Gary G. Chiang, Ph.D.
Affiliations: | University of California, San Diego, La Jolla, CA |
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"Gary Chiang"Mean distance: 19.6 (cluster 32)
Parents
Sign in to add mentor| Bartholomew M. Sefton | grad student | 2000 | UCSD (Cell Biology Tree) | |
| (Regulation of activation loop phosphorylation in the Lck tyrosine protein kinase.) | ||||
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Publications
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| Jana S, Deo R, Hough RP, et al. (2021) mRNA translation is a therapeutic vulnerability necessary for bladder epithelial transformation. Jci Insight. 6 |
| Reich SH, Sprengeler PA, Chiang GG, et al. (2018) Structure-based Design of Pyridone-aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition. Journal of Medicinal Chemistry |
| Webster KR, Goel VK, Hung IN, et al. (2015) eFT508, a Potent and Selective Mitogen-Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 Inhibitor, Is Efficacious in Preclinical Models of Diffuse Large B-Cell Lymphoma (DLBCL) Blood. 126: 1554-1554 |
| Barile E, De SK, Carlson CB, et al. (2010) Design, synthesis, and structure-activity relationships of 3-ethynyl-1H-indazoles as inhibitors of the phosphatidylinositol 3-kinase signaling pathway. Journal of Medicinal Chemistry. 53: 8368-75 |
| Zhang YW, Otterness DM, Chiang GG, et al. (2005) Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway. Molecular Cell. 19: 607-18 |
| Chiang GG, Abraham RT. (2005) Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. The Journal of Biological Chemistry. 280: 25485-90 |
| Wipf P, Minion DJ, Halter RJ, et al. (2004) Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin. Organic & Biomolecular Chemistry. 2: 1911-20 |
| Chiang GG, Abraham RT. (2004) Determination of the catalytic activities of mTOR and other members of the phosphoinositide-3-kinase-related kinase family. Methods in Molecular Biology (Clifton, N.J.). 281: 125-41 |
| Edinger AL, Linardic CM, Chiang GG, et al. (2003) Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. Cancer Research. 63: 8451-60 |
| Chiang GG, Sefton BM. (2001) Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase. The Journal of Biological Chemistry. 276: 23173-8 |