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Mark E. Zak, Ph.D. - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
chemistry, biology, and medicine of natural and designed molecules
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26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Zak M, Yuen PW, Liu X, Patel S, Sampath D, Oeh J, Liederer BM, Wang W, O'Brien T, Xiao Y, Skelton N, Hua R, Sodhi J, Wang Y, Zhang L, et al. Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors. Journal of Medicinal Chemistry. PMID 27541271 DOI: 10.1021/Acs.Jmedchem.6B00697  0.324
2014 Oh A, Ho YC, Zak M, Liu Y, Chen X, Yuen PW, Zheng X, Liu Y, Dragovich PS, Wang W. Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. Chembiochem : a European Journal of Chemical Biology. 15: 1121-30. PMID 24797455 DOI: 10.1002/Cbic.201402023  0.304
2014 Dragovich PS, Zhao G, Baumeister T, Bravo B, Giannetti AM, Ho YC, Hua R, Li G, Liang X, Ma X, O'Brien T, Oh A, Skelton NJ, Wang C, Wang W, ... ... Zak M, et al. Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorganic & Medicinal Chemistry Letters. 24: 954-62. PMID 24433859 DOI: 10.1016/J.Bmcl.2013.12.062  0.317
2013 Labadie S, Barrett K, Blair WS, Chang C, Deshmukh G, Eigenbrot C, Gibbons P, Johnson A, Kenny JR, Kohli PB, Liimatta M, Lupardus PJ, Shia S, Steffek M, Ubhayakar S, ... ... Zak M, et al. Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 5923-30. PMID 24042009 DOI: 10.1016/J.Bmcl.2013.08.082  0.305
2013 Zheng X, Bair KW, Bauer P, Baumeister T, Bowman KK, Buckmelter AJ, Caligiuri M, Clodfelter KH, Feng Y, Han B, Ho YC, Kley N, Li H, Liang X, Liederer BM, ... ... Zak M, et al. Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorganic & Medicinal Chemistry Letters. 23: 5488-97. PMID 24021463 DOI: 10.1016/J.Bmcl.2013.08.074  0.319
2013 Zheng X, Bauer P, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Han B, Ho YC, Kley N, Lin J, Reynolds DJ, Sharma G, Smith CC, Wang Z, Dragovich PS, ... ... Zak M, et al. Structure-based discovery of novel amide-containing nicotinamide phosphoribosyltransferase (nampt) inhibitors. Journal of Medicinal Chemistry. 56: 6413-33. PMID 23859118 DOI: 10.1021/Jm4008664  0.315
2013 Gunzner-Toste J, Zhao G, Bauer P, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Fu B, Han B, Ho YC, Kley N, Liang X, Liederer BM, Lin J, Mukadam S, ... ... Zak M, et al. Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. Bioorganic & Medicinal Chemistry Letters. 23: 3531-8. PMID 23668988 DOI: 10.1016/J.Bmcl.2013.04.040  0.31
2013 Zak M, Hurley CA, Ward SI, Bergeron P, Barrett K, Balazs M, Blair WS, Bull R, Chakravarty P, Chang C, Crackett P, Deshmukh G, DeVoss J, Dragovich PS, Eigenbrot C, et al. Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2. Journal of Medicinal Chemistry. 56: 4764-85. PMID 23659214 DOI: 10.1021/Jm4004895  0.301
2013 Zheng X, Bauer P, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Han B, Ho YC, Kley N, Lin J, Reynolds DJ, Sharma G, Smith CC, Wang Z, Dragovich PS, ... ... Zak M, et al. Structure-based identification of ureas as novel nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Journal of Medicinal Chemistry. 56: 4921-37. PMID 23617784 DOI: 10.1021/Jm400186H  0.301
2013 Savage S, Babu S, Zak M, Mao Z, Cao J, Ge Y, Ma D, Jiang G. Kilogram Synthesis of (S)-3-Aminopyran from l-Glutamic Acid Synlett. 24: 987-990. DOI: 10.1055/S-0033-1338422  0.474
2012 Labadie S, Dragovich PS, Barrett K, Blair WS, Bergeron P, Chang C, Deshmukh G, Eigenbrot C, Ghilardi N, Gibbons P, Hurley CA, Johnson A, Kenny JR, Kohli PB, Kulagowski JJ, ... ... Zak M, et al. Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2. Bioorganic & Medicinal Chemistry Letters. 22: 7627-33. PMID 23107482 DOI: 10.1016/J.Bmcl.2012.10.008  0.323
