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High-probability grants
According to our matching algorithm, Arthur D. Loewy is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
1985 — 1993 |
Loewy, Arthur D |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. R37Activity Code Description: To provide long-term grant support to investigators whose research competence and productivity are distinctly superior and who are highly likely to continue to perform in an outstanding manner. Investigators may not apply for a MERIT award. Program staff and/or members of the cognizant National Advisory Council/Board will identify candidates for the MERIT award during the course of review of competing research grant applications prepared and submitted in accordance with regular PHS requirements. |
Cns Autonomic Pathways: Central Cardiovascular Control
The objective of this grant is to analyze the neural pathways involved in central regulation of the cardiovascular system. Using neuroanatomical transport techniques, we wish to study the efferent connections of specific subnuclei of the nucleus tractus solitarius. The efferent connections of the rostral, intermediate, and caudal regions of the ventral medulla oblongata will be studied with both anterograde and retrograde transport techniques. In some experiments, these will be combined with immunohistochemical methods. The role of substance P in central control of blood pressure will be examined. The descending ventral medulla substance P pathway which appears to regulate the sympathetic outflow will be examined. The objective will be to determine if substance P is synthesized and transported from the ventral medulla to the intermediolateral cell column. The presence of substance P receptors on sympathetic preganglionic neuron will be studied in normal and spontaneously hypertensive rats. Inhibitors of substance P will be used to determine potential differences in blood pressure regulation in hypertensive and normotensive rats. Finally, the regional vascular flow patterns and cardiac output will be examined after chemical excitation of the ventral medulla in normal, sympathectomized, and midbrain transected rats.
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1 |
1992 — 1999 |
Loewy, Arthur D |
R37Activity Code Description: To provide long-term grant support to investigators whose research competence and productivity are distinctly superior and who are highly likely to continue to perform in an outstanding manner. Investigators may not apply for a MERIT award. Program staff and/or members of the cognizant National Advisory Council/Board will identify candidates for the MERIT award during the course of review of competing research grant applications prepared and submitted in accordance with regular PHS requirements. |
Cns Autonomic Pathways--Central Cardiovascular Control
The objective of this grant is to analyze the neural pathways involved in central regulation of the cardiovascular system. Using neuroanatomical transport techniques, we wish to study the efferent connections of specific subnuclei of the nucleus tractus solitarius. The efferent connections of the rostral, intermediate, and caudal regions of the ventral medulla oblongata will be studied with both anterograde and retrograde transport techniques. In some experiments, these will be combined with immunohistochemical methods. The role of substance P in central control of blood pressure will be examined. The descending ventral medulla substance P pathway which appears to regulate the sympathetic outflow will be examined. The objective will be to determine if substance P is synthesized and transported from the ventral medulla to the intermediolateral cell column. The presence of substance P receptors on sympathetic preganglionic neuron will be studied in normal and spontaneously hypertensive rats. Inhibitors of substance P will be used to determine potential differences in blood pressure regulation in hypertensive and normotensive rats. Finally, the regional vascular flow patterns and cardiac output will be examined after chemical excitation of the ventral medulla in normal, sympathectomized, and midbrain transected rats.
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1 |
2000 — 2012 |
Loewy, Arthur D |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Cns Autonomic Pathways: Central Cardiovascular Control
DESCRIPTION (provided by applicant): The research proposed here will provide new information regarding the CNS autonomic circuits that regulate cardiovascular functions. The grant is focused on the nucleus tractus solitarius (NTS) of the rat, in particular, and we will analyze the anatomical connections and functional responses of a newly discovered group of aldosterone- and sodium-sensitive neurons. There neurons co-express both mineralocorticoid receptors and 11 2-hydroxysteroid dehydrogenase type 2 (HSD2) - the critical enzyme that permits aldosterone to bind selectively to mineralocorticoid receptors. The proposed studies are designed to evaluate the central sites that project to these neurons, and establish the putative neurotransmitter systems that regulate them. These include the analysis of inputs from the hypothalamus and selected forebrain sites. In addition, the organization of vagal inputs to the HSD2 neurons will be studied in order to determine the peripheral origin of this innervation. The HSD2 neurons have been hypothesized to be the key neural elements driving salt appetite, and another one of the objectives is to map the efferent connections of one of its major relay sites in the dorsolateral pons called the pre-locus coeruleus nucleus. Another study is designed to generate transgenic rats for conditional cell ablation experiments in which the HSD2-containing of the NTS neurons will be selectively destroyed with diphtheria toxin, and then, these rats will be tested for salt and water intake. The long-term goal of this research is to establish a better understanding of the central sites involved in blood pressure regulation, including gaining new insights into the central pathways which function in sodium homeostasis. PUBLIC HEALTH RELEVANCE: The brain regulates vital functions, including control of blood pressure and heart functions - which depend upon a wide range of feedback signals. One of the important internal bodily messages provides information about the sodium homeostasis, and since salt-induced hypertension is a significant health risk in some humans, research in this area is important. The studies presented here deal with the brain circuits controlling salt intake, and will provide new insights into the brain pathways which control sodium balance and ultimately, central regulation of the cardiovascular system.
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1 |