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Mark E. Zak, Ph.D.

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
chemistry, biology, and medicine of natural and designed molecules
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"Mark Zak"
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K. C. Nicolaou grad student 2005 Scripps Institute
 (The total synthesis of thiostrepton.)

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Publications

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Zak M, Yuen PW, Liu X, et al. (2016) Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. Journal of Medicinal Chemistry
Oh A, Ho YC, Zak M, et al. (2014) Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. Chembiochem : a European Journal of Chemical Biology. 15: 1121-30
Dragovich PS, Zhao G, Baumeister T, et al. (2014) Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorganic & Medicinal Chemistry Letters. 24: 954-62
Labadie S, Barrett K, Blair WS, et al. (2013) Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 5923-30
Zheng X, Bair KW, Bauer P, et al. (2013) Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorganic & Medicinal Chemistry Letters. 23: 5488-97
Zheng X, Bauer P, Baumeister T, et al. (2013) Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. Journal of Medicinal Chemistry. 56: 6413-33
Gunzner-Toste J, Zhao G, Bauer P, et al. (2013) Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. Bioorganic & Medicinal Chemistry Letters. 23: 3531-8
Zak M, Hurley CA, Ward SI, et al. (2013) Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2. Journal of Medicinal Chemistry. 56: 4764-85
Zheng X, Bauer P, Baumeister T, et al. (2013) Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Journal of Medicinal Chemistry. 56: 4921-37
Savage S, Babu S, Zak M, et al. (2013) Kilogram Synthesis of (S)-3-Aminopyran from l-Glutamic Acid Synlett. 24: 987-990
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