Elizabeth B. Lynch, Ph.D. - US grants
Affiliations: | 2000 | Northwestern University, Evanston, IL |
Area:
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The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
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High-probability grants
According to our matching algorithm, Elizabeth B. Lynch is the likely recipient of the following grants.Years | Recipients | Code | Title / Keywords | Matching score |
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2008 | Lynch, Elizabeth B | R34Activity Code Description: To provide support for the initial development of a clinical trial or research project, including the establishment of the research team; the development of tools for data management and oversight of the research; the development of a trial design or experimental research designs and other essential elements of the study or project, such as the protocol, recruitment strategies, procedure manuals and collection of feasibility data. |
Self-Management in African Americans With Diabetes and Hypertension @ Rush University Medical Center [unreadable] DESCRIPTION (provided by applicant): Little data exists that addresses success in lifestyle change for African-Americans living with diabetes and co- morbid hypertension, who represent a high risk group with multiple adherence challenges related to lifestyle and medical management. African-Americans are more likely to develop complications related these co-morbid conditions, such as retinopathy, nephropathy, and lower-extremity amputations. This increased burden of disease is partly due to poor management of patient initiated risk factors which include lack of exercise, being overweight or obese, and poor dietary practices. Effective management of comorbid Diabetes and Hyper- tension involves initiating and sustaining complex behavioral changes to accommodate the large number of lifestyle modification recommendations that both conditions require. African-Americans are less likely to engage in self-management behaviors known to improve outcomes related to hypertension and diabetes and are in need of interventions that improve self-management. Peer-led interventions have shown moderate success at influencing self-efficacy, caloric intake, and physical activity and hold promise for future development. The primary aims of the proposal are 1) to design a group-based, culturally appropriate self- management skills training intervention for disadvantaged African-Americans with both diabetes and hypertension and to compile an intervention Manual of Operations (MOO);2) to recruit and train peer leaders to deliver the self-management skills training intervention; 3) to determine, in this population, whether the addition of a culturally sensitive, peer-led self-management skills training intervention, added to standard diabetes education, can achieve an improvement in self-efficacy at adherence that is 1 standard deviation greater than that achieved by standard diabetes education alone at one year; to determine, in this disadvantaged population, whether the addition of a culturally sensitive, peer-led self-management skills training intervention, added to standard diabetes education, can achieve a 35% greater improvement in adherence to relevant risk factor recommendations than that achieved by standard diabetes education alone at one year. The relevant risk factor goals are physical activity, dietary goals of <2400 mg. of salt/day and 45-65% intake of carbohydrates/ day; weight reduction goal of >5% of baseline weight. The pilot study will also help to determine the key elements needed to calculate sample size for a larger trial. The results of this pilot work will be used to plan a large-scale behavioral clinical trial to initiate, maintain, and sustain necessary self-management behaviors in this important, underserved population. Public health impact: Findings from this study and future studies of the same can help identify cost-effective, culturally effective ways to help African-Americans who have both diabetes and hypertension to approach and make lifestyle changes that will make them healthier. Little data exists that addresses success in lifestyle change for African-Americans living with diabetes and co-morbid hypertension, who represent a high risk group with multiple adherence challenges related to lifestyle and medical management. This increased burden of disease is partly due to poor management of patient initiated risk factors which include lack of exercise, being overweight or obese, and poor dietary practices. Effective management of co-morbid Diabetes and Hypertension involves initiating and sustaining complex behavioral changes to accommodate the large number of lifestyle modification recommendations that both conditions require. African-Americans are less likely to engage in self-management behaviors known to improve outcomes related to hypertension and diabetes and are in need of interventions that improve self- management. Peer-led interventions have shown moderate success at influencing self-efficacy, caloric intake, and physical activity and hold promise for future development. The step proposed to be taken in this grant application will draw on the support that does exist for the use of peer educators and, in hopes of strengthening treatment effects, will draw on the proven strategy of frequent, intensive contacts and highly organized training to promote a beneficial treatment outcome in this difficult to reach sample of underserved minority patients living with co-morbid diabetes and hypertension. [unreadable] [unreadable] |
