Isabelle Aubert - Publications

Affiliations: 
Laboratory Medicine and Pathobiology University of Toronto, Toronto, ON, Canada 

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Weber-Adrian D, Kofoed RH, Chan JWY, Silburt J, Noroozian Z, Kügler S, Hynynen K, Aubert I. Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease. Theranostics. 9: 8127-8137. PMID 31754385 DOI: 10.7150/thno.36718  1
2019 Abrahao A, Meng Y, Llinas M, Huang Y, Hamani C, Mainprize T, Aubert I, Heyn C, Black SE, Hynynen K, Lipsman N, Zinman L. First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound. Nature Communications. 10: 4373. PMID 31558719 DOI: 10.1038/s41467-019-12426-9  1
2019 Meng Y, Abrahao A, Heyn CC, Bethune AJ, Huang Y, Pople C, Aubert I, Hamani C, Zinman L, Hynynen K, Black SE, Lipsman N. Glymphatics visualization after focused ultrasound induced blood-brain barrier opening in humans. Annals of Neurology. PMID 31525269 DOI: 10.1002/ana.25604  1
2019 Noroozian Z, Xhima K, Huang Y, Kaspar BK, Kügler S, Hynynen K, Aubert I. MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain. Methods in Molecular Biology (Clifton, N.J.). 1950: 177-197. PMID 30783974 DOI: 10.1007/978-1-4939-9139-6_10  1
2018 Vecchio LM, Meng Y, Xhima K, Lipsman N, Hamani C, Aubert I. The Neuroprotective Effects of Exercise: Maintaining a Healthy Brain Throughout Aging. Brain Plasticity (Amsterdam, Netherlands). 4: 17-52. PMID 30564545 DOI: 10.3233/BPL-180069  0.68
2018 Xhima K, Nabbouh F, Hynynen K, Aubert I, Tandon A. Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 30264465 DOI: 10.1002/mds.101  1
2018 Poon CT, Shah K, Lin C, Tse R, Kim KK, Mooney S, Aubert I, Stefanovic B, Hynynen K. Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer's disease. Scientific Reports. 8: 14061. PMID 30232364 DOI: 10.1038/s41598-018-32250-3  1
2018 Lipsman N, Meng Y, Bethune AJ, Huang Y, Lam B, Masellis M, Herrmann N, Heyn C, Aubert I, Boutet A, Smith GS, Hynynen K, Black SE. Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound. Nature Communications. 9: 2336. PMID 30046032 DOI: 10.1038/s41467-018-04529-6  1
2017 Liu M, Jevtic S, Markham-Coultes K, Ellens NPK, O'Reilly MA, Hynynen K, Aubert I, McLaurin J. Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer's disease. Brain Research. PMID 29066368 DOI: 10.1016/j.brainres.2017.10.015  1
2017 Silburt J, Lipsman N, Aubert I. Disrupting the blood-brain barrier with focused ultrasound: Perspectives on inflammation and regeneration. Proceedings of the National Academy of Sciences of the United States of America. PMID 28798067 DOI: 10.1073/pnas.1710761114  0.76
2016 Weber-Adrian D, Heinen S, Silburt J, Noroozian Z, Aubert I. The human brain endothelial barrier: transcytosis of AAV9, transduction by AAV2: An Editorial Highlight for 'Trafficking of adeno-associated virus vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells'. Journal of Neurochemistry. PMID 27976378 DOI: 10.1111/jnc.13898  0.76
2016 Morrone CD, Thomason LA, Brown ME, Aubert I, McLaurin J. Effects of Neurotrophic Support and Amyloid-Targeted Combined Therapy on Adult Hippocampal Neurogenesis in a Transgenic Model of Alzheimer's Disease. Plos One. 11: e0165393. PMID 27768761 DOI: 10.1371/journal.pone.0165393  0.64
