnyk R, Partridge A. Resorufin butyrate as a soluble and monomeric high-throughput substrate for a triglyceride lipase. Journal of Biomolecular Screening. 17: 245-51. PMID 21956174 DOI: 10.1177/1087057111422944  0.625
2011 Tam J, Henault M, Li L, Wang Z, Partridge AW, Melnyk RA. An activity-based probe for high-throughput measurements of triacylglycerol lipases. Analytical Biochemistry. 414: 254-60. PMID 21397586 DOI: 10.1016/J.Ab.2011.03.008  0.643
2007 Wimalasena DS, Cramer JC, Janowiak BE, Juris SJ, Melnyk RA, Anderson DE, Kirk KL, Collier RJ, Bann JG. Effect of 2-fluorohistidine labeling of the anthrax protective antigen on stability, pore formation, and translocation. Biochemistry. 46: 14928-36. PMID 18044973 DOI: 10.1021/Bi701763Z  0.52
2007 Juris SJ, Melnyk RA, Bolcome RE, Chan J, Collier RJ. Cross-linked forms of the isolated N-terminal domain of the lethal factor are potent inhibitors of anthrax toxin. Infection and Immunity. 75: 5052-8. PMID 17635861 DOI: 10.1128/Iai.00490-07  0.526
2006 Johnson RM, Rath A, Melnyk RA, Deber CM. Lipid solvation effects contribute to the affinity of Gly-xxx-Gly motif-mediated helix-helix interactions. Biochemistry. 45: 8507-15. PMID 16834324 DOI: 10.1021/Bi060063F  0.609
2006 Melnyk RA, Collier RJ. A loop network within the anthrax toxin pore positions the phenylalanine clamp in an active conformation. Proceedings of the National Academy of Sciences of the United States of America. 103: 9802-7. PMID 16785422 DOI: 10.1073/pnas.0604000103  0.553
2006 Go MY, Kim S, Partridge AW, Melnyk RA, Rath A, Deber CM, Mogridge J. Self-association of the transmembrane domain of an anthrax toxin receptor. Journal of Molecular Biology. 360: 145-56. PMID 16756998 DOI: 10.1016/J.Jmb.2006.04.072  0.732
2006 Rath A, Melnyk RA, Deber CM. Evidence for assembly of small multidrug resistance proteins by a "two-faced" transmembrane helix. The Journal of Biological Chemistry. 281: 15546-53. PMID 16574656 DOI: 10.1074/Jbc.M600434200  0.588
2006 Melnyk RA, Hewitt KM, Lacy DB, Lin HC, Gessner CR, Li S, Woods VL, Collier RJ. Structural determinants for the binding of anthrax lethal factor to oligomeric protective antigen. The Journal of Biological Chemistry. 281: 1630-5. PMID 16293620 DOI: 10.1074/Jbc.M511164200  0.539
2005 Lacy DB, Lin HC, Melnyk RA, Schueler-Furman O, Reither L, Cunningham K, Baker D, Collier RJ. A model of anthrax toxin lethal factor bound to protective antigen. Proceedings of the National Academy of Sciences of the United States of America. 102: 16409-14. PMID 16251269 DOI: 10.1073/Pnas.0508259102  0.52
2005 Krantz BA, Melnyk RA, Zhang S, Juris SJ, Lacy DB, Wu Z, Finkelstein A, Collier RJ. A phenylalanine clamp catalyzes protein translocation through the anthrax toxin pore. Science (New York, N.Y.). 309: 777-81. PMID 16051798 DOI: 10.1126/Science.1113380  0.72
2005 Christensen KA, Krantz BA, Melnyk RA, Collier RJ. Interaction of the 20 kDa and 63 kDa fragments of anthrax protective antigen: kinetics and thermodynamics. Biochemistry. 44: 1047-53. PMID 15654761 DOI: 10.1021/Bi047791S  0.664
2004 Lacy DB, Wigelsworth DJ, Melnyk RA, Harrison SC, Collier RJ. Structure of heptameric protective antigen bound to an anthrax toxin receptor: a role for receptor in pH-dependent pore formation. Proceedings of the National Academy of Sciences of the United States of America. 101: 13147-51. PMID 15326297 DOI: 10.1073/Pnas.0405405101  0.445
2004 Melnyk RA, Kim S, Curran AR, Engelman DM, Bowie JU, Deber CM. The affinity of GXXXG motifs in transmembrane helix-helix interactions is modulated by long-range communication. The Journal of Biological Chemistry. 279: 16591-7. PMID 14766751 DOI: 10.1074/Jbc.M313936200  0.634
2003 Melnyk RA, Partridge AW, Yip J, Wu Y, Goto NK, Deber CM. Polar residue tagging of transmembrane peptides. Biopolymers. 71: 675-85. PMID 14991677 DOI: 10.1002/Bip.10595  0.759
2003 Dawson JP, Melnyk RA, Deber CM, Engelman DM. Sequence context strongly modulates association of polar residues in transmembrane helices. Journal of Molecular Biology. 331: 255-62. PMID 12875850 DOI: 10.1016/S0022-2836(03)00714-9  0.595
2003 Maeda M, Melnyk RA, Partridge AW, Liu LP, Deber CM. Transmembrane segment peptides with double D-amino acid replacements: helicity, hydrophobicity, and antimicrobial activity. Biopolymers. 71: 77-84. PMID 12712502 DOI: 10.1002/Bip.10383  0.724
2003 Partridge AW, Melnyk RA, Yang D, Bowie JU, Deber CM. A transmembrane segment mimic derived from Escherichia coli diacylglycerol kinase inhibits protein activity Journal of Biological Chemistry. 278: 22056-22060. PMID 12686537 DOI: 10.1074/Jbc.M210685200  0.751
2002 Partridge AW, Melnyk RA, Deber CM. Polar residues in membrane domains of proteins: molecular basis for helix-helix association in a mutant CFTR transmembrane segment. Biochemistry. 41: 3647-53. PMID 11888281 DOI: 10.1021/Bi0120502  0.744
2002 Melnyk RA, Partridge AW, Deber CM. Transmembrane domain mediated self-assembly of major coat protein subunits from Ff bacteriophage. Journal of Molecular Biology. 315: 63-72. PMID 11771966 DOI: 10.1006/Jmbi.2001.5214  0.769
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