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2011 — 2015 | Lynch, Elizabeth B | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
The Life Program: a Behavioral Approach to Glycemic Control in African Americans @ Rush University Medical Center DESCRIPTION (provided by applicant): African Americans experience rates of diabetes complications and hospitalization which are between 1.5 and 4 times greater than white patients. Glycemic control reduces risk of diabetes complications and hospitalization, and can be improved through medication as well as lifestyle changes. No trial of lifestyle has achieved sustained improvements in glycemic control in low-income African Americans. This project is a randomized controlled trial to test an innovative lifestyle intervention to achieve sustained improvements in glycemic control among low-income African American diabetes patients. The LIFE (Lifestyle Improvement through Food and Exercise) program is a diabetes self-management program focused on diet and exercise, informed by anthropological research on models of food and health among low-income African-Americans. Pilot work demonstrated that the LIFE Program is effective in improving glycemic control among low-income African Americans at 6-months. The main goal of the current study is to determine whether the LIFE Program can achieve sustained improvements in glycemic control for 12 months. The trial will randomize low-income African American adults with diabetes to a control group, which receives standard diabetes education, or an intervention group, which receives the LIFE Program, featuring a 6-month intervention (20 group meetings with peer support telephone calls) followed by an 18-month maintenance phase (monthly peer support phone calls and quarterly group sessions). The primary aim of the proposed research is to compare low-income African American diabetes patients receiving the LIFE Program with those in a standard of care control group on change in glycemic control at 12 months. Our primary hypothesis is that patients in the intervention group will achieve a change in A1c from baseline that is less than patients in the control group. Secondary aims are to compare low-income African American diabetes patients receiving the LIFE Program with those in a standard of care control group on (a) change in glycemic control at 24 months; (b) change in physical activity and total energy intake at 12 months; (c) change in physical activity and total energy intake at 24 months; and (d) to obtain estimates needed for a subsequent trial, including weight, blood pressure, and diabetes-related hospitalizations. For secondary aims we hypothesize that a) the intervention group will achieve a mean 24- month change in A1C that is less than the change in the control group; b) at 12 months, a greater proportion of intervention patients will have achieved the activity goal of 150 minutes of moderate activity per week, and the intervention group will achieve a greater reduction from baseline in mean total energy intake than the control group; and c) at 24 months, a greater proportion of intervention patients will have achieved the activity goal of 150 minutes of moderate activity per week, and the intervention group will achieve a greater reduction from baseline in mean total energy intake than the control group. |
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2013 — 2015 | Lynch, Elizabeth B | R24Activity Code Description: Undocumented code - click on the grant title for more information. |
Partnership For Congregational Wellness @ Rush University Medical Center DESCRIPTION (provided by applicant): Black-white health disparities in cardiopulmonary diseases can be reduced by behavioral interventions to improve diet and increase physical activity in African Americans. African Americans have experienced reduced benefit from behavioral interventions due to lack of cultural tailoring and mistrust of medical research. Church-based interventions have the potential to overcome these barriers and have had success in improving diet and activity. Using a community-based participatory research (CBPR) approach may increase engagement in intervention among church leaders and result in greater effectiveness. The Rush Clergy Health Partnership is a CBPR partnership which is optimally positioned to design, implement, and achieve successful results from a church-based behavioral intervention for African Americans. This Partnership is a university-community collaboration that was initiated by the community. It draws on an innovative train the trainer model where church leaders make lifestyle changes first and then are well-equipped to model and advocate for these changes in church peers. Aims of the project are to assess community needs, develop an intervention for the congregation, and test it in a preliminary pilot study. These goals will be accomplished through the following aims: 1) Collaboratively design and conduct a needs assessment, 2) identify the target condition of the intervention, 3) develop the intervention methodology by refining the existing Clergy/Lay Leader Lifestyle Programs, developing appropriate environmental-level strategies, and developing spiritually-based print materials, 4) develop a plan for collaborative