2016 Mooney SJ, Shah K, Yeung S, Burgess A, Aubert I, Hynynen K. Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability. Plos One. 11: e0159892. PMID 27459643 DOI: 10.1371/journal.pone.0159892  1
2016 Maliszewska-Cyna E, Xhima K, Aubert I. A Comparative Study Evaluating the Impact of Physical Exercise on Disease Progression in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 27163797 DOI: 10.3233/JAD-150660  0.68
2015 Nagy PM, Aubert I. Overexpression of the vesicular acetylcholine transporter enhances dendritic complexity of adult-born hippocampal neurons and improves acquisition of spatial memory during aging. Neurobiology of Aging. 36: 1881-9. PMID 25813545 DOI: 10.1016/j.neurobiolaging.2015.02.021  1
2015 Weber-Adrian D, Thévenot E, O'Reilly MA, Oakden W, Akens MK, Ellens N, Markham-Coultes K, Burgess A, Finkelstein J, Yee AJ, Whyne CM, Foust KD, Kaspar BK, Stanisz GJ, Chopra R, ... ... Aubert I, et al. Gene delivery to the spinal cord using MRI-guided focused ultrasound. Gene Therapy. 22: 568-77. PMID 25781651 DOI: 10.1038/gt.2015.25  1
2014 Burgess A, Dubey S, Yeung S, Hough O, Eterman N, Aubert I, Hynynen K. Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior. Radiology. 273: 736-45. PMID 25222068 DOI: 10.1148/radiol.14140245  1
2014 Oakden W, Kwiecien JM, O'Reilly MA, Lake EM, Akens MK, Aubert I, Whyne C, Finkelstein J, Hynynen K, Stanisz GJ. A non-surgical model of cervical spinal cord injury induced with focused ultrasound and microbubbles. Journal of Neuroscience Methods. 235: 92-100. PMID 24970578 DOI: 10.1016/j.jneumeth.2014.06.018  1
2014 Scarcelli T, Jordão JF, O'Reilly MA, Ellens N, Hynynen K, Aubert I. Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice. Brain Stimulation. 7: 304-7. PMID 24629831 DOI: 10.1016/j.brs.2013.12.012  1
2014 Kanemoto S, Griffin J, Markham-Coultes K, Aubert I, Tandon A, George-Hyslop PS, Fraser PE. Proliferation, differentiation and amyloid-β production in neural progenitor cells isolated from TgCRND8 mice. Neuroscience. 261: 52-9. PMID 24361736 DOI: 10.1016/j.neuroscience.2013.12.021  1
2013 Nagy PM, Aubert I. B6eGFPChAT mice overexpressing the vesicular acetylcholine transporter exhibit spontaneous hypoactivity and enhanced exploration in novel environments. Brain and Behavior. 3: 367-83. PMID 24381809 DOI: 10.1002/brb3.139  1
2013 Jordão JF, Thévenot E, Markham-Coultes K, Scarcelli T, Weng YQ, Xhima K, O'Reilly M, Huang Y, McLaurin J, Hynynen K, Aubert I. Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound. Experimental Neurology. 248: 16-29. PMID 23707300 DOI: 10.1016/j.expneurol.2013.05.008  1
2013 Veloso AJ, Nagy PM, Zhang B, Dhar D, Liang A, Ibrahim T, Mikhaylichenko S, Aubert I, Kerman K. Miniaturized electrochemical system for cholinesterase inhibitor detection. Analytica Chimica Acta. 774: 73-8. PMID 23567119 DOI: 10.1016/j.aca.2013.02.033  1
2013 Burgess A, Eterman N, Aubert I, Hynynen K. Two-photon microscopy for real-time monitoring of focused ultrasoundmediated drug delivery to the brain in a mouse model of Alzheimer's disease Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8588. DOI: 10.1117/12.2002124  1
2012 Thévenot E, Jordão JF, O'Reilly MA, Markham K, Weng YQ, Foust KD, Kaspar BK, Hynynen K, Aubert I. Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound. Human Gene Therapy. 23: 1144-55. PMID 22838844 DOI: 10.1089/hum.2012.013  1
