Panos Zanos, Ph.D.
Affiliations: | 2014-2021 | Psychiatry | University of Maryland School of Medicine, Baltimore, MD, United States |
2021- | Psychology | University of Cyprus, Nicosia, Nicosia, Cyprus |
Area:
opioid addiction, ketamine, rodent models, rapid-acting antidepressants, substance use disordersWebsite:
https://zanoslab.com/Google:
"Panos Zanos"Bio:
Dr. Zanos is a prominent figure in brain disease research, focusing on innovative therapies for major depressive disorders and related conditions. His groundbreaking work, particularly on the use of ketamine metabolites as rapid-acting antidepressants, has shown promise in transforming depression treatment. Notably, his discoveries have led to a phase I clinical trial with positive outcomes, paving the way for a phase II trial. Despite being an early career researcher, Dr. Zanos has achieved remarkable accomplishments, securing significant grant funding and publishing over 60 peer-reviewed articles in prestigious journals. His research has gained global recognition, with collaborations and partnerships with influential figures in addiction and depression research. Additionally, Dr. Zanos is involved in a groundbreaking clinical trial on ketamine's efficacy in preventing opioid relapse, marking a milestone in Cyprus. Beyond ketamine research, he has contributed to neuropharmacology, exploring oxytocin's role in drug addiction and investigating receptor interactions, genetic vulnerabilities, and sleep disorders in mental health conditions.
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Parents
Sign in to add mentorAlexis Bailey | grad student | 2010-2013 | University of Surrey (United Kingdom) |
Ian Kitchen | grad student | 2010-2013 | University of Surrey |
Raphaelle Winsky-Sommerer | grad student | 2010-2013 | University of Surrey (United Kingdom) |
Todd D. Gould | post-doc | 2013- | University of Maryland Medical School |
Children
Sign in to add traineeMorfeas Koumas | research assistant | 2023- | University of Cyprus |
Tellos Fatta | research assistant | 2024- | University of Cyprus |
Despina Melanthiou | grad student | 2023- | University of Cyprus |
Stylianos Valiantis | grad student | 2023- | University of Cyprus |
Derrick Phillips | grad student | 2020-2021 | University of Idaho |
Andria Michael | post-doc | 2022- | University of Cyprus |
Anna Onisiforou | post-doc | 2022- | University of Cyprus |
Markos Apostolakis | post-doc | 2023- | University of Cyprus |
Eleftheria Charalambous | post-doc | 2023- | University of Cyprus |
Andrea Georgiou | post-doc | 2023- | University of Cyprus |
Mary Haddad | post-doc | 2024- | University of Cyprus |
Elmar Mammadov | post-doc | 2019-2021 | University of Maryland Baltimore, School of Medicine |
Publications
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Raja SM, Guptill JT, Mack M, et al. (2024) A Phase 1 Assessment of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of (2R,6R)-Hydroxynorketamine in Healthy Volunteers. Clinical Pharmacology and Therapeutics |
Loan Nguyen TM, Guilloux JP, Defaix C, et al. (2024) Ketamine metabolism via hepatic CYP450 isoforms contributes to its sustained antidepressant actions. Neuropharmacology. 110065 |
Onisiforou A, Zanos P, Georgiou P. (2024) Molecular signatures of premature aging in Major Depression and Substance Use Disorders. Scientific Data. 11: 698 |
Onisiforou A, Christodoulou CC, Zamba-Papanicolaou E, et al. (2024) Transcriptomic analysis reveals sex-specific patterns in the hippocampus in Alzheimer's disease. Frontiers in Endocrinology. 15: 1345498 |
Bendis PC, Zimmerman S, Onisiforou A, et al. (2024) The impact of estradiol on serotonin, glutamate, and dopamine systems. Frontiers in Neuroscience. 18: 1348551 |
Christodoulou CC, Onisiforou A, Zanos P, et al. (2023) Unraveling the transcriptomic signatures of Parkinson's disease and major depression using single-cell and bulk data. Frontiers in Aging Neuroscience. 15: 1273855 |
Onisiforou A, Georgiou P, Zanos P. (2023) Role of group II metabotropic glutamate receptors in ketamine's antidepressant actions. Pharmacology, Biochemistry, and Behavior. 223: 173531 |
Zanos P, Brown KA, Georgiou P, et al. (2023) NMDA RECEPTOR ACTIVATION-DEPENDENT ANTIDEPRESSANT-RELEVANT BEHAVIORAL AND SYNAPTIC ACTIONS OF KETAMINE. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience |
Brown KA, Zanos P, Powels CF, et al. (2022) Ketamine preservative benzethonium chloride potentiates hippocampal synaptic transmission and binds neurotransmitter receptors and transporters. Neuropharmacology. 225: 109403 |
Georgiou P, Zanos P, Mou TM, et al. (2022) Experimenters' sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor. Nature Neuroscience |