1985 — 1990 |
Enoch, Jay M |
S07Activity Code Description: To strengthen, balance, and stabilize Public Health Service supported biomedical and behavioral research programs at qualifying institutions through flexible funds, awarded on a formula basis, that permit grantee institutions to respond quickly and effectively to emerging needs and opportunities, to enhance creativity and innovation, to support pilot studies, and to improve research resources, both physical and human. |
Biomedical Research Support @ University of California Berkeley
This application requests funds to upgrade existing computing equipment to meet the data management and statistical computing needs of clinical investigators served by the Columbia University GCRC. Specifically, we request $190,275.25 to purchase a Digital Equipment Corporation VAX 6310 with 32-Mbytes of memory, one 622-Mbyte disk drive, TU81A-Plus tape drive, four DECserver 200 8-port terminal servers, ethernet interfaces for the terminals, and associated cables, licenses and media. The disk drives of the VAX 750 are compatible with the VAX 6310 and will be moved to it. The VAX 6310 will provide approximately 8-10 times the processing throughput of the VAX 750, which is currently operating at capacity. The Columbia University GCRC Information Systems unit is the only multi- user computing installation at the Health Sciences campus specifically serving the clinical research chemistry. PHS-funded projects account for over 90% of annual user connect hours and over 95% of annual cpu hours. The compute-intensive data analytic tasks and I/O demand associated with current utilization has exceeded the capacity of the VAX 750. Every system management and user education step has been taken to increase the capacity and decrease superflous demand upon the system. Despite these efforts, the equipment operates at nearly 100% of cpu capacity during daytime hours and almost all processing time is spent in statistical analyses. This request to expand is partly in response to need for the GCRC to serve as the data management center for large multi-center trials and a steady influx of new single center protocols. Furthermore, planned expansion of the GCRC and pending electronic availability of patient clinical data from Presbyterian Hospital are anticipated to increase the number of clinical investigations. The requested VAX 6310 will enable the GCRC to support the growing demand for clinical research computing services and enable the institution to serve the NIH in multi-center trials.
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1 |
1985 |
Enoch, Jay M |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Clinical Application of Hyperacuity and Related Studies @ University of California Berkeley
perimetry; computer assisted diagnosis; psychophysics; vision disorders; retinal pigment epithelium; retina disorder; human subject;
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1 |
1985 — 1990 |
Enoch, Jay M |
P30Activity Code Description: To support shared resources and facilities for categorical research by a number of investigators from different disciplines who provide a multidisciplinary approach to a joint research effort or from the same discipline who focus on a common research problem. The core grant is integrated with the center's component projects or program projects, though funded independently from them. This support, by providing more accessible resources, is expected to assure a greater productivity than from the separate projects and program projects. |
Core Grant For Vision Research @ University of California Berkeley
We are seeking continued support for Core facilities to be used by researchers who are funded by the National Eye Institute or by other sources. The Core resources requested in this proposal include support for electronics and machine shops, histological and biochemical analysis, and animal care. These facilities are central to the research function and capabilities that make new and collaborative research possible. Research areas of proposed Core grant members include: the influence of lateral interaction on visual resolution, the development of form perception in infancy, motile models of teleost retinal cones, roles of cyclic nucleotides in retinal motility, processing of two-dimensional luminance patterns, inhibitory interactions in visual cortex, electrophysiology of color vision, etiology of reduced visual function, clinical applications of hyperacuity, binocular interaction in normal and abnormal vision, mechanisms of chloride transport in epithelia, computational models of the visual system, Raman studies of excited states in proteins as related to initial photochemical events in visual excitation, immunocytochemical studies of herpatic keratitis, homeostatic properties of retinal pigment epithelium, cytoplasmic free calcium in intact amphibian rods, signal transfer between receptors and bipolar cells, recovery from hard contact lens extended wear, visual development of sensory and motor functions, animal models of developmental visual disorders, and membrane events in retinal neurons. Core facilities have provided resources that would not have been available otherwise. A primary benefit is the availability of highly skilled technical support personnel to perform functions that are utilized by many investigators. The general atmosphere created by the Core is one which fosters collaboration and extended studies of investigations initiated by individual research projects.
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1 |
1985 — 1993 |
Enoch, Jay M |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Etiology of Reduced Visual Function @ University of California Berkeley
The goal of the research is to investigate the functional visual effects of different visual system anomalies using noninvasive tests of function. Basic psychophysical tests, which have been extensively used to study the properties of the normal visual system, are chosen carefully for the clinical situation. These clinical tests allow one to specifically address different levels of response within the visual system. Our present battery of tests includes measurement of retinal photoreceptor function, outer-plexiform and inner-plexiform layer function, optic pathway function (i.e., pre- or post-optic nerve head), and visual cortex function. These "quantitative layer-by-layer perimetry" tests will enable the clinician or researcher to follow (across the various levels of visual processing and in selected visual field areas) the time course of progression, effectiveness of therapy and/or the natural remission of functional disruption. As part of the study of retinal photoreceptor function, we have special interest in the directional sensitivity of the retina, both from a basic and clinical point of view. In particular, we seek to understand mechanisms subserving photoreceptor alignment properties.
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1 |
1985 — 1991 |
Enoch, Jay M |
S03Activity Code Description: Undocumented code - click on the grant title for more information. |
Minority High School Student Research Apprentice Program @ University of California Berkeley
minority institution research support; secondary schools;
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1 |
1987 |
Enoch, Jay M |
S15Activity Code Description: Undocumented code - click on the grant title for more information. |
Weitek 7100 Array Processor and a Ph Stat Controller @ University of California Berkeley
biomedical equipment resource;
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1 |
1988 — 1989 |
Enoch, Jay M |
S15Activity Code Description: Undocumented code - click on the grant title for more information. |
Small Instrumentation Program @ University of California Berkeley
biomedical equipment resource; biomedical equipment purchase;
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1 |
1990 — 1991 |
Enoch, Jay M |
S15Activity Code Description: Undocumented code - click on the grant title for more information. |
Small Instrumentation Grant @ University of California Berkeley
biomedical equipment purchase;
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1 |