2002 — 2004 |
Frank, Deborah J |
F32Activity Code Description: To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in specified health-related areas. |
Actin-Microtubule Interaction-Myosin Vi and D-Clip-190
DESCRIPTION (provided by applicant): An important problem in cell and developmental biology is to understand how coordination between the actin and microtubule cytoskeletons is achieved. This proposal aims to address this by exploring the interaction between an actin motor, myosin VI, and a microtubule binding protein, D-CLIP-190. Biochemical assays will be performed to determine how the association between these two proteins is regulated. Furthermore, the interacting domains of these proteins will be mapped. Finally, using reagents developed in the course of this work, the in vivo functional relevance of this interaction will be explored. This work will utilize the fruit fly Drosophila melanogaster as a model system. This system is ideally suited both for biochemical experiments as well as enabling one to address the functions of molecules of interest in many different cell and tissue types in vivo. Because of the molecular and functional conservation of proteins across species, this work should expand our understanding of the interaction between the actin and microtubule cytoskeletons in all organisms. These two cytoskeletal systems are vital to nearly all aspects of cellular function, including those functions that go awry in cancerous states. Thus, learning more about how they function in a coordinated way in normal cells will aid us in understanding the causes and mechanisms of cancer.
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1 |
2003 — 2010 |
Elmesky, Rowhea (co-PI) [⬀] Tate, William (co-PI) [⬀] Jordan, James (co-PI) [⬀] Hardin, Sharonica Addelson, Barbara Granger, Charles (co-PI) [⬀] Miller, Diane Balcerzak, Phyllis Smith, Frieda Frank, Deborah Klein, Christine (co-PI) [⬀] Confrey, Jere (co-PI) [⬀] |
N/AActivity Code Description: No activity code was retrieved: click on the grant title for more information |
St. Louis Center For Inquiry in Science Teaching & Learning
The St. Louis Center for Inquiry in Science Teaching and Learning (CISTL) combines a focus on research into science teaching and learning with a focus on professional development and support needed to bring inquiry-based teaching and learning into K-12 science education in both formal and informal settings. Joining together in this effort are three informal science institutions, two universities, five school districts, one community college system and the Association of Science-Technology Centers (ASTC). CISTL will address the full continuum of science educators -- those entering the field, those in the field and those retooling from one area of expertise to another. Their research agenda focuses on the effect of varying types of collaboration on professional development and the interfaces among the collaborators (education and scientific; formal and informal). A diagnostic tool for assessing strengths and weaknesses in science and inquiry backgrounds will be developed for teachers and other science educators. In addition, the project will create a synergy between research and practice through research based in practice, practice based on research and the translation of results into practical suggestions for educators.
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0.915 |