Travis L. Biechele, Ph.D.

University of Washington, Seattle, Seattle, WA 
Wnt signaling
"Travis Biechele"
Mean distance: 17.6 (cluster 11)


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Randall Moon grad student 2009 University of Washington
 (Chemical -genetic screening identifies novel protein regulators of Wnt /beta -catenin signaling.)
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Chien AJ, Haydu LE, Biechele TL, et al. (2014) Targeted BRAF inhibition impacts survival in melanoma patients with high levels of Wnt/β-catenin signaling. Plos One. 9: e94748
Robin NC, Agoston Z, Biechele TL, et al. (2014) Simvastatin promotes adult hippocampal neurogenesis by enhancing Wnt/β-catenin signaling. Stem Cell Reports. 2: 9-17
James RG, Bosch KA, Kulikauskas RM, et al. (2013) Protein kinase PKN1 represses Wnt/β-catenin signaling in human melanoma cells. The Journal of Biological Chemistry. 288: 34658-70
James RG, Davidson KC, Bosch KA, et al. (2012) WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling. Plos One. 7: e50457
Conrad WH, Swift RD, Biechele TL, et al. (2012) Regulating the response to targeted MEK inhibition in melanoma: enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/β-catenin activation. Cell Cycle (Georgetown, Tex.). 11: 3724-30
Davidson KC, Adams AM, Goodson JM, et al. (2012) Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4. Proceedings of the National Academy of Sciences of the United States of America. 109: 4485-90
Biechele TL, Kulikauskas RM, Toroni RA, et al. (2012) Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma. Science Signaling. 5: ra3
Anastas JN, Biechele TL, Robitaille M, et al. (2012) A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression. Oncogene. 31: 3696-708
Zhou W, Dosey TL, Biechele T, et al. (2011) Assessment of hypoxia inducible factor levels in cancer cell lines upon hypoxic induction using a novel reporter construct. Plos One. 6: e27460
Oikonomopoulos A, Sereti KI, Conyers F, et al. (2011) Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3. Circulation Research. 109: 1363-74
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