Andrea Sawczuk - US grants
Affiliations: | Physiology & Biophysics | University of Washington, Seattle, Seattle, WA |
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The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
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High-probability grants
According to our matching algorithm, Andrea Sawczuk is the likely recipient of the following grants.| Years | Recipients | Code | Title / Keywords | Matching score |
|---|---|---|---|---|
| 1993 | Sawczuk, Andrea | K08Activity Code Description: To provide the opportunity for promising medical scientists with demonstrated aptitude to develop into independent investigators, or for faculty members to pursue research aspects of categorical areas applicable to the awarding unit, and aid in filling the academic faculty gap in these shortage areas within health profession's institutions of the country. |
Adaptation in Sustained Motoneuron Discharge @ University of Washington The long-term objective of the proposed research is to understand the contribution of motoneuron discharge properties to long-lasting changes in motor function. Of particular interest is adaptation in firing frequency during sustained repetitive discharge which has been implicated as a contributor to motor fatigue, a significant component of movement control. The two phases of adaptation, early and late, are thought to result from the activity of different membrane conductances. These conductances have not been identified. In this application, there are two specific aims. The first specific aim is to extend pilot studies of hypoglossal motoneuron repetitive discharge by including a more detailed analysis of the role of specific ionic conductances in generating adaptation. Adaptation will be studied in hypoglossal motoneurons of an in vitro rat brainstem slice preparation. The motoneurons will be stimulated intracellularly with constant current pulses of suprathreshold intensity in order to produce 60 second trains of sustained repetitive discharge. The membrane conductances that will be studied with electrophysiologic and pharmacologic manipulations are the Na+-K+ pump, the voltage sensitive Na+ and K+ channels, and the Ca++ mediated K+ channels. Attempts will be made to identify changes in these conductances associated with both early and late adaptation. The second specific aim is to determine if changes in motor fatigue properties are correlated with changes in motoneuron adaptation. The rat model of tardive dyskinesia (TD) will be established as a model for chronic increases in tongue movement. The representation of different muscle fiber types will be compared in the tongue of normal and TD rats to determine whether a change in motor fatigue properties has occurred. Motoneuron discharge will be examined in the same animals for changes in the character of adaptation by the techniques used for the first specific aim. These data will be used to determine if the changes in muscle fiber type are accompanied by changes in motoneuron adaptation. Alterations in specific membrane conductances that relate to the changes in adaptation will also be examined in the motoneurons of these TD animals using electrophysiologic and pharmacologic interventions. The results of the projects for these specific aims are expected to further our understanding of motoneuron discharge patterns and the functional significance of motoneuron adaptation in movement. |
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| 1994 — 1997 | Sawczuk, Andrea | K08Activity Code Description: To provide the opportunity for promising medical scientists with demonstrated aptitude to develop into independent investigators, or for faculty members to pursue research aspects of categorical areas applicable to the awarding unit, and aid in filling the academic faculty gap in these shortage areas within health profession's institutions of the country. |
Adaptation in Sustained Motor Neuron Discharge @ University of Washington The long-term objective of the proposed research is to understand the contribution of motoneuron discharge properties to long-lasting changes in motor function. Of particular interest is adaptation in firing frequency during sustained repetitive discharge which has been implicated as a contributor to motor fatigue, a significant component of movement control. The two phases of adaptation, early and late, are thought to result from the activity of different membrane conductances. These conductances have not been identified. In this application, there are two specific aims. The first specific aim is to extend pilot studies of hypoglossal motoneuron repetitive discharge by including a more detailed analysis of the role of specific ionic conductances in generating adaptation. Adaptation will be studied in hypoglossal motoneurons of an in vitro rat brainstem slice preparation. The motoneurons will be stimulated intracellularly with constant current pulses of suprathreshold intensity in order to produce 60 second trains of sustained repetitive discharge. The membrane conductances that will be studied with electrophysiologic and pharmacologic manipulations are the Na+-K+ pump, the voltage sensitive Na+ and K+ channels, and the Ca++ mediated K+ channels. Attempts will be made to identify changes in these conductances associated with both early and late adaptation. The second specific aim is to determine if changes in motor fatigue properties are correlated with changes in motoneuron adaptation. The rat model of tardive dyskinesia (TD) will be established as a model for chronic increases in tongue movement. The representation of different muscle fiber types will be compared in the tongue of normal and TD rats to determine whether a change in motor fatigue properties has occurred. Motoneuron discharge will be examined in the same animals for changes in the character of adaptation by the techniques used for the first specific aim. These data will be used to determine if the changes in muscle fiber type are accompanied by changes in motoneuron adaptation. Alterations in specific membrane conductances that relate to the changes in adaptation will also be examined in the motoneurons of these TD animals using electrophysiologic and pharmacologic interventions. The results of the projects for these specific aims are expected to further our understanding of motoneuron discharge patterns and the functional significance of motoneuron adaptation in movement. |
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