oversight of data collection and sharing of interim data, 5) conduct a 12-month cluster randomized pilot study in which 6 churches are randomized to an intervention or a delayed intervention control arm, 6) assess the feasibility and acceptability of the intervention, 7) Develop and implement a dissemination plan, 8) evaluate the effectiveness of the collaboration process, and 9) Obtain estimates needed for subsequent trial and prepare grant proposal. RELEVANCE (See instructions): To reduce black-white health disparities, culturally-tailored interventions are needed to improve diet and increase physical activity in African Americans. In the proposed research, a partnership consisting of black pastors and researchers will collaboratively develop and design a pilot church-based behavioral intervention to improve lifestyle behaviors in African American church members. |
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2017 | Lynch, Elizabeth B | R56Activity Code Description: To provide limited interim research support based on the merit of a pending R01 application while applicant gathers additional data to revise a new or competing renewal application. This grant will underwrite highly meritorious applications that if given the opportunity to revise their application could meet IC recommended standards and would be missed opportunities if not funded. Interim funded ends when the applicant succeeds in obtaining an R01 or other competing award built on the R56 grant. These awards are not renewable. |
@ Rush University Medical Center Project Summary/Abstract Low-income African Americans suffer increased risk of cardiovascular disease and death due to high levels of cardiovascular (CVD) risk factors, such as hypertension, diabetes and obesity. Improving diet quality in African Americans could reduce black-white health disparities but dietary interventions have been less successful in African Americans than other groups. ALIVE is a culturally-tailored, church-based diet intervention designed by a partnership of researchers, African American pastors and congregants using a community-based participatory research methodology. The main components of the intervention include a Bible study to increase intrinsic motivation to eat healthier, paired with small group sessions focused on bui lding self-efficacy through nutrition education, cooking instruction and behavior change techniques. All intervention components are delivered by church members in 24 sessions over 9 months. The ALIVE Pilot study resulted in clinically and statistically significant improvements in vegetable consumption, as well as increased diet quality and reductions in weight and blood pressure. The goal of the proposed study is to conduct a 21 -month behavioral clusterrandomizedcontrolledtrialinwhichchurchesarerandomizedtooneoftwoarms:theinterventionarm, which receives ALIVE intervention in year 1 and Money Smart, a financial education intervention, in year 2, or the comparison arm, which receives the interventions in the reverse order. This study design ad dresses the needs of community partners while controlling for a number of possible confounders such as attention. The primary aim of the study is to assess the efficacy of the ALIVE intervention by comparing enrolled congregants from intervention and comparison churches on change in diet quality as measured by the Alternative Healthy Eating Index (AHEI). Secondary study aims are to evaluate the effect of the ALIVE intervention on plasma carotenoids and evaluate potential mediators of change in diet quality, including self-efficacy, intrinsic motivation, attitudes and subjective social norms for eating healthy. Exploratory aims of the study are to evaluatesustainabilityofchangeinAHEIscoreat12monthspost-interventionintheinterventionarm,evaluate the effect of the ALIVE intervention on changes in blood pressure, lipids, and adiposity, and assess the implementation and participant opportunity costs of the ALIVE intervention. The proposed study is the second phase of an integrated program of research aimed at reducing CVD mortality in African American adults. Phase one showed that the ALIVE intervention resulted in a clinically and statistically significant increase in vegetable consumption. Phase 2, the proposed study, will test whether we can expand this effect to overall diet quality among a larger number of churches and when compared to a control group. Phase 3 will be to conduct a larger trial to test the efficacy of this intervention in reducing blood pressure. |
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2020 — 2021 | Lynch, Elizabeth B | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Alive Blood Pressure Project: a Church-Based Intervention to Improve Blood Pressure @ Rush University Medical Center Hypertension is largely responsible for AAs living 5.5 fewer years than whites. Over half (55%) of AA adults now have hypertension and 45% have uncontrolled blood pressure (BP). Improving BP control in AAs is critical to improving health equity for AAs. A reduction of 10 mmHg in systolic BP is associated with 28% reduced risk of heart failure, 27% risk reduction for stroke, 20% for major cardiovascular events, 17% for coronary heart disease. Medication and diet change are the most effective strategies for reducing blood pressure, but adherence to both is especially low in AAs. Low trust, cultural preference for unhealthy foods, and logistical barriers due