Steven C. Leiser, Ph.D.

Affiliations: 
Synaptic Transmission Lundbeck Research USA 
Area:
Electrophysiology
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"Steven Leiser"
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Cross-listing: PsychTree

Parents

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John K. Chapin research assistant 1999 Drexel
Karen A. Moxon grad student 2005 Drexel Medical School
 (Fundamental properties of rapidly and slowly adapting cells in the trigeminal ganglion of the awake freely moving rat.)
Rita J. Valentino post-doc Children’s Hospital of Philadelphia / University of Pennsylvania
BETA: Related publications

Publications

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Laursen B, Bundgaard CH, Graversen C, et al. (2017) Acute dosing of vortioxetine strengthens event-related brain activity associated with engagement of attention and cognitive functioning in rats. Brain Research
Amat-Foraster M, Leiser SC, Herrik KF, et al. (2016) The 5-HT6 receptor antagonist idalopirdine potentiates the effects of donepezil on gamma oscillations in the frontal cortex of anesthetized and awake rats without affecting sleep-wake architecture. Neuropharmacology
Leiser SC, Iglesias-Bregna D, Westrich L, et al. (2015) Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 2, pharmacological interactions in rodents suggest a role of serotonin-3 receptor antagonism. Journal of Psychopharmacology (Oxford, England). 29: 1092-105
Leiser SC, Li Y, Pehrson AL, et al. (2015) Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine. Acs Chemical Neuroscience. 6: 970-86
Leiser SC, Foraster MA, Herrik KF, et al. (2015) P2-319: The 5-ht6 receptor antagonist idalopirdine in combination with donepezil potentiates theta and gamma eeg oscillations in the frontal cortex of the freely moving rat Alzheimer's & Dementia. 11: P616-P617
Dale E, Zhang H, Leiser SC, et al. (2014) Vortioxetine disinhibits pyramidal cell function and enhances synaptic plasticity in the rat hippocampus. Journal of Psychopharmacology (Oxford, England). 28: 891-902
Leiser SC, Pehrson AL, Robichaud PJ, et al. (2014) Multimodal antidepressant vortioxetine increases frontal cortical oscillations unlike escitalopram and duloxetine--a quantitative EEG study in rats. British Journal of Pharmacology. 171: 4255-72
Corbett BF, Leiser SC, Ling HP, et al. (2013) Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7020-6
Mørk A, Pehrson A, Betry C, et al. (2013) P.2.e.002 Vortioxetine (Lu AA21004), a multimodal antidepressant: differentiation from current antidepressants in animal models of depression European Neuropsychopharmacology. 23: S392-S393
Curtis AL, Leiser SC, Snyder K, et al. (2012) Predator stress engages corticotropin-releasing factor and opioid systems to alter the operating mode of locus coeruleus norepinephrine neurons. Neuropharmacology. 62: 1737-45
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