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Barry G. W. Arnason, MD, University of Manitoba - US grants
Affiliations: | Neurology | University of Chicago, Chicago, IL |
Area:
immune cell function in multiple sclerosisWebsite:
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The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
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High-probability grants
According to our matching algorithm, Barry G. W. Arnason is the likely recipient of the following grants.| Years | Recipients | Code | Title / Keywords | Matching score |
|---|---|---|---|---|
| 1985 — 1995 | Arnason, Barry G | T32Activity Code Description: To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas. |
Immunology of Nervous System Diseases @ University of Chicago |
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| 1988 — 1990 | Arnason, Barry G | P01Activity Code Description: For the support of a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme. A program project generally involves the organized efforts of relatively large groups, members of which are conducting research projects designed to elucidate the various aspects or components of this objective. Each research project is usually under the leadership of an established investigator. The grant can provide support for certain basic resources used by these groups in the program, including clinical components, the sharing of which facilitates the total research effort. A program project is directed toward a range of problems having a central research focus, in contrast to the usually narrower thrust of the traditional research project. Each project supported through this mechanism should contribute or be directly related to the common theme of the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence, i.e., a system of research activities and projects directed toward a well-defined research program goal. |
Multiple Sclerosis: a Program Project @ University of Chicago Project 1 is directed towards a systematic study of suppressor cell function in multiple sclerosis. Changes in surface phenotype will be analyzed in conjunction with functional assays looking for liaison or lack of liaison between the two. Effects of activating and abrogating agents will also be determined. Project 2 examines oligodendrocyte plasma membrane and myelin compartments and oligodendrocyte-neuron interactions as well as the effects of proteoglycans and glycoproteins secreted by oligodendrocytes on these interactions. Project 3 examines a unique surface glycoprotein (gp 105) of myelin and oligodendrocytes. Its structure will be determined as will its distribution and hopefully its function. Monoclonal antibodies to gp105 will be raised and cDNA's coding for it obtained. Project 4 is directed towards an antigen-specific immunoglobulin response within the brain using the TMEV virus-mediated demyelinating disease model that he has been studying. He will also develop TMEV-reactive T cell lines and clones and determine the viral epitopes against which they react as well as whether they will react with CNS antigens. Project 5 addresses the potential role of neuroleukin production by astrocytes in immunocyte activation in brain. Project 6 employs patch clamp techniques to study ion channels on oligodendrocytes and on T suppressor cell lines and clones derived from multiple sclerosis patients and controls. |
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| 1991 — 1993 | Arnason, Barry G | P01Activity Code Description: For the support of a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme. A program project generally involves the organized efforts of relatively large groups, members of which are conducting research projects designed to elucidate the various aspects or components of this objective. Each research project is usually under the leadership of an established investigator. The grant can provide support for certain basic resources used by these groups in the program, including clinical components, the sharing of which facilitates the total research effort. A program project is directed toward a range of problems having a central research focus, in contrast to the usually narrower thrust of the traditional research project. Each project supported through this mechanism should contribute or be directly related to the common theme of the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence, i.e., a system of research activities and projects directed toward a well-defined research program goal. |
Multiple Sclerosis--a Program Project @ University of Chicago This program project deals with myelination, demyelination, and remyelination as it pertains to multiple sclerosis (MS). Project 1 is concerned with immunocyte function (particularly that of T suppressor cells and monocytes) in MS and how it can be manipulated so as to favorably influence the course of the disease. Suppressor function is decreased when MS is active, whereas monocyte function is increased. Emphasis is placed on beta2-adrenergic and muscarinic cholinergic receptors on lymphocytes and monocytes and their role in cell function. Both classes of receptor are up-regulated on immunocytes in progressive MS. Project 2 deals with proteoglycans and glycoproteins synthesized by oligodendrocyte known as OMgp which has been cloned and sequenced. The function of OMgp remains to be determined and is a major goal of Project 3. There is reason to believe, based on its structure, that OMgp will prove to be an adhesion molecule. Project 4 is directed towards Theiler's virus-induced demyelination as a model for the demyelination that characterized MS. The goal is to establish the determinants on Theiler's virus responsible for demyelination using molecular biologic techniques. The entire genome of three strains of Theiler's virus has been sequenced which should facilitate this task. Project 6 is directed to a study of the effects of cytokines on ion channels in sympathetic neurons. There are extensive interactions between the various projects and the two cores - Core A administrative and Core B scientific. The latter provides patient and control samples to the various projects. |
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| 1994 — 1995 | Arnason, Barry G | P01Activity Code Description: For the support of a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme. A program project generally involves the organized efforts of relatively large groups, members of which are conducting research projects designed to elucidate the various aspects or components of this objective. Each research project is usually under the leadership of an established investigator. The grant can provide support for certain basic resources used by these groups in the program, including clinical components, the sharing of which facilitates the total research effort. A program project is directed toward a range of problems having a central research focus, in contrast to the usually narrower thrust of the traditional research project. Each project supported through this mechanism should contribute or be directly related to the common theme of the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence, i.e., a system of research activities and projects directed toward a well-defined research program goal. |
@ University of Chicago This program project deals with myelination, demyelination, and remyelination as it pertains to multiple sclerosis (MS). Project 1 is concerned with immunocyte function (particularly that of T suppressor cells and monocytes) in MS and how it can be manipulated so as to favorably influence the course of the disease. Suppressor function is decreased when MS is active, whereas monocyte function is increased. Emphasis is placed on beta2-adrenergic and muscarinic cholinergic receptors on lymphocytes and monocytes and their role in cell function. Both classes of receptor are up-regulated on immunocytes in progressive MS. Project 2 deals with proteoglycans and glycoproteins synthesized by oligodendrocyte known as OMgp which has been cloned and sequenced. The function of OMgp remains to be determined and is a major goal of Project 3. There is reason to believe, based on its structure, that OMgp will prove to be an adhesion molecule. Project 4 is directed towards Theiler's virus-induced demyelination as a model for the demyelination that characterized MS. The goal is to establish the determinants on Theiler's virus responsible for demyelination using molecular biologic techniques. The entire genome of three strains of Theiler's virus has been sequenced which should facilitate this task. Project 6 is directed to a study of the effects of cytokines on ion channels in sympathetic neurons. There are extensive interactions between the various projects and the two cores - Core A administrative and Core B scientific. The latter provides patient and control samples to the various projects. |
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| 1997 — 1999 | Arnason, Barry G | M01Activity Code Description: An award made to an institution solely for the support of a General Clinical Research Center where scientists conduct studies on a wide range of human diseases using the full spectrum of the biomedical sciences. Costs underwritten by these grants include those for renovation, for operational expenses such as staff salaries, equipment, and supplies, and for hospitalization. A General Clinical Research Center is a discrete unit of research beds separated from the general care wards. |
Safety and Efficacy of Ro45-2081 in Multiple Sclerosis Patients @ University of Chicago The primary hypothesis of this study is to determine whether the cumulative number of newly active lesions developing over a treatment period of 24 weeks, as seen on MRI scanning performed every 4 weeks, is 50% lower in any of the three Ro 45-2081 treatment groups as compared to placebo. This study aims to determine whether or not Ro 45-2081 has the potential to halt or prevent disease progression in patients with multiple sclerosis by assessing the rate of newly active lesions seen on MRI. |
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