Kristen J. Brennand, Ph.D.
Affiliations: | 2002-2007 | Molecular and Cellular Biology | Harvard University, Cambridge, MA, United States |
| 2007-2012 | Laboratory of Genetics | Salk Institute for Biological Studies, La Jolla, CA, United States | |
| 2012-2020 | Genetics, Neuroscience, Psychatry | Icahn School of Medicine at Mount Sinai, New York, NY, United States | |
| 2021- | Psychiatry and Genetics | Yale University, New Haven, CT |
Area:
Psychiatric genomics, human induced pluripotent stem cells, CRISPRWebsite:
http://labs.neuroscience.mssm.edu/project/brennand-lab/Google:
"Kristen Brennand"Bio:
My laboratory combines expertise in genetics, neuroscience and stem cells, in order to identify the mechanisms that underlie brain disease. Our focus lies in resolving the convergence of, and complex interplay between, the many risk variants linked to disease, towards the goal of facilitating the clinical translation of genetic findings.
Mean distance: 17.08 (cluster 18) | S | N | B | C | P |
Parents
Sign in to add mentor| Douglas A. Melton | grad student | 2002-2007 | Harvard | |
| (Beta cell replication and differentiation.) | ||||
| Fred H. (Rusty) Gage | post-doc | 2007-2012 | Salk Institute of Biological Studies | |
Children
Sign in to add trainee| Annabel Sen | research assistant | 2020-2024 | |
| Sarah E Williams | grad student | ||
| Michael B. Fernando | grad student | 2019- | Mount Sinai School of Medicine |
| Seok-Man Ho | grad student | 2014-2018 | Mount Sinai School of Medicine |
| Erin Flaherty | grad student | 2015-2019 | Mount Sinai School of Medicine |
| Prashanth Rajarajan | grad student | 2015-2019 | Mount Sinai School of Medicine |
| Thanh Thanh L Nguyen | post-doc | 2022- | Yale |
| Xi Xiao | post-doc | 2022- | Yale |
| Nadine Schrode | post-doc | 2016-2020 | Mount Sinai School of Medicine (DevTree) |
| Meilin Fernandez Garcia | post-doc | 2020-2023 | Yale |
Collaborators
Sign in to add collaborator| Schahram Akbarian | collaborator | Mount Sinai School of Medicine | |
| Paul A. Slesinger | collaborator | Mount Sinai School of Medicine |
BETA: Related publications
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Publications
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| Schrode N, Seah C, Deans PJM, et al. (2021) Analysis framework and experimental design for evaluating synergy-driving gene expression. Nature Protocols |
| Wang M, Li A, Sekiya M, et al. (2020) Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease. Neuron |
| Townsley KG, Brennand KJ, Huckins LM. (2020) Massively parallel techniques for cataloguing the regulome of the human brain. Nature Neuroscience |
| Powell SK, O'Shea C, Brennand KJ, et al. (2020) Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome. Biological Psychiatry |
| Dobrindt K, Hoagland DA, Seah C, et al. (2020) Common genetic variation in humans impacts susceptibility to SARS-CoV-2 infection. Biorxiv : the Preprint Server For Biology |
| Matos MR, Ho SM, Schrode N, et al. (2020) Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomics. Molecular and Cellular Neurosciences. 103532 |
| Powell SK, O'Shea CP, Shannon SR, et al. (2020) Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells. Advances in Neurobiology. 25: 155-206 |
| Breen MS, Browne A, Hoffman GE, et al. (2020) Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism. Molecular Autism. 11: 53 |
| Han L, Zhao X, Benton ML, et al. (2020) Functional annotation of rare structural variation in the human brain. Nature Communications. 11: 2990 |
| Gregory JA, Hoelzli E, Abdelaal R, et al. (2020) Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models. Cells. 9 |