2012 Girão da Cruz MT, Jordão J, Dasilva KA, Ayala-Grosso CA, Ypsilanti A, Weng YQ, Laferla FM, McLaurin J, Aubert I. Early increases in soluble amyloid-β levels coincide with cholinergic degeneration in 3xTg-AD mice. Journal of Alzheimer's Disease : Jad. 32: 267-72. PMID 22776965 DOI: 10.3233/JAD-2012-100732  0.64
2012 Lu F, Li YQ, Aubert I, Wong CS. Endothelial cells regulate p53-dependent apoptosis of neural progenitors after irradiation. Cell Death & Disease. 3: e324. PMID 22717579 DOI: 10.1038/cddis.2012.59  1
2012 Nagy PM, Aubert I. Overexpression of the vesicular acetylcholine transporter increased acetylcholine release in the hippocampus. Neuroscience. 218: 1-11. PMID 22641085 DOI: 10.1016/j.neuroscience.2012.05.047  1
2012 Krantic S, Isorce N, Mechawar N, Davoli MA, Vignault E, Albuquerque M, Chabot JG, Moyse E, Chauvin JP, Aubert I, McLaurin J, Quirion R. Hippocampal GABAergic neurons are susceptible to amyloid-β toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model. Journal of Alzheimer's Disease : Jad. 29: 293-308. PMID 22232004 DOI: 10.3233/JAD-2011-110830  1
2011 Burgess A, Aubert I, Hynynen K. Focused ultrasound: crossing barriers to treat Alzheimer's disease. Therapeutic Delivery. 2: 281-6. PMID 22833998 DOI: 10.4155/tde.11.5  1
2011 Cui X, Weng YQ, Frappé I, Burgess A, Girão da Cruz MT, Schachner M, Aubert I. The cell adhesion molecule L1 regulates the expression of choline acetyltransferase and the development of septal cholinergic neurons. Brain and Behavior. 1: 73-86. PMID 22399087 DOI: 10.1002/brb3.15  1
2011 Burgess A, Ayala-Grosso CA, Ganguly M, Jordão JF, Aubert I, Hynynen K. Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier. Plos One. 6: e27877. PMID 22114718 DOI: 10.1371/journal.pone.0027877  1
2011 Fenili D, Weng YQ, Aubert I, Nitz M, McLaurin J. Sodium/myo-Inositol transporters: substrate transport requirements and regional brain expression in the TgCRND8 mouse model of amyloid pathology. Plos One. 6: e24032. PMID 21887366 DOI: 10.1371/journal.pone.0024032  1
2011 Visanji NP, Wislet-Gendebien S, Oschipok LW, Zhang G, Aubert I, Fraser PE, Tandon A. Effect of Ser-129 phosphorylation on interaction of α-synuclein with synaptic and cellular membranes. The Journal of Biological Chemistry. 286: 35863-73. PMID 21849493 DOI: 10.1074/jbc.M111.253450  1
2011 Burgess A, Ayala-Grosso CA, Ganguly M, Jordão J, Aubert I, Hynynen K. Delivery of stem cells to the brain using MRIgFUS Ieee International Ultrasonics Symposium, Ius. 13-16. DOI: 10.1109/ULTSYM.2011.0004  1
2010 Li YQ, Aubert I, Wong CS. Abrogation of early apoptosis does not alter late inhibition of hippocampal neurogenesis after irradiation. International Journal of Radiation Oncology, Biology, Physics. 77: 1213-22. PMID 20610042 DOI: 10.1016/j.ijrobp.2010.01.015  1
2010 Jordão JF, Ayala-Grosso CA, Markham K, Huang Y, Chopra R, McLaurin J, Hynynen K, Aubert I. Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease. Plos One. 5: e10549. PMID 20485502 DOI: 10.1371/journal.pone.0010549  1
2010 Park KJ, Grosso CA, Aubert I, Kaplan DR, Miller FD. p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain. Nature Neuroscience. 13: 559-66. PMID 20348920 DOI: 10.1038/nn.2513  1
