Area:
Synaptic development, synaptic physiology, synaptic plasticity
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High-probability grants
According to our matching algorithm, Michelle R. Emond is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2002 — 2003 |
Emond, Michelle R |
F31Activity Code Description: To provide predoctoral individuals with supervised research training in specified health and health-related areas leading toward the research degree (e.g., Ph.D.). |
Psd-95 Dynamics and Its Role in Synaptogenesis
DESCRIPTION (provided by applicant): Neuronal communication relies on the localization of specialized proteins to sites of synaptic transmission in both presynaptic and postsynaptic cells. Our research focus is on the characterization of PSD-95, an abundant protein found within the postsynaptic density, and its localization and function during development in dissociated hippocampal neuron cultures. Various GFP-fusion constructs will be used to study PSD-95 trafficking and localization in real time using confocal microscopy and then other synaptic proteins will be analyzed and their relative localization compared to PSD-95 using fusions containing variants of GFP and retrospective immunocytochemistry. The questions to be addressed are as follows: i) are there compensatory mechanisms between the MAGUK family of proteins that regulate their expression? ii) is PSD-95 a determinant factor in the process of synaptogenesis, or merely another protein recruited to the synapse? iii) does PSD-95 play a role in the synaptic targeting and localization of NMDA receptors? Real time analysis of these fundamental processes will significantly contribute to our understanding of synapse formation, a function required for organization of circuits throughout the entire nervous system.
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0.954 |