2012 Zak M, Mendonca R, Balazs M, Barrett K, Bergeron P, Blair WS, Chang C, Deshmukh G, Devoss J, Dragovich PS, Eigenbrot C, Ghilardi N, Gibbons P, Gradl S, Hamman C, et al. Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2. Journal of Medicinal Chemistry. 55: 6176-93. PMID 22698084 DOI: 10.1021/Jm300628C  0.311
2005 Nicolaou KC, Zak M, Rahimipour S, Estrada AA, Lee SH, O'Brate A, Giannakakou P, Ghadiri MR. Discovery of a biologically active thiostrepton fragment. Journal of the American Chemical Society. 127: 15042-4. PMID 16248640 DOI: 10.1021/Ja0552803  0.693
2005 Nicolaou KC, Zak M, Safina BS, Estrada AA, Lee SH, Nevalainen M. Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis Journal of the American Chemical Society. 127: 11176-11183. PMID 16076225 DOI: 10.1021/Ja052934Z  0.774
2005 Nicolaou KC, Safina BS, Zak M, Lee SH, Nevalainen M, Bella M, Estrada AA, Funke C, Zécri FJ, Bulat S. Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks. Journal of the American Chemical Society. 127: 11159-75. PMID 16076224 DOI: 10.1021/Ja0529337  0.774
2005 Nicolaou KC, Sang HL, Estrada AA, Zak M. Construction of substituted N-hydroxyindoles: Synthesis of a nocathiacin I model system Angewandte Chemie - International Edition. 44: 3736-3740. PMID 15892095 DOI: 10.1002/Anie.200500724  0.752
2005 Nicolaou KC, Estrada AA, Zak M, Lee SH, Safina BS. A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide Angewandte Chemie - International Edition. 44: 1378-1382. PMID 15674985 DOI: 10.1002/Anie.200462207  0.713
2005 Nicolaou K, Safina B, Zak M, Lee S, Navalainen M, Bella M, Estrada A, Funke C, Zecri F, Bulat S. Synthesis of Thiostrepton Synfacts. 2006: 0014-0014. DOI: 10.1055/S-2005-921667  0.766
2005 Nicolaou KC, Lee SH, Estrada AA, Zak M. Construction of Substituted N-Hydroxyindoles Synfacts. 2005: 199-199. DOI: 10.1055/S-2005-916069  0.703
2004 Nicolaou KC, Safina BS, Zak M, Estrada AA, Lee SH. Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle. Angewandte Chemie (International Ed. in English). 43: 5087-92. PMID 15372631 DOI: 10.1002/Anie.200461340  0.79
2004 Nicolaou KC, Zak M, Safina BS, Lee SH, Estrada AA. Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis. Angewandte Chemie (International Ed. in English). 43: 5092-7. PMID 15372630 DOI: 10.1002/Anie.200461341  0.779
2003 Nicolaou KC, Nevalainen M, Zak M, Bulat S, Bella M, Safina BS. Synthetic studies on thiostrepton: construction of thiostrepton analogues with the thiazoline-containing macrocycle. Angewandte Chemie (International Ed. in English). 42: 3418-24. PMID 12888975 DOI: 10.1002/Anie.200351745  0.776
2002 Nicolaou KC, Nevalainen M, Safina BS, Zak M, Bulat S. A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton. Angewandte Chemie (International Ed. in English). 41: 1941-5. PMID 19750640 DOI: 10.1002/1521-3773(20020603)41:11<1941::Aid-Anie1941>3.0.Co;2-V  0.723
2002 Nicolaou KC, Safina BS, Funke C, Zak M, Zécri FJ. Stereocontrolled synthesis of the quinaldic acid macrocyclic system of thiostrepton. Angewandte Chemie (International Ed. in English). 41: 1937-40. PMID 19750639 DOI: 10.1002/1521-3773(20020603)41:11<1937::Aid-Anie1937>3.0.Co;2-Y  0.76
2002 Gravel M, Thompson KA, Zak M, Bérubé C, Hall DG. Universal solid-phase approach for the immobilization, derivatization, and resin-to-resin transfer reactions of boronic acids. The Journal of Organic Chemistry. 67: 3-15. PMID 11777432 DOI: 10.1021/Jo0106501  0.383
2000 Wang X, Zak M, Maddess M, O’Shea P, Tillyer R, Grabowski E, Reider PJ. Highly asymmetric dihydroxylation of 1-aryl-1′-pyridyl alkenes Tetrahedron Letters. 41: 4865-4869. DOI: 10.1016/S0040-4039(00)00741-3  0.386
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