2010 Wu KL, Li YQ, Tabassum A, Lu WY, Aubert I, Wong CS. Loss of neuronal protein expression in mouse hippocampus after irradiation. Journal of Neuropathology and Experimental Neurology. 69: 272-80. PMID 20142763 DOI: 10.1097/NEN.0b013e3181d1afe4  1
2010 Shihabuddin LS, Aubert I. Stem cell transplantation for neurometabolic and neurodegenerative diseases. Neuropharmacology. 58: 845-54. PMID 20036262 DOI: 10.1016/j.neuropharm.2009.12.015  1
2009 Nagra G, Koh L, Aubert I, Kim M, Johnston M. Intraventricular injection of antibodies to beta1-integrins generates pressure gradients in the brain favoring hydrocephalus development in rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 297: R1312-21. PMID 19726708 DOI: 10.1152/ajpregu.00307.2009  1
2009 Burgess A, Saini S, Weng YQ, Aubert I. Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand. Journal of Neuroscience Research. 87: 609-16. PMID 18855942 DOI: 10.1002/jnr.21888  1
2009 Jordao JF, Ayala-Grosso CA, Chopra R, McLaurin J, Aubert I, Hynynena K. Ultrasound delivery of an anti-Aβ therapeutic agent to the brain in a mouse model of Alzheimer's disease Aip Conference Proceedings. 1113: 428-432. DOI: 10.1063/1.3131464  1
2008 Burgess A, Wainwright SR, Shihabuddin LS, Rutishauser U, Seki T, Aubert I. Polysialic acid regulates the clustering, migration, and neuronal differentiation of progenitor cells in the adult hippocampus. Developmental Neurobiology. 68: 1580-90. PMID 18844212 DOI: 10.1002/dneu.20681  1
2008 Ypsilanti AR, Girão da Cruz MT, Burgess A, Aubert I. The length of hippocampal cholinergic fibers is reduced in the aging brain. Neurobiology of Aging. 29: 1666-79. PMID 17507114 DOI: 10.1016/j.neurobiolaging.2007.04.001  1
2007 Burgess A, Weng YQ, Ypsilanti AR, Cui X, Caines G, Aubert I. Polysialic acid limits septal neurite outgrowth on laminin. Brain Research. 1144: 52-8. PMID 17335782 DOI: 10.1016/j.brainres.2007.01.072  1
2006 Dasilva KA, Aubert I, McLaurin J. Vaccine development for Alzheimer's disease. Current Pharmaceutical Design. 12: 4283-93. PMID 17105428 DOI: 10.2174/138161206778793001  1
2006 Burgess A, Aubert I. Polysialic acid limits choline acetyltransferase activity induced by brain-derived neurotrophic factor. Journal of Neurochemistry. 99: 797-806. PMID 16903870 DOI: 10.1111/j.1471-4159.2006.04110.x  1
2004 Frappé I, Wang C, Caines G, Rideout-Gros S, Aubert I. Cell adhesion molecule L1 promotes neurite outgrowth of septal neurons. Journal of Neuroscience Research. 75: 667-77. PMID 14991842 DOI: 10.1002/jnr.20026  1
1998 Aubert I, Ridet JL, Schachner M, Rougon G, Gage FH. Expression of L1 and PSA during sprouting and regeneration in the adult hippocampal formation. The Journal of Comparative Neurology. 399: 1-19. PMID 9725697 DOI: 10.1002/(SICI)1096-9861(19980914)399:1<1::AID-CNE1>3.0.CO;2-5  1
1998 Dickinson-Anson H, Aubert I, Gage FH, Fisher LJ. Hippocampal grafts of acetylcholine-producing cells are sufficient to improve behavioural performance following a unilateral fimbria-fornix lesion. Neuroscience. 84: 771-81. PMID 9579782 DOI: 10.1016/S0306-4522(97)00543-5  1
1997 Gage FH, Bloemer U, Aubert I, Suhr S, Homer P, Senut MC, Palmer T, Ray J. Gene and cell transfer to the damaged adult brain Faseb Journal. 11: A862.  1
