Hao Qian, Ph.D.
Affiliations: | 2007-2013 | Institute of Biophysics, Chinese Academy of Sciences, Beijing, Beijing Shi, China | |
| 2013-2021 | CMM | University of California, San Diego, La Jolla, CA | |
| 2021- | School of Medicine | University of Electronic Science and Technology of China, Chengdu Shi, Sichuan Sheng, China |
Area:
Interaction between neurons and oligodendrocytesWebsite:
https://faculty.uestc.edu.cn/qianhao/zh_CN/index.htmGoogle:
"Hao Qian"Bio:
Dr. Qian Hao is a professor within the School of Medicine at the University of Electronic Science and Technology. His research is dedicated to leveraging cutting-edge discoveries in basic neuroscience to propel the development of innovative therapeutic methodologies for neurological disorders. Through his prior contributions, Dr. Qian has elucidated two regulatory loops that oversee neuronal trans-differentiation and has devised an effective protocol for reprogramming human fibroblasts into functional neurons. Furthermore, he has pioneered a revolutionary approach for provoking direct glia-to-neuron transformation in vivo, resulting in the production of new neurons within the mammalian brain. This methodology has demonstrated its capacity to reconstruct impaired neural pathways and alleviate symptoms in animal models of Parkinson's disease, offering promising avenues for the creation of clinically viable treatments for neurodegenerative diseases. Dr. Qian’s findings have been published in prestigious scientific journals such as Nature, Nature Neuroscience, PNAS, among others.
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Mean distance: 106866
Cross-listing: Chemistry Tree
Parents
Sign in to add mentor| Jin-Hui Wang | grad student | 2007-2013 | |
| Xiang-Dong Fu | post-doc | 2013-2021 | (Chemistry Tree) |
Publications
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| Zhang X, Xu J, Hu J, et al. (2024) Cockayne Syndrome Linked to Elevated R-Loops Induced by Stalled RNA Polymerase II during Transcription Elongation. Nature Communications. 15: 6031 |
| Hao Y, Hu J, Xue Y, et al. (2023) Reply to: Ptbp1 deletion does not induce astrocyte-to-neuron conversion. Nature. 618: E8-E13 |
| Qian H, Fu XD. (2021) Brain Repair by Cell Replacement via In Situ Neuronal Reprogramming. Annual Review of Genetics |
| Qian H, Kang X, Hu J, et al. (2020) Author Correction: Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature |
| Qian H, Kang X, Hu J, et al. (2020) Reversing a model of Parkinson's disease with in situ converted nigral neurons. Nature. 582: 550-556 |
| Hu J, Qian H, Xue Y, et al. (2018) PTB/nPTB: master regulators of neuronal fate in mammals. Biophysics Reports. 4: 204-214 |
| Chen L, Chen JY, Huang YJ, et al. (2018) The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations. Molecular Cell. 69: 412-425.e6 |
| Chen L, Chen JY, Zhang X, et al. (2017) R-ChIP Using Inactive RNase H Reveals Dynamic Coupling of R-loops with Transcriptional Pausing at Gene Promoters. Molecular Cell |
| Yang Z, Chen N, Ge R, et al. (2017) Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum. Oncotarget. 8: 72424-72437 |
| Xue Y, Qian H, Hu J, et al. (2016) Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells. Nature Neuroscience |