Panos Zanos, Ph.D.

Affiliations: 
2014-2021 Psychiatry University of Maryland School of Medicine, Baltimore, MD, United States 
 2021- Psychology University of Cyprus, Nicosia, Nicosia, Cyprus 
Area:
opioid addiction, ketamine, rodent models, rapid-acting antidepressants, substance use disorders
Website:
https://zanoslab.com/
Google:
"Panos Zanos"
Bio:

Dr. Zanos is a prominent figure in brain disease research, focusing on innovative therapies for major depressive disorders and related conditions. His groundbreaking work, particularly on the use of ketamine metabolites as rapid-acting antidepressants, has shown promise in transforming depression treatment. Notably, his discoveries have led to a phase I clinical trial with positive outcomes, paving the way for a phase II trial. Despite being an early career researcher, Dr. Zanos has achieved remarkable accomplishments, securing significant grant funding and publishing over 60 peer-reviewed articles in prestigious journals. His research has gained global recognition, with collaborations and partnerships with influential figures in addiction and depression research. Additionally, Dr. Zanos is involved in a groundbreaking clinical trial on ketamine's efficacy in preventing opioid relapse, marking a milestone in Cyprus. Beyond ketamine research, he has contributed to neuropharmacology, exploring oxytocin's role in drug addiction and investigating receptor interactions, genetic vulnerabilities, and sleep disorders in mental health conditions.
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Publications

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Raja SM, Guptill JT, Mack M, et al. (2024) A Phase 1 Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (2R,6R)-Hydroxynorketamine in Healthy Volunteers. Clinical Pharmacology and Therapeutics
Loan Nguyen TM, Guilloux JP, Defaix C, et al. (2024) Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions. Neuropharmacology. 110065
Onisiforou A, Zanos P, Georgiou P. (2024) Molecular signatures of premature aging in Major Depression and Substance Use Disorders. Scientific Data. 11: 698
Onisiforou A, Christodoulou CC, Zamba-Papanicolaou E, et al. (2024) Transcriptomic analysis reveals sex-specific patterns in the hippocampus in Alzheimer's disease. Frontiers in Endocrinology. 15: 1345498
Bendis PC, Zimmerman S, Onisiforou A, et al. (2024) The impact of estradiol on serotonin, glutamate, and dopamine systems. Frontiers in Neuroscience. 18: 1348551
Christodoulou CC, Onisiforou A, Zanos P, et al. (2023) Unraveling the transcriptomic signatures of Parkinson's disease and major depression using single-cell and bulk data. Frontiers in Aging Neuroscience. 15: 1273855
Onisiforou A, Georgiou P, Zanos P. (2023) Role of group II metabotropic glutamate receptors in ketamine's antidepressant actions. Pharmacology, Biochemistry, and Behavior. 223: 173531
Zanos P, Brown KA, Georgiou P, et al. (2023) NMDA RECEPTOR ACTIVATION-DEPENDENT ANTIDEPRESSANT-RELEVANT BEHAVIORAL AND SYNAPTIC ACTIONS OF KETAMINE. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience
Brown KA, Zanos P, Powels CF, et al. (2022) Ketamine preservative benzethonium chloride potentiates hippocampal synaptic transmission and binds neurotransmitter receptors and transporters. Neuropharmacology. 225: 109403
Georgiou P, Zanos P, Mou TM, et al. (2022) Experimenters' sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor. Nature Neuroscience
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