1996 Le Jeune H, Aubert I, Jourdan F, Quirion R. Developmental profiles of various cholinergic markers in the rat main olfactory bulb using quantitative autoradiography. The Journal of Comparative Neurology. 373: 433-50. PMID 8889937 DOI: 10.1002/(SICI)1096-9861(19960923)373:3<433::AID-CNE8>3.0.CO;2-3  1
1996 Aubert I, Cécyre D, Gauthier S, Quirion R. Comparative ontogenic profile of cholinergic markers, including nicotinic and muscarinic receptors, in the rat brain. The Journal of Comparative Neurology. 369: 31-55. PMID 8723701 DOI: 10.1002/(SICI)1096-9861(19960520)369:1<31::AID-CNE3>3.0.CO;2-L  1
1995 Poirier J, Delisle MC, Quirion R, Aubert I, Farlow M, Lahiri D, Hui S, Bertrand P, Nalbantoglu J, Gilfix BM, Gauthier S. Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 92: 12260-4. PMID 8618881 DOI: 10.1073/pnas.92.26.12260  1
1995 Aubert I, Ridet JL, Gage FH. Regeneration in the adult mammalian CNS: guided by development. Current Opinion in Neurobiology. 5: 625-35. PMID 8580714 DOI: 10.1016/0959-4388(95)80068-9  1
1995 Le Jeune H, Aubert I, Jourdan F, Quirion R. Comparative laminar distribution of various autoradiographic cholinergic markers in adult rat main olfactory bulb. Journal of Chemical Neuroanatomy. 9: 99-112. PMID 8561953 DOI: 10.1016/0891-0618(95)00070-N  1
1995 Quirion R, Wilson A, Rowe W, Aubert I, Richard J, Doods H, Parent A, White N, Meaney MJ. Facilitation of acetylcholine release and cognitive performance by an M(2)-muscarinic receptor antagonist in aged memory-impaired. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 1455-62. PMID 7869110  1
1995 Aubert I, Rowe W, Meaney MJ, Gauthier S, Quirion R. Cholinergic markers in aged cognitively impaired Long-Evans rats. Neuroscience. 67: 277-92. PMID 7675169 DOI: 10.1016/0306-4522(95)00056-O  1
1994 Aubert I, Poirier J, Gauthier S, Quirion R. Multiple cholinergic markers are unexpectedly not altered in the rat dentate gyrus following entorhinal cortex lesions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 2476-84. PMID 8182423  1
1993 Quirion R, Aubert I, Araujo DM, Hersi A, Gaudreau P. Autoradiographic distribution of putative muscarinic receptor sub-types in mammalian brain. Progress in Brain Research. 98: 85-93. PMID 8248541  1
1992 Aubert I, Araujo DM, Cécyre D, Robitaille Y, Gauthier S, Quirion R. Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer's and Parkinson's diseases. Journal of Neurochemistry. 58: 529-41. PMID 1729398  1
1992 Aubert I, Cécyre D, Gauthier S, Quirion R. Characterization and autoradiographic distribution of [3H]AF-DX 384 binding to putative muscarinic M2 receptors in the rat brain. European Journal of Pharmacology. 217: 173-84. PMID 1425938 DOI: 10.1016/0014-2999(92)90843-S  1
1990 Quirion R, Aubert I, Robitaille Y, Gauthier S, Araujo DM, Chabot JG. Neurochemical deficits in pathological brain aging: specificity and possible relevance for treatment strategies. Clinical Neuropharmacology. 13: S73-80. PMID 2093419  1
1989 Quirion R, Aubert I, Lapchak PA, Schaum RP, Teolis S, Gauthier S, Araujo DM. Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease. Trends in Pharmacological Sciences. 80-4. PMID 2694529  1
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