to poor access are underlying causes of poor adherence. Church-based interventions for individuals with uncontrolled BP have potential to increase adherence among AAs because the church is a trusted setting with strong social support. The proposed church-based intervention consists of a 9-month group-based Basic intervention for all participants, supplemented by a 3-month individualized CHW intervention for participants that do not achieve BP reduction milestones at 3 and 6 months. The Basic intervention is a culturally-tailored, group-based BP education intervention that consists of two components: a Bible study, led by the Pastor, to encourage a link between healthy lifestyle and spiritual values, and Behavior Change small groups, led by a trained church member, to promote behavior change strategies (education, goal-setting, self-monitoring, problem-solving). The CHW intervention consists of one-on-one meetings between participants and a CHW twice per month for 3-months, focused on addressing individual barriers to medication adherence and healthy diet. CHWs will also connect participants to community resources to address barriers, as needed. We propose to conduct a 24-month behavioral cluster randomized controlled trial in which 18 churches (n=342) are randomized to one of two arms. The intervention arm will receive the Alive BP intervention in the first year and Money Smart, a financial education intervention, in the second year. The comparator (control) arm will receive the two interventions in the reverse order. The primary aim is to compare African American church members with uncontrolled BP in the intervention churches with those in the comparator churches on mean change in systolic BP at 12 months. The secondary aim is to evaluate the effect of the intervention on diet quality, medication adherence, self-efficacy, intrinsic motivation, social support, knowledge, beliefs about medications, and barriers to medication use. An exploratory aim is to evaluate sustainability of change in SBP at 24 months post-intervention in the intervention arm. |
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2021 | Lynch, Elizabeth B | R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Alive Church Network: Increasing Covid-19 Testing in Chicago's African American Testing Deserts @ Rush University Medical Center ABSTRACT The epidemic of novel coronavirus disease 2019 (COVID-19) has caused an unprecedented public health crisis in the United States. African Americans (AA) have been disproportionately impacted, as systemic inequities have contributed to increased exposure and vulnerability to COVID-19. Evidence suggests that AAs are delaying testing and care for COVID-19, which increases risk of transmission and poor outcomes. In Chicago, segregated AA neighborhoods have experienced some of the highest COVID-19 mortality rates in the city, yet large portions of these neighborhoods remain testing deserts. Providing trusted, accessible, community-based testing in underserved AA communities is critical to ensuring that AAs receive an early diagnosis, thereby reducing the risk of further transmission and improving clinical outcomes. This study leverages the Alive Church Network (ACN), a long-standing, community-driven coalition of African American pastors and public health researchers that was developed as a sustainable infrastructure to address health inequities in chronic disease in segregated AA neighborhoods in Chicago. The ACN was designed to address lack of access to health care, cultural insensitivity, and lack of trust, which are the root cause of disparities in chronic disease as well as infectious disease, including COVID-19. The proposed project utilizes the ACN infrastructure to create a network of church- based testing sites in a segregated and underserved AA neighborhood in Chicago that will provide COVID-19 testing and education as well as linkage to healthcare and social resources. Thirteen ACN pastors who serve predominantly AA congregations in the West Side of Chicago will form a coalition to promote community-wide COVID-19 testing in local churches. Residents of all ages will receive COVID-19 education and free SARS-CoV- 2 PCR testing with rapid turn-around of results from an on-site clinical team, as well as connection to local resources to address social needs, including food, housing, and medical care. Our specific aims are: (1) Conduct a rapid needs assessment to identify barriers to and facilitators of COVID-19 testing to inform a tailored outreach and intervention strategy to increase COVID-19 testing among high-risk AAs; (2) (Primary Aim) Evaluate the impact of the ACN COVID-19 testing intervention on uptake of testing among residents of target high poverty AA neighborhoods in Chicago; (3) Use the RE-AIM framework to assess the reach, adoption, implementation, maintenance and cost of the ACN COVID-19 testing intervention. Our primary analysis uses an interrupted time series framework, which is a quasi-experimental approach, to test whether the ACN testing intervention is successful at increasing uptake of testing by at least 20% among residents in the target neighborhoods. Completion of these aims will provide crucial evidence about the public health utility of this approach and inform efforts to scale this intervention to increase testing uptake in other vulnerable urban areas in Chicago and nationally. |
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